UniProtKB - Q96P09 (BIRC8_HUMAN)
Protein
Baculoviral IAP repeat-containing protein 8
Gene
BIRC8
Organism
Homo sapiens (Human)
Status
Functioni
Protects against apoptosis mediated by BAX.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 39 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 42 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 59 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 66 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 189 – 224 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- negative regulation of apoptotic process Source: GO_Central
- positive regulation of canonical Wnt signaling pathway Source: GO_Central
- positive regulation of protein ubiquitination Source: GO_Central
- regulation of cell cycle Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96P09 |
SignaLinki | Q96P09 |
Protein family/group databases
MEROPSi | I32.008 |
Names & Taxonomyi
Protein namesi | Recommended name: Baculoviral IAP repeat-containing protein 8Alternative name(s): Inhibitor of apoptosis-like protein 2 Short name: IAP-like protein 2 Short name: ILP-2 Testis-specific inhibitor of apoptosis |
Gene namesi | Name:BIRC8 Synonyms:ILP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14878, BIRC8 |
neXtProti | NX_Q96P09 |
VEuPathDBi | HostDB:ENSG00000163098.4 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytoskeleton
- spindle microtubule Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
PharmGKBi | PA25365 |
Miscellaneous databases
Pharosi | Q96P09, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5851 |
Genetic variation databases
BioMutai | BIRC8 |
DMDMi | 311033354 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122363 | 1 – 236 | Baculoviral IAP repeat-containing protein 8Add BLAST | 236 |
Proteomic databases
MassIVEi | Q96P09 |
PaxDbi | Q96P09 |
PeptideAtlasi | Q96P09 |
PRIDEi | Q96P09 |
ProteomicsDBi | 77588 |
PTM databases
iPTMneti | Q96P09 |
PhosphoSitePlusi | Q96P09 |
Expressioni
Tissue specificityi
Testis specific in normal tissues.
Gene expression databases
Bgeei | ENSG00000163098, Expressed in testis and 5 other tissues |
Organism-specific databases
HPAi | ENSG00000163098, Tissue enriched (testis) |
Interactioni
Subunit structurei
Binds to caspase-9.
Protein-protein interaction databases
BioGRIDi | 125186, 19 interactors |
IntActi | Q96P09, 15 interactors |
STRINGi | 9606.ENSP00000412957 |
Chemistry databases
BindingDBi | Q96P09 |
Miscellaneous databases
RNActi | Q96P09, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96P09 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96P09 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 70 | BIRAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the IAP family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 189 – 224 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1101, Eukaryota |
HOGENOMi | CLU_016347_2_0_1 |
InParanoidi | Q96P09 |
OMAi | HCGGGLA |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q96P09 |
TreeFami | TF105356 |
Family and domain databases
CDDi | cd00022, BIR, 1 hit cd14395, UBA_BIRC4_8, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR042579, XIAP/BIRC8_UBA IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00653, BIR, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 1 hit PS50143, BIR_REPEAT_2, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96P09-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK
60 70 80 90 100
PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS
110 120 130 140 150
LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLEVLV
160 170 180 190 200
ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV
210 220 230
FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055944 | 156 | A → T. Corresponds to variant dbSNP:rs35880972Ensembl. | 1 | |
Natural variantiVAR_055945 | 165 | L → S. Corresponds to variant dbSNP:rs34092035Ensembl. | 1 | |
Natural variantiVAR_028282 | 196 | H → Y2 PublicationsCorresponds to variant dbSNP:rs8109165Ensembl. | 1 | |
Natural variantiVAR_055946 | 225 | A → T. Corresponds to variant dbSNP:rs35700345Ensembl. | 1 | |
Natural variantiVAR_055947 | 225 | A → V. Corresponds to variant dbSNP:rs34683072Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF420440 mRNA Translation: AAL30369.1 AF164682 Genomic DNA Translation: AAK81892.1 AC092070 Genomic DNA No translation available. BC071665 mRNA Translation: AAH71665.2 |
RefSeqi | NP_203127.3, NM_033341.4 |
Genome annotation databases
UCSCi | uc002qbk.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF420440 mRNA Translation: AAL30369.1 AF164682 Genomic DNA Translation: AAK81892.1 AC092070 Genomic DNA No translation available. BC071665 mRNA Translation: AAH71665.2 |
RefSeqi | NP_203127.3, NM_033341.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XB0 | X-ray | 2.20 | A/B/C/D/E/F | 1-95 | [»] | |
1XB1 | X-ray | 2.70 | A/B/C/D/E/F | 1-95 | [»] | |
SMRi | Q96P09 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125186, 19 interactors |
IntActi | Q96P09, 15 interactors |
STRINGi | 9606.ENSP00000412957 |
Chemistry databases
BindingDBi | Q96P09 |
ChEMBLi | CHEMBL5851 |
Protein family/group databases
MEROPSi | I32.008 |
PTM databases
iPTMneti | Q96P09 |
PhosphoSitePlusi | Q96P09 |
Genetic variation databases
BioMutai | BIRC8 |
DMDMi | 311033354 |
Proteomic databases
MassIVEi | Q96P09 |
PaxDbi | Q96P09 |
PeptideAtlasi | Q96P09 |
PRIDEi | Q96P09 |
ProteomicsDBi | 77588 |
Protocols and materials databases
DNASUi | 112401 |
Genome annotation databases
UCSCi | uc002qbk.4, human |
Organism-specific databases
GeneCardsi | BIRC8 |
HGNCi | HGNC:14878, BIRC8 |
HPAi | ENSG00000163098, Tissue enriched (testis) |
neXtProti | NX_Q96P09 |
PharmGKBi | PA25365 |
VEuPathDBi | HostDB:ENSG00000163098.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1101, Eukaryota |
HOGENOMi | CLU_016347_2_0_1 |
InParanoidi | Q96P09 |
OMAi | HCGGGLA |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q96P09 |
TreeFami | TF105356 |
Enzyme and pathway databases
PathwayCommonsi | Q96P09 |
SignaLinki | Q96P09 |
Miscellaneous databases
BioGRID-ORCSi | 112401, 7 hits in 983 CRISPR screens |
EvolutionaryTracei | Q96P09 |
GenomeRNAii | 112401 |
Pharosi | Q96P09, Tchem |
PROi | PR:Q96P09 |
RNActi | Q96P09, protein |
Gene expression databases
Bgeei | ENSG00000163098, Expressed in testis and 5 other tissues |
Family and domain databases
CDDi | cd00022, BIR, 1 hit cd14395, UBA_BIRC4_8, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR042579, XIAP/BIRC8_UBA IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00653, BIR, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 1 hit SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 1 hit PS50143, BIR_REPEAT_2, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIRC8_HUMAN | |
Accessioni | Q96P09Primary (citable) accession number: Q96P09 Secondary accession number(s): Q6IPY1, Q96RW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2002 |
Last sequence update: | November 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families