BIRC8

Functionⁱ

Protects against apoptosis mediated by BAX.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	39	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	42	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	59	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	66	ZincPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	189 – 224	RING-typePROSITE-ProRule annotationAdd BLAST		36

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
ubiquitin protein ligase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of canonical Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q96P09

SignaLinkⁱ

Q96P09

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I32.008

MEROPSⁱ

I32.008

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Baculoviral IAP repeat-containing protein 8 Alternative name(s): Inhibitor of apoptosis-like protein 2 Short name: IAP-like protein 2 Short name: ILP-2 Testis-specific inhibitor of apoptosis
Gene namesⁱ	Name:BIRC8 Synonyms:ILP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163098.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14878 BIRC8
neXtProtⁱ	NX_Q96P09

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	112401
Open Targets More...OpenTargetsⁱ	ENSG00000163098
PharmGKBⁱ	PA25365

Chemistry databases

ChEMBLⁱ	CHEMBL5851

ChEMBLⁱ

CHEMBL5851

Polymorphism and mutation databases

BioMutaⁱ	BIRC8
DMDMⁱ	311033354

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122363	1 – 236	Baculoviral IAP repeat-containing protein 8Add BLAST		236

Proteomic databases

PaxDbⁱ	Q96P09
PeptideAtlas More...PeptideAtlasⁱ	Q96P09
PRIDEⁱ	Q96P09
ProteomicsDBⁱ	77588

PTM databases

iPTMnetⁱ	Q96P09
PhosphoSitePlusⁱ	Q96P09

Expressionⁱ

Tissue specificityⁱ

Testis specific in normal tissues.

Gene expression databases

Bgeeⁱ	ENSG00000163098 Expressed in 5 organ(s), highest expression level in testis
CleanExⁱ	HS_BIRC8

Interactionⁱ

Subunit structureⁱ

Binds to caspase-9.

Protein-protein interaction databases

BioGridⁱ	125186, 18 interactors
IntActⁱ	Q96P09, 9 interactors
STRINGⁱ	9606.ENSP00000412957

Chemistry databases

BindingDBⁱ

Q96P09

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 8	Combined sources	5
Helixⁱ	9 – 11	Combined sources	3
Beta strandⁱ	16 – 18	Combined sources	3
Helixⁱ	20 – 25	Combined sources	6
Beta strandⁱ	28 – 30	Combined sources	3
Beta strandⁱ	37 – 39	Combined sources	3
Turnⁱ	40 – 42	Combined sources	3
Beta strandⁱ	45 – 48	Combined sources	4
Helixⁱ	55 – 62	Combined sources	8
Helixⁱ	67 – 73	Combined sources	7
Helixⁱ	75 – 81	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96P09
SMRⁱ	Q96P09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q96P09

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	7 – 70	BIRAdd BLAST		64

Sequence similaritiesⁱ

Belongs to the IAP family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	189 – 224	RING-typePROSITE-ProRule annotationAdd BLAST		36

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044782
HOGENOMⁱ	HOG000232059
HOVERGENⁱ	HBG104450
InParanoidⁱ	Q96P09
KEGG Orthology (KO) More...KOⁱ	K16061
OMAⁱ	HCGGGLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CXH
PhylomeDBⁱ	Q96P09
TreeFamⁱ	TF105356

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00022 BIR, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00653 BIR, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 1 hit SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282 BIR_REPEAT_1, 1 hit PS50143 BIR_REPEAT_2, 1 hit PS50089 ZF_RING_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96P09-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK 
        60         70         80         90        100
PKEDPWEQHA KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS 
       110        120        130        140        150
LTKRISDTIF PNPMLQEAIR MGFDFKDVKK IMEERIQTSG SNYKTLEVLV 
       160        170        180        190        200
ADLVSAQKDT TENELNQTSL QREISPEEPL RRLQEEKLCK ICMDRHIAVV 
       210        220        230 
FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS

Length:236

Mass (Da):27,089

Last modified:November 2, 2010 - v2

Checksum:ⁱDF3A170E0DDFAD9D

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055944	156	A → T. Corresponds to variant dbSNP:rs35880972Ensembl.	1
Natural variantⁱVAR_055945	165	L → S. Corresponds to variant dbSNP:rs34092035Ensembl.	1
Natural variantⁱVAR_028282	196	H → Y2 PublicationsCorresponds to variant dbSNP:rs8109165Ensembl.	1
Natural variantⁱVAR_055946	225	A → T. Corresponds to variant dbSNP:rs35700345Ensembl.	1
Natural variantⁱVAR_055947	225	A → V. Corresponds to variant dbSNP:rs34683072Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF420440 mRNA Translation: AAL30369.1 AF164682 Genomic DNA Translation: AAK81892.1 AC092070 Genomic DNA No translation available. BC071665 mRNA Translation: AAH71665.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12863.1
NCBI Reference Sequences More...RefSeqⁱ	NP_203127.3, NM_033341.4
UniGeneⁱ	Hs.348263

Genome annotation databases

Ensemblⁱ	ENST00000426466; ENSP00000412957; ENSG00000163098
GeneIDⁱ	112401
KEGGⁱ	hsa:112401
UCSC genome browser More...UCSCⁱ	uc002qbk.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96P09	Baculoviral IAP repeat-containing protein 8		GORGO		236	UniRef90_Q96P09
Baculoviral IAP repeat-containing 8		HUMAN		236

Protein	Similar proteins		Species	Score	Length	Source
Q96P09	Baculoviral IAP repeat-containing protein 8		GORGO		236	UniRef50_Q96P09
Baculoviral IAP repeat-containing 8		HUMAN		236
E3 ubiquitin-protein ligase XIAP (Fragment)		APAVI		214
Baculoviral IAP repeat-containing 4 (Predicted)		OTOGA		236
Uncharacterized protein		CHLSB		236
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF420440 mRNA Translation: AAL30369.1 AF164682 Genomic DNA Translation: AAK81892.1 AC092070 Genomic DNA No translation available. BC071665 mRNA Translation: AAH71665.2
CCDSⁱ	CCDS12863.1
RefSeqⁱ	NP_203127.3, NM_033341.4
UniGeneⁱ	Hs.348263

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XB0	X-ray	2.20	A/B/C/D/E/F	1-95	[»]
	1XB1	X-ray	2.70	A/B/C/D/E/F	1-95	[»]
ProteinModelPortalⁱ	Q96P09
SMRⁱ	Q96P09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125186, 18 interactors
IntActⁱ	Q96P09, 9 interactors
STRINGⁱ	9606.ENSP00000412957

Chemistry databases

BindingDBⁱ	Q96P09
ChEMBLⁱ	CHEMBL5851

Protein family/group databases

MEROPSⁱ	I32.008

MEROPSⁱ

I32.008

PTM databases

iPTMnetⁱ	Q96P09
PhosphoSitePlusⁱ	Q96P09

Polymorphism and mutation databases

BioMutaⁱ	BIRC8
DMDMⁱ	311033354

Proteomic databases

PaxDbⁱ	Q96P09
PeptideAtlasⁱ	Q96P09
PRIDEⁱ	Q96P09
ProteomicsDBⁱ	77588

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	112401
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000426466; ENSP00000412957; ENSG00000163098
GeneIDⁱ	112401
KEGGⁱ	hsa:112401
UCSCⁱ	uc002qbk.4 human

Organism-specific databases

CTDⁱ	112401
DisGeNETⁱ	112401
EuPathDBⁱ	HostDB:ENSG00000163098.4
GeneCardsⁱ	BIRC8
H-InvDBⁱ	HIX0040006
HGNCⁱ	HGNC:14878 BIRC8
neXtProtⁱ	NX_Q96P09
OpenTargetsⁱ	ENSG00000163098
PharmGKBⁱ	PA25365
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
GeneTreeⁱ	ENSGT00500000044782
HOGENOMⁱ	HOG000232059
HOVERGENⁱ	HBG104450
InParanoidⁱ	Q96P09
KOⁱ	K16061
OMAⁱ	HCGGGLA
OrthoDBⁱ	EOG091G0CXH
PhylomeDBⁱ	Q96P09
TreeFamⁱ	TF105356

Enzyme and pathway databases

SignaLinkⁱ	Q96P09

SignaLinkⁱ

Q96P09

Miscellaneous databases

EvolutionaryTraceⁱ	Q96P09
GenomeRNAiⁱ	112401
Protein Ontology More...PROⁱ	PR:Q96P09

Gene expression databases

Bgeeⁱ	ENSG00000163098 Expressed in 5 organ(s), highest expression level in testis
CleanExⁱ	HS_BIRC8

Family and domain databases

CDDⁱ	cd00022 BIR, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF00653 BIR, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 1 hit SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS01282 BIR_REPEAT_1, 1 hit PS50143 BIR_REPEAT_2, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BIRC8_HUMAN
Accessionⁱ	Q96P09Primary (citable) accession number: Q96P09 Secondary accession number(s): Q6IPY1, Q96RW5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96P09 (BIRC8_HUMAN)

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Baculoviral IAP repeat-containing protein 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ