PRAP1

Functionⁱ

May play an important role in maintaining normal growth homeostasis in epithelial cells.1 Publication

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proline-rich acidic protein 1 Alternative name(s): Epididymis tissue protein Li 178 Uterine-specific proline-rich acidic protein
Gene namesⁱ	Name:PRAP1 Synonyms:UPA ORF Names:UNQ608/PRO1195
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165828.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23304 PRAP1
MIMⁱ	609776 gene
neXtProtⁱ	NX_Q96NZ9

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	118471
Open Targets More...OpenTargetsⁱ	ENSG00000165828
PharmGKBⁱ	PA134981678

Polymorphism and mutation databases

BioMutaⁱ	PRAP1
DMDMⁱ	317373269

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000299416	21 – 151	Proline-rich acidic protein 1Add BLAST		131

Proteomic databases

PaxDbⁱ	Q96NZ9
PeptideAtlas More...PeptideAtlasⁱ	Q96NZ9
PRIDEⁱ	Q96NZ9
ProteomicsDBⁱ	77583 77584 [Q96NZ9-2] 77585 [Q96NZ9-3] 77586 [Q96NZ9-4]

PTM databases

iPTMnetⁱ	Q96NZ9
PhosphoSitePlusⁱ	Q96NZ9

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level).2 Publications

Inductionⁱ

Up-regulated by butyrate, trichostatin A and 5'-aza-2' deoxycytidine.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000165828 Expressed in 99 organ(s), highest expression level in duodenum
CleanExⁱ	HS_PRAP1
ExpressionAtlasⁱ	Q96NZ9 baseline and differential
Genevisibleⁱ	Q96NZ9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038713 HPA052451

HPAⁱ

HPA038713
HPA052451

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
SGTA	O43765	5	EBI-2116102,EBI-347996
UBQLN1	Q9UMX0	5	EBI-2116102,EBI-741480
UBQLN1	Q9UMX0-2	3	EBI-2116102,EBI-10173939
UBQLN2	Q9UHD9	4	EBI-2116102,EBI-947187

Protein-protein interaction databases

BioGridⁱ	125610, 8 interactors
IntActⁱ	Q96NZ9, 10 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96NZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3WZ Eukaryota ENOG4111CMU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012626
HOVERGENⁱ	HBG099538
InParanoidⁱ	Q96NZ9
KEGG Orthology (KO) More...KOⁱ	K21250
PhylomeDBⁱ	Q96NZ9
TreeFamⁱ	TF337049

Family and domain databases

InterProⁱ	View protein in InterPro IPR027922 PRAP
PANTHERⁱ	PTHR37861 PTHR37861, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15314 PRAP, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96NZ9-1) [UniParc]FASTA Add to basket

Also known as: PRAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PEKAWGARVV 
        60         70         80         90        100
EPPEKDDQLV VLFPVQKPKL LTTEEKPRGQ GRGPILPGTK AWMETEDTLG 
       110        120        130        140        150
HVLSPEPDHD SLYHPPPEED QGEERPRLWV MPNHQVLLGP EEDQDHIYHP 

Q

Length:151

Mass (Da):17,208

Last modified:January 11, 2011 - v2

Checksum:ⁱB751EDBFD24D08CA

GO

Isoform 2 (identifier: Q96NZ9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
79-87: Missing.
95-151: TEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ → SRARP

« Hide

        10         20         30         40         50
MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PEKAWGARVV 
        60         70         80         90
EPPEKDDQLV VLFPVQKPKL LTTEEKPRGT KAWMESRARP

Show »

Length:90

Mass (Da):10,259

Checksum:ⁱE8C3C22D12F8E9CC

GO

Isoform 3 (identifier: Q96NZ9-3) [UniParc]FASTA Add to basket

Also known as: PRAPV1

The sequence of this isoform differs from the canonical sequence as follows:
43-43: K → NR

« Hide

        10         20         30         40         50
MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PENRAWGARV 
        60         70         80         90        100
VEPPEKDDQL VVLFPVQKPK LLTTEEKPRG QGRGPILPGT KAWMETEDTL 
       110        120        130        140        150
GHVLSPEPDH DSLYHPPPEE DQGEERPRLW VMPNHQVLLG PEEDQDHIYH 

PQ

Show »

Length:152

Mass (Da):17,350

Checksum:ⁱ026C7D3AE8C988E1

GO

Isoform 4 (identifier: Q96NZ9-4) [UniParc]FASTA Add to basket

Also known as: PRAPV2

The sequence of this isoform differs from the canonical sequence as follows:
79-87: Missing.

« Hide

        10         20         30         40         50
MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PEKAWGARVV 
        60         70         80         90        100
EPPEKDDQLV VLFPVQKPKL LTTEEKPRGT KAWMETEDTL GHVLSPEPDH 
       110        120        130        140 
DSLYHPPPEE DQGEERPRLW VMPNHQVLLG PEEDQDHIYH PQ

Show »

Length:142

Mass (Da):16,332

Checksum:ⁱ149282D65B6346E6

GO

Sequence cautionⁱ

The sequence AAP97247 differs from that shown. Reason: Frameshift at positions 81 and 86.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034815	54	E → G1 Publication	1
Natural variantⁱVAR_034816	69	K → R1 Publication	1
Natural variantⁱVAR_034817	81	G → S. Corresponds to variant dbSNP:rs34780987Ensembl.	1
Natural variantⁱVAR_034818	101	H → R6 PublicationsCorresponds to variant dbSNP:rs4369319Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_027660	43	K → NR in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_027661	79 – 87	Missing in isoform 2 and isoform 4. 2 Publications	9
Alternative sequenceⁱVSP_027662	95 – 151	TEDTL…IYHPQ → SRARP in isoform 2. 1 PublicationAdd BLAST	57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF421885 mRNA Translation: AAL16670.1 AY158074 mRNA Translation: AAN87018.1 AF123768 mRNA Translation: AAP97247.1 Frameshift. AY358908 mRNA Translation: AAQ89267.1 GU727628 mRNA Translation: ADU87630.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61336.1 BC029447 mRNA Translation: AAH29447.2 BC061643 mRNA Translation: AAH61643.1 BC071872 mRNA Translation: AAH71872.1 BC093853 mRNA Translation: AAH93853.1 BC101743 mRNA Translation: AAI01744.1 BC143590 mRNA Translation: AAI43591.1 BC143592 mRNA Translation: AAI43593.1 BC143591 mRNA Translation: AAI43592.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44498.1 [Q96NZ9-4] CCDS7679.1 [Q96NZ9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138673.1, NM_001145201.1 [Q96NZ9-4] NP_660203.3, NM_145202.4 [Q96NZ9-1]
UniGeneⁱ	Hs.15951

Genome annotation databases

Ensemblⁱ	ENST00000433452; ENSP00000416126; ENSG00000165828 [Q96NZ9-1] ENST00000463201; ENSP00000486265; ENSG00000165828 [Q96NZ9-4]
GeneIDⁱ	118471
KEGGⁱ	hsa:118471
UCSC genome browser More...UCSCⁱ	uc001lmp.3 human [Q96NZ9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96NZ9	Isoform 3 of Proline-rich acidic protein 1		HUMAN		152	UniRef90_Q96NZ9
Uncharacterized protein		PANPA		151
Proline rich acidic protein 1		GORGO		150
Zinc finger protein 511		PANTR		128
Proline-rich acidic protein 1		HUMAN		142
+10

Protein	Similar proteins		Species	Score	Length	Source
Q96NZ9	Isoform 3 of Proline-rich acidic protein 1		HUMAN		152	UniRef50_Q96NZ9
Uncharacterized protein		PANPA		151
Proline rich acidic protein 1		GORGO		150
Zinc finger protein 511		PANTR		128
Uncharacterized protein		COLAP		145
+39
Q96NZ9-2	Uncharacterized protein		RABIT		100	UniRef50_Q96NZ9-2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF421885 mRNA Translation: AAL16670.1 AY158074 mRNA Translation: AAN87018.1 AF123768 mRNA Translation: AAP97247.1 Frameshift. AY358908 mRNA Translation: AAQ89267.1 GU727628 mRNA Translation: ADU87630.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61336.1 BC029447 mRNA Translation: AAH29447.2 BC061643 mRNA Translation: AAH61643.1 BC071872 mRNA Translation: AAH71872.1 BC093853 mRNA Translation: AAH93853.1 BC101743 mRNA Translation: AAI01744.1 BC143590 mRNA Translation: AAI43591.1 BC143592 mRNA Translation: AAI43593.1 BC143591 mRNA Translation: AAI43592.1
CCDSⁱ	CCDS44498.1 [Q96NZ9-4] CCDS7679.1 [Q96NZ9-1]
RefSeqⁱ	NP_001138673.1, NM_001145201.1 [Q96NZ9-4] NP_660203.3, NM_145202.4 [Q96NZ9-1]
UniGeneⁱ	Hs.15951

3D structure databases

ProteinModelPortalⁱ	Q96NZ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125610, 8 interactors
IntActⁱ	Q96NZ9, 10 interactors

PTM databases

iPTMnetⁱ	Q96NZ9
PhosphoSitePlusⁱ	Q96NZ9

Polymorphism and mutation databases

BioMutaⁱ	PRAP1
DMDMⁱ	317373269

Proteomic databases

PaxDbⁱ	Q96NZ9
PeptideAtlasⁱ	Q96NZ9
PRIDEⁱ	Q96NZ9
ProteomicsDBⁱ	77583 77584 [Q96NZ9-2] 77585 [Q96NZ9-3] 77586 [Q96NZ9-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	118471
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000433452; ENSP00000416126; ENSG00000165828 [Q96NZ9-1] ENST00000463201; ENSP00000486265; ENSG00000165828 [Q96NZ9-4]
GeneIDⁱ	118471
KEGGⁱ	hsa:118471
UCSCⁱ	uc001lmp.3 human [Q96NZ9-1]

Organism-specific databases

CTDⁱ	118471
DisGeNETⁱ	118471
EuPathDBⁱ	HostDB:ENSG00000165828.13
GeneCardsⁱ	PRAP1
H-InvDBⁱ	HIX0009332
HGNCⁱ	HGNC:23304 PRAP1
HPAⁱ	HPA038713 HPA052451
MIMⁱ	609776 gene
neXtProtⁱ	NX_Q96NZ9
OpenTargetsⁱ	ENSG00000165828
PharmGKBⁱ	PA134981678
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J3WZ Eukaryota ENOG4111CMU LUCA
GeneTreeⁱ	ENSGT00390000012626
HOVERGENⁱ	HBG099538
InParanoidⁱ	Q96NZ9
KOⁱ	K21250
PhylomeDBⁱ	Q96NZ9
TreeFamⁱ	TF337049

Miscellaneous databases

GenomeRNAiⁱ	118471
Protein Ontology More...PROⁱ	PR:Q96NZ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165828 Expressed in 99 organ(s), highest expression level in duodenum
CleanExⁱ	HS_PRAP1
ExpressionAtlasⁱ	Q96NZ9 baseline and differential
Genevisibleⁱ	Q96NZ9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027922 PRAP
PANTHERⁱ	PTHR37861 PTHR37861, 1 hit
Pfamⁱ	View protein in Pfam PF15314 PRAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRAP1_HUMAN
Accessionⁱ	Q96NZ9Primary (citable) accession number: Q96NZ9 Secondary accession number(s): B7ZL57 Q8NCS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q96NZ9 (PRAP1_HUMAN)

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Proline-rich acidic protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ