UniProtKB - Q96NZ9 (PRAP1_HUMAN)
Proline-rich acidic protein 1
PRAP1
Functioni
Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity).
Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity).
May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459).
Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459).
May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861).
By similarity3 PublicationsGO - Molecular functioni
- triglyceride binding Source: UniProtKB
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to X-ray Source: UniProtKB
- deactivation of mitotic spindle assembly checkpoint Source: UniProtKB
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of intestinal lipid absorption Source: UniProtKB
- positive regulation of phospholipid transport Source: UniProtKB
- positive regulation of triglyceride transport Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96NZ9 |
SignaLinki | Q96NZ9 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-rich acidic protein 1Alternative name(s): Epididymis tissue protein Li 178 Uterine-specific proline-rich acidic protein |
Gene namesi | Name:PRAP1 Synonyms:UPA ORF Names:UNQ608/PRO1195 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23304, PRAP1 |
MIMi | 609776, gene |
neXtProti | NX_Q96NZ9 |
VEuPathDBi | HostDB:ENSG00000165828 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 118471 |
OpenTargetsi | ENSG00000165828 |
PharmGKBi | PA134981678 |
Miscellaneous databases
Pharosi | Q96NZ9, Tbio |
Genetic variation databases
BioMutai | PRAP1 |
DMDMi | 317373269 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000299416 | 21 – 151 | Proline-rich acidic protein 1Add BLAST | 131 |
Proteomic databases
MassIVEi | Q96NZ9 |
PaxDbi | Q96NZ9 |
PeptideAtlasi | Q96NZ9 |
PRIDEi | Q96NZ9 |
ProteomicsDBi | 77584 [Q96NZ9-2] 77585 [Q96NZ9-3] 77586 [Q96NZ9-4] |
PTM databases
GlyGeni | Q96NZ9, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96NZ9 |
PhosphoSitePlusi | Q96NZ9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000165828, Expressed in small intestine and 132 other tissues |
ExpressionAtlasi | Q96NZ9, baseline and differential |
Genevisiblei | Q96NZ9, HS |
Organism-specific databases
HPAi | ENSG00000165828, Group enriched (intestine, liver) |
Interactioni
Subunit structurei
Interacts with isoform 1 and isoform 3 of MAD1L1 (PubMed:24374861).
Interacts with MTTP (By similarity).
By similarity1 PublicationBinary interactionsi
Q96NZ9
Protein-protein interaction databases
BioGRIDi | 125610, 16 interactors |
IntActi | Q96NZ9, 16 interactors |
STRINGi | 9606.ENSP00000416126 |
Miscellaneous databases
RNActi | Q96NZ9, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 71 – 151 | DisorderedSequence analysisAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 101 – 127 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TDVH, Eukaryota |
GeneTreei | ENSGT00390000012626 |
InParanoidi | Q96NZ9 |
OMAi | WVETEDI |
OrthoDBi | 1574174at2759 |
PhylomeDBi | Q96NZ9 |
TreeFami | TF337049 |
Family and domain databases
InterProi | View protein in InterPro IPR027922, PRAP |
PANTHERi | PTHR37861, PTHR37861, 1 hit |
Pfami | View protein in Pfam PF15314, PRAP, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PEKAWGARVV
60 70 80 90 100
EPPEKDDQLV VLFPVQKPKL LTTEEKPRGQ GRGPILPGTK AWMETEDTLG
110 120 130 140 150
HVLSPEPDHD SLYHPPPEED QGEERPRLWV MPNHQVLLGP EEDQDHIYHP
Q
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034815 | 54 | E → G1 Publication | 1 | |
Natural variantiVAR_034816 | 69 | K → R1 Publication | 1 | |
Natural variantiVAR_034817 | 81 | G → S. Corresponds to variant dbSNP:rs34780987Ensembl. | 1 | |
Natural variantiVAR_034818 | 101 | H → R6 PublicationsCorresponds to variant dbSNP:rs4369319Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027660 | 43 | K → NR in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_027661 | 79 – 87 | Missing in isoform 2 and isoform 4. 2 Publications | 9 | |
Alternative sequenceiVSP_027662 | 95 – 151 | TEDTL…IYHPQ → SRARP in isoform 2. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421885 mRNA Translation: AAL16670.1 AY158074 mRNA Translation: AAN87018.1 AF123768 mRNA Translation: AAP97247.1 Frameshift. AY358908 mRNA Translation: AAQ89267.1 GU727628 mRNA Translation: ADU87630.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61336.1 BC029447 mRNA Translation: AAH29447.2 BC061643 mRNA Translation: AAH61643.1 BC071872 mRNA Translation: AAH71872.1 BC093853 mRNA Translation: AAH93853.1 BC101743 mRNA Translation: AAI01744.1 BC143590 mRNA Translation: AAI43591.1 BC143592 mRNA Translation: AAI43593.1 BC143591 mRNA Translation: AAI43592.1 |
CCDSi | CCDS44498.1 [Q96NZ9-4] CCDS7679.1 [Q96NZ9-1] |
RefSeqi | NP_001138673.1, NM_001145201.1 [Q96NZ9-4] NP_660203.3, NM_145202.4 [Q96NZ9-1] |
Genome annotation databases
Ensembli | ENST00000433452; ENSP00000416126; ENSG00000165828 ENST00000463201; ENSP00000486265; ENSG00000165828 [Q96NZ9-4] |
GeneIDi | 118471 |
KEGGi | hsa:118471 |
MANE-Selecti | ENST00000433452.6; ENSP00000416126.2; NM_145202.5; NP_660203.3 |
UCSCi | uc001lmp.3, human [Q96NZ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421885 mRNA Translation: AAL16670.1 AY158074 mRNA Translation: AAN87018.1 AF123768 mRNA Translation: AAP97247.1 Frameshift. AY358908 mRNA Translation: AAQ89267.1 GU727628 mRNA Translation: ADU87630.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61336.1 BC029447 mRNA Translation: AAH29447.2 BC061643 mRNA Translation: AAH61643.1 BC071872 mRNA Translation: AAH71872.1 BC093853 mRNA Translation: AAH93853.1 BC101743 mRNA Translation: AAI01744.1 BC143590 mRNA Translation: AAI43591.1 BC143592 mRNA Translation: AAI43593.1 BC143591 mRNA Translation: AAI43592.1 |
CCDSi | CCDS44498.1 [Q96NZ9-4] CCDS7679.1 [Q96NZ9-1] |
RefSeqi | NP_001138673.1, NM_001145201.1 [Q96NZ9-4] NP_660203.3, NM_145202.4 [Q96NZ9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125610, 16 interactors |
IntActi | Q96NZ9, 16 interactors |
STRINGi | 9606.ENSP00000416126 |
PTM databases
GlyGeni | Q96NZ9, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96NZ9 |
PhosphoSitePlusi | Q96NZ9 |
Genetic variation databases
BioMutai | PRAP1 |
DMDMi | 317373269 |
Proteomic databases
MassIVEi | Q96NZ9 |
PaxDbi | Q96NZ9 |
PeptideAtlasi | Q96NZ9 |
PRIDEi | Q96NZ9 |
ProteomicsDBi | 77584 [Q96NZ9-2] 77585 [Q96NZ9-3] 77586 [Q96NZ9-4] |
Protocols and materials databases
Antibodypediai | 48788, 64 antibodies from 18 providers |
DNASUi | 118471 |
Genome annotation databases
Ensembli | ENST00000433452; ENSP00000416126; ENSG00000165828 ENST00000463201; ENSP00000486265; ENSG00000165828 [Q96NZ9-4] |
GeneIDi | 118471 |
KEGGi | hsa:118471 |
MANE-Selecti | ENST00000433452.6; ENSP00000416126.2; NM_145202.5; NP_660203.3 |
UCSCi | uc001lmp.3, human [Q96NZ9-1] |
Organism-specific databases
CTDi | 118471 |
DisGeNETi | 118471 |
GeneCardsi | PRAP1 |
HGNCi | HGNC:23304, PRAP1 |
HPAi | ENSG00000165828, Group enriched (intestine, liver) |
MIMi | 609776, gene |
neXtProti | NX_Q96NZ9 |
OpenTargetsi | ENSG00000165828 |
PharmGKBi | PA134981678 |
VEuPathDBi | HostDB:ENSG00000165828 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDVH, Eukaryota |
GeneTreei | ENSGT00390000012626 |
InParanoidi | Q96NZ9 |
OMAi | WVETEDI |
OrthoDBi | 1574174at2759 |
PhylomeDBi | Q96NZ9 |
TreeFami | TF337049 |
Enzyme and pathway databases
PathwayCommonsi | Q96NZ9 |
SignaLinki | Q96NZ9 |
Miscellaneous databases
BioGRID-ORCSi | 118471, 3 hits in 1024 CRISPR screens |
ChiTaRSi | PRAP1, human |
GenomeRNAii | 118471 |
Pharosi | Q96NZ9, Tbio |
PROi | PR:Q96NZ9 |
RNActi | Q96NZ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165828, Expressed in small intestine and 132 other tissues |
ExpressionAtlasi | Q96NZ9, baseline and differential |
Genevisiblei | Q96NZ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027922, PRAP |
PANTHERi | PTHR37861, PTHR37861, 1 hit |
Pfami | View protein in Pfam PF15314, PRAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRAP1_HUMAN | |
Accessioni | Q96NZ9Primary (citable) accession number: Q96NZ9 Secondary accession number(s): B7ZL57 Q8NCS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot