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Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

Gene

WFIKKN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei122 – 123Reactive bondPROSITE-ProRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.953

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
Alternative name(s):
Growth and differentiation factor-associated serum protein 2
Short name:
GASP-2
Short name:
hGASP-2
WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WFIKKN1
Synonyms:C16orf12, GASP2, WFIKKN
ORF Names:PSEC0040
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127578.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30912 WFIKKN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608021 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NZ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000127578

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134897686

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WFIKKN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74717044

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030781620 – 548WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 66By similarity
Disulfide bondi49 ↔ 70By similarity
Disulfide bondi53 ↔ 65By similarity
Disulfide bondi59 ↔ 75By similarity
Disulfide bondi116 ↔ 146By similarity
Disulfide bondi120 ↔ 139By similarity
Disulfide bondi128 ↔ 157By similarity
Disulfide bondi207 ↔ 263By similarity
Disulfide bondi299 ↔ 351By similarity
Disulfide bondi306 ↔ 334By similarity
Disulfide bondi326 ↔ 347By similarity
Disulfide bondi359 ↔ 409By similarity
Disulfide bondi368 ↔ 392By similarity
Disulfide bondi384 ↔ 405By similarity
Disulfide bondi417 ↔ 489By similarity
Disulfide bondi420 ↔ 491By similarity
Disulfide bondi431 ↔ 540By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96NZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NZ8

PeptideAtlas

More...
PeptideAtlasi
Q96NZ8

PRoteomics IDEntifications database

More...
PRIDEi
Q96NZ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77582

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96NZ8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreas, kidney, liver, placenta, and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127578 Expressed in 87 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_WFIKKN1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NZ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025858
HPA043362
HPA044237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MSTNO147934EBI-2363713,EBI-8542977

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125565, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NZ8, 10 interactors

Molecular INTeraction database

More...
MINTi
Q96NZ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324763

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1548
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DDINMR-A357-411[»]
2DDJNMR-A357-411[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96NZ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NZ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96NZ8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 79WAPPROSITE-ProRule annotationAdd BLAST54
Domaini108 – 159Kazal-likePROSITE-ProRule annotationAdd BLAST52
Domaini186 – 279Ig-like C2-typeAdd BLAST94
Domaini299 – 351BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST53
Domaini359 – 409BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini409 – 540NTRPROSITE-ProRule annotationAdd BLAST132

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WFIKKN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4597 Eukaryota
ENOG41102GD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158031

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154855

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108676

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NZ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEPRWAY

Database of Orthologous Groups

More...
OrthoDBi
324177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NZ8

TreeFam database of animal gene trees

More...
TreeFami
TF315349

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109 KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033638 WFIKKN1

The PANTHER Classification System

More...
PANTHERi
PTHR10083:SF212 PTHR10083:SF212, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PF00095 WAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00131 KU, 2 hits
SM00217 WAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF50242 SSF50242, 1 hit
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS51465 KAZAL_2, 1 hit
PS50189 NTR, 1 hit
PS51390 WAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q96NZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPALRPLLPL LLLLRLTSGA GLLPGLGSHP GVCPNQLSPN LWVDAQSTCE
60 70 80 90 100
RECSRDQDCA AAEKCCINVC GLHSCVAARF PGSPAAPTTA ASCEGFVCPQ
110 120 130 140 150
QGSDCDIWDG QPVCRCRDRC EKEPSFTCAS DGLTYYNRCY MDAEACLRGL
160 170 180 190 200
HLHIVPCKHV LSWPPSSPGP PETTARPTPG AAPVPPALYS SPSPQAVQVG
210 220 230 240 250
GTASLHCDVS GRPPPAVTWE KQSHQRENLI MRPDQMYGNV VVTSIGQLVL
260 270 280 290 300
YNARPEDAGL YTCTARNAAG LLRADFPLSV VQREPARDAA PSIPAPAECL
310 320 330 340 350
PDVQACTGPT SPHLVLWHYD PQRGGCMTFP ARGCDGAARG FETYEACQQA
360 370 380 390 400
CARGPGDACV LPAVQGPCRG WEPRWAYSPL LQQCHPFVYG GCEGNGNNFH
410 420 430 440 450
SRESCEDACP VPRTPPCRAC RLRSKLALSL CRSDFAIVGR LTEVLEEPEA
460 470 480 490 500
AGGIARVALE DVLKDDKMGL KFLGTKYLEV TLSGMDWACP CPNMTAGDGP
510 520 530 540
LVIMGEVRDG VAVLDAGSYV RAASEKRVKK ILELLEKQAC ELLNRFQD
Length:548
Mass (Da):58,798
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72BB28708D3EFB1F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK61237 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC11566 differs from that shown. Reason: Frameshift at position 147.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF422194 mRNA Translation: AAL18839.1
AK075356 mRNA Translation: BAC11566.1 Frameshift.
AE006464 Genomic DNA Translation: AAK61237.1 Sequence problems.
BC101602 mRNA Translation: AAI01603.1
BC101606 mRNA Translation: AAI01607.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10414.1

NCBI Reference Sequences

More...
RefSeqi
NP_444514.1, NM_053284.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.345818

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319070; ENSP00000324763; ENSG00000127578

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:117166

UCSC genome browser

More...
UCSCi
uc002cht.2 human

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422194 mRNA Translation: AAL18839.1
AK075356 mRNA Translation: BAC11566.1 Frameshift.
AE006464 Genomic DNA Translation: AAK61237.1 Sequence problems.
BC101602 mRNA Translation: AAI01603.1
BC101606 mRNA Translation: AAI01607.1
CCDSiCCDS10414.1
RefSeqiNP_444514.1, NM_053284.2
UniGeneiHs.345818

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DDINMR-A357-411[»]
2DDJNMR-A357-411[»]
ProteinModelPortaliQ96NZ8
SMRiQ96NZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125565, 6 interactors
IntActiQ96NZ8, 10 interactors
MINTiQ96NZ8
STRINGi9606.ENSP00000324763

Protein family/group databases

MEROPSiI02.953

PTM databases

iPTMnetiQ96NZ8
PhosphoSitePlusiQ96NZ8

Polymorphism and mutation databases

BioMutaiWFIKKN1
DMDMi74717044

Proteomic databases

EPDiQ96NZ8
PaxDbiQ96NZ8
PeptideAtlasiQ96NZ8
PRIDEiQ96NZ8
ProteomicsDBi77582
TopDownProteomicsiQ96NZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319070; ENSP00000324763; ENSG00000127578
GeneIDi117166
KEGGihsa:117166
UCSCiuc002cht.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
117166
EuPathDBiHostDB:ENSG00000127578.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WFIKKN1
HGNCiHGNC:30912 WFIKKN1
HPAiCAB025858
HPA043362
HPA044237
MIMi608021 gene
neXtProtiNX_Q96NZ8
OpenTargetsiENSG00000127578
PharmGKBiPA134897686

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4597 Eukaryota
ENOG41102GD LUCA
GeneTreeiENSGT00940000158031
HOGENOMiHOG000154855
HOVERGENiHBG108676
InParanoidiQ96NZ8
OMAiWEPRWAY
OrthoDBi324177at2759
PhylomeDBiQ96NZ8
TreeFamiTF315349

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WFIKKN1 human
EvolutionaryTraceiQ96NZ8

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WFIKKN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
117166

Protein Ontology

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PROi
PR:Q96NZ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000127578 Expressed in 87 organ(s), highest expression level in cerebellum
CleanExiHS_WFIKKN1
GenevisibleiQ96NZ8 HS

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR001134 Netrin_domain
IPR020901 Prtase_inh_Kunz-CS
IPR008993 TIMP-like_OB-fold
IPR008197 WAP_dom
IPR033638 WFIKKN1
PANTHERiPTHR10083:SF212 PTHR10083:SF212, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PF00095 WAP, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00131 KU, 2 hits
SM00217 WAP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF50242 SSF50242, 1 hit
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS51465 KAZAL_2, 1 hit
PS50189 NTR, 1 hit
PS51390 WAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWFKN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NZ8
Secondary accession number(s): Q7LDW0, Q8NBQ1, Q96S20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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