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UniProtKB - Q96NY9 (MUS81_HUMAN)

Entry version 174 (25 May 2022)
Sequence version 3 (05 Feb 2008)
Previous versions | rss
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Protein

Crossover junction endonuclease MUS81

Gene

MUS81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks (PubMed:28575661).

10 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.22.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96NY9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310, Fanconi Anemia Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96NY9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Crossover junction endonuclease MUS81 (EC:3.1.22.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUS81
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29814, MUS81

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606591, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96NY9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000172732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi306 – 307GD → AE: Loss of activity. 1 Publication2
Mutagenesisi333 – 334ER → AG: Loss of activity. 1 Publication2
Mutagenesisi338 – 339DD → AA: Loss of activity. 2 Publications2

Organism-specific databases

DisGeNET

More...DisGeNETi		80198

MalaCards human disease database

More...MalaCardsi		MUS81

Open Targets

More...OpenTargetsi		ENSG00000172732

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134881809

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96NY9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MUS81

Domain mapping of disease mutations (DMDM)

More...DMDMi		166898077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988581 – 551Crossover junction endonuclease MUS81Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei95PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96NY9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96NY9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96NY9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96NY9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96NY9

PeptideAtlas

More...PeptideAtlasi		Q96NY9

PRoteomics IDEntifications database

More...PRIDEi		Q96NY9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77579

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96NY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96NY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in S phase and G2 phase.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in cells treated with agents that damage DNA or block replication. This up-regulation seems to be independent of transcription.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172732, Expressed in body of uterus and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96NY9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96NY9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172732, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May self-associate.

Interacts with EME1, EME2 and CHEK2.

Interacts with BLM, and this interaction may stimulate the endonuclease activity of MUS81.

Interacts with SLX4/BTBD12; this interaction is direct and links the MUS81-EME1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.

Interacts with DCLRE1B/Apollo.

Interacts with RECQL5; this interaction stimulates mitotic DNA synthesis (PubMed:28575661).

11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123170, 107 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-511, Deoxyribonuclease complex MUS81-EME1
CPX-586, Deoxyribonuclease complex MUS81-EME2

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96NY9

Database of interacting proteins

More...DIPi		DIP-48630N

Protein interaction database and analysis system

More...IntActi		Q96NY9, 16 interactors

Molecular INTeraction database

More...MINTi		Q96NY9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000307853

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96NY9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96NY9

Biological Magnetic Resonance Data Bank

More...BMRBi		Q96NY9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96NY9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96NY9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini270 – 372ERCC4Add BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 130DisorderedSequence analysisAdd BLAST47
Regioni125 – 244Interaction with BLM1 PublicationAdd BLAST120

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2379, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005498

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014329_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96NY9

Identification of Orthologs from Complete Genome Data

More...OMAi		WIKEWLD

Database of Orthologous Groups

More...OrthoDBi		738810at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96NY9

TreeFam database of animal gene trees

More...TreeFami		TF315113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
1.10.150.110, 1 hit
1.10.150.670, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00098

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR042530, EME1/EME2_C
IPR006166, ERCC4_domain
IPR033309, Mus81
IPR011335, Restrct_endonuc-II-like
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR13451, PTHR13451, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02732, ERCC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00891, ERCC4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47802, SSF47802, 1 hit
SSF52980, SSF52980, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96NY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPVRLGRK RPLPACPNPL FVRWLTEWRD EATRSRRRTR FVFQKALRSL 
        60         70         80         90        100
RRYPLPLRSG KEAKILQHFG DGLCRMLDER LQRHRTSGGD HAPDSPSGEN 
       110        120        130        140        150
SPAPQGRLAE VQDSSMPVPA QPKAGGSGSY WPARHSGARV ILLVLYREHL 
       160        170        180        190        200
NPNGHHFLTK EELLQRCAQK SPRVAPGSAR PWPALRSLLH RNLVLRTHQP 
       210        220        230        240        250
ARYSLTPEGL ELAQKLAESE GLSLLNVGIG PKEPPGEETA VPGAASAELA 
       260        270        280        290        300
SEAGVQQQPL ELRPGEYRVL LCVDIGETRG GGHRPELLRE LQRLHVTHTV 
       310        320        330        340        350
RKLHVGDFVW VAQETNPRDP ANPGELVLDH IVERKRLDDL CSSIIDGRFR 
       360        370        380        390        400
EQKFRLKRCG LERRVYLVEE HGSVHNLSLP ESTLLQAVTN TQVIDGFFVK 
       410        420        430        440        450
RTADIKESAA YLALLTRGLQ RLYQGHTLRS RPWGTPGNPE SGAMTSPNPL 
       460        470        480        490        500
CSLLTFSDFN AGAIKNKAQS VREVFARQLM QVRGVSGEKA AALVDRYSTP 
       510        520        530        540        550
ASLLAAYDAC ATPKEQETLL STIKCGRLQR NLGPALSRTL SQLYCSYGPL 

T
Length:551
Mass (Da):61,173
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0F331CC2269D847
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRI1E9PRI1_HUMAN
Crossover junction endonuclease MUS...
MUS81
476Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDU2H0YDU2_HUMAN
Crossover junction endonuclease MUS...
MUS81
411Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDE3H0YDE3_HUMAN
Crossover junction endonuclease MUS...
MUS81
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PII7E9PII7_HUMAN
Crossover junction endonuclease MUS...
MUS81
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDK3H0YDK3_HUMAN
Crossover junction endonuclease MUS...
MUS81
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE94H0YE94_HUMAN
Crossover junction endonuclease MUS...
MUS81
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL60E9PL60_HUMAN
Crossover junction endonuclease MUS...
MUS81
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14953 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02534037R → H3 PublicationsCorresponds to variant dbSNP:rs13817Ensembl.1
Natural variantiVAR_061988115S → F. Corresponds to variant dbSNP:rs34381357Ensembl.1
Natural variantiVAR_038521180R → P3 PublicationsCorresponds to variant dbSNP:rs545500Ensembl.1
Natural variantiVAR_021990189L → F. Corresponds to variant dbSNP:rs2298447Ensembl.1
Natural variantiVAR_038522350R → W. Corresponds to variant dbSNP:rs34891773Ensembl.1
Natural variantiVAR_025341481Q → H. Corresponds to variant dbSNP:rs765593Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF425646 mRNA Translation: AAL28065.1
BC009999 mRNA Translation: AAH09999.2
AK024665 mRNA Translation: BAB14953.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8115.1

NCBI Reference Sequences

More...RefSeqi		NP_079404.3, NM_025128.4
XP_011543572.1, XM_011545270.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308110.9; ENSP00000307853.4; ENSG00000172732.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80198

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000308110.9; ENSP00000307853.4; NM_025128.5; NP_079404.3

UCSC genome browser

More...UCSCi		uc001ofv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF425646 mRNA Translation: AAL28065.1
BC009999 mRNA Translation: AAH09999.2
AK024665 mRNA Translation: BAB14953.1 Different initiation.
CCDSiCCDS8115.1
RefSeqiNP_079404.3, NM_025128.4
XP_011543572.1, XM_011545270.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MC3NMR-A127-230[»]
2ZIXX-ray3.50A246-551[»]
4P0PX-ray2.80A246-551[»]
4P0QX-ray2.85A246-551[»]
4P0RX-ray6.50A/C246-551[»]
4P0SX-ray6.00A/C/E/G246-551[»]
6VWBNMR-A2-90[»]
7BU5X-ray1.80A2-99[»]
AlphaFoldDBiQ96NY9
BMRBiQ96NY9
SMRiQ96NY9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123170, 107 interactors
ComplexPortaliCPX-511, Deoxyribonuclease complex MUS81-EME1
CPX-586, Deoxyribonuclease complex MUS81-EME2
CORUMiQ96NY9
DIPiDIP-48630N
IntActiQ96NY9, 16 interactors
MINTiQ96NY9
STRINGi9606.ENSP00000307853

PTM databases

iPTMnetiQ96NY9
PhosphoSitePlusiQ96NY9

Genetic variation databases

BioMutaiMUS81
DMDMi166898077

Proteomic databases

EPDiQ96NY9
jPOSTiQ96NY9
MassIVEiQ96NY9
MaxQBiQ96NY9
PaxDbiQ96NY9
PeptideAtlasiQ96NY9
PRIDEiQ96NY9
ProteomicsDBi77579

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16020, 194 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		80198

Genome annotation databases

EnsembliENST00000308110.9; ENSP00000307853.4; ENSG00000172732.12
GeneIDi80198
KEGGihsa:80198
MANE-SelectiENST00000308110.9; ENSP00000307853.4; NM_025128.5; NP_079404.3
UCSCiuc001ofv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80198
DisGeNETi80198

GeneCards: human genes, protein and diseases

More...GeneCardsi		MUS81
HGNCiHGNC:29814, MUS81
HPAiENSG00000172732, Low tissue specificity
MalaCardsiMUS81
MIMi606591, gene
neXtProtiNX_Q96NY9
OpenTargetsiENSG00000172732
PharmGKBiPA134881809
VEuPathDBiHostDB:ENSG00000172732

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2379, Eukaryota
GeneTreeiENSGT00390000005498
HOGENOMiCLU_014329_3_0_1
InParanoidiQ96NY9
OMAiWIKEWLD
OrthoDBi738810at2759
PhylomeDBiQ96NY9
TreeFamiTF315113

Enzyme and pathway databases

BRENDAi3.1.22.4, 2681
PathwayCommonsiQ96NY9
ReactomeiR-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310, Fanconi Anemia Pathway
SignaLinkiQ96NY9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80198, 67 hits in 1082 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MUS81, human
EvolutionaryTraceiQ96NY9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MUS81

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80198
PharosiQ96NY9, Tbio

Protein Ontology

More...PROi		PR:Q96NY9
RNActiQ96NY9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172732, Expressed in body of uterus and 235 other tissues
ExpressionAtlasiQ96NY9, baseline and differential
GenevisibleiQ96NY9, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.110, 1 hit
1.10.150.670, 1 hit
IDEALiIID00098
InterProiView protein in InterPro
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR042530, EME1/EME2_C
IPR006166, ERCC4_domain
IPR033309, Mus81
IPR011335, Restrct_endonuc-II-like
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR13451, PTHR13451, 1 hit
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF52980, SSF52980, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUS81_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NY9
Secondary accession number(s): Q9H7D9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: February 5, 2008
Last modified: May 25, 2022
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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