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Entry version 171 (10 Feb 2021)
Sequence version 3 (14 Nov 2003)
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Protein

Chloride intracellular channel protein 6

Gene

CLIC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96NY7

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.12.1.4, the intracellular chloride channel (clic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride intracellular channel protein 6
Alternative name(s):
Parchorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLIC6
Synonyms:CLIC1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2065, CLIC6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615321, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NY7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000159212.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei489 – 509Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54102

Open Targets

More...
OpenTargetsi
ENSG00000159212

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26593

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96NY7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLIC6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001442171 – 704Chloride intracellular channel protein 6Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineBy similarity1
Modified residuei397PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96NY7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96NY7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96NY7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NY7

PeptideAtlas

More...
PeptideAtlasi
Q96NY7

PRoteomics IDEntifications database

More...
PRIDEi
Q96NY7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77576 [Q96NY7-1]
77577 [Q96NY7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NY7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, placenta, pancreas and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159212, Expressed in pigmented layer of retina and 159 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NY7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000159212, Group enriched (brain, retina, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with dopamine receptors DRD2, DRD3 and DRD4.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119900, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NY7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96NY7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NY7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati157 – 166110
Repeati167 – 176210
Repeati177 – 186310
Repeati187 – 196410
Repeati197 – 206510
Repeati207 – 216610
Repeati217 – 226710
Repeati227 – 236810
Repeati237 – 246910
Repeati247 – 2561010
Repeati257 – 2661110
Repeati267 – 2761210
Repeati277 – 2861310
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini556 – 704GST C-terminalAdd BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 28213 X 10 AA tandem repeat of G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP]Add BLAST126

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1422, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023994_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96NY7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGASMEA

Database of Orthologous Groups

More...
OrthoDBi
974249at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NY7

TreeFam database of animal gene trees

More...
TreeFami
TF315438

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002946, CLIC
IPR030257, CLIC-4/6
IPR010987, Glutathione-S-Trfase_C-like
IPR036282, Glutathione-S-Trfase_C_sf
IPR040079, Glutathione_S-Trfase
IPR036249, Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45476:SF1, PTHR45476:SF1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01263, INTCLCHANNEL

Structure-Function Linkage Database

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SFLDi
SFLDS00019, Glutathione_Transferase_(cytos, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47616, SSF47616, 1 hit
SSF52833, SSF52833, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00862, O-ClC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50405, GST_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: Q96NY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAAEPEGV APGPQGPPEV PAPLAERPGE PGAAGGEAEG PEGSEGAEEA
60 70 80 90 100
PRGAAAVKEA GGGGPDRGPE AEARGTRGAH GETEAEEGAP EGAEVPQGGE
110 120 130 140 150
ETSGAQQVEG ASPGRGAQGE PRGEAQREPE DSAAPERQEE AEQRPEVPEG
160 170 180 190 200
SASGEAGDSV DAEGPLGDNI EAEGPAGDSV EAEGRVGDSV DAEGPAGDSV
210 220 230 240 250
DAEGPLGDNI QAEGPAGDSV DAEGRVGDSV DAEGPAGDSV DAEGRVGDSV
260 270 280 290 300
EAGDPAGDGV EAGVPAGDSV EAEGPAGDSM DAEGPAGRAR RVSGEPQQSG
310 320 330 340 350
DGSLSPQAEA IEVAAGESAG RSPGELAWDA AEEAEVPGVK GSEEAAPGDA
360 370 380 390 400
RADAGEDRVG DGPQQEPGED EERRERSPEG PREEEAAGGE EESPDSSPHG
410 420 430 440 450
EASRGAAEPE AQLSNHLAEE GPAEGSGEAA RVNGRREDGE ASEPRALGQE
460 470 480 490 500
HDITLFVKVK LTALGCSRIA IKKYLRAGYD GESIGNCPFS QRLFMILWLK
510 520 530 540 550
GVIFNVTTVD LKRKPADLQN LAPGTNPPFM TFDGEVKTDV NKIEEFLEEK
560 570 580 590 600
LAPPRYPKLG TQHPESNSAG NDVFAKFSAF IKNTKKDANE IHEKNLLKAL
610 620 630 640 650
RKLDNYLNSP LPDEIDAYST EDVTVSGRKF LDGDELTLAD CNLLPKLHII
660 670 680 690 700
KIVAKKYRDF EFPSEMTGIW RYLNNAYARD EFTNTCPADQ EIEHAYSDVA

KRMK
Length:704
Mass (Da):73,012
Last modified:November 14, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA58F30E099BFE357
GO
Isoform A (identifier: Q96NY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-476: Missing.

Show »
Length:686
Mass (Da):70,996
Checksum:iCA7F2571EB91490D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03959 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014139632D → G. Corresponds to variant dbSNP:rs3171439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008963459 – 476Missing in isoform A. 4 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF448439 mRNA Translation: AAN76730.1
AF448438 mRNA Translation: AAN76729.1
AF426169 mRNA Translation: AAL24813.1
AK092733 mRNA Translation: BAC03959.1 Different initiation.
AK289663 mRNA Translation: BAF82352.1
AP001720 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09775.1
BC040196 mRNA Translation: AAH40196.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13638.1 [Q96NY7-2]
CCDS82669.1 [Q96NY7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001303938.1, NM_001317009.1 [Q96NY7-1]
NP_444507.1, NM_053277.2 [Q96NY7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349499; ENSP00000290332; ENSG00000159212 [Q96NY7-2]
ENST00000360731; ENSP00000353959; ENSG00000159212 [Q96NY7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54102

UCSC genome browser

More...
UCSCi
uc002yuf.2, human [Q96NY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448439 mRNA Translation: AAN76730.1
AF448438 mRNA Translation: AAN76729.1
AF426169 mRNA Translation: AAL24813.1
AK092733 mRNA Translation: BAC03959.1 Different initiation.
AK289663 mRNA Translation: BAF82352.1
AP001720 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09775.1
BC040196 mRNA Translation: AAH40196.1
CCDSiCCDS13638.1 [Q96NY7-2]
CCDS82669.1 [Q96NY7-1]
RefSeqiNP_001303938.1, NM_001317009.1 [Q96NY7-1]
NP_444507.1, NM_053277.2 [Q96NY7-2]

3D structure databases

SMRiQ96NY7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119900, 4 interactors
IntActiQ96NY7, 1 interactor
STRINGi9606.ENSP00000290332

Protein family/group databases

TCDBi1.A.12.1.4, the intracellular chloride channel (clic) family

PTM databases

iPTMnetiQ96NY7
PhosphoSitePlusiQ96NY7

Genetic variation databases

BioMutaiCLIC6
DMDMi38372885

Proteomic databases

jPOSTiQ96NY7
MassIVEiQ96NY7
MaxQBiQ96NY7
PaxDbiQ96NY7
PeptideAtlasiQ96NY7
PRIDEiQ96NY7
ProteomicsDBi77576 [Q96NY7-1]
77577 [Q96NY7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8114, 189 antibodies

Genome annotation databases

EnsembliENST00000349499; ENSP00000290332; ENSG00000159212 [Q96NY7-2]
ENST00000360731; ENSP00000353959; ENSG00000159212 [Q96NY7-1]
GeneIDi54102
KEGGihsa:54102
UCSCiuc002yuf.2, human [Q96NY7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54102
DisGeNETi54102

GeneCards: human genes, protein and diseases

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GeneCardsi
CLIC6
HGNCiHGNC:2065, CLIC6
HPAiENSG00000159212, Group enriched (brain, retina, stomach)
MIMi615321, gene
neXtProtiNX_Q96NY7
OpenTargetsiENSG00000159212
PharmGKBiPA26593
VEuPathDBiHostDB:ENSG00000159212.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1422, Eukaryota
GeneTreeiENSGT00940000159602
HOGENOMiCLU_023994_0_0_1
InParanoidiQ96NY7
OMAiQGASMEA
OrthoDBi974249at2759
PhylomeDBiQ96NY7
TreeFamiTF315438

Enzyme and pathway databases

PathwayCommonsiQ96NY7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54102, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLIC6, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLIC6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54102
PharosiQ96NY7, Tbio

Protein Ontology

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PROi
PR:Q96NY7
RNActiQ96NY7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000159212, Expressed in pigmented layer of retina and 159 other tissues
GenevisibleiQ96NY7, HS

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR002946, CLIC
IPR030257, CLIC-4/6
IPR010987, Glutathione-S-Trfase_C-like
IPR036282, Glutathione-S-Trfase_C_sf
IPR040079, Glutathione_S-Trfase
IPR036249, Thioredoxin-like_sf
PANTHERiPTHR45476:SF1, PTHR45476:SF1, 2 hits
PRINTSiPR01263, INTCLCHANNEL
SFLDiSFLDS00019, Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616, SSF47616, 1 hit
SSF52833, SSF52833, 1 hit
TIGRFAMsiTIGR00862, O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405, GST_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLIC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NY7
Secondary accession number(s): A8K0U8, Q8IX31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 14, 2003
Last modified: February 10, 2021
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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