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Protein

Dachshund homolog 2

Gene

DACH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dachshund homolog 2
Short name:
Dach2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DACH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000126733.20

Human Gene Nomenclature Database

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HGNCi
HGNC:16814 DACH2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300608 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NX9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
117154

Open Targets

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OpenTargetsi
ENSG00000126733

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DACH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44887818

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000955991 – 599Dachshund homolog 2Add BLAST599

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96NX9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96NX9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NX9

PeptideAtlas

More...
PeptideAtlasi
Q96NX9

PRoteomics IDEntifications database

More...
PRIDEi
Q96NX9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77573
77574 [Q96NX9-2]
77575 [Q96NX9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000126733 Expressed in 88 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_DACH2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96NX9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96NX9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000258

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIX6 and EYA2.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125560, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362217

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96NX9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NX9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 155DACHbox-NAdd BLAST87
Regioni453 – 533DACHbox-CAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili459 – 554Sequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 61Poly-Gly6
Compositional biasi350 – 353Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3915 Eukaryota
ENOG4111FAG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293309

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG065810

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96NX9

Identification of Orthologs from Complete Genome Data

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OMAi
MAQQFYS

Database of Orthologous Groups

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OrthoDBi
429758at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96NX9

TreeFam database of animal gene trees

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TreeFami
TF316697

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.260.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02437 Ski_Sno, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46955 SSF46955, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96NX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSASPVIS ATSSGAGVPG GLFRAEPLYS TPREPPRLTP NMINSFVVNN
60 70 80 90 100
HSNSAGGGGR GNTNTNECRM VDMHGMKVAS FLMDGQELIC LPQVFDLFLK
110 120 130 140 150
HLVGGLHTVY TKLKRLDISP VVCTVEQVRI LRGLGAIQPG VNRCKLITRK
160 170 180 190 200
DFETLFTDCT NARRKRQMTR KQAVNSSRPG RPPKRSLGVL QENARLLTHA
210 220 230 240 250
VPGLLSPGLI TPTGITAAAM AEAMKLQKMK LMAMNTLQGN GSQNGTESEP
260 270 280 290 300
DDLNSNTGGS ESSWDKDKMQ SPFAAPGPQH GIAHAALAGQ PGIGGAPTLN
310 320 330 340 350
PLQQNHLLTN RLDLPFMMMP HPLLPVSLPP ASVAMAMNQM NHLNTIANMA
360 370 380 390 400
AAAQIHSPLS RAGTSVIKER IPESPSPAPS LEENHRPGSQ TSSHTSSSVS
410 420 430 440 450
SSPSQMDHHL ERMEEVPVQI PIMKSPLDKI QLTPGQALPA GFPGPFIFAD
460 470 480 490 500
SLSSVETLLT NIQGLLKVAL DNARIQEKQI QQEKKELRLE LYREREIREN
510 520 530 540 550
LERQLAVELQ SRTTMQKRLK KEKKTKRKLQ EALEFESKRR EQVEQALKQA
560 570 580 590
TTSDSGLRML KDTGIPDIEI ENNGTPHDSA AMQGGNYYCL EMAQQLYSA
Length:599
Mass (Da):65,323
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EE435720A83BAA0
GO
Isoform 2 (identifier: Q96NX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-175: Missing.
     584-599: GGNYYCLEMAQQLYSA → A

Show »
Length:571
Mass (Da):61,947
Checksum:i9594DA631D3DA2A7
GO
Isoform 3 (identifier: Q96NX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-219: Missing.

Note: No experimental confirmation available.
Show »
Length:380
Mass (Da):41,772
Checksum:i1EB661514C165A0D
GO
Isoform 4 (identifier: Q96NX9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:432
Mass (Da):47,156
Checksum:i6A57F75AAE9BE15D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y912H0Y912_HUMAN
Dachshund homolog 2
DACH2
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTT5A0A087WTT5_HUMAN
Dachshund homolog 2
DACH2
427Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REJ4D6REJ4_HUMAN
Dachshund homolog 2
DACH2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFG7D6RFG7_HUMAN
Dachshund homolog 2
DACH2
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0094921 – 219Missing in isoform 3. 1 PublicationAdd BLAST219
Alternative sequenceiVSP_0442751 – 167Missing in isoform 4. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_009490163 – 175Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_009491584 – 599GGNYY…QLYSA → A in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF428101 mRNA Translation: AAL26561.1
AK055953 mRNA Translation: BAB71054.1
AK091842 mRNA Translation: BAC03761.1
AK298787 mRNA Translation: BAG60925.1
AL390058 Genomic DNA No translation available.
AL023095 Genomic DNA No translation available.
AL109752 Genomic DNA No translation available.
AL034406 Genomic DNA No translation available.
AL138747 Genomic DNA No translation available.
AL157381 Genomic DNA No translation available.
AL591465 Genomic DNA No translation available.
Z95124 Genomic DNA No translation available.
Z95325 Genomic DNA No translation available.
AL834456 mRNA Translation: CAD39116.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14455.1 [Q96NX9-1]
CCDS48140.1 [Q96NX9-2]
CCDS55457.1 [Q96NX9-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001132986.1, NM_001139514.1 [Q96NX9-2]
NP_001132987.1, NM_001139515.1 [Q96NX9-4]
NP_444511.1, NM_053281.3 [Q96NX9-1]
XP_016884745.1, XM_017029256.1 [Q96NX9-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.86603

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373125; ENSP00000362217; ENSG00000126733 [Q96NX9-1]
ENST00000373131; ENSP00000362223; ENSG00000126733 [Q96NX9-2]
ENST00000508860; ENSP00000420896; ENSG00000126733 [Q96NX9-4]
ENST00000510272; ENSP00000421919; ENSG00000126733 [Q96NX9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
117154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:117154

UCSC genome browser

More...
UCSCi
uc004eew.3 human [Q96NX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF428101 mRNA Translation: AAL26561.1
AK055953 mRNA Translation: BAB71054.1
AK091842 mRNA Translation: BAC03761.1
AK298787 mRNA Translation: BAG60925.1
AL390058 Genomic DNA No translation available.
AL023095 Genomic DNA No translation available.
AL109752 Genomic DNA No translation available.
AL034406 Genomic DNA No translation available.
AL138747 Genomic DNA No translation available.
AL157381 Genomic DNA No translation available.
AL591465 Genomic DNA No translation available.
Z95124 Genomic DNA No translation available.
Z95325 Genomic DNA No translation available.
AL834456 mRNA Translation: CAD39116.1
CCDSiCCDS14455.1 [Q96NX9-1]
CCDS48140.1 [Q96NX9-2]
CCDS55457.1 [Q96NX9-4]
RefSeqiNP_001132986.1, NM_001139514.1 [Q96NX9-2]
NP_001132987.1, NM_001139515.1 [Q96NX9-4]
NP_444511.1, NM_053281.3 [Q96NX9-1]
XP_016884745.1, XM_017029256.1 [Q96NX9-2]
UniGeneiHs.86603

3D structure databases

ProteinModelPortaliQ96NX9
SMRiQ96NX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125560, 7 interactors
STRINGi9606.ENSP00000362217

PTM databases

iPTMnetiQ96NX9
PhosphoSitePlusiQ96NX9

Polymorphism and mutation databases

BioMutaiDACH2
DMDMi44887818

Proteomic databases

EPDiQ96NX9
jPOSTiQ96NX9
PaxDbiQ96NX9
PeptideAtlasiQ96NX9
PRIDEiQ96NX9
ProteomicsDBi77573
77574 [Q96NX9-2]
77575 [Q96NX9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373125; ENSP00000362217; ENSG00000126733 [Q96NX9-1]
ENST00000373131; ENSP00000362223; ENSG00000126733 [Q96NX9-2]
ENST00000508860; ENSP00000420896; ENSG00000126733 [Q96NX9-4]
ENST00000510272; ENSP00000421919; ENSG00000126733 [Q96NX9-3]
GeneIDi117154
KEGGihsa:117154
UCSCiuc004eew.3 human [Q96NX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
117154
DisGeNETi117154
EuPathDBiHostDB:ENSG00000126733.20

GeneCards: human genes, protein and diseases

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GeneCardsi
DACH2
HGNCiHGNC:16814 DACH2
HPAiHPA000258
MIMi300608 gene
neXtProtiNX_Q96NX9
OpenTargetsiENSG00000126733
PharmGKBiPA27135

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3915 Eukaryota
ENOG4111FAG LUCA
GeneTreeiENSGT00390000001134
HOGENOMiHOG000293309
HOVERGENiHBG065810
InParanoidiQ96NX9
OMAiMAQQFYS
OrthoDBi429758at2759
PhylomeDBiQ96NX9
TreeFamiTF316697

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DACH2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DACH2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
117154

Protein Ontology

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PROi
PR:Q96NX9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000126733 Expressed in 88 organ(s), highest expression level in metanephros
CleanExiHS_DACH2
ExpressionAtlasiQ96NX9 baseline and differential
GenevisibleiQ96NX9 HS

Family and domain databases

Gene3Di3.10.260.20, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
PfamiView protein in Pfam
PF02437 Ski_Sno, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDACH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NX9
Secondary accession number(s): B1AJV3
, B4DQG3, Q8NAY3, Q8ND17, Q96N55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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