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Protein

Calcium/calmodulin-dependent protein kinase type 1G

Gene

CAMK1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei143Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17 2681
SignaLinkiQ96NX5
SIGNORiQ96NX5

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1G (EC:2.7.11.17)
Alternative name(s):
CaM kinase I gamma
Short name:
CaM kinase IG
Short name:
CaM-KI gamma
Short name:
CaMKI gamma
Short name:
CaMKIG
CaMK-like CREB kinase III
Short name:
CLICK III
Gene namesi
Name:CAMK1G
Synonyms:CLICK3, VWS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000008118.9
HGNCiHGNC:14585 CAMK1G
MIMi614994 gene
neXtProtiNX_Q96NX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57172
OpenTargetsiENSG00000008118
PharmGKBiPA26049

Chemistry databases

ChEMBLiCHEMBL5258
GuidetoPHARMACOLOGYi1954

Polymorphism and mutation databases

BioMutaiCAMK1G
DMDMi73620970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860841 – 476Calcium/calmodulin-dependent protein kinase type 1GAdd BLAST476

Post-translational modificationi

May be prenylated on Cys-473.By similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ96NX5
PaxDbiQ96NX5
PeptideAtlasiQ96NX5
PRIDEiQ96NX5
ProteomicsDBi77570
77571 [Q96NX5-2]

PTM databases

iPTMnetiQ96NX5
PhosphoSitePlusiQ96NX5

Expressioni

Tissue specificityi

Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system.1 Publication

Gene expression databases

BgeeiENSG00000008118
CleanExiHS_CAMK1G
ExpressionAtlasiQ96NX5 baseline and differential
GenevisibleiQ96NX5 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121424, 6 interactors
IntActiQ96NX5, 2 interactors
STRINGi9606.ENSP00000009105

Chemistry databases

BindingDBiQ96NX5

Structurei

Secondary structure

1476
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi181 – 184Combined sources4
Beta strandi185 – 193Combined sources9
Beta strandi195 – 200Combined sources6
Turni218 – 221Combined sources4
Helixi223 – 230Combined sources8
Beta strandi233 – 236Combined sources4
Turni243 – 245Combined sources3
Helixi253 – 260Combined sources8
Helixi268 – 272Combined sources5
Helixi275 – 278Combined sources4
Beta strandi293 – 295Combined sources3
Turni299 – 301Combined sources3
Beta strandi303 – 305Combined sources3
Helixi321 – 324Combined sources4
Turni331 – 333Combined sources3
Beta strandi334 – 336Combined sources3

3D structure databases

ProteinModelPortaliQ96NX5
SMRiQ96NX5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96NX5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 317Autoinhibitory domainBy similarityAdd BLAST41
Regioni297 – 318Calmodulin-bindingBy similarityAdd BLAST22

Domaini

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ96NX5
KOiK08794
OMAiHPWINGN
OrthoDBiEOG091G0HK9
PhylomeDBiQ96NX5
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKEEDDCS SWKKQTTNIR KTFIFMEVLG SGAFSEVFLV KQRLTGKLFA
60 70 80 90 100
LKCIKKSPAF RDSSLENEIA VLKKIKHENI VTLEDIYEST THYYLVMQLV
110 120 130 140 150
SGGELFDRIL ERGVYTEKDA SLVIQQVLSA VKYLHENGIV HRDLKPENLL
160 170 180 190 200
YLTPEENSKI MITDFGLSKM EQNGIMSTAC GTPGYVAPEV LAQKPYSKAV
210 220 230 240 250
DCWSIGVITY ILLCGYPPFY EETESKLFEK IKEGYYEFES PFWDDISESA
260 270 280 290 300
KDFICHLLEK DPNERYTCEK ALSHPWIDGN TALHRDIYPS VSLQIQKNFA
310 320 330 340 350
KSKWRQAFNA AAVVHHMRKL HMNLHSPGVR PEVENRPPET QASETSRPSS
360 370 380 390 400
PEITITEAPV LDHSVALPAL TQLPCQHGRR PTAPGGRSLN CLVNGSLHIS
410 420 430 440 450
SSLVPMHQGS LAAGPCGCCS SCLNIGSKGK SSYCSEPTLL KKANKKQNFK
460 470
SEVMVPVKAS GSSHCRAGQT GVCLIM
Length:476
Mass (Da):53,087
Last modified:August 16, 2005 - v3
Checksum:iDD009D9CF2FE3CBE
GO
Isoform 2 (identifier: Q96NX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-476: NFKSEVMVPVKASGSSHCRAGQTGVCLIM → YVFLAKDGAPAWV

Show »
Length:460
Mass (Da):51,486
Checksum:iA16971DC50344496
GO

Sequence cautioni

The sequence CAB41259 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427S → N in AAL28100 (PubMed:10645953).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040600259E → Q1 PublicationCorresponds to variant dbSNP:rs35561962Ensembl.1
Natural variantiVAR_020530329V → I2 PublicationsCorresponds to variant dbSNP:rs11119315Ensembl.1
Natural variantiVAR_040601443A → T in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012138448 – 476NFKSE…VCLIM → YVFLAKDGAPAWV in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF428261 mRNA Translation: AAL28100.1
AY212935 mRNA Translation: AAP29964.1
AL049688 mRNA Translation: CAB41259.1 Different initiation.
AL023754 Genomic DNA No translation available.
BC032787 mRNA Translation: AAH32787.1
CCDSiCCDS1486.1 [Q96NX5-1]
RefSeqiNP_065172.1, NM_020439.2 [Q96NX5-1]
XP_016857355.1, XM_017001866.1 [Q96NX5-1]
UniGeneiHs.199068

Genome annotation databases

EnsembliENST00000009105; ENSP00000009105; ENSG00000008118 [Q96NX5-1]
ENST00000361322; ENSP00000354861; ENSG00000008118 [Q96NX5-1]
GeneIDi57172
KEGGihsa:57172
UCSCiuc001hhd.4 human [Q96NX5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCC1G_HUMAN
AccessioniPrimary (citable) accession number: Q96NX5
Secondary accession number(s): Q86UH5, Q9Y3J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2005
Last modified: July 18, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

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