Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (07 Apr 2021)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Probable imidazolonepropionase

Gene

AMDHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity, Fe2+By similarityNote: Binds 1 zinc or iron ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (HAL)
  2. Urocanate hydratase (UROC1)
  3. Amidohydrolase domain-containing protein 1 (AMDHD1), Amidohydrolase domain-containing protein 1, Probable imidazolonepropionase (AMDHD1)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi87Zinc or ironBy similarity1
Metal bindingi89Zinc or ironBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei96SubstrateBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei159SubstrateBy similarity1
Binding sitei192SubstrateBy similarity1
Metal bindingi260Zinc or ironBy similarity1
Binding sitei263SubstrateBy similarity1
Metal bindingi334Zinc or ironBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96NU7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70921, Histidine catabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00379;UER00551

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M38.980

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable imidazolonepropionase (EC:3.5.2.7)
Alternative name(s):
Amidohydrolase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMDHD1
ORF Names:HMFT1272
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28577, AMDHD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NU7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000139344.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
144193

Open Targets

More...
OpenTargetsi
ENSG00000139344

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96NU7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMDHD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033395

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002825821 – 426Probable imidazolonepropionaseAdd BLAST426

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96NU7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96NU7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96NU7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NU7

PeptideAtlas

More...
PeptideAtlasi
Q96NU7

PRoteomics IDEntifications database

More...
PRIDEi
Q96NU7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77565

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139344, Expressed in liver and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NU7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NU7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139344, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126836, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NU7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266736

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96NU7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NU7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3968, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008645

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041647_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NU7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNPGSSF

Database of Orthologous Groups

More...
OrthoDBi
776380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NU7

TreeFam database of animal gene trees

More...
TreeFami
TF312878

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01296, Imidazolone-5PH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006680, Amidohydro-rel
IPR005920, HutI
IPR011059, Metal-dep_hydrolase_composite
IPR032466, Metal_Hydrolase

The PANTHER Classification System

More...
PANTHERi
PTHR42752, PTHR42752, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01979, Amidohydro_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51338, SSF51338, 1 hit
SSF51556, SSF51556, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01224, hutI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96NU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGHSLLLE NAQQVVLVCA RGERFLARDA LRSLAVLEGA SLVVGKDGFI
60 70 80 90 100
KAIGPADVIQ RQFSGETFEE IIDCSGKCIL PGLVDAHTHP VWAGERVHEF
110 120 130 140 150
AMKLAGATYM EIHQAGGGIH FTVERTRQAT EEELFRSLQQ RLQCMMRAGT
160 170 180 190 200
TLVECKSGYG LDLETELKML RVIERARREL DIGISATYCG AHSVPKGKTA
210 220 230 240 250
TEAADDIINN HLPKLKELGR NGEIHVDNID VFCEKGVFDL DSTRRILQRG
260 270 280 290 300
KDIGLQINFH GDELHPMKAA ELGAELGAQA ISHLEEVSDE GIVAMATARC
310 320 330 340 350
SAILLPTTAY MLRLKQPRAR KMLDEGVIVA LGSDFNPNAY CFSMPMVMHL
360 370 380 390 400
ACVNMRMSMP EALAAATINA AYALGKSHTH GSLEVGKQGD LIIINSSRWE
410 420
HLIYQFGGHH ELIEYVIAKG KLIYKT
Length:426
Mass (Da):46,743
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD747F82BD00ACD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YI62H0YI62_HUMAN
Probable imidazolonepropionase
AMDHD1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD38660 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0314193S → G4 PublicationsCorresponds to variant dbSNP:rs7955450Ensembl.1
Natural variantiVAR_031420360P → H. Corresponds to variant dbSNP:rs17024904Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK054617 mRNA Translation: BAB70775.1
AK290828 mRNA Translation: BAF83517.1
AB075878 mRNA Translation: BAD38660.1 Different initiation.
AC126174 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97552.1
BC029146 mRNA Translation: AAH29146.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9057.1

NCBI Reference Sequences

More...
RefSeqi
NP_689648.2, NM_152435.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266736; ENSP00000266736; ENSG00000139344

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
144193

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:144193

UCSC genome browser

More...
UCSCi
uc001tel.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054617 mRNA Translation: BAB70775.1
AK290828 mRNA Translation: BAF83517.1
AB075878 mRNA Translation: BAD38660.1 Different initiation.
AC126174 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97552.1
BC029146 mRNA Translation: AAH29146.1
CCDSiCCDS9057.1
RefSeqiNP_689648.2, NM_152435.2

3D structure databases

SMRiQ96NU7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126836, 3 interactors
IntActiQ96NU7, 1 interactor
STRINGi9606.ENSP00000266736

Protein family/group databases

MEROPSiM38.980

PTM databases

iPTMnetiQ96NU7
PhosphoSitePlusiQ96NU7

Genetic variation databases

BioMutaiAMDHD1
DMDMi311033395

Proteomic databases

jPOSTiQ96NU7
MassIVEiQ96NU7
MaxQBiQ96NU7
PaxDbiQ96NU7
PeptideAtlasiQ96NU7
PRIDEiQ96NU7
ProteomicsDBi77565

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30145, 106 antibodies

Genome annotation databases

EnsembliENST00000266736; ENSP00000266736; ENSG00000139344
GeneIDi144193
KEGGihsa:144193
UCSCiuc001tel.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144193
DisGeNETi144193

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMDHD1
HGNCiHGNC:28577, AMDHD1
HPAiENSG00000139344, Tissue enriched (liver)
neXtProtiNX_Q96NU7
OpenTargetsiENSG00000139344
PharmGKBiPA143485297
VEuPathDBiHostDB:ENSG00000139344.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3968, Eukaryota
GeneTreeiENSGT00390000008645
HOGENOMiCLU_041647_2_0_1
InParanoidiQ96NU7
OMAiCNPGSSF
OrthoDBi776380at2759
PhylomeDBiQ96NU7
TreeFamiTF312878

Enzyme and pathway databases

UniPathwayiUPA00379;UER00551
PathwayCommonsiQ96NU7
ReactomeiR-HSA-70921, Histidine catabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
144193, 3 hits in 987 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
144193
PharosiQ96NU7, Tdark

Protein Ontology

More...
PROi
PR:Q96NU7
RNActiQ96NU7, protein

Gene expression databases

BgeeiENSG00000139344, Expressed in liver and 120 other tissues
ExpressionAtlasiQ96NU7, baseline and differential
GenevisibleiQ96NU7, HS

Family and domain databases

CDDicd01296, Imidazolone-5PH, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680, Amidohydro-rel
IPR005920, HutI
IPR011059, Metal-dep_hydrolase_composite
IPR032466, Metal_Hydrolase
PANTHERiPTHR42752, PTHR42752, 1 hit
PfamiView protein in Pfam
PF01979, Amidohydro_1, 1 hit
SUPFAMiSSF51338, SSF51338, 1 hit
SSF51556, SSF51556, 1 hit
TIGRFAMsiTIGR01224, hutI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHUTI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NU7
Secondary accession number(s): A8K463, Q68CI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 2, 2010
Last modified: April 7, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again