We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q96NU1 (SAM11_HUMAN)
Protein
Sterile alpha motif domain-containing protein 11
Gene
SAMD11
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in photoreceptor development.
By similarityGO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96NU1 |
SignaLinki | Q96NU1 |
Names & Taxonomyi
Protein namesi | Recommended name: Sterile alpha motif domain-containing protein 11Short name: SAM domain-containing protein 11 |
Gene namesi | Name:SAMD11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28706, SAMD11 |
neXtProti | NX_Q96NU1 |
VEuPathDBi | HostDB:ENSG00000187634 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 148398 |
OpenTargetsi | ENSG00000187634 |
PharmGKBi | PA134968665 |
Miscellaneous databases
Pharosi | Q96NU1, Tdark |
Genetic variation databases
BioMutai | SAMD11 |
DMDMi | 166215037 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279500 | 1 – 681 | Sterile alpha motif domain-containing protein 11Add BLAST | 681 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 72 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 485 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 640 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q96NU1 |
MassIVEi | Q96NU1 |
MaxQBi | Q96NU1 |
PaxDbi | Q96NU1 |
PeptideAtlasi | Q96NU1 |
PRIDEi | Q96NU1 |
ProteomicsDBi | 77562 [Q96NU1-3] 77563 [Q96NU1-1] 77564 [Q96NU1-2] |
PTM databases
iPTMneti | Q96NU1 |
PhosphoSitePlusi | Q96NU1 |
SwissPalmi | Q96NU1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187634, Expressed in pituitary gland and 142 other tissues |
ExpressionAtlasi | Q96NU1, baseline and differential |
Genevisiblei | Q96NU1, HS |
Organism-specific databases
HPAi | ENSG00000187634, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
By similarityBinary interactionsi
Q96NU1
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127146, 34 interactors |
IntActi | Q96NU1, 27 interactors |
MINTi | Q96NU1 |
STRINGi | 9606.ENSP00000342313 |
Miscellaneous databases
RNActi | Q96NU1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 543 – 608 | SAMPROSITE-ProRule annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 77 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 212 – 234 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 251 – 307 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 407 – 498 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 625 – 681 | DisorderedSequence analysisAdd BLAST | 57 |
Phylogenomic databases
eggNOGi | KOG4333, Eukaryota |
GeneTreei | ENSGT00940000160830 |
InParanoidi | Q96NU1 |
OrthoDBi | 622508at2759 |
PhylomeDBi | Q96NU1 |
TreeFami | TF331299 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketNote: Many additional isoforms seem to exist.
This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: Q96NU1-3) [UniParc]FASTAAdd to basket
Also known as: FL-SAMD11
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKGILQVHP PICDCPGCRI SSPVNRGRLA DKRTVALPAA RNLKKERTPS
60 70 80 90 100
FSASDGDSDG SGPTCGRRPG LKQEDGPHIR IMKRRVHTHW DVNISFREAS
110 120 130 140 150
CSQDGNLPTL ISSVHRSRHL VMPEHQSRCE FQRGSLEIGL RPAGDLLGKR
160 170 180 190 200
LGRSPRISSD CFSEKRARSE SPQEALLLPR ELGPSMAPED HYRRLVSALS
210 220 230 240 250
EASTFEDPQR LYHLGLPSHG EDPPWHDPPH HLPSHDLLRV RQEVAAAALR
260 270 280 290 300
GPSGLEAHLP SSTAGQRRKQ GLAQHREGAA PAAAPSFSER ELPQPPPLLS
310 320 330 340 350
PQNAPHVALG PHLRPPFLGV PSALCQTPGY GFLPPAQAEM FAWQQELLRK
360 370 380 390 400
QNLARLELPA DLLRQKELES ARPQLLAPET ALRPNDGAEE LQRRGALLVL
410 420 430 440 450
NHGAAPLLAL PPQGPPGSGP PTPSRDSARR APRKGGPGPA SARPSESKEM
460 470 480 490 500
TGARLWAQDG SEDEPPKDSD GEDPETAAVG CRGPTPGQAP AGGAGAEGKG
510 520 530 540 550
LFPGSTLPLG FPYAVSPYFH TGAVGGLSMD GEEAPAPEDV TKWTVDDVCS
560 570 580 590 600
FVGGLSGCGE YTRVFREQGI DGETLPLLTE EHLLTNMGLK LGPALKIRAQ
610 620 630 640 650
VARRLGRVFY VASFPVALPL QPPTLRAPER ELGTGEQPLS PTTATSPYGG
660 670 680
GHALAGQTSP KQENGTLALL PGAPDPSQPL C
Isoform 2 (identifier: Q96NU1-2) [UniParc]FASTAAdd to basket
Also known as: AP-SAMD11-ASV
The sequence of this isoform differs from the canonical sequence as follows:
1-185: Missing.
601-601: V → VRRWGVRSGSPDHSWAESSGWVCDSPHQAISLQV
Note: Produced by alternative promoter usage and alternative splicing.Curated
Show »Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WX24 | A0A087WX24_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 845 | Annotation score: | ||
A0A087WU74 | A0A087WU74_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 844 | Annotation score: | ||
H7C3J6 | H7C3J6_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 541 | Annotation score: | ||
H7BY14 | H7BY14_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 589 | Annotation score: | ||
A0A087WYW1 | A0A087WYW1_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 682 | Annotation score: | ||
A0A087X1J5 | A0A087X1J5_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 619 | Annotation score: | ||
A0A087WXB3 | A0A087WXB3_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 556 | Annotation score: | ||
A0A087WYU3 | A0A087WYU3_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 661 | Annotation score: | ||
A0A087X223 | A0A087X223_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 573 | Annotation score: | ||
Q5SV95 | Q5SV95_HUMAN | Sterile alpha motif domain-containi... | SAMD11 | 109 | Annotation score: |
Sequence cautioni
The sequence BAB70781 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 129 | C → L in AAH24295 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 162 | F → L in AFP36417 (PubMed:23978614).Curated | 1 | |
Sequence conflicti | 343 | W → R in AFP36417 (PubMed:23978614).Curated | 1 | |
Sequence conflicti | 343 | W → R in AFP36421 (PubMed:23978614).Curated | 1 | |
Sequence conflicti | 343 | W → R in AFP36422 (PubMed:23978614).Curated | 1 | |
Sequence conflicti | 343 | W → R in BAB70781 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 343 | W → R in AAH24295 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 343 | W → R in AAH33213 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053647 | 1 – 185 | Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST | 185 | |
Alternative sequenceiVSP_053648 | 173 | Q → QA in isoform 4 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_053649 | 220 – 235 | Missing in isoform 1, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_053650 | 601 | V → VRRWGVRSGSPDHSWAESSG WVCDSPHQAISLQV in isoform 2 and isoform 5. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX093066 mRNA Translation: AFP36417.1 JX093070 mRNA Translation: AFP36421.1 JX093071 mRNA Translation: AFP36422.1 AK054643 mRNA Translation: BAB70781.1 Different initiation. AL645608 Genomic DNA No translation available. BC024295 mRNA Translation: AAH24295.1 BC033213 mRNA Translation: AAH33213.1 |
CCDSi | CCDS2.2 [Q96NU1-3] |
RefSeqi | NP_689699.2, NM_152486.2 [Q96NU1-3] |
Genome annotation databases
Ensembli | ENST00000342066; ENSP00000342313; ENSG00000187634 |
GeneIDi | 148398 |
KEGGi | hsa:148398 |
UCSCi | uc001abw.2, human [Q96NU1-3] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX093066 mRNA Translation: AFP36417.1 JX093070 mRNA Translation: AFP36421.1 JX093071 mRNA Translation: AFP36422.1 AK054643 mRNA Translation: BAB70781.1 Different initiation. AL645608 Genomic DNA No translation available. BC024295 mRNA Translation: AAH24295.1 BC033213 mRNA Translation: AAH33213.1 |
CCDSi | CCDS2.2 [Q96NU1-3] |
RefSeqi | NP_689699.2, NM_152486.2 [Q96NU1-3] |
3D structure databases
SMRi | Q96NU1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127146, 34 interactors |
IntActi | Q96NU1, 27 interactors |
MINTi | Q96NU1 |
STRINGi | 9606.ENSP00000342313 |
PTM databases
iPTMneti | Q96NU1 |
PhosphoSitePlusi | Q96NU1 |
SwissPalmi | Q96NU1 |
Genetic variation databases
BioMutai | SAMD11 |
DMDMi | 166215037 |
Proteomic databases
jPOSTi | Q96NU1 |
MassIVEi | Q96NU1 |
MaxQBi | Q96NU1 |
PaxDbi | Q96NU1 |
PeptideAtlasi | Q96NU1 |
PRIDEi | Q96NU1 |
ProteomicsDBi | 77562 [Q96NU1-3] 77563 [Q96NU1-1] 77564 [Q96NU1-2] |
Protocols and materials databases
Antibodypediai | 56168, 21 antibodies from 8 providers |
DNASUi | 148398 |
Genome annotation databases
Ensembli | ENST00000342066; ENSP00000342313; ENSG00000187634 |
GeneIDi | 148398 |
KEGGi | hsa:148398 |
UCSCi | uc001abw.2, human [Q96NU1-3] |
Organism-specific databases
CTDi | 148398 |
DisGeNETi | 148398 |
GeneCardsi | SAMD11 |
HGNCi | HGNC:28706, SAMD11 |
HPAi | ENSG00000187634, Low tissue specificity |
neXtProti | NX_Q96NU1 |
OpenTargetsi | ENSG00000187634 |
PharmGKBi | PA134968665 |
VEuPathDBi | HostDB:ENSG00000187634 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4333, Eukaryota |
GeneTreei | ENSGT00940000160830 |
InParanoidi | Q96NU1 |
OrthoDBi | 622508at2759 |
PhylomeDBi | Q96NU1 |
TreeFami | TF331299 |
Enzyme and pathway databases
PathwayCommonsi | Q96NU1 |
SignaLinki | Q96NU1 |
Miscellaneous databases
BioGRID-ORCSi | 148398, 4 hits in 1040 CRISPR screens |
ChiTaRSi | SAMD11, human |
GenomeRNAii | 148398 |
Pharosi | Q96NU1, Tdark |
PROi | PR:Q96NU1 |
RNActi | Q96NU1, protein |
Gene expression databases
Bgeei | ENSG00000187634, Expressed in pituitary gland and 142 other tissues |
ExpressionAtlasi | Q96NU1, baseline and differential |
Genevisiblei | Q96NU1, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAM11_HUMAN | |
Accessioni | Q96NU1Primary (citable) accession number: Q96NU1 Secondary accession number(s): A2AA76 Q8TB59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM