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Entry version 122 (08 May 2019)
Sequence version 3 (15 Jan 2008)
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Protein

Sterile alpha motif domain-containing protein 11

Gene

SAMD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in photoreceptor development.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 11
Short name:
SAM domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAMD11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28706 SAMD11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
148398

Open Targets

More...
OpenTargetsi
ENSG00000187634

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134968665

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAMD11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166215037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002795001 – 681Sterile alpha motif domain-containing protein 11Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei485PhosphothreonineCombined sources1
Modified residuei640PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96NU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NU1

PeptideAtlas

More...
PeptideAtlasi
Q96NU1

PRoteomics IDEntifications database

More...
PRIDEi
Q96NU1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77562
77563 [Q96NU1-1]
77564 [Q96NU1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NU1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96NU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187634 Expressed in 118 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NU1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NU1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030110

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127146, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NU1, 20 interactors

Molecular INTeraction database

More...
MINTi
Q96NU1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NU1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 608SAMPROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGHY Eukaryota
ENOG4112BEA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160830

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154248

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NU1

Database of Orthologous Groups

More...
OrthoDBi
622508at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NU1

TreeFam database of animal gene trees

More...
TreeFami
TF331299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Many additional isoforms seem to exist.

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q96NU1-3) [UniParc]FASTAAdd to basket
Also known as: FL-SAMD11

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGILQVHP PICDCPGCRI SSPVNRGRLA DKRTVALPAA RNLKKERTPS
60 70 80 90 100
FSASDGDSDG SGPTCGRRPG LKQEDGPHIR IMKRRVHTHW DVNISFREAS
110 120 130 140 150
CSQDGNLPTL ISSVHRSRHL VMPEHQSRCE FQRGSLEIGL RPAGDLLGKR
160 170 180 190 200
LGRSPRISSD CFSEKRARSE SPQEALLLPR ELGPSMAPED HYRRLVSALS
210 220 230 240 250
EASTFEDPQR LYHLGLPSHG EDPPWHDPPH HLPSHDLLRV RQEVAAAALR
260 270 280 290 300
GPSGLEAHLP SSTAGQRRKQ GLAQHREGAA PAAAPSFSER ELPQPPPLLS
310 320 330 340 350
PQNAPHVALG PHLRPPFLGV PSALCQTPGY GFLPPAQAEM FAWQQELLRK
360 370 380 390 400
QNLARLELPA DLLRQKELES ARPQLLAPET ALRPNDGAEE LQRRGALLVL
410 420 430 440 450
NHGAAPLLAL PPQGPPGSGP PTPSRDSARR APRKGGPGPA SARPSESKEM
460 470 480 490 500
TGARLWAQDG SEDEPPKDSD GEDPETAAVG CRGPTPGQAP AGGAGAEGKG
510 520 530 540 550
LFPGSTLPLG FPYAVSPYFH TGAVGGLSMD GEEAPAPEDV TKWTVDDVCS
560 570 580 590 600
FVGGLSGCGE YTRVFREQGI DGETLPLLTE EHLLTNMGLK LGPALKIRAQ
610 620 630 640 650
VARRLGRVFY VASFPVALPL QPPTLRAPER ELGTGEQPLS PTTATSPYGG
660 670 680
GHALAGQTSP KQENGTLALL PGAPDPSQPL C
Length:681
Mass (Da):72,708
Last modified:January 15, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5ED0792A8997DFF7
GO
Isoform 1 (identifier: Q96NU1-1) [UniParc]FASTAAdd to basket
Also known as: SAMD11-ASV

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: Missing.
     220-235: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:480
Mass (Da):50,485
Checksum:i49417F0B6AF75DAD
GO
Isoform 2 (identifier: Q96NU1-2) [UniParc]FASTAAdd to basket
Also known as: AP-SAMD11-ASV

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: Missing.
     601-601: V → VRRWGVRSGSPDHSWAESSGWVCDSPHQAISLQV

Note: Produced by alternative promoter usage and alternative splicing.
Show »
Length:529
Mass (Da):55,983
Checksum:i866D06458EBEB3AC
GO
Isoform 4 (identifier: Q96NU1-4) [UniParc]FASTAAdd to basket
Also known as: SAMD11-ASV5

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: Q → QA
     220-235: Missing.

Note: Produced by alternative splicing.
Show »
Length:666
Mass (Da):70,942
Checksum:iDDA6EB5A74B3A39B
GO
Isoform 5 (identifier: Q96NU1-5) [UniParc]FASTAAdd to basket
Also known as: SAMD11-ASV1

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: Q → QA
     220-235: Missing.
     601-601: V → VRRWGVRSGSPDHSWAESSGWVCDSPHQAISLQV

Note: Produced by alternative splicing.
Show »
Length:699
Mass (Da):74,603
Checksum:iA8FDB0C5F9DB4452
GO
Isoform 6 (identifier: Q96NU1-6) [UniParc]FASTAAdd to basket
Also known as: SAMD11-ASV6

The sequence of this isoform differs from the canonical sequence as follows:
     220-235: Missing.

Note: Produced by alternative splicing.
Show »
Length:665
Mass (Da):70,871
Checksum:iDD27AA0A40248F50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PWC8A6PWC8_HUMAN
Sterile alpha motif domain-containi...
SAMD11
358Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY14H7BY14_HUMAN
Sterile alpha motif domain-containi...
SAMD11
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3J6H7C3J6_HUMAN
Sterile alpha motif domain-containi...
SAMD11
541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYW1A0A087WYW1_HUMAN
Sterile alpha motif domain-containi...
SAMD11
682Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X223A0A087X223_HUMAN
Sterile alpha motif domain-containi...
SAMD11
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXB3A0A087WXB3_HUMAN
Sterile alpha motif domain-containi...
SAMD11
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYU3A0A087WYU3_HUMAN
Sterile alpha motif domain-containi...
SAMD11
601Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1J5A0A087X1J5_HUMAN
Sterile alpha motif domain-containi...
SAMD11
619Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SV95Q5SV95_HUMAN
Sterile alpha motif domain-containi...
SAMD11
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2A3A0A087X2A3_HUMAN
Sterile alpha motif domain-containi...
SAMD11
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB70781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129C → L in AAH24295 (PubMed:15489334).Curated1
Sequence conflicti162F → L in AFP36417 (PubMed:23978614).Curated1
Sequence conflicti343W → R in AFP36417 (PubMed:23978614).Curated1
Sequence conflicti343W → R in AFP36421 (PubMed:23978614).Curated1
Sequence conflicti343W → R in AFP36422 (PubMed:23978614).Curated1
Sequence conflicti343W → R in BAB70781 (PubMed:14702039).Curated1
Sequence conflicti343W → R in AAH24295 (PubMed:15489334).Curated1
Sequence conflicti343W → R in AAH33213 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536471 – 185Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST185
Alternative sequenceiVSP_053648173Q → QA in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_053649220 – 235Missing in isoform 1, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_053650601V → VRRWGVRSGSPDHSWAESSG WVCDSPHQAISLQV in isoform 2 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX093066 mRNA Translation: AFP36417.1
JX093070 mRNA Translation: AFP36421.1
JX093071 mRNA Translation: AFP36422.1
AK054643 mRNA Translation: BAB70781.1 Different initiation.
AL645608 Genomic DNA No translation available.
BC024295 mRNA Translation: AAH24295.1
BC033213 mRNA Translation: AAH33213.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2.2 [Q96NU1-3]

NCBI Reference Sequences

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RefSeqi
NP_689699.2, NM_152486.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342066; ENSP00000342313; ENSG00000187634 [Q96NU1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148398

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:148398

UCSC genome browser

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UCSCi
uc001abw.2 human [Q96NU1-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX093066 mRNA Translation: AFP36417.1
JX093070 mRNA Translation: AFP36421.1
JX093071 mRNA Translation: AFP36422.1
AK054643 mRNA Translation: BAB70781.1 Different initiation.
AL645608 Genomic DNA No translation available.
BC024295 mRNA Translation: AAH24295.1
BC033213 mRNA Translation: AAH33213.1
CCDSiCCDS2.2 [Q96NU1-3]
RefSeqiNP_689699.2, NM_152486.2

3D structure databases

SMRiQ96NU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127146, 9 interactors
IntActiQ96NU1, 20 interactors
MINTiQ96NU1
STRINGi9606.ENSP00000342313

PTM databases

iPTMnetiQ96NU1
PhosphoSitePlusiQ96NU1
SwissPalmiQ96NU1

Polymorphism and mutation databases

BioMutaiSAMD11
DMDMi166215037

Proteomic databases

jPOSTiQ96NU1
PaxDbiQ96NU1
PeptideAtlasiQ96NU1
PRIDEiQ96NU1
ProteomicsDBi77562
77563 [Q96NU1-1]
77564 [Q96NU1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342066; ENSP00000342313; ENSG00000187634 [Q96NU1-3]
GeneIDi148398
KEGGihsa:148398
UCSCiuc001abw.2 human [Q96NU1-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
148398
DisGeNETi148398

GeneCards: human genes, protein and diseases

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GeneCardsi
SAMD11
HGNCiHGNC:28706 SAMD11
HPAiHPA030110
neXtProtiNX_Q96NU1
OpenTargetsiENSG00000187634
PharmGKBiPA134968665

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGHY Eukaryota
ENOG4112BEA LUCA
GeneTreeiENSGT00940000160830
HOGENOMiHOG000154248
InParanoidiQ96NU1
OrthoDBi622508at2759
PhylomeDBiQ96NU1
TreeFamiTF331299

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SAMD11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
148398

Protein Ontology

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PROi
PR:Q96NU1

Gene expression databases

BgeeiENSG00000187634 Expressed in 118 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ96NU1 baseline and differential
GenevisibleiQ96NU1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAM11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NU1
Secondary accession number(s): A2AA76
, I7FV78, I7FV81, I7G0Z6, Q5SV96, Q5SV99, Q5SVA0, Q8N195, Q8TB59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 15, 2008
Last modified: May 8, 2019
This is version 122 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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