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Entry version 123 (13 Nov 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Protein GUCD1

Gene

GUCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein GUCD1
Alternative name(s):
Guanylyl cyclase domain-containing protein 1
Protein LLN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GUCD1
Synonyms:C22orf13, LLN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14237 GUCD1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NT3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83606

Open Targets

More...
OpenTargetsi
ENSG00000138867

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25882

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96NT3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GUCD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811383

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795741 – 240Protein GUCD1Add BLAST240

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96NT3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96NT3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96NT3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NT3

PeptideAtlas

More...
PeptideAtlasi
Q96NT3

PRoteomics IDEntifications database

More...
PRIDEi
Q96NT3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6066
77555 [Q96NT3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138867 Expressed in 199 organ(s), highest expression level in apex of heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NT3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NT3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022786

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123697, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NT3, 78 interactors

Molecular INTeraction database

More...
MINTi
Q96NT3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4621 Eukaryota
ENOG4111HS3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015782

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NT3

Database of Orthologous Groups

More...
OrthoDBi
1348354at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NT3

TreeFam database of animal gene trees

More...
TreeFami
TF324062

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018616 GUCD1

The PANTHER Classification System

More...
PANTHERi
PTHR31400 PTHR31400, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09778 Guanylate_cyc_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD
60 70 80 90 100
SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF
110 120 130 140 150
YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV
160 170 180 190 200
NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI
210 220 230 240
FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS
Length:240
Mass (Da):27,207
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i164875E32F70D1E0
GO
Isoform 2 (identifier: Q96NT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: PG → R

Show »
Length:239
Mass (Da):27,209
Checksum:i671CC5ABE4236335
GO
Isoform 3 (identifier: Q96NT3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MRTEAEAAGPPLE → MTGPGGRRND...SQFHLLIPAP
     210-211: PG → R

Show »
Length:295
Mass (Da):33,476
Checksum:i0D00A1849B036EB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVD9A0A087WVD9_HUMAN
Protein GUCD1
GUCD1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX77E7EX77_HUMAN
Protein GUCD1
GUCD1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGZ7E9PGZ7_HUMAN
Protein GUCD1
GUCD1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCF3B5MCF3_HUMAN
Protein GUCD1
GUCD1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB68411 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12 – 13LE → AP in AAH02924 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557531 – 13MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_044730210 – 211PG → R in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK054681 mRNA Translation: BAB70791.1
AK098754 mRNA No translation available.
AP000356 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59667.1
BC002924 mRNA Translation: AAH02924.2
BC070109 mRNA Translation: AAH70109.1
AB049215 Genomic DNA Translation: BAB68411.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33621.1 [Q96NT3-1]
CCDS63426.1 [Q96NT3-2]
CCDS63427.1 [Q96NT3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001271180.1, NM_001284251.1
NP_001271181.1, NM_001284252.1 [Q96NT3-3]
NP_001271183.1, NM_001284254.1 [Q96NT3-2]
NP_001271184.1, NM_001284255.1
NP_001271185.1, NM_001284256.1
NP_001271186.1, NM_001284257.1
NP_113632.2, NM_031444.3 [Q96NT3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398245; ENSP00000381297; ENSG00000138867 [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867 [Q96NT3-3]
ENST00000407471; ENSP00000386076; ENSG00000138867 [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867 [Q96NT3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83606

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83606

UCSC genome browser

More...
UCSCi
uc003aah.4 human [Q96NT3-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054681 mRNA Translation: BAB70791.1
AK098754 mRNA No translation available.
AP000356 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59667.1
BC002924 mRNA Translation: AAH02924.2
BC070109 mRNA Translation: AAH70109.1
AB049215 Genomic DNA Translation: BAB68411.1 Different initiation.
CCDSiCCDS33621.1 [Q96NT3-1]
CCDS63426.1 [Q96NT3-2]
CCDS63427.1 [Q96NT3-3]
RefSeqiNP_001271180.1, NM_001284251.1
NP_001271181.1, NM_001284252.1 [Q96NT3-3]
NP_001271183.1, NM_001284254.1 [Q96NT3-2]
NP_001271184.1, NM_001284255.1
NP_001271185.1, NM_001284256.1
NP_001271186.1, NM_001284257.1
NP_113632.2, NM_031444.3 [Q96NT3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123697, 17 interactors
IntActiQ96NT3, 78 interactors
MINTiQ96NT3
STRINGi9606.ENSP00000479370

PTM databases

iPTMnetiQ96NT3
PhosphoSitePlusiQ96NT3

Polymorphism and mutation databases

BioMutaiGUCD1
DMDMi143811383

Proteomic databases

jPOSTiQ96NT3
MassIVEiQ96NT3
MaxQBiQ96NT3
PaxDbiQ96NT3
PeptideAtlasiQ96NT3
PRIDEiQ96NT3
ProteomicsDBi6066
77555 [Q96NT3-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83606

Genome annotation databases

EnsembliENST00000398245; ENSP00000381297; ENSG00000138867 [Q96NT3-2]
ENST00000404664; ENSP00000384121; ENSG00000138867 [Q96NT3-3]
ENST00000407471; ENSP00000386076; ENSG00000138867 [Q96NT3-1]
ENST00000435822; ENSP00000405985; ENSG00000138867 [Q96NT3-2]
GeneIDi83606
KEGGihsa:83606
UCSCiuc003aah.4 human [Q96NT3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83606
DisGeNETi83606

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GUCD1
HGNCiHGNC:14237 GUCD1
HPAiHPA022786
neXtProtiNX_Q96NT3
OpenTargetsiENSG00000138867
PharmGKBiPA25882

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4621 Eukaryota
ENOG4111HS3 LUCA
GeneTreeiENSGT00390000000571
HOGENOMiHOG000015782
InParanoidiQ96NT3
OrthoDBi1348354at2759
PhylomeDBiQ96NT3
TreeFamiTF324062

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GUCD1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83606
PharosiQ96NT3

Protein Ontology

More...
PROi
PR:Q96NT3

Gene expression databases

BgeeiENSG00000138867 Expressed in 199 organ(s), highest expression level in apex of heart
ExpressionAtlasiQ96NT3 baseline and differential
GenevisibleiQ96NT3 HS

Family and domain databases

InterProiView protein in InterPro
IPR018616 GUCD1
PANTHERiPTHR31400 PTHR31400, 1 hit
PfamiView protein in Pfam
PF09778 Guanylate_cyc_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUCD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NT3
Secondary accession number(s): B5MCB8
, B5MCL7, Q96Q79, Q9BU32
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 3, 2007
Last modified: November 13, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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