UniProtKB - Q96NT3 (GUCD1_HUMAN)
Protein
Protein GUCD1
Gene
GUCD1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein GUCD1Alternative name(s): Guanylyl cyclase domain-containing protein 1 Protein LLN4 |
Gene namesi | Name:GUCD1 Synonyms:C22orf13, LLN4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138867.16 |
HGNCi | HGNC:14237, GUCD1 |
neXtProti | NX_Q96NT3 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 83606 |
OpenTargetsi | ENSG00000138867 |
PharmGKBi | PA25882 |
Miscellaneous databases
Pharosi | Q96NT3, Tdark |
Polymorphism and mutation databases
BioMutai | GUCD1 |
DMDMi | 143811383 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079574 | 1 – 240 | Protein GUCD1Add BLAST | 240 |
Proteomic databases
jPOSTi | Q96NT3 |
MassIVEi | Q96NT3 |
MaxQBi | Q96NT3 |
PaxDbi | Q96NT3 |
PeptideAtlasi | Q96NT3 |
PRIDEi | Q96NT3 |
ProteomicsDBi | 6066 77555 [Q96NT3-1] |
PTM databases
iPTMneti | Q96NT3 |
PhosphoSitePlusi | Q96NT3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138867, Expressed in apex of heart and 213 other tissues |
ExpressionAtlasi | Q96NT3, baseline and differential |
Genevisiblei | Q96NT3, HS |
Organism-specific databases
HPAi | ENSG00000138867, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Q96NT3
Isoform 2 [Q96NT3-2]
Protein-protein interaction databases
BioGRIDi | 123697, 87 interactors |
IntActi | Q96NT3, 78 interactors |
MINTi | Q96NT3 |
STRINGi | 9606.ENSP00000479370 |
Miscellaneous databases
RNActi | Q96NT3, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG4621, Eukaryota |
GeneTreei | ENSGT00390000000571 |
HOGENOMi | CLU_064395_0_1_1 |
InParanoidi | Q96NT3 |
OrthoDBi | 1348354at2759 |
PhylomeDBi | Q96NT3 |
TreeFami | TF324062 |
Family and domain databases
InterProi | View protein in InterPro IPR018616, GUCD1 |
PANTHERi | PTHR31400, PTHR31400, 1 hit |
Pfami | View protein in Pfam PF09778, Guanylate_cyc_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96NT3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRTEAEAAGP PLEPGDFVQL PVPVIQQLYH WDCGLACSRM VLRYLGQLDD
60 70 80 90 100
SEFERALQKL QLTRSIWTID LAYLMHHFGV RHRFCTQTLG VDKGYKNQSF
110 120 130 140 150
YRKHFDTEET RVNQLFAQAK ACKVLVEKCT VSVKDIQAHL AQGHVAIVLV
160 170 180 190 200
NSGVLHCDLC SSPVKYCCFT PSGHHCFCRT PDYQGHFIVL RGYNRATGCI
210 220 230 240
FYNNPAYADP GMCSTSISNF EEARTSYGTD EDILFVYLDS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVD9 | A0A087WVD9_HUMAN | Protein GUCD1 | GUCD1 | 296 | Annotation score: | ||
E7EX77 | E7EX77_HUMAN | Protein GUCD1 | GUCD1 | 136 | Annotation score: | ||
E9PGZ7 | E9PGZ7_HUMAN | Protein GUCD1 | GUCD1 | 137 | Annotation score: | ||
B5MCF3 | B5MCF3_HUMAN | Protein GUCD1 | GUCD1 | 127 | Annotation score: |
Sequence cautioni
The sequence BAB68411 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 13 | LE → AP in AAH02924 (PubMed:15489334).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055753 | 1 – 13 | MRTEA…GPPLE → MTGPGGRRNDPWGRQRAREG AHTSKHPTPRTGWTARRRRG AWALRPGTAGGWAKGQDFPS QFHLLIPAP in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_044730 | 210 – 211 | PG → R in isoform 2 and isoform 3. 2 Publications | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK054681 mRNA Translation: BAB70791.1 AK098754 mRNA No translation available. AP000356 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59667.1 BC002924 mRNA Translation: AAH02924.2 BC070109 mRNA Translation: AAH70109.1 AB049215 Genomic DNA Translation: BAB68411.1 Different initiation. |
CCDSi | CCDS33621.1 [Q96NT3-1] CCDS63426.1 [Q96NT3-2] CCDS63427.1 [Q96NT3-3] |
RefSeqi | NP_001271180.1, NM_001284251.1 NP_001271181.1, NM_001284252.1 [Q96NT3-3] NP_001271183.1, NM_001284254.1 [Q96NT3-2] NP_001271184.1, NM_001284255.1 NP_001271185.1, NM_001284256.1 NP_001271186.1, NM_001284257.1 NP_113632.2, NM_031444.3 [Q96NT3-1] |
Genome annotation databases
Ensembli | ENST00000398245; ENSP00000381297; ENSG00000138867 [Q96NT3-2] ENST00000404664; ENSP00000384121; ENSG00000138867 [Q96NT3-3] ENST00000407471; ENSP00000386076; ENSG00000138867 [Q96NT3-1] ENST00000435822; ENSP00000405985; ENSG00000138867 [Q96NT3-2] |
GeneIDi | 83606 |
KEGGi | hsa:83606 |
UCSCi | uc003aah.4, human [Q96NT3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK054681 mRNA Translation: BAB70791.1 AK098754 mRNA No translation available. AP000356 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59667.1 BC002924 mRNA Translation: AAH02924.2 BC070109 mRNA Translation: AAH70109.1 AB049215 Genomic DNA Translation: BAB68411.1 Different initiation. |
CCDSi | CCDS33621.1 [Q96NT3-1] CCDS63426.1 [Q96NT3-2] CCDS63427.1 [Q96NT3-3] |
RefSeqi | NP_001271180.1, NM_001284251.1 NP_001271181.1, NM_001284252.1 [Q96NT3-3] NP_001271183.1, NM_001284254.1 [Q96NT3-2] NP_001271184.1, NM_001284255.1 NP_001271185.1, NM_001284256.1 NP_001271186.1, NM_001284257.1 NP_113632.2, NM_031444.3 [Q96NT3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123697, 87 interactors |
IntActi | Q96NT3, 78 interactors |
MINTi | Q96NT3 |
STRINGi | 9606.ENSP00000479370 |
PTM databases
iPTMneti | Q96NT3 |
PhosphoSitePlusi | Q96NT3 |
Polymorphism and mutation databases
BioMutai | GUCD1 |
DMDMi | 143811383 |
Proteomic databases
jPOSTi | Q96NT3 |
MassIVEi | Q96NT3 |
MaxQBi | Q96NT3 |
PaxDbi | Q96NT3 |
PeptideAtlasi | Q96NT3 |
PRIDEi | Q96NT3 |
ProteomicsDBi | 6066 77555 [Q96NT3-1] |
Protocols and materials databases
Antibodypediai | 9753, 77 antibodies |
DNASUi | 83606 |
Genome annotation databases
Ensembli | ENST00000398245; ENSP00000381297; ENSG00000138867 [Q96NT3-2] ENST00000404664; ENSP00000384121; ENSG00000138867 [Q96NT3-3] ENST00000407471; ENSP00000386076; ENSG00000138867 [Q96NT3-1] ENST00000435822; ENSP00000405985; ENSG00000138867 [Q96NT3-2] |
GeneIDi | 83606 |
KEGGi | hsa:83606 |
UCSCi | uc003aah.4, human [Q96NT3-1] |
Organism-specific databases
CTDi | 83606 |
DisGeNETi | 83606 |
EuPathDBi | HostDB:ENSG00000138867.16 |
GeneCardsi | GUCD1 |
HGNCi | HGNC:14237, GUCD1 |
HPAi | ENSG00000138867, Tissue enhanced (liver) |
neXtProti | NX_Q96NT3 |
OpenTargetsi | ENSG00000138867 |
PharmGKBi | PA25882 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4621, Eukaryota |
GeneTreei | ENSGT00390000000571 |
HOGENOMi | CLU_064395_0_1_1 |
InParanoidi | Q96NT3 |
OrthoDBi | 1348354at2759 |
PhylomeDBi | Q96NT3 |
TreeFami | TF324062 |
Enzyme and pathway databases
PathwayCommonsi | Q96NT3 |
Miscellaneous databases
BioGRID-ORCSi | 83606, 3 hits in 843 CRISPR screens |
ChiTaRSi | GUCD1, human |
GenomeRNAii | 83606 |
Pharosi | Q96NT3, Tdark |
PROi | PR:Q96NT3 |
RNActi | Q96NT3, protein |
Gene expression databases
Bgeei | ENSG00000138867, Expressed in apex of heart and 213 other tissues |
ExpressionAtlasi | Q96NT3, baseline and differential |
Genevisiblei | Q96NT3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018616, GUCD1 |
PANTHERi | PTHR31400, PTHR31400, 1 hit |
Pfami | View protein in Pfam PF09778, Guanylate_cyc_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GUCD1_HUMAN | |
Accessioni | Q96NT3Primary (citable) accession number: Q96NT3 Secondary accession number(s): B5MCB8 Q9BU32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM