UniProtKB - Q96NM4 (TOX2_HUMAN)
Protein
TOX high mobility group box family member 2
Gene
TOX2
Organism
Homo sapiens (Human)
Status
Functioni
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
Caution
It is uncertain whether Met-1 or Met-52 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 255 – 323 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin DNA binding Source: GO_Central
- transcription coactivator activity Source: NTNU_SB
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q96NM4 |
Names & Taxonomyi
Protein namesi | Recommended name: TOX high mobility group box family member 2Alternative name(s): Granulosa cell HMG box protein 1 Short name: GCX-1 |
Gene namesi | Name:TOX2 Synonyms:C20orf100, GCX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124191.17 |
HGNCi | HGNC:16095, TOX2 |
MIMi | 611163, gene |
neXtProti | NX_Q96NM4 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84969 |
OpenTargetsi | ENSG00000124191 |
PharmGKBi | PA162406727 |
Miscellaneous databases
Pharosi | Q96NM4, Tbio |
Polymorphism and mutation databases
BioMutai | TOX2 |
DMDMi | 24211591 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048571 | 1 – 488 | TOX high mobility group box family member 2Add BLAST | 488 |
Proteomic databases
jPOSTi | Q96NM4 |
MassIVEi | Q96NM4 |
MaxQBi | Q96NM4 |
PeptideAtlasi | Q96NM4 |
PRIDEi | Q96NM4 |
ProteomicsDBi | 15213 33713 77537 [Q96NM4-1] 77538 [Q96NM4-2] |
PTM databases
iPTMneti | Q96NM4 |
PhosphoSitePlusi | Q96NM4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124191, Expressed in right lung and 160 other tissues |
ExpressionAtlasi | Q96NM4, baseline and differential |
Genevisiblei | Q96NM4, HS |
Organism-specific databases
HPAi | ENSG00000124191, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
Hide detailsIsoform 3 [Q96NM4-3]
Protein-protein interaction databases
BioGRIDi | 124399, 27 interactors |
IntActi | Q96NM4, 25 interactors |
STRINGi | 9606.ENSP00000344724 |
Miscellaneous databases
RNActi | Q96NM4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 114 | Required for transcriptional activationBy similarityAdd BLAST | 39 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 223 – 252 | Nuclear localization signalBy similarityAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 245 – 250 | Poly-Lys | 6 | |
Compositional biasi | 372 – 456 | Pro-richAdd BLAST | 85 |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158764 |
HOGENOMi | CLU_030650_2_0_1 |
InParanoidi | Q96NM4 |
OMAi | PPSKMIP |
OrthoDBi | 818359at2759 |
PhylomeDBi | Q96NM4 |
TreeFami | TF106481 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96NM4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQQTRTEAVA GAFSRCLGFC GMRLGLLLLA RHWCIAGVFP QKFDGDSAYV
60 70 80 90 100
GMSDGNPELL STSQTYNGQS ENNEDYEIPP ITPPNLPEPS LLHLGDHEAS
110 120 130 140 150
YHSLCHGLTP NGLLPAYSYQ AMDLPAIMVS NMLAQDSHLL SGQLPTIQEM
160 170 180 190 200
VHSEVAAYDS GRPGPLLGRP AMLASHMSAL SQSQLISQMG IRSSIAHSSP
210 220 230 240 250
SPPGSKSATP SPSSSTQEEE SEVHFKISGE KRPSADPGKK AKNPKKKKKK
260 270 280 290 300
DPNEPQKPVS AYALFFRDTQ AAIKGQNPSA TFGDVSKIVA SMWDSLGEEQ
310 320 330 340 350
KQSSPDQGET KSTQANPPAK MLPPKQPMYA MPGLASFLTP SDLQAFRSGA
360 370 380 390 400
SPASLARTLG SKSLLPGLSA SPPPPPSFPL SPTLHQQLSL PPHAQGALLS
410 420 430 440 450
PPVSMSPAPQ PPVLPTPMAL QVQLAMSPSP PGPQDFPHIS EFPSSSGSCS
460 470 480
PGPSNPTSSG DWDSSYPSGE CGISTCSLLP RDKSLYLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JYD4 | Q5JYD4_HUMAN | TOX high mobility group box family ... | TOX2 | 196 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 372 | P → PP in BAF82595 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 482 | D → N in BAB70860 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049560 | 223 | V → A. Corresponds to variant dbSNP:rs6103584Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045645 | 1 – 51 | Missing in isoform 3. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_047108 | 1 – 41 | MQQTR…GVFPQ → MDVRLYPSAPAVGARPGAEP AGLAHLDYYHGG in isoform 4. CuratedAdd BLAST | 41 | |
Alternative sequenceiVSP_002187 | 302 | Q → QAYKRKTEAAKKEYLKALAA YRASLVSK in isoform 2, isoform 3 and isoform 4. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055135 mRNA Translation: BAB70860.1 AK289906 mRNA Translation: BAF82595.1 AL034419 Genomic DNA No translation available. AL121587 Genomic DNA No translation available. AL035089 Genomic DNA No translation available. AL353797 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75944.1 CH471077 Genomic DNA Translation: EAW75945.1 CH471077 Genomic DNA Translation: EAW75946.1 BC007636 mRNA No translation available. |
CCDSi | CCDS13324.1 [Q96NM4-3] CCDS42875.1 [Q96NM4-1] CCDS46603.1 [Q96NM4-4] |
RefSeqi | NP_001092266.1, NM_001098796.1 [Q96NM4-3] NP_001092267.1, NM_001098797.1 [Q96NM4-4] NP_001092268.1, NM_001098798.1 [Q96NM4-1] NP_116272.1, NM_032883.2 [Q96NM4-3] XP_006723947.1, XM_006723884.1 [Q96NM4-2] |
Genome annotation databases
Ensembli | ENST00000341197; ENSP00000344724; ENSG00000124191 [Q96NM4-4] ENST00000358131; ENSP00000350849; ENSG00000124191 [Q96NM4-1] ENST00000372999; ENSP00000362090; ENSG00000124191 [Q96NM4-3] ENST00000423191; ENSP00000390278; ENSG00000124191 [Q96NM4-3] |
GeneIDi | 84969 |
KEGGi | hsa:84969 |
UCSCi | uc002xle.5, human [Q96NM4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055135 mRNA Translation: BAB70860.1 AK289906 mRNA Translation: BAF82595.1 AL034419 Genomic DNA No translation available. AL121587 Genomic DNA No translation available. AL035089 Genomic DNA No translation available. AL353797 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75944.1 CH471077 Genomic DNA Translation: EAW75945.1 CH471077 Genomic DNA Translation: EAW75946.1 BC007636 mRNA No translation available. |
CCDSi | CCDS13324.1 [Q96NM4-3] CCDS42875.1 [Q96NM4-1] CCDS46603.1 [Q96NM4-4] |
RefSeqi | NP_001092266.1, NM_001098796.1 [Q96NM4-3] NP_001092267.1, NM_001098797.1 [Q96NM4-4] NP_001092268.1, NM_001098798.1 [Q96NM4-1] NP_116272.1, NM_032883.2 [Q96NM4-3] XP_006723947.1, XM_006723884.1 [Q96NM4-2] |
3D structure databases
SMRi | Q96NM4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124399, 27 interactors |
IntActi | Q96NM4, 25 interactors |
STRINGi | 9606.ENSP00000344724 |
PTM databases
iPTMneti | Q96NM4 |
PhosphoSitePlusi | Q96NM4 |
Polymorphism and mutation databases
BioMutai | TOX2 |
DMDMi | 24211591 |
Proteomic databases
jPOSTi | Q96NM4 |
MassIVEi | Q96NM4 |
MaxQBi | Q96NM4 |
PeptideAtlasi | Q96NM4 |
PRIDEi | Q96NM4 |
ProteomicsDBi | 15213 33713 77537 [Q96NM4-1] 77538 [Q96NM4-2] |
Protocols and materials databases
Antibodypediai | 27319, 125 antibodies |
DNASUi | 84969 |
Genome annotation databases
Ensembli | ENST00000341197; ENSP00000344724; ENSG00000124191 [Q96NM4-4] ENST00000358131; ENSP00000350849; ENSG00000124191 [Q96NM4-1] ENST00000372999; ENSP00000362090; ENSG00000124191 [Q96NM4-3] ENST00000423191; ENSP00000390278; ENSG00000124191 [Q96NM4-3] |
GeneIDi | 84969 |
KEGGi | hsa:84969 |
UCSCi | uc002xle.5, human [Q96NM4-1] |
Organism-specific databases
CTDi | 84969 |
DisGeNETi | 84969 |
EuPathDBi | HostDB:ENSG00000124191.17 |
GeneCardsi | TOX2 |
HGNCi | HGNC:16095, TOX2 |
HPAi | ENSG00000124191, Tissue enhanced (lymphoid) |
MIMi | 611163, gene |
neXtProti | NX_Q96NM4 |
OpenTargetsi | ENSG00000124191 |
PharmGKBi | PA162406727 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000158764 |
HOGENOMi | CLU_030650_2_0_1 |
InParanoidi | Q96NM4 |
OMAi | PPSKMIP |
OrthoDBi | 818359at2759 |
PhylomeDBi | Q96NM4 |
TreeFami | TF106481 |
Enzyme and pathway databases
PathwayCommonsi | Q96NM4 |
Miscellaneous databases
BioGRID-ORCSi | 84969, 7 hits in 863 CRISPR screens |
ChiTaRSi | TOX2, human |
GenomeRNAii | 84969 |
Pharosi | Q96NM4, Tbio |
PROi | PR:Q96NM4 |
RNActi | Q96NM4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124191, Expressed in right lung and 160 other tissues |
ExpressionAtlasi | Q96NM4, baseline and differential |
Genevisiblei | Q96NM4, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TOX2_HUMAN | |
Accessioni | Q96NM4Primary (citable) accession number: Q96NM4 Secondary accession number(s): A8K1J1 Q9BQN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | October 19, 2002 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations