UniProtKB - Q96NL3 (ZN599_HUMAN)
Protein
Zinc finger protein 599
Gene
ZNF599
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 199 – 221 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 479 – 501 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 535 – 557 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 563 – 585 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96NL3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 599 |
Gene namesi | Name:ZNF599 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153896.17 |
HGNCi | HGNC:26408, ZNF599 |
neXtProti | NX_Q96NL3 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 148103 |
OpenTargetsi | ENSG00000153896 |
PharmGKBi | PA134983786 |
Miscellaneous databases
Pharosi | Q96NL3, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF599 |
DMDMi | 74762682 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234592 | 1 – 588 | Zinc finger protein 599Add BLAST | 588 |
Proteomic databases
jPOSTi | Q96NL3 |
MassIVEi | Q96NL3 |
PaxDbi | Q96NL3 |
PeptideAtlasi | Q96NL3 |
PRIDEi | Q96NL3 |
ProteomicsDBi | 77530 [Q96NL3-1] 77531 [Q96NL3-2] |
PTM databases
iPTMneti | Q96NL3 |
PhosphoSitePlusi | Q96NL3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153896, Expressed in secondary oocyte and 159 other tissues |
ExpressionAtlasi | Q96NL3, baseline and differential |
Genevisiblei | Q96NL3, HS |
Organism-specific databases
HPAi | ENSG00000153896, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96NL3
Protein-protein interaction databases
BioGRIDi | 127117, 9 interactors |
IntActi | Q96NL3, 8 interactors |
MINTi | Q96NL3 |
STRINGi | 9606.ENSP00000333802 |
Miscellaneous databases
RNActi | Q96NL3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 80 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 199 – 221 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 277 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 283 – 305 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 311 – 333 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 339 – 361 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 395 – 417 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 423 – 445 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 451 – 473 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 479 – 501 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 507 – 529 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 535 – 557 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 563 – 585 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159953 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q96NL3 |
OMAi | QSTCAGE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96NL3 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96NL3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPALALVS FEDVVVTFTG EEWGHLDLAQ RTLYQEVMLE TCRLLVSLGH
60 70 80 90 100
PVPKPELIYL LEHGQELWTV KRGLSQSTCA GEKAKPKITE PTASQLAFSE
110 120 130 140 150
ESSFQELLAQ RSSRDSRLGQ ARDEEKLIKI QEGNLRPGTN PHKEICPEKL
160 170 180 190 200
SYKHDDLEPD DSLGLRVLQE RVTPQDALHE CDSQGPGKDP MTDARNNPYT
210 220 230 240 250
CTECGKGFSK KWALVRHQQI HAGVKPYECN ECGKACRYMA DVIRHMRLHT
260 270 280 290 300
GEKPYKCIEC GKAFKRRFHL TEHQRIHTGD KPYECKECGK AFTHRSSFIQ
310 320 330 340 350
HNMTHTREKP FLCKECGKAF YYSSSFAQHM RIHTGKKLYE CGECGKAFTH
360 370 380 390 400
RSTFIQHNVT HTGEKPFLCK ECGKTFCLNS SFTQHMRIHT GEKPYECGEC
410 420 430 440 450
GKAFTHRSTF IRHKRTHTGE KPFECKECGK AFCDSSSLIQ HMRIHTGEKP
460 470 480 490 500
YECSECGKAF THHSVFIRHN RTHSGQKPLE CKECAKAFYY SSSFTRHMRI
510 520 530 540 550
HTGEKPYVCR ECGKAFTQPA NFVRHNRIHT GEKPFECKEC EKAFCDNFAL
560 570 580
TQHMRTHTGE KPFECNECGK TFSHSSSFTH HRKIHTRV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJP3 | K7EJP3_HUMAN | Zinc finger protein 599 | ZNF599 | 82 | Annotation score: | ||
A0A669KB57 | A0A669KB57_HUMAN | Zinc finger protein 599 | ZNF599 | 45 | Annotation score: |
Sequence cautioni
The sequence AAH44615 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 459 | A → T in AAH44615 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065087 | 178 | L → F De novo variant found in a patient with mental retardation. 1 PublicationCorresponds to variant dbSNP:rs146342141Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018385 | 81 – 95 | GEKAK…PTASQ → ASFSLLWKSYHPGHG in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_018386 | 96 – 588 | Missing in isoform 2. 1 PublicationAdd BLAST | 493 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055225 mRNA Translation: BAB70879.1 BC044615 mRNA Translation: AAH44615.1 Different initiation. BC092428 mRNA Translation: AAH92428.1 |
CCDSi | CCDS32991.1 [Q96NL3-1] |
RefSeqi | NP_001007249.1, NM_001007248.2 [Q96NL3-1] |
Genome annotation databases
Ensembli | ENST00000329285; ENSP00000333802; ENSG00000153896 [Q96NL3-1] ENST00000587354; ENSP00000468446; ENSG00000153896 [Q96NL3-2] |
GeneIDi | 148103 |
KEGGi | hsa:148103 |
UCSCi | uc010edn.2, human [Q96NL3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055225 mRNA Translation: BAB70879.1 BC044615 mRNA Translation: AAH44615.1 Different initiation. BC092428 mRNA Translation: AAH92428.1 |
CCDSi | CCDS32991.1 [Q96NL3-1] |
RefSeqi | NP_001007249.1, NM_001007248.2 [Q96NL3-1] |
3D structure databases
SMRi | Q96NL3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127117, 9 interactors |
IntActi | Q96NL3, 8 interactors |
MINTi | Q96NL3 |
STRINGi | 9606.ENSP00000333802 |
PTM databases
iPTMneti | Q96NL3 |
PhosphoSitePlusi | Q96NL3 |
Polymorphism and mutation databases
BioMutai | ZNF599 |
DMDMi | 74762682 |
Proteomic databases
jPOSTi | Q96NL3 |
MassIVEi | Q96NL3 |
PaxDbi | Q96NL3 |
PeptideAtlasi | Q96NL3 |
PRIDEi | Q96NL3 |
ProteomicsDBi | 77530 [Q96NL3-1] 77531 [Q96NL3-2] |
Protocols and materials databases
Antibodypediai | 847, 103 antibodies |
DNASUi | 148103 |
Genome annotation databases
Ensembli | ENST00000329285; ENSP00000333802; ENSG00000153896 [Q96NL3-1] ENST00000587354; ENSP00000468446; ENSG00000153896 [Q96NL3-2] |
GeneIDi | 148103 |
KEGGi | hsa:148103 |
UCSCi | uc010edn.2, human [Q96NL3-1] |
Organism-specific databases
CTDi | 148103 |
DisGeNETi | 148103 |
EuPathDBi | HostDB:ENSG00000153896.17 |
GeneCardsi | ZNF599 |
HGNCi | HGNC:26408, ZNF599 |
HPAi | ENSG00000153896, Low tissue specificity |
neXtProti | NX_Q96NL3 |
OpenTargetsi | ENSG00000153896 |
PharmGKBi | PA134983786 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159953 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | Q96NL3 |
OMAi | QSTCAGE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96NL3 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q96NL3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 148103, 3 hits in 861 CRISPR screens |
GenomeRNAii | 148103 |
Pharosi | Q96NL3, Tdark |
PROi | PR:Q96NL3 |
RNActi | Q96NL3, protein |
Gene expression databases
Bgeei | ENSG00000153896, Expressed in secondary oocyte and 159 other tissues |
ExpressionAtlasi | Q96NL3, baseline and differential |
Genevisiblei | Q96NL3, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN599_HUMAN | |
Accessioni | Q96NL3Primary (citable) accession number: Q96NL3 Secondary accession number(s): Q569K0, Q5PRG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations