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Protein

Transmembrane protein 74

Gene

TMEM74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.2 Publications

GO - Biological processi

  • macroautophagy Source: HGNC

Keywordsi

Biological processAutophagy

Protein family/group databases

TCDBi9.B.189.2.1 the vesicular membrane neurensin (neurensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 74
Gene namesi
Name:TMEM74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164841.4
HGNCiHGNC:26409 TMEM74
MIMi613935 gene
neXtProtiNX_Q96NL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164841
PharmGKBiPA142670785

Polymorphism and mutation databases

BioMutaiTMEM74
DMDMi74732587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596001 – 305Transmembrane protein 74Add BLAST305

Proteomic databases

PaxDbiQ96NL1
PeptideAtlasiQ96NL1
PRIDEiQ96NL1
ProteomicsDBi77529

PTM databases

PhosphoSitePlusiQ96NL1

Expressioni

Tissue specificityi

Expressed in heart, lung, and placenta.1 Publication

Gene expression databases

BgeeiENSG00000164841 Expressed in 106 organ(s), highest expression level in caput epididymis
CleanExiHS_TMEM74
ExpressionAtlasiQ96NL1 baseline and differential
GenevisibleiQ96NL1 HS

Organism-specific databases

HPAiHPA015672

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10292091,EBI-743099

Protein-protein interaction databases

BioGridi127621, 2 interactors
IntActiQ96NL1, 5 interactors
STRINGi9606.ENSP00000297459

Structurei

3D structure databases

ProteinModelPortaliQ96NL1
SMRiQ96NL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM74 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKFA Eukaryota
ENOG4111KEB LUCA
GeneTreeiENSGT00530000063880
HOGENOMiHOG000112021
HOVERGENiHBG094072
InParanoidiQ96NL1
OMAiNEWSHEA
OrthoDBiEOG091G0NPC
PhylomeDBiQ96NL1
TreeFamiTF335735

Family and domain databases

InterProiView protein in InterPro
IPR029696 Tmem74
IPR029695 TMEM74-like
PANTHERiPTHR16125 PTHR16125, 1 hit
PTHR16125:SF3 PTHR16125:SF3, 1 hit

Sequencei

Sequence statusi: Complete.

Q96NL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELHYLAKKS NQADLCDARD WSSRGLPGDQ ADTAATRAAL CCQKQCASTP
60 70 80 90 100
RATEMEGSKL SSSPASPSSS LQNSTLQPDA FPPGLLHSGN NQITAERKVC
110 120 130 140 150
NCCSQELETS FTYVDKNINL EQRNRSSPSA KGHNHPGELG WENPNEWSQE
160 170 180 190 200
AAISLISEEE DDTSSEATSS GKSIDYGFIS AILFLVTGIL LVIISYIVPR
210 220 230 240 250
EVTVDPNTVA AREMERLEKE SARLGAHLDR CVIAGLCLLT LGGVILSCLL
260 270 280 290 300
MMSMWKGELY RRNRFASSKE SAKLYGSFNF RMKTSTNENT LELSLVEEDA

LAVQS
Length:305
Mass (Da):33,338
Last modified:December 1, 2001 - v1
Checksum:i9521A382F126B683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055230 mRNA Translation: BAB70881.1
BC030710 mRNA Translation: AAH30710.1
CCDSiCCDS6310.1
RefSeqiNP_694560.1, NM_153015.2
UniGeneiHs.99439

Genome annotation databases

EnsembliENST00000297459; ENSP00000297459; ENSG00000164841
GeneIDi157753
KEGGihsa:157753
UCSCiuc003ymy.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055230 mRNA Translation: BAB70881.1
BC030710 mRNA Translation: AAH30710.1
CCDSiCCDS6310.1
RefSeqiNP_694560.1, NM_153015.2
UniGeneiHs.99439

3D structure databases

ProteinModelPortaliQ96NL1
SMRiQ96NL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127621, 2 interactors
IntActiQ96NL1, 5 interactors
STRINGi9606.ENSP00000297459

Protein family/group databases

TCDBi9.B.189.2.1 the vesicular membrane neurensin (neurensin) family

PTM databases

PhosphoSitePlusiQ96NL1

Polymorphism and mutation databases

BioMutaiTMEM74
DMDMi74732587

Proteomic databases

PaxDbiQ96NL1
PeptideAtlasiQ96NL1
PRIDEiQ96NL1
ProteomicsDBi77529

Protocols and materials databases

DNASUi157753
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297459; ENSP00000297459; ENSG00000164841
GeneIDi157753
KEGGihsa:157753
UCSCiuc003ymy.2 human

Organism-specific databases

CTDi157753
EuPathDBiHostDB:ENSG00000164841.4
GeneCardsiTMEM74
HGNCiHGNC:26409 TMEM74
HPAiHPA015672
MIMi613935 gene
neXtProtiNX_Q96NL1
OpenTargetsiENSG00000164841
PharmGKBiPA142670785
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKFA Eukaryota
ENOG4111KEB LUCA
GeneTreeiENSGT00530000063880
HOGENOMiHOG000112021
HOVERGENiHBG094072
InParanoidiQ96NL1
OMAiNEWSHEA
OrthoDBiEOG091G0NPC
PhylomeDBiQ96NL1
TreeFamiTF335735

Miscellaneous databases

ChiTaRSiTMEM74 human
GenomeRNAii157753
PROiPR:Q96NL1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164841 Expressed in 106 organ(s), highest expression level in caput epididymis
CleanExiHS_TMEM74
ExpressionAtlasiQ96NL1 baseline and differential
GenevisibleiQ96NL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR029696 Tmem74
IPR029695 TMEM74-like
PANTHERiPTHR16125 PTHR16125, 1 hit
PTHR16125:SF3 PTHR16125:SF3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM74_HUMAN
AccessioniPrimary (citable) accession number: Q96NL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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