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Protein

Kelch-like protein 32

Gene

KLHL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 32
Alternative name(s):
BTB and kelch domain-containing protein 5
Gene namesi
Name:KLHL32
Synonyms:BKLHD5, KIAA1900
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000186231.16
HGNCiHGNC:21221 KLHL32
neXtProtiNX_Q96NJ5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186231
PharmGKBiPA162393552

Polymorphism and mutation databases

BioMutaiKLHL32
DMDMi116241269

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190831 – 620Kelch-like protein 32Add BLAST620

Proteomic databases

MaxQBiQ96NJ5
PaxDbiQ96NJ5
PeptideAtlasiQ96NJ5
PRIDEiQ96NJ5
ProteomicsDBi77522

PTM databases

iPTMnetiQ96NJ5
PhosphoSitePlusiQ96NJ5

Expressioni

Gene expression databases

BgeeiENSG00000186231
CleanExiHS_KLHL32
ExpressionAtlasiQ96NJ5 baseline and differential
GenevisibleiQ96NJ5 HS

Organism-specific databases

HPAiHPA039150

Interactioni

Protein-protein interaction databases

BioGridi125354, 10 interactors
IntActiQ96NJ5, 2 interactors
STRINGi9606.ENSP00000358265

Structurei

3D structure databases

ProteinModelPortaliQ96NJ5
SMRiQ96NJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 109BTBPROSITE-ProRule annotationAdd BLAST68
Repeati290 – 346Kelch 1Add BLAST57
Repeati347 – 398Kelch 2Add BLAST52
Repeati399 – 446Kelch 3Add BLAST48
Repeati447 – 494Kelch 4Add BLAST48
Repeati496 – 547Kelch 5Add BLAST52
Repeati549 – 599Kelch 6Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000231583
HOVERGENiHBG107125
InParanoidiQ96NJ5
KOiK10468
OMAiQIWQLAV
OrthoDBiEOG091G035Z
PhylomeDBiQ96NJ5
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030570 KLHL32
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF65 PTHR24412:SF65, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96NJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE
60 70 80 90 100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA
110 120 130 140 150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL
160 170 180 190 200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT
210 220 230 240 250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL
260 270 280 290 300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
310 320 330 340 350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV
360 370 380 390 400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL
410 420 430 440 450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI
460 470 480 490 500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG
510 520 530 540 550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY
560 570 580 590 600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
610 620
YFTCPNLQTL QVPHHRIGTI
Length:620
Mass (Da):70,362
Last modified:October 17, 2006 - v2
Checksum:iAABDC5F667854931
GO
Isoform 2 (identifier: Q96NJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):66,562
Checksum:i6948DE1F0828FB14
GO
Isoform 3 (identifier: Q96NJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.
     105-137: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):62,953
Checksum:iABBF742A7ABFC9E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti331P → S in BAB70899 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0500535R → C. Corresponds to variant dbSNP:rs35143662Ensembl.1
Natural variantiVAR_028279129N → S. Corresponds to variant dbSNP:rs2294763Ensembl.1
Natural variantiVAR_028280146D → G. Corresponds to variant dbSNP:rs12662753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05488869 – 104Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_054889105 – 137Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055292 mRNA Translation: BAB70899.1
AK295479 mRNA Translation: BAH12082.1
AK297240 mRNA Translation: BAH12528.1
AL033375 Genomic DNA No translation available.
AL023656 Genomic DNA No translation available.
AL356958 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48499.1
CH471051 Genomic DNA Translation: EAW48500.1
AB067487 mRNA Translation: BAB67793.1
CCDSiCCDS5038.1 [Q96NJ5-1]
CCDS69154.1 [Q96NJ5-2]
CCDS69155.1 [Q96NJ5-3]
RefSeqiNP_001273179.1, NM_001286250.1 [Q96NJ5-2]
NP_001273180.1, NM_001286251.1 [Q96NJ5-3]
NP_001273183.1, NM_001286254.2
NP_001310181.1, NM_001323252.1 [Q96NJ5-1]
NP_001310182.1, NM_001323253.1
NP_001310183.1, NM_001323254.1
NP_001310184.1, NM_001323255.1
NP_001310185.1, NM_001323256.1
NP_001310186.1, NM_001323257.1
NP_001310188.1, NM_001323259.1
NP_001310189.1, NM_001323260.1
NP_001310190.1, NM_001323261.1
NP_001310191.1, NM_001323262.1
NP_001310192.1, NM_001323263.1
NP_001310193.1, NM_001323264.1
NP_443136.2, NM_052904.3 [Q96NJ5-1]
UniGeneiHs.45056
Hs.742749

Genome annotation databases

EnsembliENST00000369261; ENSP00000358265; ENSG00000186231 [Q96NJ5-1]
ENST00000536676; ENSP00000440382; ENSG00000186231 [Q96NJ5-2]
ENST00000539200; ENSP00000441527; ENSG00000186231 [Q96NJ5-3]
GeneIDi114792
KEGGihsa:114792
UCSCiuc010kcm.2 human [Q96NJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLH32_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ5
Secondary accession number(s): B7Z346
, B7Z4E2, E1P528, Q5THT0, Q96PY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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