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Entry version 137 (13 Feb 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Kelch-like protein 32

Gene

KLHL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 32
Alternative name(s):
BTB and kelch domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL32
Synonyms:BKLHD5, KIAA1900
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186231.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21221 KLHL32

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NJ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000186231

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393552

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHL32

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190831 – 620Kelch-like protein 32Add BLAST620

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96NJ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96NJ5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96NJ5

PeptideAtlas

More...
PeptideAtlasi
Q96NJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q96NJ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77522

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186231 Expressed in 118 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NJ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NJ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039150

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125354, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NJ5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358265

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96NJ5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96NJ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 109BTBPROSITE-ProRule annotationAdd BLAST68
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati290 – 346Kelch 1Add BLAST57
Repeati347 – 398Kelch 2Add BLAST52
Repeati399 – 446Kelch 3Add BLAST48
Repeati447 – 494Kelch 4Add BLAST48
Repeati496 – 547Kelch 5Add BLAST52
Repeati549 – 599Kelch 6Add BLAST51

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1072 Eukaryota
ENOG4110X8D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157179

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231583

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107125

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96NJ5

KEGG Orthology (KO)

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KOi
K10468

Identification of Orthologs from Complete Genome Data

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OMAi
DQWTRCS

Database of Orthologous Groups

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OrthoDBi
250404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NJ5

TreeFam database of animal gene trees

More...
TreeFami
TF328485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030570 KLHL32
IPR011333 SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24412:SF65 PTHR24412:SF65, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96NJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE
60 70 80 90 100
QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA
110 120 130 140 150
YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL
160 170 180 190 200
ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT
210 220 230 240 250
SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL
260 270 280 290 300
VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
310 320 330 340 350
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV
360 370 380 390 400
AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL
410 420 430 440 450
YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI
460 470 480 490 500
SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG
510 520 530 540 550
GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY
560 570 580 590 600
LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
610 620
YFTCPNLQTL QVPHHRIGTI
Length:620
Mass (Da):70,362
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAABDC5F667854931
GO
Isoform 2 (identifier: Q96NJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.

Note: No experimental confirmation available.
Show »
Length:584
Mass (Da):66,562
Checksum:i6948DE1F0828FB14
GO
Isoform 3 (identifier: Q96NJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-104: Missing.
     105-137: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):62,953
Checksum:iABBF742A7ABFC9E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5THT1Q5THT1_HUMAN
Kelch-like protein 32
KLHL32
139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IXH0Q8IXH0_HUMAN
KIAA1900, isoform CRA_a
KLHL32 KIAA1900, hCG_1639824
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYQ8A0A087WYQ8_HUMAN
Kelch-like protein 32
KLHL32
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5THS9Q5THS9_HUMAN
Kelch-like protein 32
KLHL32
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti331P → S in BAB70899 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0500535R → C. Corresponds to variant dbSNP:rs35143662Ensembl.1
Natural variantiVAR_028279129N → S. Corresponds to variant dbSNP:rs2294763Ensembl.1
Natural variantiVAR_028280146D → G. Corresponds to variant dbSNP:rs12662753Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05488869 – 104Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_054889105 – 137Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055292 mRNA Translation: BAB70899.1
AK295479 mRNA Translation: BAH12082.1
AK297240 mRNA Translation: BAH12528.1
AL033375 Genomic DNA No translation available.
AL023656 Genomic DNA No translation available.
AL356958 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48499.1
CH471051 Genomic DNA Translation: EAW48500.1
AB067487 mRNA Translation: BAB67793.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5038.1 [Q96NJ5-1]
CCDS69154.1 [Q96NJ5-2]
CCDS69155.1 [Q96NJ5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001273179.1, NM_001286250.1 [Q96NJ5-2]
NP_001273180.1, NM_001286251.1 [Q96NJ5-3]
NP_001273183.1, NM_001286254.2
NP_001310181.1, NM_001323252.1 [Q96NJ5-1]
NP_001310182.1, NM_001323253.1
NP_001310183.1, NM_001323254.1
NP_001310184.1, NM_001323255.1
NP_001310185.1, NM_001323256.1
NP_001310186.1, NM_001323257.1
NP_001310188.1, NM_001323259.1
NP_001310189.1, NM_001323260.1
NP_001310190.1, NM_001323261.1
NP_001310191.1, NM_001323262.1
NP_001310192.1, NM_001323263.1
NP_001310193.1, NM_001323264.1
NP_443136.2, NM_052904.3 [Q96NJ5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.45056
Hs.742749

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369261; ENSP00000358265; ENSG00000186231 [Q96NJ5-1]
ENST00000536676; ENSP00000440382; ENSG00000186231 [Q96NJ5-2]
ENST00000539200; ENSP00000441527; ENSG00000186231 [Q96NJ5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114792

UCSC genome browser

More...
UCSCi
uc010kcm.2 human [Q96NJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055292 mRNA Translation: BAB70899.1
AK295479 mRNA Translation: BAH12082.1
AK297240 mRNA Translation: BAH12528.1
AL033375 Genomic DNA No translation available.
AL023656 Genomic DNA No translation available.
AL356958 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48499.1
CH471051 Genomic DNA Translation: EAW48500.1
AB067487 mRNA Translation: BAB67793.1
CCDSiCCDS5038.1 [Q96NJ5-1]
CCDS69154.1 [Q96NJ5-2]
CCDS69155.1 [Q96NJ5-3]
RefSeqiNP_001273179.1, NM_001286250.1 [Q96NJ5-2]
NP_001273180.1, NM_001286251.1 [Q96NJ5-3]
NP_001273183.1, NM_001286254.2
NP_001310181.1, NM_001323252.1 [Q96NJ5-1]
NP_001310182.1, NM_001323253.1
NP_001310183.1, NM_001323254.1
NP_001310184.1, NM_001323255.1
NP_001310185.1, NM_001323256.1
NP_001310186.1, NM_001323257.1
NP_001310188.1, NM_001323259.1
NP_001310189.1, NM_001323260.1
NP_001310190.1, NM_001323261.1
NP_001310191.1, NM_001323262.1
NP_001310192.1, NM_001323263.1
NP_001310193.1, NM_001323264.1
NP_443136.2, NM_052904.3 [Q96NJ5-1]
UniGeneiHs.45056
Hs.742749

3D structure databases

ProteinModelPortaliQ96NJ5
SMRiQ96NJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125354, 10 interactors
IntActiQ96NJ5, 2 interactors
STRINGi9606.ENSP00000358265

PTM databases

iPTMnetiQ96NJ5
PhosphoSitePlusiQ96NJ5

Polymorphism and mutation databases

BioMutaiKLHL32
DMDMi116241269

Proteomic databases

jPOSTiQ96NJ5
MaxQBiQ96NJ5
PaxDbiQ96NJ5
PeptideAtlasiQ96NJ5
PRIDEiQ96NJ5
ProteomicsDBi77522

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369261; ENSP00000358265; ENSG00000186231 [Q96NJ5-1]
ENST00000536676; ENSP00000440382; ENSG00000186231 [Q96NJ5-2]
ENST00000539200; ENSP00000441527; ENSG00000186231 [Q96NJ5-3]
GeneIDi114792
KEGGihsa:114792
UCSCiuc010kcm.2 human [Q96NJ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114792
EuPathDBiHostDB:ENSG00000186231.16

GeneCards: human genes, protein and diseases

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GeneCardsi
KLHL32

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006082
HGNCiHGNC:21221 KLHL32
HPAiHPA039150
neXtProtiNX_Q96NJ5
OpenTargetsiENSG00000186231
PharmGKBiPA162393552

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00940000157179
HOGENOMiHOG000231583
HOVERGENiHBG107125
InParanoidiQ96NJ5
KOiK10468
OMAiDQWTRCS
OrthoDBi250404at2759
PhylomeDBiQ96NJ5
TreeFamiTF328485

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114792

Protein Ontology

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PROi
PR:Q96NJ5

Gene expression databases

BgeeiENSG00000186231 Expressed in 118 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ96NJ5 baseline and differential
GenevisibleiQ96NJ5 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030570 KLHL32
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF65 PTHR24412:SF65, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLH32_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NJ5
Secondary accession number(s): B7Z346
, B7Z4E2, E1P528, Q5THT0, Q96PY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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