UniProtKB - Q96NJ3 (ZN285_HUMAN)
Protein
Zinc finger protein 285
Gene
ZNF285
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 232 – 254 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96NJ3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 285Alternative name(s): Zinc finger protein 285A |
Gene namesi | Name:ZNF285 Synonyms:ZNF285A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000267508.5 |
HGNCi | HGNC:13079, ZNF285 |
neXtProti | NX_Q96NJ3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26974 |
PharmGKBi | PA165394833 |
Miscellaneous databases
Pharosi | Q96NJ3, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF285 |
DMDMi | 239938813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000378106 | 1 – 590 | Zinc finger protein 285Add BLAST | 590 |
Proteomic databases
jPOSTi | Q96NJ3 |
MassIVEi | Q96NJ3 |
PaxDbi | Q96NJ3 |
PeptideAtlasi | Q96NJ3 |
PRIDEi | Q96NJ3 |
ProteomicsDBi | 77520 [Q96NJ3-1] 77521 [Q96NJ3-2] |
PTM databases
iPTMneti | Q96NJ3 |
PhosphoSitePlusi | Q96NJ3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000267508, Expressed in secondary oocyte and 172 other tissues |
ExpressionAtlasi | Q96NJ3, baseline and differential |
Genevisiblei | Q96NJ3, HS |
Organism-specific databases
HPAi | ENSG00000267508, Low tissue specificity |
Interactioni
Binary interactionsi
Q96NJ3
With | #Exp. | IntAct |
---|---|---|
CARD10 [Q9BWT7] | 3 | EBI-18064466,EBI-3866279 |
Protein-protein interaction databases
BioGRIDi | 117930, 1 interactor |
IntActi | Q96NJ3, 3 interactors |
STRINGi | 9606.ENSP00000464788 |
Miscellaneous databases
RNActi | Q96NJ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 86 | KRABPROSITE-ProRule annotationAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 232 – 254 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q96NJ3 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96NJ3 |
TreeFami | TF350845 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96NJ3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG
60 70 80 90 100
IKNNILNLQA KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP
110 120 130 140 150
HLEDVSLSEE WAGISLQISE NENYVVNAII KNQDITAWQS LTQVLTPESW
160 170 180 190 200
RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ HDDSLSWTSC DHHESQECKG
210 220 230 240 250
EDPGRHPNCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA FADDTDPHVH
260 270 280 290 300
HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
310 320 330 340 350
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG
360 370 380 390 400
KGFGFRSLLC IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY
410 420 430 440 450
KCSECGKCFS SSSVLQVHWR FHTGEKPYRC GECGKGFSQC THLHIHQRVH
460 470 480 490 500
TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG EKPYKCEVCG KCFSYSSYFH
510 520 530 540 550
LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTRERPY KCKACGKGFS
560 570 580 590
RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EIK6 | K7EIK6_HUMAN | Zinc finger protein 285 | ZNF285 | 597 | Annotation score: | ||
K7EQE9 | K7EQE9_HUMAN | Zinc finger protein 285 | ZNF285 | 56 | Annotation score: | ||
K7ERT5 | K7ERT5_HUMAN | Zinc finger protein 285 | ZNF285 | 39 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057972 | 208 | N → S2 PublicationsCorresponds to variant dbSNP:rs2571089Ensembl. | 1 | |
Natural variantiVAR_057973 | 536 | R → G2 PublicationsCorresponds to variant dbSNP:rs12610859Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037502 | 1 – 155 | Missing in isoform 2. 2 PublicationsAdd BLAST | 155 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055309 mRNA Translation: BAB70901.1 AC138473 Genomic DNA No translation available. BC117300 mRNA Translation: AAI17301.1 BC117302 mRNA Translation: AAI17303.1 BC069384 mRNA Translation: AAH69384.2 BC074875 mRNA Translation: AAH74875.2 |
CCDSi | CCDS12638.1 [Q96NJ3-1] |
RefSeqi | NP_001278417.1, NM_001291488.1 NP_001278418.1, NM_001291489.1 NP_001278419.1, NM_001291490.1 NP_001278420.1, NM_001291491.1 NP_689567.4, NM_152354.5 |
Genome annotation databases
Ensembli | ENST00000544719; ENSP00000439431; ENSG00000267508 ENST00000614994; ENSP00000483662; ENSG00000267508 |
GeneIDi | 26974 |
KEGGi | hsa:26974 |
UCSCi | uc002ozd.5, human [Q96NJ3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055309 mRNA Translation: BAB70901.1 AC138473 Genomic DNA No translation available. BC117300 mRNA Translation: AAI17301.1 BC117302 mRNA Translation: AAI17303.1 BC069384 mRNA Translation: AAH69384.2 BC074875 mRNA Translation: AAH74875.2 |
CCDSi | CCDS12638.1 [Q96NJ3-1] |
RefSeqi | NP_001278417.1, NM_001291488.1 NP_001278418.1, NM_001291489.1 NP_001278419.1, NM_001291490.1 NP_001278420.1, NM_001291491.1 NP_689567.4, NM_152354.5 |
3D structure databases
SMRi | Q96NJ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117930, 1 interactor |
IntActi | Q96NJ3, 3 interactors |
STRINGi | 9606.ENSP00000464788 |
PTM databases
iPTMneti | Q96NJ3 |
PhosphoSitePlusi | Q96NJ3 |
Polymorphism and mutation databases
BioMutai | ZNF285 |
DMDMi | 239938813 |
Proteomic databases
jPOSTi | Q96NJ3 |
MassIVEi | Q96NJ3 |
PaxDbi | Q96NJ3 |
PeptideAtlasi | Q96NJ3 |
PRIDEi | Q96NJ3 |
ProteomicsDBi | 77520 [Q96NJ3-1] 77521 [Q96NJ3-2] |
Protocols and materials databases
Antibodypediai | 65032, 62 antibodies |
DNASUi | 26974 |
Genome annotation databases
Ensembli | ENST00000544719; ENSP00000439431; ENSG00000267508 ENST00000614994; ENSP00000483662; ENSG00000267508 |
GeneIDi | 26974 |
KEGGi | hsa:26974 |
UCSCi | uc002ozd.5, human [Q96NJ3-1] |
Organism-specific databases
CTDi | 26974 |
DisGeNETi | 26974 |
EuPathDBi | HostDB:ENSG00000267508.5 |
GeneCardsi | ZNF285 |
HGNCi | HGNC:13079, ZNF285 |
HPAi | ENSG00000267508, Low tissue specificity |
neXtProti | NX_Q96NJ3 |
PharmGKBi | PA165394833 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q96NJ3 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96NJ3 |
TreeFami | TF350845 |
Enzyme and pathway databases
PathwayCommonsi | Q96NJ3 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 26974, 118 hits in 839 CRISPR screens |
GenomeRNAii | 26974 |
Pharosi | Q96NJ3, Tdark |
PROi | PR:Q96NJ3 |
RNActi | Q96NJ3, protein |
Gene expression databases
Bgeei | ENSG00000267508, Expressed in secondary oocyte and 172 other tissues |
ExpressionAtlasi | Q96NJ3, baseline and differential |
Genevisiblei | Q96NJ3, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN285_HUMAN | |
Accessioni | Q96NJ3Primary (citable) accession number: Q96NJ3 Secondary accession number(s): Q17RJ3, Q6B0A8, Q6ISR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | June 16, 2009 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations