ZNF285

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	232 – 254	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	260 – 282	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	316 – 338	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	344 – 366	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	372 – 394	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 422	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	428 – 450	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	456 – 478	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	484 – 506	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	512 – 534	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	540 – 562	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 285 Alternative name(s): Zinc finger protein 285A
Gene namesⁱ	Name:ZNF285 Synonyms:ZNF285A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000267508.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13079 ZNF285
neXtProtⁱ	NX_Q96NJ3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA165394833

PharmGKBⁱ

PA165394833

Polymorphism and mutation databases

BioMutaⁱ	ZNF285
DMDMⁱ	239938813

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000378106	1 – 590	Zinc finger protein 285Add BLAST		590

Proteomic databases

PaxDbⁱ	Q96NJ3
PeptideAtlas More...PeptideAtlasⁱ	Q96NJ3
PRIDEⁱ	Q96NJ3
ProteomicsDBⁱ	77520 77521 [Q96NJ3-2]

PTM databases

iPTMnetⁱ	Q96NJ3
PhosphoSitePlusⁱ	Q96NJ3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000267508 Expressed in 151 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_ZNF285A
ExpressionAtlasⁱ	Q96NJ3 baseline and differential
Genevisibleⁱ	Q96NJ3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046100 HPA049212

HPAⁱ

HPA046100
HPA049212

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q96NJ3, 1 interactor
STRINGⁱ	9606.ENSP00000333595

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96NJ3
SMRⁱ	Q96NJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 86	KRABPROSITE-ProRule annotationAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	232 – 254	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	260 – 282	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	316 – 338	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	344 – 366	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	372 – 394	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	400 – 422	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	428 – 450	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	456 – 478	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	484 – 506	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	512 – 534	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	540 – 562	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q96NJ3
KEGG Orthology (KO) More...KOⁱ	K09228
PhylomeDBⁱ	Q96NJ3
TreeFamⁱ	TF350845

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 11 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 10 hits PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96NJ3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG 
        60         70         80         90        100
IKNNILNLQA KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP 
       110        120        130        140        150
HLEDVSLSEE WAGISLQISE NENYVVNAII KNQDITAWQS LTQVLTPESW 
       160        170        180        190        200
RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ HDDSLSWTSC DHHESQECKG 
       210        220        230        240        250
EDPGRHPNCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA FADDTDPHVH 
       260        270        280        290        300
HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS 
       310        320        330        340        350
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG 
       360        370        380        390        400
KGFGFRSLLC IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY 
       410        420        430        440        450
KCSECGKCFS SSSVLQVHWR FHTGEKPYRC GECGKGFSQC THLHIHQRVH 
       460        470        480        490        500
TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG EKPYKCEVCG KCFSYSSYFH 
       510        520        530        540        550
LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTRERPY KCKACGKGFS 
       560        570        580        590
RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL

Length:590

Mass (Da):68,261

Last modified:June 16, 2009 - v2

Checksum:ⁱ0A3F51DEE2396462

GO

Isoform 2 (identifier: Q96NJ3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-155: Missing.

« Hide

        10         20         30         40         50
MTEPQNSQGR YKGIYMEEKL YRRAQHDDSL SWTSCDHHES QECKGEDPGR 
        60         70         80         90        100
HPNCGKNLGM KSTVEKRNAA HVLPQPFPCN NCGVAFADDT DPHVHHSTHL 
       110        120        130        140        150
GEKSYKCDQY GKNFSQSQDL IVHCKTHSGK TPYEFHEWPM GCKQSSDLPR 
       160        170        180        190        200
YQKVSSGDKP YKCKECGKGF RRSSSLHNHH RVHTGEMPYK CDECGKGFGF 
       210        220        230        240        250
RSLLCIHQGV HTGKKPYKCE ECGKGFDQSS NLLVHQRVHT GEKPYKCSEC 
       260        270        280        290        300
GKCFSSSSVL QVHWRFHTGE KPYRCGECGK GFSQCTHLHI HQRVHTGEKP 
       310        320        330        340        350
YKCNVCGKDF AYSSVLHTHQ RVHTGEKPYK CEVCGKCFSY SSYFHLHQRD 
       360        370        380        390        400
HIREKPYKCD ECGKGFSRNS DLNVHLRVHT RERPYKCKAC GKGFSRNSYL 
       410        420        430 
LAHQRVHIDE TQYTHCERGK DLLTHQRLHE QRETL

Show »

Length:435

Mass (Da):50,168

Checksum:ⁱB7845B029FCE167C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
K7EIK6	K7EIK6_HUMAN	Zinc finger protein 285 Zinc finger protein 285	ZNF285	597	Annotation score:
K7EQE9	K7EQE9_HUMAN	Zinc finger protein 285 Zinc finger protein 285	ZNF285	56	Annotation score:
K7ERT5	K7ERT5_HUMAN	Zinc finger protein 285 Zinc finger protein 285	ZNF285	39	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057972	208	N → S2 PublicationsCorresponds to variant dbSNP:rs2571089Ensembl.		1
Natural variantⁱVAR_057973	536	R → G2 PublicationsCorresponds to variant dbSNP:rs12610859Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037502	1 – 155	Missing in isoform 2. 2 PublicationsAdd BLAST		155

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK055309 mRNA Translation: BAB70901.1 AC138473 Genomic DNA No translation available. BC117300 mRNA Translation: AAI17301.1 BC117302 mRNA Translation: AAI17303.1 BC069384 mRNA Translation: AAH69384.2 BC074875 mRNA Translation: AAH74875.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12638.1 [Q96NJ3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001278417.1, NM_001291488.1 NP_001278418.1, NM_001291489.1 NP_001278419.1, NM_001291490.1 NP_001278420.1, NM_001291491.1 NP_689567.4, NM_152354.5
UniGeneⁱ	Hs.709428

Genome annotation databases

Ensemblⁱ	ENST00000544719; ENSP00000439431; ENSG00000267508 ENST00000614994; ENSP00000483662; ENSG00000267508
GeneIDⁱ	26974
KEGGⁱ	hsa:26974
UCSC genome browser More...UCSCⁱ	uc002ozd.5 human [Q96NJ3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96NJ3	Isoform 2 of Zinc finger protein 285		HUMAN		435	UniRef90_Q96NJ3
Uncharacterized protein		RHIBE		622
Zinc finger protein 285		MACNE		607
Zinc finger protein 285		PANTR		597
Zinc finger protein 285		PANPA		597
+60

Protein	Similar proteins		Species	Score	Length	Source
Q96NJ3	Isoform 2 of Zinc finger protein 285		HUMAN		435	UniRef50_Q96NJ3
Uncharacterized protein		RHIBE		622
Zinc finger protein 285		MACNE		607
Zinc finger protein 285		PANTR		597
Zinc finger protein 285		PANPA		597
+79

Entry informationⁱ

Entry nameⁱ	ZN285_HUMAN
Accessionⁱ	Q96NJ3Primary (citable) accession number: Q96NJ3 Secondary accession number(s): Q17RJ3, Q6B0A8, Q6ISR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	June 16, 2009
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96NJ3 (ZN285_HUMAN)

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Zinc finger protein 285

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ