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Protein

Zinc finger protein 285

Gene

ZNF285

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 254C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 285
Alternative name(s):
Zinc finger protein 285A
Gene namesi
Name:ZNF285
Synonyms:ZNF285A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267508.5
HGNCiHGNC:13079 ZNF285
neXtProtiNX_Q96NJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394833

Polymorphism and mutation databases

BioMutaiZNF285
DMDMi239938813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003781061 – 590Zinc finger protein 285Add BLAST590

Proteomic databases

PaxDbiQ96NJ3
PeptideAtlasiQ96NJ3
PRIDEiQ96NJ3
ProteomicsDBi77520
77521 [Q96NJ3-2]

PTM databases

iPTMnetiQ96NJ3
PhosphoSitePlusiQ96NJ3

Expressioni

Gene expression databases

BgeeiENSG00000267508 Expressed in 151 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF285A
ExpressionAtlasiQ96NJ3 baseline and differential
GenevisibleiQ96NJ3 HS

Organism-specific databases

HPAiHPA046100
HPA049212

Interactioni

Protein-protein interaction databases

IntActiQ96NJ3, 1 interactor
STRINGi9606.ENSP00000333595

Structurei

3D structure databases

ProteinModelPortaliQ96NJ3
SMRiQ96NJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri232 – 254C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOVERGENiHBG018163
InParanoidiQ96NJ3
KOiK09228
PhylomeDBiQ96NJ3
TreeFamiTF350845

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q96NJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG
60 70 80 90 100
IKNNILNLQA KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP
110 120 130 140 150
HLEDVSLSEE WAGISLQISE NENYVVNAII KNQDITAWQS LTQVLTPESW
160 170 180 190 200
RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ HDDSLSWTSC DHHESQECKG
210 220 230 240 250
EDPGRHPNCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA FADDTDPHVH
260 270 280 290 300
HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
310 320 330 340 350
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG
360 370 380 390 400
KGFGFRSLLC IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY
410 420 430 440 450
KCSECGKCFS SSSVLQVHWR FHTGEKPYRC GECGKGFSQC THLHIHQRVH
460 470 480 490 500
TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG EKPYKCEVCG KCFSYSSYFH
510 520 530 540 550
LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTRERPY KCKACGKGFS
560 570 580 590
RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL
Length:590
Mass (Da):68,261
Last modified:June 16, 2009 - v2
Checksum:i0A3F51DEE2396462
GO
Isoform 2 (identifier: Q96NJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:435
Mass (Da):50,168
Checksum:iB7845B029FCE167C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIK6K7EIK6_HUMAN
Zinc finger protein 285
ZNF285
597Annotation score:
K7EQE9K7EQE9_HUMAN
Zinc finger protein 285
ZNF285
56Annotation score:
K7ERT5K7ERT5_HUMAN
Zinc finger protein 285
ZNF285
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057972208N → S2 PublicationsCorresponds to variant dbSNP:rs2571089Ensembl.1
Natural variantiVAR_057973536R → G2 PublicationsCorresponds to variant dbSNP:rs12610859Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0375021 – 155Missing in isoform 2. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055309 mRNA Translation: BAB70901.1
AC138473 Genomic DNA No translation available.
BC117300 mRNA Translation: AAI17301.1
BC117302 mRNA Translation: AAI17303.1
BC069384 mRNA Translation: AAH69384.2
BC074875 mRNA Translation: AAH74875.2
CCDSiCCDS12638.1 [Q96NJ3-1]
RefSeqiNP_001278417.1, NM_001291488.1
NP_001278418.1, NM_001291489.1
NP_001278419.1, NM_001291490.1
NP_001278420.1, NM_001291491.1
NP_689567.4, NM_152354.5
UniGeneiHs.709428

Genome annotation databases

EnsembliENST00000544719; ENSP00000439431; ENSG00000267508
ENST00000614994; ENSP00000483662; ENSG00000267508
GeneIDi26974
KEGGihsa:26974
UCSCiuc002ozd.5 human [Q96NJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN285_HUMAN
AccessioniPrimary (citable) accession number: Q96NJ3
Secondary accession number(s): Q17RJ3, Q6B0A8, Q6ISR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 16, 2009
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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