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Entry version 138 (12 Aug 2020)
Sequence version 4 (18 May 2010)
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Protein

Protein broad-minded

Gene

TBC1D32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity).By similarity

Caution

The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96NH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein broad-minded
Alternative name(s):
TBC1 domain family member 32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D32
Synonyms:BROMI, C6orf170, C6orf171
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146350.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21485, TBC1D32

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615867, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221322

Open Targets

More...
OpenTargetsi
ENSG00000146350

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134871908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96NH3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D32

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439461

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895571 – 1257Protein broad-mindedAdd BLAST1257

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96NH3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NH3

PeptideAtlas

More...
PeptideAtlasi
Q96NH3

PRoteomics IDEntifications database

More...
PRIDEi
Q96NH3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77512 [Q96NH3-1]
77513 [Q96NH3-4]
77514 [Q96NH3-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96NH3, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96NH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146350, Expressed in intestine and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NH3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NH3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146350, Tissue enhanced (pituitary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK20, which promotes CDK20 stability and function.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128710, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NH3, 8 interactors

Molecular INTeraction database

More...
MINTi
Q96NH3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381270

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96NH3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1119 – 1242Rab-GAP TBCAdd BLAST124

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR93, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_260246_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NH3

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCVQYLE

Database of Orthologous Groups

More...
OrthoDBi
74051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NH3

TreeFam database of animal gene trees

More...
TreeFami
TF329092

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032735, BROMI
IPR035969, Rab-GTPase_TBC_sf
IPR039156, UPF0183/BROMI

The PANTHER Classification System

More...
PANTHERi
PTHR13465, PTHR13465, 1 hit
PTHR13465:SF3, PTHR13465:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14961, BROMI, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96NH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHFSSEDQA MLQAMLRRLF QSVKEKITGA PSLECAEEIL LHLEETDENF
60 70 80 90 100
HNYEFVKYLR QHIGNTLGSM IEEEMEKCTS DRNQGEECGY DTVVQQVTKR
110 120 130 140 150
TQESKEYKEM MHYLKNIMIA VVESMINKFE EDETRNQERQ KKIQKEKSHS
160 170 180 190 200
YRTDNCSDSD SSLNQSYKFC QGKLQLILDQ LDPGQPKEVR YEALQTLCSA
210 220 230 240 250
PPSDVLNCEN WTTLCEKLTV SLSDPDPVFS DRILKFCAQT FLLSPLHMTK
260 270 280 290 300
EIYTSLAKYL ESYFLSRENH IPTLSAGVDI TNPNMTRLLK KVRLLNEYQK
310 320 330 340 350
EAPSFWIRHP EKYMEEIVES TLSLLTVKHN QSHVVSQKIL DPIYFFALVD
360 370 380 390 400
TKAVWFKKWM HAHYSRTTVL RLLETKYKSL VTTAIQQCVQ YFEMCKTRKA
410 420 430 440 450
DETLGHSKHC RNKQKTFYYL GQELQYIYFI HSLCLLGRLL IYKQGRKLFP
460 470 480 490 500
IKLKNKKGLV SLIDLLVLFT QLIYYSPSCP KMTSAAHSEN YSPASMVTEV
510 520 530 540 550
LWILSDQKEC AVECLYNNIV IETLLQPIHN LMKGNEASPN CSETALIHIA
560 570 580 590 600
GILARIASVE EGLILLLYGA NMNSSEESPT GAHIIAQFSK KLLDEDISIF
610 620 630 640 650
SGSEMLPVVK GAFISVCRHI YSTCEGLQVL ITYNLHESIA KAWKKTSLLS
660 670 680 690 700
ERIPTPVEGS DSVSSVSQES QNIMAWEDNL LDDLLHFAAT PKGLLLLQRT
710 720 730 740 750
GAINECVTFI FNRYAKKLQV SRHKKFGYGV LVTRVASTAA GGIALKKSGF
760 770 780 790 800
INELITELWS NLEYGRDDVR VTHPRTTPVD PIDRSCQKSF LALVNLLSYP
810 820 830 840 850
AIYELVRNQD LPNKTEYSLR EVPTCVIDII DRLIILNSEA KIRSLFNYEQ
860 870 880 890 900
SHIFGLRDFI IDGLSVERNH VLVRINLVGG PLERILPPRL LEKSDNPYPW
910 920 930 940 950
PMFSSYPLPN CYLSDITRNA GIKQDNDLDK LLLCLKISDK QTEWIENCQR
960 970 980 990 1000
QFCKMMKAKP DIISGEALIE LLEKFVLHLT ESPSECYFPS VEYTATDANV
1010 1020 1030 1040 1050
KNESLSSVQQ LGIKMTVRYG KFLSLLKDGA ENDLTWVLKH CERFLKQQQT
1060 1070 1080 1090 1100
SIKSSLLCLQ GNYAGHDWFV SSLFMIMLGD KEKTFQFLHQ FSRLLTSAFL
1110 1120 1130 1140 1150
WLPRLHISSY LPNDTVESGI HPVYFCSTHY IEMLLKAELP LVFSAFHMSG
1160 1170 1180 1190 1200
FAPSQICLQW ITQCFWNYLD WIEICHYIAT CVFLGPDYQV YICIAVFKHL
1210 1220 1230 1240 1250
QQDILQHTQT QDLQVFLKEE ALHGFRVSDY FEYMEILEQN YRTVLLRDMR

NIRLQST
Length:1,257
Mass (Da):144,756
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3370457AB4238DC0
GO
Isoform 2 (identifier: Q96NH3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: R → RLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHR

Show »
Length:1,298
Mass (Da):149,428
Checksum:i5C26F7B38708E92C
GO
Isoform 3 (identifier: Q96NH3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-108: EYK → ELP
     109-1257: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:108
Mass (Da):12,529
Checksum:i36820D1BD1936EB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A304A2A304_HUMAN
Protein broad-minded
TBC1D32
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBP0H0YBP0_HUMAN
Protein broad-minded
TBC1D32
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB70925 differs from that shown. Reason: Frameshift.Curated
The sequence BAC03694 differs from that shown. Aberrant splicing.Curated
The sequence BAC03694 differs from that shown. Reason: Frameshift.Curated
The sequence BAC86152 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD18591 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti554A → V in BAC86152 (PubMed:14702039).Curated1
Sequence conflicti906Y → H in BAC03694 (PubMed:14702039).Curated1
Sequence conflicti1210T → A in BAC86152 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04695882R → Q1 PublicationCorresponds to variant dbSNP:rs7767455Ensembl.1
Natural variantiVAR_046959280I → V. Corresponds to variant dbSNP:rs9490157Ensembl.1
Natural variantiVAR_046960375T → K1 PublicationCorresponds to variant dbSNP:rs9387944Ensembl.1
Natural variantiVAR_046961599I → V. Corresponds to variant dbSNP:rs7745023Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035579106 – 108EYK → ELP in isoform 3. 1 Publication3
Alternative sequenceiVSP_035580109 – 1257Missing in isoform 3. 1 PublicationAdd BLAST1149
Alternative sequenceiVSP_014546857R → RLLSVICCDLDTLLLLEAQY QVSEMLLNAQEENILEISES HR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055461 mRNA Translation: BAB70925.1 Frameshift.
AK091554 mRNA Translation: BAC03694.1 Sequence problems.
AK125385 mRNA Translation: BAC86152.1 Different initiation.
AK131446 mRNA Translation: BAD18591.1 Sequence problems.
AL035593 Genomic DNA No translation available.
AL139098 Genomic DNA No translation available.
AL365508 Genomic DNA No translation available.
AL589910 Genomic DNA No translation available.
AL590225 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43501.1 [Q96NH3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_689943.4, NM_152730.5 [Q96NH3-1]
XP_005266918.1, XM_005266861.2
XP_016865886.1, XM_017010397.1
XP_016865887.1, XM_017010398.1 [Q96NH3-4]
XP_016865890.1, XM_017010401.1 [Q96NH3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275159; ENSP00000275159; ENSG00000146350 [Q96NH3-4]
ENST00000398212; ENSP00000381270; ENSG00000146350 [Q96NH3-1]
ENST00000464622; ENSP00000428839; ENSG00000146350 [Q96NH3-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221322

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221322

UCSC genome browser

More...
UCSCi
uc003pyo.3, human [Q96NH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055461 mRNA Translation: BAB70925.1 Frameshift.
AK091554 mRNA Translation: BAC03694.1 Sequence problems.
AK125385 mRNA Translation: BAC86152.1 Different initiation.
AK131446 mRNA Translation: BAD18591.1 Sequence problems.
AL035593 Genomic DNA No translation available.
AL139098 Genomic DNA No translation available.
AL365508 Genomic DNA No translation available.
AL589910 Genomic DNA No translation available.
AL590225 Genomic DNA No translation available.
CCDSiCCDS43501.1 [Q96NH3-1]
RefSeqiNP_689943.4, NM_152730.5 [Q96NH3-1]
XP_005266918.1, XM_005266861.2
XP_016865886.1, XM_017010397.1
XP_016865887.1, XM_017010398.1 [Q96NH3-4]
XP_016865890.1, XM_017010401.1 [Q96NH3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128710, 9 interactors
IntActiQ96NH3, 8 interactors
MINTiQ96NH3
STRINGi9606.ENSP00000381270

PTM databases

GlyGeniQ96NH3, 1 site
iPTMnetiQ96NH3
PhosphoSitePlusiQ96NH3

Polymorphism and mutation databases

BioMutaiTBC1D32
DMDMi296439461

Proteomic databases

MassIVEiQ96NH3
PaxDbiQ96NH3
PeptideAtlasiQ96NH3
PRIDEiQ96NH3
ProteomicsDBi77512 [Q96NH3-1]
77513 [Q96NH3-4]
77514 [Q96NH3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
35180, 58 antibodies

Genome annotation databases

EnsembliENST00000275159; ENSP00000275159; ENSG00000146350 [Q96NH3-4]
ENST00000398212; ENSP00000381270; ENSG00000146350 [Q96NH3-1]
ENST00000464622; ENSP00000428839; ENSG00000146350 [Q96NH3-5]
GeneIDi221322
KEGGihsa:221322
UCSCiuc003pyo.3, human [Q96NH3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221322
DisGeNETi221322
EuPathDBiHostDB:ENSG00000146350.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D32
HGNCiHGNC:21485, TBC1D32
HPAiENSG00000146350, Tissue enhanced (pituitary)
MIMi615867, gene
neXtProtiNX_Q96NH3
OpenTargetsiENSG00000146350
PharmGKBiPA134871908

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QR93, Eukaryota
GeneTreeiENSGT00940000153528
HOGENOMiCLU_260246_0_0_1
InParanoidiQ96NH3
OMAiQCVQYLE
OrthoDBi74051at2759
PhylomeDBiQ96NH3
TreeFamiTF329092

Enzyme and pathway databases

PathwayCommonsiQ96NH3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
221322, 3 hits in 855 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D32, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221322
PharosiQ96NH3, Tbio

Protein Ontology

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PROi
PR:Q96NH3
RNActiQ96NH3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000146350, Expressed in intestine and 175 other tissues
ExpressionAtlasiQ96NH3, baseline and differential
GenevisibleiQ96NH3, HS

Family and domain databases

InterProiView protein in InterPro
IPR032735, BROMI
IPR035969, Rab-GTPase_TBC_sf
IPR039156, UPF0183/BROMI
PANTHERiPTHR13465, PTHR13465, 1 hit
PTHR13465:SF3, PTHR13465:SF3, 1 hit
PfamiView protein in Pfam
PF14961, BROMI, 2 hits
SUPFAMiSSF47923, SSF47923, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBROMI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NH3
Secondary accession number(s): Q5SZD6
, Q5SZM6, Q6ZMY4, Q6ZUR7, Q8NB47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 138 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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