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Protein

Zinc finger protein 582

Gene

ZNF582

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 582
Gene namesi
Name:ZNF582
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000018869.16
HGNCiHGNC:26421 ZNF582
MIMi615600 gene
neXtProtiNX_Q96NG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi147948
OpenTargetsiENSG00000018869
PharmGKBiPA134989661

Polymorphism and mutation databases

BioMutaiZNF582
DMDMi74732564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345911 – 517Zinc finger protein 582Add BLAST517

Proteomic databases

PaxDbiQ96NG8
PeptideAtlasiQ96NG8
PRIDEiQ96NG8
ProteomicsDBi77511

PTM databases

iPTMnetiQ96NG8
PhosphoSitePlusiQ96NG8

Expressioni

Gene expression databases

BgeeiENSG00000018869 Expressed in 141 organ(s), highest expression level in gastrocnemius
CleanExiHS_ZNF582
ExpressionAtlasiQ96NG8 baseline and differential
GenevisibleiQ96NG8 HS

Organism-specific databases

HPAiHPA028858

Interactioni

Protein-protein interaction databases

BioGridi127104, 1 interactor
STRINGi9606.ENSP00000301310

Structurei

3D structure databases

ProteinModelPortaliQ96NG8
SMRiQ96NG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96NG8
KOiK09228
OMAiIIREFML
OrthoDBiEOG091G02KC
PhylomeDBiQ96NG8
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q96NG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLGSELFRD VAIVFSQEEW QWLAPAQRDL YRDVMLETYS NLVSLGLAVS
60 70 80 90 100
KPDVISFLEQ GKEPWMVERV VSGGLCPVLE SRYDTKELFP KQHVYEVESP
110 120 130 140 150
QWEIMESLTS YGLECSSFQD DWECRNQFDR QQGNPDRHFH QMIIRHEEMP
160 170 180 190 200
TFDQHASLTF YQKIHTREKP FGYNKCRKDF WQKELLINHQ GIYTNEKPYK
210 220 230 240 250
CKECGKAFKY GSRLIQHENI HSGKKPYECK ECGKAFNSGS NFIQHQRVHT
260 270 280 290 300
GEKPYECKDC EKAFSRSSQL IEHQRTHTGE KPYQCKECGK AFNRISHLKV
310 320 330 340 350
HYRIHTGEKP YACKECGKTF SHRSQLIQHQ TVHTGRKLYE CKECGKAFNQ
360 370 380 390 400
GSTLIRHQRI HTGEKPYECK VCGKAFRVSS QLKQHQRIHT GEKPYQCKVC
410 420 430 440 450
GRAFKRVSHL TVHYRIHTGE KPYECKECGK AFSHCSQLIH HQVIHTEKKP
460 470 480 490 500
YEYKECEKTL SHDSTTVQPQ RMHNRETHVN IINVEKPSIS SYPLLIIREF
510
MLASNHMNGS NGESPLA
Length:517
Mass (Da):60,498
Last modified:December 1, 2001 - v1
Checksum:iFEE3AE28C6F8B53A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B772A0A075B772_HUMAN
Zinc finger protein 582
ZNF582
181Annotation score:
K7EKI7K7EKI7_HUMAN
Zinc finger protein 582
ZNF582
78Annotation score:
K7ESE7K7ESE7_HUMAN
Zinc finger protein 582
ZNF582
103Annotation score:
A0A075B771A0A075B771_HUMAN
Zinc finger protein 582
ZNF582
178Annotation score:

Sequence cautioni

The sequence AAH11796 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAG61111 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAH14399 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW72447 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286K → R in BAH14399 (PubMed:14702039).Curated1
Sequence conflicti365K → R in BAH14399 (PubMed:14702039).Curated1
Sequence conflicti411T → A in BAH14399 (PubMed:14702039).Curated1
Sequence conflicti426K → G in BAH14399 (PubMed:14702039).Curated1
Sequence conflicti475R → G in BAH14399 (PubMed:14702039).Curated1
Sequence conflicti487P → A in BAH14399 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07055765W → G Found in a patient with mild intellectual disability and eye movement disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs369155373Ensembl.1
Natural variantiVAR_03357869R → T. Corresponds to variant dbSNP:rs11883260Ensembl.1
Natural variantiVAR_070558345G → E Found in a patient with mild intellectual disability and eye movement disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149022328Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055489 mRNA Translation: BAB70931.1
AK299036 mRNA Translation: BAG61111.1 Different initiation.
AK316028 mRNA Translation: BAH14399.1 Different initiation.
CH471135 Genomic DNA Translation: EAW72447.1 Sequence problems.
BC011796 mRNA Translation: AAH11796.1 Sequence problems.
BC101008 mRNA Translation: AAI01009.1
BC101009 mRNA Translation: AAI01010.1
BC101010 mRNA Translation: AAI01011.1
BC101011 mRNA Translation: AAI01012.1
CCDSiCCDS33121.1
RefSeqiNP_001307300.1, NM_001320371.1
NP_653291.1, NM_144690.2
UniGeneiHs.244391
Hs.655905

Genome annotation databases

EnsembliENST00000301310; ENSP00000301310; ENSG00000018869
ENST00000586929; ENSP00000465619; ENSG00000018869
ENST00000619584; ENSP00000483414; ENSG00000018869
GeneIDi147948
KEGGihsa:147948
UCSCiuc002qmz.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN582_HUMAN
AccessioniPrimary (citable) accession number: Q96NG8
Secondary accession number(s): B4DQZ9, B7Z9R3, Q6PJT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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