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Entry version 150 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

FERM domain-containing protein 6

Gene

FRMD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM domain-containing protein 6
Alternative name(s):
Willin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRMD6
Synonyms:C14orf31
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:19839 FRMD6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614555 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96NE9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
122786

Open Targets

More...
OpenTargetsi
ENSG00000139926

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134913028

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96NE9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FRMD6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34098678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194481 – 622FERM domain-containing protein 6Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei522PhosphoserineBy similarity1
Modified residuei523PhosphothreonineBy similarity1
Modified residuei525PhosphoserineBy similarity1
Modified residuei542PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96NE9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96NE9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96NE9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96NE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96NE9

PeptideAtlas

More...
PeptideAtlasi
Q96NE9

PRoteomics IDEntifications database

More...
PRIDEi
Q96NE9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77504 [Q96NE9-1]
77505 [Q96NE9-2]
77506 [Q96NE9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96NE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96NE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139926 Expressed in 204 organ(s), highest expression level in tibia

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96NE9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96NE9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001297

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125795, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q96NE9, 57 interactors

Molecular INTeraction database

More...
MINTi
Q96NE9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343899

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96NE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 328FERMPROSITE-ProRule annotationAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 133Poly-Tyr4
Compositional biasi506 – 512Poly-Ser7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUGZ Eukaryota
ENOG410Z6XT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155517

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294082

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96NE9

KEGG Orthology (KO)

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KOi
K16822

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTKPRDP

Database of Orthologous Groups

More...
OrthoDBi
339620at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96NE9

TreeFam database of animal gene trees

More...
TreeFami
TF319780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd13185 FERM_C_FRMD1_FRMD6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR040179 FRMD6
IPR041781 FRMD6-FERM_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR23280:SF9 PTHR23280:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96NE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR
60 70 80 90 100
LKDCHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI
110 120 130 140 150
DQFGPPMIIH FRVQYYVENG RLISDRAARY YYYWHLRKQV LHSQCVLREE
160 170 180 190 200
AYFLLAAFAL QADLGNFKRN KHYGKYFEPE AYFPSWVVSK RGKDYILKHI
210 220 230 240 250
PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK REIEASLTLG
260 270 280 290 300
LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
310 320 330 340 350
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY
360 370 380 390 400
ISDNLDLDMD QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD
410 420 430 440 450
TKPRDTGPED SYSSSAIHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDL
460 470 480 490 500
QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC IYITEDMLMS RKLNGHSGLI
510 520 530 540 550
VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL
560 570 580 590 600
YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP
610 620
VKRTSKYFSL DLTHDEVPEF VV
Note: No experimental confirmation available.
Length:622
Mass (Da):72,044
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AE617F769B29CF6
GO
Isoform 2 (identifier: Q96NE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-98: Missing.

Show »
Length:614
Mass (Da):70,982
Checksum:i7B5165CC7F3BC191
GO
Isoform 3 (identifier: Q96NE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-358: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,235
Checksum:i1232D8C9C9542AB2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJC1H0YJC1_HUMAN
FERM domain-containing protein 6
FRMD6
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2L4G3V2L4_HUMAN
FERM domain-containing protein 6
FRMD6
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ19H0YJ19_HUMAN
FERM domain-containing protein 6
FRMD6
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V517G3V517_HUMAN
FERM domain-containing protein 6
FRMD6
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52K → E in CAI46062 (PubMed:17974005).Curated1
Sequence conflicti67H → Y in CAI46062 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0080221 – 358Missing in isoform 3. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_00802391 – 98Missing in isoform 2. 3 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055545 mRNA Translation: BAB70950.1
BX161430 mRNA Translation: CAD61902.1
BX647863 mRNA Translation: CAI46062.1
AL079307 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65666.1
CH471078 Genomic DNA Translation: EAW65671.1
BC020521 mRNA Translation: AAH20521.1
BC029870 mRNA Translation: AAH29870.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58318.1 [Q96NE9-1]
CCDS58319.1 [Q96NE9-3]
CCDS9704.1 [Q96NE9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035946.1, NM_001042481.2 [Q96NE9-2]
NP_001253975.1, NM_001267046.1 [Q96NE9-1]
NP_001253976.1, NM_001267047.1 [Q96NE9-3]
NP_689543.1, NM_152330.3 [Q96NE9-2]
XP_006720092.1, XM_006720029.1 [Q96NE9-1]
XP_006720093.1, XM_006720030.1 [Q96NE9-2]
XP_011534725.1, XM_011536423.1 [Q96NE9-1]
XP_011534726.1, XM_011536424.1 [Q96NE9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344768; ENSP00000343899; ENSG00000139926 [Q96NE9-1]
ENST00000356218; ENSP00000348550; ENSG00000139926 [Q96NE9-2]
ENST00000395718; ENSP00000379068; ENSG00000139926 [Q96NE9-2]
ENST00000553556; ENSP00000452529; ENSG00000139926 [Q96NE9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
122786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122786

UCSC genome browser

More...
UCSCi
uc001wzb.5 human [Q96NE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055545 mRNA Translation: BAB70950.1
BX161430 mRNA Translation: CAD61902.1
BX647863 mRNA Translation: CAI46062.1
AL079307 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65666.1
CH471078 Genomic DNA Translation: EAW65671.1
BC020521 mRNA Translation: AAH20521.1
BC029870 mRNA Translation: AAH29870.1
CCDSiCCDS58318.1 [Q96NE9-1]
CCDS58319.1 [Q96NE9-3]
CCDS9704.1 [Q96NE9-2]
RefSeqiNP_001035946.1, NM_001042481.2 [Q96NE9-2]
NP_001253975.1, NM_001267046.1 [Q96NE9-1]
NP_001253976.1, NM_001267047.1 [Q96NE9-3]
NP_689543.1, NM_152330.3 [Q96NE9-2]
XP_006720092.1, XM_006720029.1 [Q96NE9-1]
XP_006720093.1, XM_006720030.1 [Q96NE9-2]
XP_011534725.1, XM_011536423.1 [Q96NE9-1]
XP_011534726.1, XM_011536424.1 [Q96NE9-1]

3D structure databases

SMRiQ96NE9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125795, 31 interactors
IntActiQ96NE9, 57 interactors
MINTiQ96NE9
STRINGi9606.ENSP00000343899

PTM databases

iPTMnetiQ96NE9
PhosphoSitePlusiQ96NE9

Polymorphism and mutation databases

BioMutaiFRMD6
DMDMi34098678

Proteomic databases

EPDiQ96NE9
jPOSTiQ96NE9
MassIVEiQ96NE9
MaxQBiQ96NE9
PaxDbiQ96NE9
PeptideAtlasiQ96NE9
PRIDEiQ96NE9
ProteomicsDBi77504 [Q96NE9-1]
77505 [Q96NE9-2]
77506 [Q96NE9-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
122786

Genome annotation databases

EnsembliENST00000344768; ENSP00000343899; ENSG00000139926 [Q96NE9-1]
ENST00000356218; ENSP00000348550; ENSG00000139926 [Q96NE9-2]
ENST00000395718; ENSP00000379068; ENSG00000139926 [Q96NE9-2]
ENST00000553556; ENSP00000452529; ENSG00000139926 [Q96NE9-3]
GeneIDi122786
KEGGihsa:122786
UCSCiuc001wzb.5 human [Q96NE9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
122786
DisGeNETi122786

GeneCards: human genes, protein and diseases

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GeneCardsi
FRMD6
HGNCiHGNC:19839 FRMD6
HPAiHPA001297
MIMi614555 gene
neXtProtiNX_Q96NE9
OpenTargetsiENSG00000139926
PharmGKBiPA134913028

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IUGZ Eukaryota
ENOG410Z6XT LUCA
GeneTreeiENSGT00940000155517
HOGENOMiHOG000294082
InParanoidiQ96NE9
KOiK16822
OMAiDTKPRDP
OrthoDBi339620at2759
PhylomeDBiQ96NE9
TreeFamiTF319780

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FRMD6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FRMD6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
122786
PharosiQ96NE9

Protein Ontology

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PROi
PR:Q96NE9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139926 Expressed in 204 organ(s), highest expression level in tibia
ExpressionAtlasiQ96NE9 baseline and differential
GenevisibleiQ96NE9 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13185 FERM_C_FRMD1_FRMD6, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR040179 FRMD6
IPR041781 FRMD6-FERM_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF9 PTHR23280:SF9, 1 hit
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRMD6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96NE9
Secondary accession number(s): D3DSB9
, Q5HYF2, Q8N2X1, Q8WUH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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