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UniProtKB - Q96ND8 (ZN583_HUMAN)
Protein
Zinc finger protein 583
Gene
ZNF583
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 234 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96ND8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q96ND8 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 583Alternative name(s): Zinc finger protein L3-5 |
Gene namesi | Name:ZNF583 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26427, ZNF583 |
neXtProti | NX_Q96ND8 |
VEuPathDBi | HostDB:ENSG00000198440 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 147949 |
OpenTargetsi | ENSG00000198440 |
PharmGKBi | PA134982111 |
Miscellaneous databases
Pharosi | Q96ND8, Tdark |
Genetic variation databases
BioMutai | ZNF583 |
DMDMi | 116242861 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047674 | 1 – 569 | Zinc finger protein 583Add BLAST | 569 |
Proteomic databases
jPOSTi | Q96ND8 |
MassIVEi | Q96ND8 |
MaxQBi | Q96ND8 |
PaxDbi | Q96ND8 |
PeptideAtlasi | Q96ND8 |
PRIDEi | Q96ND8 |
ProteomicsDBi | 77503 |
PTM databases
GlyGeni | Q96ND8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96ND8 |
PhosphoSitePlusi | Q96ND8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198440, Expressed in cerebellum and 130 other tissues |
ExpressionAtlasi | Q96ND8, baseline and differential |
Genevisiblei | Q96ND8, HS |
Organism-specific databases
HPAi | ENSG00000198440, Low tissue specificity |
Interactioni
Protein-protein interaction databases
IntActi | Q96ND8, 2 interactors |
MINTi | Q96ND8 |
STRINGi | 9606.ENSP00000388502 |
Miscellaneous databases
RNActi | Q96ND8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 77 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 549 – 569 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 234 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161925 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q96ND8 |
OMAi | QKRSYQK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96ND8 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q96ND8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS
60 70 80 90 100
KPDVISLLEQ GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK
110 120 130 140 150
VVTVGARHLS YSLDYPSLRE DCQSEDWYKN QLGSQEVHLS QLIITHKEIL
160 170 180 190 200
PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK EKAHKHEPQK KSYRKKSVEM
210 220 230 240 250
KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY ACVECGKTFS
260 270 280 290 300
QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE
310 320 330 340 350
CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK
360 370 380 390 400
PYVCNVCGKA FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR
410 420 430 440 450
VHTGEKPYEC KVCRKAFSQI AYLDQHQRVH TGEKPYECIE CGKAFSNSSS
460 470 480 490 500
LAQHQRSHTG EKPYMCKECR KTFSQNAGLA QHQRIHTGEK PYECNVCGKA
510 520 530 540 550
FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER IHTMESFLTL
560
SSPSPSTSNQ LPRPVGFIS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZQ5 | F5GZQ5_HUMAN | Zinc finger protein 583 | ZNF583 | 129 | Annotation score: | ||
I3L0C4 | I3L0C4_HUMAN | Zinc finger protein 583 | ZNF583 | 137 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 351 | P → R in AAB81088 (Ref. 3) Curated | 1 | |
Sequence conflicti | 556 | S → P in BAB70964 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027978 | 324 | F → I. Corresponds to variant dbSNP:rs12976917Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055592 mRNA Translation: BAB70964.1 BC111772 mRNA Translation: AAI11773.1 AF024698 mRNA Translation: AAB81088.1 |
CCDSi | CCDS12943.1 |
RefSeqi | NP_001153332.1, NM_001159860.1 NP_001153333.1, NM_001159861.1 NP_689691.2, NM_152478.2 XP_011524819.1, XM_011526517.2 XP_016881839.1, XM_017026350.1 |
Genome annotation databases
Ensembli | ENST00000291598; ENSP00000291598; ENSG00000198440 ENST00000333201; ENSP00000388502; ENSG00000198440 |
GeneIDi | 147949 |
KEGGi | hsa:147949 |
MANE-Selecti | ENST00000333201.13; ENSP00000388502.2; NM_152478.3; NP_689691.2 |
UCSCi | uc002qnc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055592 mRNA Translation: BAB70964.1 BC111772 mRNA Translation: AAI11773.1 AF024698 mRNA Translation: AAB81088.1 |
CCDSi | CCDS12943.1 |
RefSeqi | NP_001153332.1, NM_001159860.1 NP_001153333.1, NM_001159861.1 NP_689691.2, NM_152478.2 XP_011524819.1, XM_011526517.2 XP_016881839.1, XM_017026350.1 |
3D structure databases
SMRi | Q96ND8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q96ND8, 2 interactors |
MINTi | Q96ND8 |
STRINGi | 9606.ENSP00000388502 |
PTM databases
GlyGeni | Q96ND8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96ND8 |
PhosphoSitePlusi | Q96ND8 |
Genetic variation databases
BioMutai | ZNF583 |
DMDMi | 116242861 |
Proteomic databases
jPOSTi | Q96ND8 |
MassIVEi | Q96ND8 |
MaxQBi | Q96ND8 |
PaxDbi | Q96ND8 |
PeptideAtlasi | Q96ND8 |
PRIDEi | Q96ND8 |
ProteomicsDBi | 77503 |
Protocols and materials databases
Antibodypediai | 33209, 111 antibodies from 18 providers |
DNASUi | 147949 |
Genome annotation databases
Ensembli | ENST00000291598; ENSP00000291598; ENSG00000198440 ENST00000333201; ENSP00000388502; ENSG00000198440 |
GeneIDi | 147949 |
KEGGi | hsa:147949 |
MANE-Selecti | ENST00000333201.13; ENSP00000388502.2; NM_152478.3; NP_689691.2 |
UCSCi | uc002qnc.3, human |
Organism-specific databases
CTDi | 147949 |
DisGeNETi | 147949 |
GeneCardsi | ZNF583 |
HGNCi | HGNC:26427, ZNF583 |
HPAi | ENSG00000198440, Low tissue specificity |
neXtProti | NX_Q96ND8 |
OpenTargetsi | ENSG00000198440 |
PharmGKBi | PA134982111 |
VEuPathDBi | HostDB:ENSG00000198440 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161925 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q96ND8 |
OMAi | QKRSYQK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96ND8 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q96ND8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q96ND8 |
Miscellaneous databases
BioGRID-ORCSi | 147949, 7 hits in 1061 CRISPR screens |
ChiTaRSi | ZNF583, human |
GenomeRNAii | 147949 |
Pharosi | Q96ND8, Tdark |
PROi | PR:Q96ND8 |
RNActi | Q96ND8, protein |
Gene expression databases
Bgeei | ENSG00000198440, Expressed in cerebellum and 130 other tissues |
ExpressionAtlasi | Q96ND8, baseline and differential |
Genevisiblei | Q96ND8, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN583_HUMAN | |
Accessioni | Q96ND8Primary (citable) accession number: Q96ND8 Secondary accession number(s): O14850, Q2NKK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families