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UniProtKB - Q96ND8 (ZN583_HUMAN)

Entry version 151 (12 Aug 2020)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Zinc finger protein 583

Gene

ZNF583

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96ND8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 583
Alternative name(s):
Zinc finger protein L3-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF583
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000198440.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:26427, ZNF583

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96ND8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		147949

Open Targets

More...OpenTargetsi		ENSG00000198440

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134982111

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96ND8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF583

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242861

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476741 – 569Zinc finger protein 583Add BLAST569

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96ND8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96ND8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96ND8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96ND8

PeptideAtlas

More...PeptideAtlasi		Q96ND8

PRoteomics IDEntifications database

More...PRIDEi		Q96ND8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77503

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96ND8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96ND8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198440, Expressed in cerebellum and 129 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96ND8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96ND8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198440, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q96ND8, 2 interactors

Molecular INTeraction database

More...MINTi		Q96ND8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388502

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96ND8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96ND8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 234C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161925

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96ND8

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		MKHKKVY

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96ND8

TreeFam database of animal gene trees

More...TreeFami		TF341817

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96ND8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS 
        60         70         80         90        100
KPDVISLLEQ GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK 
       110        120        130        140        150
VVTVGARHLS YSLDYPSLRE DCQSEDWYKN QLGSQEVHLS QLIITHKEIL 
       160        170        180        190        200
PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK EKAHKHEPQK KSYRKKSVEM 
       210        220        230        240        250
KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY ACVECGKTFS 
       260        270        280        290        300
QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE 
       310        320        330        340        350
CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK 
       360        370        380        390        400
PYVCNVCGKA FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR 
       410        420        430        440        450
VHTGEKPYEC KVCRKAFSQI AYLDQHQRVH TGEKPYECIE CGKAFSNSSS 
       460        470        480        490        500
LAQHQRSHTG EKPYMCKECR KTFSQNAGLA QHQRIHTGEK PYECNVCGKA 
       510        520        530        540        550
FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER IHTMESFLTL 
       560 
SSPSPSTSNQ LPRPVGFIS
Length:569
Mass (Da):66,033
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B0448281129F0E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZQ5F5GZQ5_HUMAN
Zinc finger protein 583
ZNF583
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0C4I3L0C4_HUMAN
Zinc finger protein 583
ZNF583
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti351P → R in AAB81088 (Ref. 3) Curated1
Sequence conflicti556S → P in BAB70964 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027978324F → I. Corresponds to variant dbSNP:rs12976917Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK055592 mRNA Translation: BAB70964.1
BC111772 mRNA Translation: AAI11773.1
AF024698 mRNA Translation: AAB81088.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12943.1

NCBI Reference Sequences

More...RefSeqi		NP_001153332.1, NM_001159860.1
NP_001153333.1, NM_001159861.1
NP_689691.2, NM_152478.2
XP_011524819.1, XM_011526517.2
XP_016881839.1, XM_017026350.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000291598; ENSP00000291598; ENSG00000198440
ENST00000333201; ENSP00000388502; ENSG00000198440

Database of genes from NCBI RefSeq genomes

More...GeneIDi		147949

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:147949

UCSC genome browser

More...UCSCi		uc002qnc.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055592 mRNA Translation: BAB70964.1
BC111772 mRNA Translation: AAI11773.1
AF024698 mRNA Translation: AAB81088.1
CCDSiCCDS12943.1
RefSeqiNP_001153332.1, NM_001159860.1
NP_001153333.1, NM_001159861.1
NP_689691.2, NM_152478.2
XP_011524819.1, XM_011526517.2
XP_016881839.1, XM_017026350.1

3D structure databases

SMRiQ96ND8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ96ND8, 2 interactors
MINTiQ96ND8
STRINGi9606.ENSP00000388502

PTM databases

iPTMnetiQ96ND8
PhosphoSitePlusiQ96ND8

Polymorphism and mutation databases

BioMutaiZNF583
DMDMi116242861

Proteomic databases

jPOSTiQ96ND8
MassIVEiQ96ND8
MaxQBiQ96ND8
PaxDbiQ96ND8
PeptideAtlasiQ96ND8
PRIDEiQ96ND8
ProteomicsDBi77503

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33209, 107 antibodies

The DNASU plasmid repository

More...DNASUi		147949

Genome annotation databases

EnsembliENST00000291598; ENSP00000291598; ENSG00000198440
ENST00000333201; ENSP00000388502; ENSG00000198440
GeneIDi147949
KEGGihsa:147949
UCSCiuc002qnc.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		147949
DisGeNETi147949
EuPathDBiHostDB:ENSG00000198440.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF583
HGNCiHGNC:26427, ZNF583
HPAiENSG00000198440, Low tissue specificity
neXtProtiNX_Q96ND8
OpenTargetsiENSG00000198440
PharmGKBiPA134982111

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161925
HOGENOMiCLU_002678_44_5_1
InParanoidiQ96ND8
KOiK09228
OMAiMKHKKVY
OrthoDBi1318335at2759
PhylomeDBiQ96ND8
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ96ND8
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		147949, 2 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF583, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		147949
PharosiQ96ND8, Tdark

Protein Ontology

More...PROi		PR:Q96ND8
RNActiQ96ND8, protein

Gene expression databases

BgeeiENSG00000198440, Expressed in cerebellum and 129 other tissues
ExpressionAtlasiQ96ND8, baseline and differential
GenevisibleiQ96ND8, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN583_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96ND8
Secondary accession number(s): O14850, Q2NKK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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