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Protein

Protein FAM210A

Gene

FAM210A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the structure and strength of both muscle and bone.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM210A
Gene namesi
Name:FAM210A
Synonyms:C18orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000177150.12
HGNCiHGNC:28346 FAM210A
MIMi617975 gene
neXtProtiNX_Q96ND0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177150
PharmGKBiPA134993051

Polymorphism and mutation databases

BioMutaiFAM210A
DMDMi296434465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002744241 – 272Protein FAM210AAdd BLAST272

Proteomic databases

EPDiQ96ND0
MaxQBiQ96ND0
PaxDbiQ96ND0
PeptideAtlasiQ96ND0
PRIDEiQ96ND0
TopDownProteomicsiQ96ND0

PTM databases

iPTMnetiQ96ND0
PhosphoSitePlusiQ96ND0

Expressioni

Gene expression databases

BgeeiENSG00000177150 Expressed in 201 organ(s), highest expression level in amniotic fluid
CleanExiHS_C18orf19
ExpressionAtlasiQ96ND0 baseline and differential
GenevisibleiQ96ND0 HS

Organism-specific databases

HPAiHPA014324
HPA051564

Interactioni

Subunit structurei

Interacts with ATAD3A.1 Publication

Protein-protein interaction databases

BioGridi125924, 15 interactors
IntActiQ96ND0, 3 interactors
STRINGi9606.ENSP00000323635

Structurei

3D structure databases

ProteinModelPortaliQ96ND0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 229DUF1279Add BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili229 – 271Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the FAM210 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4082 Eukaryota
ENOG4111GN5 LUCA
GeneTreeiENSGT00530000063556
HOGENOMiHOG000111948
HOVERGENiHBG081335
InParanoidiQ96ND0
OMAiRLAHRTC
OrthoDBiEOG091G0XJF
PhylomeDBiQ96ND0
TreeFamiTF313283

Family and domain databases

InterProiView protein in InterPro
IPR009688 DUF1279
PfamiView protein in Pfam
PF06916 DUF1279, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q96ND0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQWNVPRTVS RLARRTCLEP HNAGLFGHCQ NVKGPLLLYN AESKVVLVQG
60 70 80 90 100
PQKQWLHLSA AQCVAKERRP LDAHPPQPGV LRHKQGKQHV SFRRVFSSSA
110 120 130 140 150
TAQGTPEKKE EPDPLQDKSI SLYQRFKKTF RQYGKVLIPV HLITSGVWFG
160 170 180 190 200
TFYYAALKGV NVVPFLELIG LPDSVVSILK NSQSGNALTA YALFKIATPA
210 220 230 240 250
RYTVTLGGTS VTVKYLRSHG YMSTPPPVKE YLQDRMEETK ELITEKMEET
260 270
KDRLTEKLQE TKEKVSFKKK VE
Length:272
Mass (Da):30,777
Last modified:May 18, 2010 - v2
Checksum:i6053475E4CCF65C4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EK00K7EK00_HUMAN
Protein FAM210A
FAM210A
268Annotation score:
K7ERQ2K7ERQ2_HUMAN
Protein FAM210A
FAM210A
178Annotation score:
K7EPG9K7EPG9_HUMAN
Protein FAM210A
FAM210A
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49Q → R in BAB70973 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05684439Y → N. Corresponds to variant dbSNP:rs35493157Ensembl.1
Natural variantiVAR_03568682R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs116967198Ensembl.1
Natural variantiVAR_035687140V → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_060439167E → K. Corresponds to variant dbSNP:rs2847146Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055618 mRNA Translation: BAB70973.1
AP001010 Genomic DNA No translation available.
AP001525 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01508.1
CH471113 Genomic DNA Translation: EAX01509.1
CCDSiCCDS11866.1
RefSeqiNP_001092271.1, NM_001098801.1
NP_689565.2, NM_152352.3
UniGeneiHs.13034

Genome annotation databases

EnsembliENST00000322247; ENSP00000323635; ENSG00000177150
ENST00000402563; ENSP00000386115; ENSG00000177150
GeneIDi125228
KEGGihsa:125228
UCSCiuc002ksj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF210A_HUMAN
AccessioniPrimary (citable) accession number: Q96ND0
Secondary accession number(s): D3DUJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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