Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger matrin-type protein 2

Gene

ZMAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as a component of the spliceosome.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 104Matrin-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 2
Gene namesi
Name:ZMAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146007.10
HGNCiHGNC:26433 ZMAT2
neXtProtiNX_Q96NC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146007
PharmGKBiPA134931664

Polymorphism and mutation databases

BioMutaiZMAT2
DMDMi52783532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000473272 – 199Zinc finger matrin-type protein 2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96NC0
MaxQBiQ96NC0
PaxDbiQ96NC0
PeptideAtlasiQ96NC0
PRIDEiQ96NC0
ProteomicsDBi77501
TopDownProteomicsiQ96NC0

PTM databases

iPTMnetiQ96NC0
PhosphoSitePlusiQ96NC0

Expressioni

Gene expression databases

BgeeiENSG00000146007 Expressed in 198 organ(s), highest expression level in frontal cortex
CleanExiHS_ZMAT2
ExpressionAtlasiQ96NC0 baseline and differential
GenevisibleiQ96NC0 HS

Organism-specific databases

HPAiHPA036518

Interactioni

Subunit structurei

Component of the spliceosome B complex.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi127499, 41 interactors
IntActiQ96NC0, 44 interactors
STRINGi9606.ENSP00000274712

Structurei

3D structure databases

ProteinModelPortaliQ96NC0
SMRiQ96NC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 104Matrin-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4727 Eukaryota
ENOG4111GW4 LUCA
GeneTreeiENSGT00390000010712
HOGENOMiHOG000234390
HOVERGENiHBG055346
InParanoidiQ96NC0
KOiK12848
OMAiQAEMGGY
OrthoDBiEOG091G0R04
PhylomeDBiQ96NC0
TreeFamiTF314475

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96NC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGSGTKNL DFRRKWDKDE YEKLAEKRLT EEREKKDGKP VQPVKRELLR
60 70 80 90 100
HRDYKVDLES KLGKTIVITK TTPQSEMGGY YCNVCDCVVK DSINFLDHIN
110 120 130 140 150
GKKHQRNLGM SMRVERSTLD QVKKRFEVNK KKMEEKQKDY DFEERMKELR
160 170 180 190
EEEEKAKAYK KEKQKEKKRR AEEDLTFEED DEMAAVMGFS GFGSTKKSY
Length:199
Mass (Da):23,612
Last modified:December 1, 2001 - v1
Checksum:iEF419358B7977E36
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNG8R4GNG8_HUMAN
Zinc finger matrin-type protein 2
ZMAT2
129Annotation score:
R4GMX9R4GMX9_HUMAN
Zinc finger matrin-type protein 2
ZMAT2
53Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055683 mRNA Translation: BAB70983.1
BC056668 mRNA Translation: AAH56668.1
CCDSiCCDS4239.1
RefSeqiNP_653324.1, NM_144723.2
UniGeneiHs.350194

Genome annotation databases

EnsembliENST00000274712; ENSP00000274712; ENSG00000146007
GeneIDi153527
KEGGihsa:153527
UCSCiuc003lgy.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055683 mRNA Translation: BAB70983.1
BC056668 mRNA Translation: AAH56668.1
CCDSiCCDS4239.1
RefSeqiNP_653324.1, NM_144723.2
UniGeneiHs.350194

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9Zelectron microscopy4.50N1-199[»]
ProteinModelPortaliQ96NC0
SMRiQ96NC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127499, 41 interactors
IntActiQ96NC0, 44 interactors
STRINGi9606.ENSP00000274712

PTM databases

iPTMnetiQ96NC0
PhosphoSitePlusiQ96NC0

Polymorphism and mutation databases

BioMutaiZMAT2
DMDMi52783532

Proteomic databases

EPDiQ96NC0
MaxQBiQ96NC0
PaxDbiQ96NC0
PeptideAtlasiQ96NC0
PRIDEiQ96NC0
ProteomicsDBi77501
TopDownProteomicsiQ96NC0

Protocols and materials databases

DNASUi153527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274712; ENSP00000274712; ENSG00000146007
GeneIDi153527
KEGGihsa:153527
UCSCiuc003lgy.2 human

Organism-specific databases

CTDi153527
EuPathDBiHostDB:ENSG00000146007.10
GeneCardsiZMAT2
HGNCiHGNC:26433 ZMAT2
HPAiHPA036518
neXtProtiNX_Q96NC0
OpenTargetsiENSG00000146007
PharmGKBiPA134931664
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4727 Eukaryota
ENOG4111GW4 LUCA
GeneTreeiENSGT00390000010712
HOGENOMiHOG000234390
HOVERGENiHBG055346
InParanoidiQ96NC0
KOiK12848
OMAiQAEMGGY
OrthoDBiEOG091G0R04
PhylomeDBiQ96NC0
TreeFamiTF314475

Miscellaneous databases

ChiTaRSiZMAT2 human
GenomeRNAii153527
PROiPR:Q96NC0

Gene expression databases

BgeeiENSG00000146007 Expressed in 198 organ(s), highest expression level in frontal cortex
CleanExiHS_ZMAT2
ExpressionAtlasiQ96NC0 baseline and differential
GenevisibleiQ96NC0 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZMAT2_HUMAN
AccessioniPrimary (citable) accession number: Q96NC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again