Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 830

Gene

ZNF830

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 75C2H2-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 830Imported
Alternative name(s):
Coiled-coil domain-containing protein 16Curated
Gene namesi
Name:ZNF830Imported
Synonyms:CCDC16Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198783.5
HGNCiHGNC:28291 ZNF830
neXtProtiNX_Q96NB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198783
PharmGKBiPA162410767

Polymorphism and mutation databases

BioMutaiZNF830
DMDMi313104066

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000761932 – 372Zinc finger protein 830Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96NB3
MaxQBiQ96NB3
PaxDbiQ96NB3
PeptideAtlasiQ96NB3
PRIDEiQ96NB3
ProteomicsDBi77499

PTM databases

iPTMnetiQ96NB3
PhosphoSitePlusiQ96NB3

Expressioni

Gene expression databases

BgeeiENSG00000198783 Expressed in 210 organ(s), highest expression level in pancreas
CleanExiHS_ZNF830
ExpressionAtlasiQ96NB3 baseline and differential
GenevisibleiQ96NB3 HS

Organism-specific databases

HPAiHPA024754
HPA027211

Interactioni

Subunit structurei

Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2 (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi124850, 25 interactors
DIPiDIP-61544N
IntActiQ96NB3, 18 interactors
MINTiQ96NB3
STRINGi9606.ENSP00000354518

Structurei

3D structure databases

ProteinModelPortaliQ96NB3
SMRiQ96NB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili312 – 349Sequence analysisAdd BLAST38

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 75C2H2-typeAdd BLAST23

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3032 Eukaryota
ENOG4111GTR LUCA
GeneTreeiENSGT00390000012151
HOGENOMiHOG000246999
HOVERGENiHBG105347
InParanoidiQ96NB3
KOiK13104
OMAiQDWRVKG
OrthoDBiEOG091G0MBX
PhylomeDBiQ96NB3
TreeFamiTF315895

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96NB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSASARTP AGKRVINQEE LRRLMKEKQR LSTSRKRIES PFAKYNRLGQ
60 70 80 90 100
LSCALCNTPV KSELLWQTHV LGKQHREKVA ELKGAKEASQ GSSASSAPHS
110 120 130 140 150
VKRKAPDADD QDVKRAKATL VPQVQPSTSA WTTNFDKIGK EFIRATPSKP
160 170 180 190 200
SGLSLLPDYE DEEEEEEEEE GDGERKRGDA SKPLSDAQGK EHSVSSSREV
210 220 230 240 250
TSSVLPNDFF STNPPKAPII PHSGSIEKAE IHEKVVERRE NTAEALPEGF
260 270 280 290 300
FDDPEVDARV RKVDAPKDQM DKEWDEFQKA MRQVNTISEA IVAEEDEEGR
310 320 330 340 350
LDRQIGEIDE QIECYRRVEK LRNRQDEIKN KLKEILTIKE LQKKEEENAD
360 370
SDDEGELQDL LSQDWRVKGA LL
Length:372
Mass (Da):41,999
Last modified:November 30, 2010 - v2
Checksum:iA06403B117672C8C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQQ3J3QQQ3_HUMAN
Zinc finger protein 830
ZNF830
106Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03094016I → V. Corresponds to variant dbSNP:rs8073825Ensembl.1
Natural variantiVAR_03094193S → P. Corresponds to variant dbSNP:rs8078059Ensembl.1
Natural variantiVAR_02405999H → QCombined sources2 PublicationsCorresponds to variant dbSNP:rs931196Ensembl.1
Natural variantiVAR_030942135F → L. Corresponds to variant dbSNP:rs8078217Ensembl.1
Natural variantiVAR_024060154S → T1 PublicationCorresponds to variant dbSNP:rs3744355Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055707 mRNA Translation: BAB70992.1
AC022903 Genomic DNA No translation available.
BC002913 mRNA Translation: AAH02913.2
BC009044 mRNA Translation: AAH09044.1
BC011584 mRNA Translation: AAH11584.2
CCDSiCCDS32618.1
RefSeqiNP_443089.3, NM_052857.3
UniGeneiHs.413678

Genome annotation databases

EnsembliENST00000361952; ENSP00000354518; ENSG00000198783
GeneIDi91603
KEGGihsa:91603
UCSCiuc002hih.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055707 mRNA Translation: BAB70992.1
AC022903 Genomic DNA No translation available.
BC002913 mRNA Translation: AAH02913.2
BC009044 mRNA Translation: AAH09044.1
BC011584 mRNA Translation: AAH11584.2
CCDSiCCDS32618.1
RefSeqiNP_443089.3, NM_052857.3
UniGeneiHs.413678

3D structure databases

ProteinModelPortaliQ96NB3
SMRiQ96NB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124850, 25 interactors
DIPiDIP-61544N
IntActiQ96NB3, 18 interactors
MINTiQ96NB3
STRINGi9606.ENSP00000354518

PTM databases

iPTMnetiQ96NB3
PhosphoSitePlusiQ96NB3

Polymorphism and mutation databases

BioMutaiZNF830
DMDMi313104066

Proteomic databases

EPDiQ96NB3
MaxQBiQ96NB3
PaxDbiQ96NB3
PeptideAtlasiQ96NB3
PRIDEiQ96NB3
ProteomicsDBi77499

Protocols and materials databases

DNASUi91603
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361952; ENSP00000354518; ENSG00000198783
GeneIDi91603
KEGGihsa:91603
UCSCiuc002hih.5 human

Organism-specific databases

CTDi91603
EuPathDBiHostDB:ENSG00000198783.5
GeneCardsiZNF830
HGNCiHGNC:28291 ZNF830
HPAiHPA024754
HPA027211
neXtProtiNX_Q96NB3
OpenTargetsiENSG00000198783
PharmGKBiPA162410767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3032 Eukaryota
ENOG4111GTR LUCA
GeneTreeiENSGT00390000012151
HOGENOMiHOG000246999
HOVERGENiHBG105347
InParanoidiQ96NB3
KOiK13104
OMAiQDWRVKG
OrthoDBiEOG091G0MBX
PhylomeDBiQ96NB3
TreeFamiTF315895

Enzyme and pathway databases

ReactomeiR-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Miscellaneous databases

GenomeRNAii91603
PROiPR:Q96NB3

Gene expression databases

BgeeiENSG00000198783 Expressed in 210 organ(s), highest expression level in pancreas
CleanExiHS_ZNF830
ExpressionAtlasiQ96NB3 baseline and differential
GenevisibleiQ96NB3 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZN830_HUMAN
AccessioniPrimary (citable) accession number: Q96NB3
Secondary accession number(s): Q96F60, Q96GZ5, Q9BU38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again