ZNF830

Functionⁱ

May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	53 – 75	C2H2-typeAdd BLAST		23

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst growth Source: Ensembl
cell division Source: UniProtKB-KW
chromosome organization Source: Ensembl
intestinal epithelial structure maintenance Source: Ensembl
mitotic cell cycle Source: GO_Central
mitotic DNA damage checkpoint Source: Ensembl
mitotic DNA replication checkpoint Source: UniProtKB
mRNA processing Source: UniProtKB-KW
negative regulation of apoptotic process Source: UniProtKB
nuclear DNA replication Source: Ensembl
ovarian follicle development Source: UniProtKB
preantral ovarian follicle growth Source: UniProtKB
replication fork protection Source: UniProtKB
RNA splicing Source: UniProtKB-KW
transcription-coupled nucleotide-excision repair Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Cell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Reactomeⁱ

R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 830Imported Alternative name(s): Coiled-coil domain-containing protein 16Curated
Gene namesⁱ	Name:ZNF830Imported Synonyms:CCDC16Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198783.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28291 ZNF830
neXtProtⁱ	NX_Q96NB3

Keywords - Cellular componentⁱ

Chromosome, Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198783
PharmGKBⁱ	PA162410767

Polymorphism and mutation databases

BioMutaⁱ	ZNF830
DMDMⁱ	313104066

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076193	2 – 372	Zinc finger protein 830Add BLAST		371

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	225	PhosphoserineCombined sources	1
Modified residueⁱ	351	PhosphoserineCombined sources	1
Modified residueⁱ	362	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96NB3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96NB3
PaxDbⁱ	Q96NB3
PeptideAtlas More...PeptideAtlasⁱ	Q96NB3
PRIDEⁱ	Q96NB3
ProteomicsDBⁱ	77499

PTM databases

iPTMnetⁱ	Q96NB3
PhosphoSitePlusⁱ	Q96NB3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198783 Expressed in 210 organ(s), highest expression level in pancreas
CleanExⁱ	HS_ZNF830
ExpressionAtlasⁱ	Q96NB3 baseline and differential
Genevisibleⁱ	Q96NB3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024754 HPA027211

HPAⁱ

HPA024754
HPA027211

Interactionⁱ

Subunit structureⁱ

Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2 (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AQR	O60306	11	EBI-3920997,EBI-2512328
IK	Q13123	2	EBI-3920997,EBI-713456
PCBP1	Q15365	2	EBI-3920997,EBI-946095
PPIL2	Q13356	2	EBI-3920997,EBI-7705988
PRPF8	Q6P2Q9	2	EBI-3920997,EBI-538479
SF3B2	Q13435	2	EBI-3920997,EBI-749111
SNW1	Q13573	2	EBI-3920997,EBI-632715

Protein-protein interaction databases

BioGridⁱ	124850, 25 interactors
Database of interacting proteins More...DIPⁱ	DIP-61544N
IntActⁱ	Q96NB3, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q96NB3
STRINGⁱ	9606.ENSP00000354518

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96NB3
SMRⁱ	Q96NB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	312 – 349	Sequence analysisAdd BLAST		38

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	53 – 75	C2H2-typeAdd BLAST		23

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3032 Eukaryota ENOG4111GTR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012151
HOGENOMⁱ	HOG000246999
HOVERGENⁱ	HBG105347
InParanoidⁱ	Q96NB3
KEGG Orthology (KO) More...KOⁱ	K13104
OMAⁱ	QDWRVKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MBX
PhylomeDBⁱ	Q96NB3
TreeFamⁱ	TF315895

Family and domain databases

InterProⁱ	View protein in InterPro IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR036236 Znf_C2H2_sf
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q96NB3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASSASARTP AGKRVINQEE LRRLMKEKQR LSTSRKRIES PFAKYNRLGQ 
        60         70         80         90        100
LSCALCNTPV KSELLWQTHV LGKQHREKVA ELKGAKEASQ GSSASSAPHS 
       110        120        130        140        150
VKRKAPDADD QDVKRAKATL VPQVQPSTSA WTTNFDKIGK EFIRATPSKP 
       160        170        180        190        200
SGLSLLPDYE DEEEEEEEEE GDGERKRGDA SKPLSDAQGK EHSVSSSREV 
       210        220        230        240        250
TSSVLPNDFF STNPPKAPII PHSGSIEKAE IHEKVVERRE NTAEALPEGF 
       260        270        280        290        300
FDDPEVDARV RKVDAPKDQM DKEWDEFQKA MRQVNTISEA IVAEEDEEGR 
       310        320        330        340        350
LDRQIGEIDE QIECYRRVEK LRNRQDEIKN KLKEILTIKE LQKKEEENAD 
       360        370 
SDDEGELQDL LSQDWRVKGA LL

Length:372

Mass (Da):41,999

Last modified:November 30, 2010 - v2

Checksum:ⁱA06403B117672C8C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3QQQ3	J3QQQ3_HUMAN		Zinc finger protein 830 Zinc finger protein 830	ZNF830	106	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030940	16	I → V. Corresponds to variant dbSNP:rs8073825Ensembl.	1
Natural variantⁱVAR_030941	93	S → P. Corresponds to variant dbSNP:rs8078059Ensembl.	1
Natural variantⁱVAR_024059	99	H → QCombined sources2 PublicationsCorresponds to variant dbSNP:rs931196Ensembl.	1
Natural variantⁱVAR_030942	135	F → L. Corresponds to variant dbSNP:rs8078217Ensembl.	1
Natural variantⁱVAR_024060	154	S → T1 PublicationCorresponds to variant dbSNP:rs3744355Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK055707 mRNA Translation: BAB70992.1 AC022903 Genomic DNA No translation available. BC002913 mRNA Translation: AAH02913.2 BC009044 mRNA Translation: AAH09044.1 BC011584 mRNA Translation: AAH11584.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32618.1
NCBI Reference Sequences More...RefSeqⁱ	NP_443089.3, NM_052857.3
UniGeneⁱ	Hs.413678

Genome annotation databases

Ensemblⁱ	ENST00000361952; ENSP00000354518; ENSG00000198783
GeneIDⁱ	91603
KEGGⁱ	hsa:91603
UCSC genome browser More...UCSCⁱ	uc002hih.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96NB3	Uncharacterized protein		PANPA		392	UniRef90_Q96NB3
Zinc finger protein 830 (Fragment)		HUMAN		106
ZNF830 isoform 2 (Fragment)		PANTR		106
Uncharacterized protein		MACMU		388
Uncharacterized protein		CERAT		388
+36

Protein	Similar proteins		Species	Score	Length	Source
Q96NB3	Zinc finger protein 830		MOUSE		363	UniRef50_Q8R1N0
Zinc finger protein 830		RAT		370
Zinc finger protein 830		XENTR		357
Zinc finger protein 830		XENLA		356
Zinc finger protein 830		CRIGR		369
+260

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK055707 mRNA Translation: BAB70992.1 AC022903 Genomic DNA No translation available. BC002913 mRNA Translation: AAH02913.2 BC009044 mRNA Translation: AAH09044.1 BC011584 mRNA Translation: AAH11584.2
CCDSⁱ	CCDS32618.1
RefSeqⁱ	NP_443089.3, NM_052857.3
UniGeneⁱ	Hs.413678

3D structure databases

ProteinModelPortalⁱ	Q96NB3
SMRⁱ	Q96NB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124850, 25 interactors
DIPⁱ	DIP-61544N
IntActⁱ	Q96NB3, 18 interactors
MINTⁱ	Q96NB3
STRINGⁱ	9606.ENSP00000354518

PTM databases

iPTMnetⁱ	Q96NB3
PhosphoSitePlusⁱ	Q96NB3

Polymorphism and mutation databases

BioMutaⁱ	ZNF830
DMDMⁱ	313104066

Proteomic databases

EPDⁱ	Q96NB3
MaxQBⁱ	Q96NB3
PaxDbⁱ	Q96NB3
PeptideAtlasⁱ	Q96NB3
PRIDEⁱ	Q96NB3
ProteomicsDBⁱ	77499

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	91603
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361952; ENSP00000354518; ENSG00000198783
GeneIDⁱ	91603
KEGGⁱ	hsa:91603
UCSCⁱ	uc002hih.5 human

Organism-specific databases

CTDⁱ	91603
EuPathDBⁱ	HostDB:ENSG00000198783.5
GeneCardsⁱ	ZNF830
HGNCⁱ	HGNC:28291 ZNF830
HPAⁱ	HPA024754 HPA027211
neXtProtⁱ	NX_Q96NB3
OpenTargetsⁱ	ENSG00000198783
PharmGKBⁱ	PA162410767
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3032 Eukaryota ENOG4111GTR LUCA
GeneTreeⁱ	ENSGT00390000012151
HOGENOMⁱ	HOG000246999
HOVERGENⁱ	HBG105347
InParanoidⁱ	Q96NB3
KOⁱ	K13104
OMAⁱ	QDWRVKG
OrthoDBⁱ	EOG091G0MBX
PhylomeDBⁱ	Q96NB3
TreeFamⁱ	TF315895

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Reactomeⁱ

R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Miscellaneous databases

GenomeRNAiⁱ	91603
Protein Ontology More...PROⁱ	PR:Q96NB3

Gene expression databases

Bgeeⁱ	ENSG00000198783 Expressed in 210 organ(s), highest expression level in pancreas
CleanExⁱ	HS_ZNF830
ExpressionAtlasⁱ	Q96NB3 baseline and differential
Genevisibleⁱ	Q96NB3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR036236 Znf_C2H2_sf
SMARTⁱ	View protein in SMART SM00451 ZnF_U1, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN830_HUMAN
Accessionⁱ	Q96NB3Primary (citable) accession number: Q96NB3 Secondary accession number(s): Q96F60, Q96GZ5, Q9BU38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	November 30, 2010
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q96NB3 (ZN830_HUMAN)

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Zinc finger protein 830

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ