UniProtKB - Q96NB3 (ZN830_HUMAN)
Zinc finger protein 830
ZNF830
Functioni
May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396).
Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 53 – 75 | C2H2-typeAdd BLAST | 23 |
GO - Molecular functioni
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- blastocyst growth Source: Ensembl
- cell division Source: UniProtKB-KW
- chromosome organization Source: Ensembl
- intestinal epithelial structure maintenance Source: Ensembl
- mitotic DNA damage checkpoint signaling Source: GO_Central
- mitotic DNA replication checkpoint signaling Source: UniProtKB
- mRNA processing Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- nuclear DNA replication Source: GO_Central
- ovarian follicle development Source: UniProtKB
- preantral ovarian follicle growth Source: UniProtKB
- replication fork protection Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell cycle, Cell division, Mitosis, mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96NB3 |
Reactomei | R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135, Dual incision in TC-NER R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER |
SignaLinki | Q96NB3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 830ImportedAlternative name(s): Coiled-coil domain-containing protein 16Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28291, ZNF830 |
neXtProti | NX_Q96NB3 |
VEuPathDBi | HostDB:ENSG00000198783 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Nucleus speckle By similarity
Other locations
- Chromosome By similarity
Note: Excluded from nucleolus.By similarity
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
- spliceosomal complex Source: UniProtKB-KW
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 91603 |
OpenTargetsi | ENSG00000198783 |
PharmGKBi | PA162410767 |
Miscellaneous databases
Pharosi | Q96NB3, Tdark |
Genetic variation databases
BioMutai | ZNF830 |
DMDMi | 313104066 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076193 | 2 – 372 | Zinc finger protein 830Add BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96NB3 |
jPOSTi | Q96NB3 |
MassIVEi | Q96NB3 |
MaxQBi | Q96NB3 |
PaxDbi | Q96NB3 |
PeptideAtlasi | Q96NB3 |
PRIDEi | Q96NB3 |
ProteomicsDBi | 77499 |
PTM databases
GlyGeni | Q96NB3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96NB3 |
PhosphoSitePlusi | Q96NB3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198783, Expressed in pancreas and 223 other tissues |
ExpressionAtlasi | Q96NB3, baseline and differential |
Genevisiblei | Q96NB3, HS |
Organism-specific databases
HPAi | ENSG00000198783, Low tissue specificity |
Interactioni
Subunit structurei
Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA.
Interacts with XAB2 (PubMed:17981804).
Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex (PubMed:25599396). The IB complex does not contain PRPF19 (PubMed:25599396).
2 PublicationsBinary interactionsi
Q96NB3
Protein-protein interaction databases
BioGRIDi | 124850, 59 interactors |
DIPi | DIP-61544N |
IntActi | Q96NB3, 23 interactors |
MINTi | Q96NB3 |
STRINGi | 9606.ENSP00000354518 |
Miscellaneous databases
RNActi | Q96NB3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 126 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 143 – 225 | DisorderedSequence analysisAdd BLAST | 83 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 312 – 349 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 102 – 116 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 157 – 172 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 188 – 210 | Polar residuesSequence analysisAdd BLAST | 23 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 53 – 75 | C2H2-typeAdd BLAST | 23 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3032, Eukaryota |
GeneTreei | ENSGT00390000012151 |
HOGENOMi | CLU_058140_1_0_1 |
InParanoidi | Q96NB3 |
OMAi | EQIECYK |
OrthoDBi | 1458826at2759 |
PhylomeDBi | Q96NB3 |
TreeFami | TF315895 |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR040050, ZNF830-like IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR13278, PTHR13278, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MASSASARTP AGKRVINQEE LRRLMKEKQR LSTSRKRIES PFAKYNRLGQ
60 70 80 90 100
LSCALCNTPV KSELLWQTHV LGKQHREKVA ELKGAKEASQ GSSASSAPHS
110 120 130 140 150
VKRKAPDADD QDVKRAKATL VPQVQPSTSA WTTNFDKIGK EFIRATPSKP
160 170 180 190 200
SGLSLLPDYE DEEEEEEEEE GDGERKRGDA SKPLSDAQGK EHSVSSSREV
210 220 230 240 250
TSSVLPNDFF STNPPKAPII PHSGSIEKAE IHEKVVERRE NTAEALPEGF
260 270 280 290 300
FDDPEVDARV RKVDAPKDQM DKEWDEFQKA MRQVNTISEA IVAEEDEEGR
310 320 330 340 350
LDRQIGEIDE QIECYRRVEK LRNRQDEIKN KLKEILTIKE LQKKEEENAD
360 370
SDDEGELQDL LSQDWRVKGA LL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3QQQ3 | J3QQQ3_HUMAN | Zinc finger protein 830 | ZNF830 | 106 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030940 | 16 | I → V. Corresponds to variant dbSNP:rs8073825Ensembl. | 1 | |
Natural variantiVAR_030941 | 93 | S → P. Corresponds to variant dbSNP:rs8078059Ensembl. | 1 | |
Natural variantiVAR_024059 | 99 | H → QCombined sources2 PublicationsCorresponds to variant dbSNP:rs931196Ensembl. | 1 | |
Natural variantiVAR_030942 | 135 | F → L. Corresponds to variant dbSNP:rs8078217Ensembl. | 1 | |
Natural variantiVAR_024060 | 154 | S → T1 PublicationCorresponds to variant dbSNP:rs3744355Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055707 mRNA Translation: BAB70992.1 AC022903 Genomic DNA No translation available. BC002913 mRNA Translation: AAH02913.2 BC009044 mRNA Translation: AAH09044.1 BC011584 mRNA Translation: AAH11584.2 |
CCDSi | CCDS32618.1 |
RefSeqi | NP_443089.3, NM_052857.3 |
Genome annotation databases
Ensembli | ENST00000361952; ENSP00000354518; ENSG00000198783 |
GeneIDi | 91603 |
KEGGi | hsa:91603 |
MANE-Selecti | ENST00000361952.5; ENSP00000354518.3; NM_052857.4; NP_443089.3 |
UCSCi | uc002hih.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055707 mRNA Translation: BAB70992.1 AC022903 Genomic DNA No translation available. BC002913 mRNA Translation: AAH02913.2 BC009044 mRNA Translation: AAH09044.1 BC011584 mRNA Translation: AAH11584.2 |
CCDSi | CCDS32618.1 |
RefSeqi | NP_443089.3, NM_052857.3 |
3D structure databases
SMRi | Q96NB3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124850, 59 interactors |
DIPi | DIP-61544N |
IntActi | Q96NB3, 23 interactors |
MINTi | Q96NB3 |
STRINGi | 9606.ENSP00000354518 |
PTM databases
GlyGeni | Q96NB3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96NB3 |
PhosphoSitePlusi | Q96NB3 |
Genetic variation databases
BioMutai | ZNF830 |
DMDMi | 313104066 |
Proteomic databases
EPDi | Q96NB3 |
jPOSTi | Q96NB3 |
MassIVEi | Q96NB3 |
MaxQBi | Q96NB3 |
PaxDbi | Q96NB3 |
PeptideAtlasi | Q96NB3 |
PRIDEi | Q96NB3 |
ProteomicsDBi | 77499 |
Protocols and materials databases
Antibodypediai | 15518, 103 antibodies from 23 providers |
DNASUi | 91603 |
Genome annotation databases
Ensembli | ENST00000361952; ENSP00000354518; ENSG00000198783 |
GeneIDi | 91603 |
KEGGi | hsa:91603 |
MANE-Selecti | ENST00000361952.5; ENSP00000354518.3; NM_052857.4; NP_443089.3 |
UCSCi | uc002hih.5, human |
Organism-specific databases
CTDi | 91603 |
DisGeNETi | 91603 |
GeneCardsi | ZNF830 |
HGNCi | HGNC:28291, ZNF830 |
HPAi | ENSG00000198783, Low tissue specificity |
neXtProti | NX_Q96NB3 |
OpenTargetsi | ENSG00000198783 |
PharmGKBi | PA162410767 |
VEuPathDBi | HostDB:ENSG00000198783 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3032, Eukaryota |
GeneTreei | ENSGT00390000012151 |
HOGENOMi | CLU_058140_1_0_1 |
InParanoidi | Q96NB3 |
OMAi | EQIECYK |
OrthoDBi | 1458826at2759 |
PhylomeDBi | Q96NB3 |
TreeFami | TF315895 |
Enzyme and pathway databases
PathwayCommonsi | Q96NB3 |
Reactomei | R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135, Dual incision in TC-NER R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER |
SignaLinki | Q96NB3 |
Miscellaneous databases
BioGRID-ORCSi | 91603, 650 hits in 1053 CRISPR screens |
GenomeRNAii | 91603 |
Pharosi | Q96NB3, Tdark |
PROi | PR:Q96NB3 |
RNActi | Q96NB3, protein |
Gene expression databases
Bgeei | ENSG00000198783, Expressed in pancreas and 223 other tissues |
ExpressionAtlasi | Q96NB3, baseline and differential |
Genevisiblei | Q96NB3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR040050, ZNF830-like IPR036236, Znf_C2H2_sf |
PANTHERi | PTHR13278, PTHR13278, 1 hit |
SMARTi | View protein in SMART SM00451, ZnF_U1, 1 hit |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN830_HUMAN | |
Accessioni | Q96NB3Primary (citable) accession number: Q96NB3 Secondary accession number(s): Q96F60, Q96GZ5, Q9BU38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports