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Protein

Sideroflexin-2

Gene

SFXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-2
Gene namesi
Name:SFXN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156398.12
HGNCiHGNC:16086 SFXN2
MIMi615570 gene
neXtProtiNX_Q96NB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei174 – 192HelicalSequence analysisAdd BLAST19
Transmembranei228 – 250HelicalSequence analysisAdd BLAST23
Transmembranei265 – 287HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156398
PharmGKBiPA38091

Polymorphism and mutation databases

BioMutaiSFXN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770351 – 322Sideroflexin-2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96NB2
MaxQBiQ96NB2
PaxDbiQ96NB2
PeptideAtlasiQ96NB2
PRIDEiQ96NB2
ProteomicsDBi77498

PTM databases

iPTMnetiQ96NB2
PhosphoSitePlusiQ96NB2

Expressioni

Tissue specificityi

Widely expressed, highest levels in kidney, liver, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000156398
CleanExiHS_SFXN2
ExpressionAtlasiQ96NB2 baseline and differential
GenevisibleiQ96NB2 HS

Organism-specific databases

HPAiHPA018150
HPA026834

Interactioni

Protein-protein interaction databases

BioGridi125630, 16 interactors
IntActiQ96NB2, 6 interactors
STRINGi9606.ENSP00000358909

Structurei

3D structure databases

ProteinModelPortaliQ96NB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767 Eukaryota
ENOG410YU8V LUCA
GeneTreeiENSGT00390000002026
HOGENOMiHOG000203440
HOVERGENiHBG056083
InParanoidiQ96NB2
OMAiRRIKWIN
OrthoDBiEOG091G0BOU
PhylomeDBiQ96NB2
TreeFamiTF313205

Family and domain databases

InterProiView protein in InterPro
IPR004686 Mtc
PANTHERiPTHR11153 PTHR11153, 1 hit
PfamiView protein in Pfam
PF03820 Mtc, 1 hit
TIGRFAMsiTIGR00798 mtc, 1 hit

Sequencei

Sequence statusi: Complete.

Q96NB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV
60 70 80 90 100
EKSRMGVVPP GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM
110 120 130 140 150
IITGFMLQFY RTMPAVIFWQ WVNQSFNALV NYTNRNAASP TSVRQMALSY
160 170 180 190 200
FTATTTAVAT AVGMNMLTKK APPLVGRWVP FAAVAAANCV NIPMMRQQEL
210 220 230 240 250
IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM ILLPVIMERL
260 270 280 290 300
EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK
310 320
LQDTIKAKYG ELEPYVYFNK GL
Length:322
Mass (Da):36,232
Last modified:March 27, 2002 - v2
Checksum:i329D577B2583DF31
GO

Sequence cautioni

The sequence BAB70993 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 204QMALS…LIKGI → KRRPWWAAGCPLPLWLRLTV SISP (PubMed:14702039).CuratedAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462052 mRNA Translation: AAM09645.1
CH471066 Genomic DNA Translation: EAW49675.1
CH471066 Genomic DNA Translation: EAW49677.1
BC022091 mRNA Translation: AAH22091.1
AK055711 mRNA Translation: BAB70993.1 Different initiation.
CCDSiCCDS7539.1
RefSeqiNP_849189.1, NM_178858.4
XP_011537564.1, XM_011539262.2
XP_016871152.1, XM_017015663.1
UniGeneiHs.44070

Genome annotation databases

EnsembliENST00000369893; ENSP00000358909; ENSG00000156398
GeneIDi118980
KEGGihsa:118980
UCSCiuc001kwb.3 human

Similar proteinsi

Entry informationi

Entry nameiSFXN2_HUMAN
AccessioniPrimary (citable) accession number: Q96NB2
Secondary accession number(s): Q5JSM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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