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UniProtKB - Q96N96 (SPT13_HUMAN)

Entry version 167 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Spermatogenesis-associated protein 13

Gene

SPATA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96N96

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96N96

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 13
Alternative name(s):
APC-stimulated guanine nucleotide exchange factor 2
Short name:
Asef2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA131 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23222, SPATA13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613324, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96N96

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182957

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		221178

Open Targets

More...OpenTargetsi		ENSG00000182957

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134912609

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96N96, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPATA13

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752049

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784481 – 652Spermatogenesis-associated protein 13Add BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96N96

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96N96

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96N96

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96N96

PeptideAtlas

More...PeptideAtlasi		Q96N96

PRoteomics IDEntifications database

More...PRIDEi		Q96N96

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77489 [Q96N96-1]
77490 [Q96N96-2]
77491 [Q96N96-3]
77492 [Q96N96-4]
77493 [Q96N96-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96N96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96N96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182957, Expressed in metanephros and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96N96, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96N96, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182957, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via ABR and SH3 domain) with APC. The binding of APC enhances its GEF activity by relieving it from an autoinhibitory conformation, in which the ABR and SH3 domains are associated with the C-terminal tail.

Interacts (via C-terminal tail) with PPP1R9B (via C-terminus).

Interacts with RAC1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128693, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q96N96, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000398560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96N96, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96N96

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 206SH3PROSITE-ProRule annotationAdd BLAST60
Domaini240 – 424DHPROSITE-ProRule annotationAdd BLAST185
Domaini455 – 561PHPROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni81 – 108DisorderedSequence analysisAdd BLAST28
Regioni98 – 150ABR (APC-binding region) domainAdd BLAST53
Regioni209 – 235DisorderedSequence analysisAdd BLAST27
Regioni561 – 652C-terminal tailAdd BLAST92

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal tail is required for its GEF activity.

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3519, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154103

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008436_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96N96

Identification of Orthologs from Complete Genome Data

More...OMAi		PETECQK

Database of Orthologous Groups

More...OrthoDBi		65769at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96N96

TreeFam database of animal gene trees

More...TreeFami		TF316832

Family and domain databases

Conserved Domains Database

More...CDDi		cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N96-1) [UniParc]FASTAAdd to basket
Also known as: ASEF-2b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSASPEDQN APVGCPKGAR RRRPISVIGG VSLYGTNQTE ELDNLLTQPA 
        60         70         80         90        100
SRPPMPAHQV PPYKAVSARF RPFTFSQSTP IGLDRVGRRR QMRASNVSSD 
       110        120        130        140        150
GGTEPSALVD DNGSEEDFSY EDLCQASPRY LQPGGEQLAI NELISDGNVV 
       160        170        180        190        200
CAEALWDHVT MDDQELGFKA GDVIQVLEAS NKDWWWGRSE DKEAWFPASF 
       210        220        230        240        250
VRLRVNQEEL SENSSSTPSE EQDEEASQSR HRHCENKQQM RTNVIREIMD 
       260        270        280        290        300
TERVYIKHLR DICEGYIRQC RKHTGMFTVA QLATIFGNIE DIYKFQRKFL 
       310        320        330        340        350
KDLEKQYNKE EPHLSEIGSC FLQNQEGFAI YSEYCNNHPG ACLELANLMK 
       360        370        380        390        400
QGKYRHFFEA CRLLQQMIDI AIDGFLLTPV QKICKYPLQL AELLKYTTQE 
       410        420        430        440        450
HGDYSNIKAA YEAMKNVACL INERKRKLES IDKIARWQVS IVGWEGLDIL 
       460        470        480        490        500
DRSSELIHSG ELTKITKQGK SQQRTFFLFD HQLVSCKKDL LRRDMLYYKG 
       510        520        530        540        550
RLDMDEMELV DLGDGRDKDC NLSVKNAFKL VSRTTDEVYL FCAKKQEDKA 
       560        570        580        590        600
RWLQACADER RRVQEDKEMG MEISENQKKL AMLNAQKAGH GKSKGYNRCP 
       610        620        630        640        650
VAPPHQGLHP IHQRHITMPT SVPQQQVFGL AEPKRKSSLF WHTFNRLTPF 

RK
Length:652
Mass (Da):74,820
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C922E8AF0A9C836
GO
Isoform 2 (identifier: Q96N96-2) [UniParc]FASTAAdd to basket
Also known as: ASEF-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MTSASPEDQN...GRRRQMRASN → MVARGEIARFWSLESLHL

Show »
Length:574
Mass (Da):66,403
Checksum:i34A1B7ECAF3C4C30
GO
Isoform 3 (identifier: Q96N96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MTSASPEDQN...GRRRQMRASN → MGFIIHIQQV...EKKCASLSFE

Show »
Length:596
Mass (Da):69,108
Checksum:iCBD88B1A30AF9B9A
GO
Isoform 4 (identifier: Q96N96-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     595-652: GYNRCPVAPP...TFNRLTPFRK → VRLQQVPRGP...SMELGVKRRN

Show »
Length:616
Mass (Da):70,446
Checksum:i15F635D80BA6B3C7
GO
Isoform 5 (identifier: Q96N96-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
     203-264: Missing.

Show »
Length:536
Mass (Da):61,677
Checksum:iF449FEF56512EA27
GO
Isoform 6 (identifier: Q96N96-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQAAVRPWA...RVDEDPQASM

Show »
Length:1,277
Mass (Da):141,436
Checksum:i23BC07A9333FB2C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQJ8J3KQJ8_HUMAN
Spermatogenesis-associated protein ...
SPATA13
550Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFR9E9PFR9_HUMAN
Spermatogenesis-associated protein ...
SPATA13
512Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VX67Q5VX67_HUMAN
Spermatogenesis-associated protein ...
SPATA13
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ16V9GZ16_HUMAN
Spermatogenesis-associated protein ...
SPATA13
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04977 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304E → G in BAG61802 (PubMed:14702039).Curated1
Sequence conflicti520C → R in BAG62740 (PubMed:14702039).Curated1
Sequence conflicti537E → G in BAG62740 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03077620R → W. Corresponds to variant dbSNP:rs7330736Ensembl.1
Natural variantiVAR_08076789R → W Found in two consanguineous families with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201402934Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0410301 – 96MTSAS…MRASN → MVARGEIARFWSLESLHL in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_0410311 – 96MTSAS…MRASN → MGFIIHIQQVKKQRKKLDQG LILKKEKYRKEKKCASLSFE in isoform 3. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_0410321 – 54Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0541121M → MTQAAVRPWAPCLENMTTAP NGLGPGPAAPCAGSDLKDAK MVTSLACGNGVCGCSPGGDT DTQEAKLSPAKLVRLFSTSR KRTGAHPERPHSMVLVGNSS TWNTLASFRKMGSFKKLKSS VLKGIQSREGSNACSKGEAS EHGLGKSIPNGAVPGAQASR GSPLAPGPACGALRPAEWGT LDGSDLEDTDDAFQRSTHRS RSLRRAYGLGRICLLDAPQN HATPTIATGQVPAVCEILVR DPENNSMGYRRSKSTDNLAF LKKSSFKRKSTSNLADLRTA HDARVPQRTLSSSSTDSQKL GSGRTKRWRSPIRAKDFDRV FKLVSNVTEAAWRRESPRSG APSPGEASLRLQAHSRLHDD YSRRVSRSTEQDSRRGGAVM HGTTATCTVAPGFGSATSKG PHLDADTAVFPLETKSSWAV ESDSSCTCSSLPSPIVQDVL SKDSCDPNAGSQLTFDPEQP PTPLRPTTPKPQSPQSPQSP GAGSASCHSNHSALSANSEE SEGRAEEPAQREPGPVSLQD PLEATHGDEGSKDLLVNIGV AAGPEEKEKEEVVPDGPWRR SSSQDEERTEAQRTPKRRWG SGRRPRPRPFSDYGQLASRS LSIPEDSVAADPQKEDRVDE DPQASM in isoform 6. Curated1
Alternative sequenceiVSP_041033203 – 264Missing in isoform 5. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_041034595 – 652GYNRC…TPFRK → VRLQQVPRGPTAPGPAPHPP APHHYAHKRPPAAGLWPGGT QEEVLALLAHLQQAHPLPEM KTGGCASMELGVKRRN in isoform 4. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BK006072 mRNA Translation: DAA05848.1
AK055770 mRNA Translation: BAB71009.1
AK097217 mRNA Translation: BAC04977.1 Different initiation.
AK123031 mRNA Translation: BAG53856.1
AK298717 mRNA Translation: BAG60873.1
AK299981 mRNA Translation: BAG61802.1
AK301149 mRNA Translation: BAG62740.1
AL136963 Genomic DNA No translation available.
AL139324 Genomic DNA No translation available.
AL359736 Genomic DNA No translation available.
AL445985 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08331.1
BC109290 mRNA Translation: AAI09291.1
BC109291 mRNA Translation: AAI09292.1
AK074117 mRNA Translation: BAB84943.1
AK160371 mRNA Translation: BAD18714.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53857.1 [Q96N96-6]
CCDS66517.1 [Q96N96-2]
CCDS66518.1 [Q96N96-3]
CCDS9305.1 [Q96N96-1]

NCBI Reference Sequences

More...RefSeqi		NP_001159743.1, NM_001166271.2 [Q96N96-6]
NP_001273721.1, NM_001286792.1
NP_001273722.1, NM_001286793.1
NP_001273723.1, NM_001286794.1 [Q96N96-3]
NP_001273724.1, NM_001286795.1 [Q96N96-2]
NP_694568.1, NM_153023.3 [Q96N96-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343003; ENSP00000343631; ENSG00000182957 [Q96N96-3]
ENST00000382095; ENSP00000371527; ENSG00000182957 [Q96N96-1]
ENST00000382108; ENSP00000371542; ENSG00000182957 [Q96N96-6]
ENST00000399949; ENSP00000382830; ENSG00000182957 [Q96N96-2]
ENST00000424834; ENSP00000398560; ENSG00000182957 [Q96N96-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		221178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:221178

UCSC genome browser

More...UCSCi		uc001upg.4, human [Q96N96-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK006072 mRNA Translation: DAA05848.1
AK055770 mRNA Translation: BAB71009.1
AK097217 mRNA Translation: BAC04977.1 Different initiation.
AK123031 mRNA Translation: BAG53856.1
AK298717 mRNA Translation: BAG60873.1
AK299981 mRNA Translation: BAG61802.1
AK301149 mRNA Translation: BAG62740.1
AL136963 Genomic DNA No translation available.
AL139324 Genomic DNA No translation available.
AL359736 Genomic DNA No translation available.
AL445985 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08331.1
BC109290 mRNA Translation: AAI09291.1
BC109291 mRNA Translation: AAI09292.1
AK074117 mRNA Translation: BAB84943.1
AK160371 mRNA Translation: BAD18714.1
CCDSiCCDS53857.1 [Q96N96-6]
CCDS66517.1 [Q96N96-2]
CCDS66518.1 [Q96N96-3]
CCDS9305.1 [Q96N96-1]
RefSeqiNP_001159743.1, NM_001166271.2 [Q96N96-6]
NP_001273721.1, NM_001286792.1
NP_001273722.1, NM_001286793.1
NP_001273723.1, NM_001286794.1 [Q96N96-3]
NP_001273724.1, NM_001286795.1 [Q96N96-2]
NP_694568.1, NM_153023.3 [Q96N96-1]

3D structure databases

SMRiQ96N96
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128693, 14 interactors
IntActiQ96N96, 12 interactors
STRINGi9606.ENSP00000398560

PTM databases

iPTMnetiQ96N96
PhosphoSitePlusiQ96N96

Genetic variation databases

BioMutaiSPATA13
DMDMi74752049

Proteomic databases

jPOSTiQ96N96
MassIVEiQ96N96
MaxQBiQ96N96
PaxDbiQ96N96
PeptideAtlasiQ96N96
PRIDEiQ96N96
ProteomicsDBi77489 [Q96N96-1]
77490 [Q96N96-2]
77491 [Q96N96-3]
77492 [Q96N96-4]
77493 [Q96N96-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49852, 99 antibodies

The DNASU plasmid repository

More...DNASUi		221178

Genome annotation databases

EnsembliENST00000343003; ENSP00000343631; ENSG00000182957 [Q96N96-3]
ENST00000382095; ENSP00000371527; ENSG00000182957 [Q96N96-1]
ENST00000382108; ENSP00000371542; ENSG00000182957 [Q96N96-6]
ENST00000399949; ENSP00000382830; ENSG00000182957 [Q96N96-2]
ENST00000424834; ENSP00000398560; ENSG00000182957 [Q96N96-6]
GeneIDi221178
KEGGihsa:221178
UCSCiuc001upg.4, human [Q96N96-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		221178
DisGeNETi221178

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPATA13
HGNCiHGNC:23222, SPATA13
HPAiENSG00000182957, Low tissue specificity
MIMi613324, gene
neXtProtiNX_Q96N96
OpenTargetsiENSG00000182957
PharmGKBiPA134912609
VEuPathDBiHostDB:ENSG00000182957

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3519, Eukaryota
GeneTreeiENSGT00940000154103
HOGENOMiCLU_008436_0_0_1
InParanoidiQ96N96
OMAiPETECQK
OrthoDBi65769at2759
PhylomeDBiQ96N96
TreeFamiTF316832

Enzyme and pathway databases

PathwayCommonsiQ96N96
ReactomeiR-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
SIGNORiQ96N96

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		221178, 11 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPATA13, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		221178
PharosiQ96N96, Tbio

Protein Ontology

More...PROi		PR:Q96N96
RNActiQ96N96, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182957, Expressed in metanephros and 215 other tissues
ExpressionAtlasiQ96N96, baseline and differential
GenevisibleiQ96N96, HS

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N96
Secondary accession number(s): A2VEA9
, A6NF85, B4DQB1, B4DSZ0, B4DVM8, J3KPJ7, J3KQH2, Q5VX68, Q6ZML1, Q8N873, Q8TEK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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