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Protein

Inactive sodium-dependent neutral amino acid transporter B(0)AT3

Gene

SLC6A18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not show neutral amino acid transporter activity.1 Publication

Caution

The mouse ortholog protein is an active neutral amino acid transporter.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619079 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
R-HSA-5659729 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.6.4 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A18
Synonyms:XTRP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164363.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26441 SLC6A18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610300 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96N87

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 51ExtracellularSequence analysis4
Transmembranei52 – 74Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini75 – 88CytoplasmicSequence analysisAdd BLAST14
Transmembranei89 – 111Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini112 – 178ExtracellularSequence analysisAdd BLAST67
Transmembranei179 – 201Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini202 – 207CytoplasmicSequence analysis6
Transmembranei208 – 230Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini231 – 253ExtracellularSequence analysisAdd BLAST23
Transmembranei254 – 276Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini277 – 288CytoplasmicSequence analysisAdd BLAST12
Transmembranei289 – 311Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini312 – 399ExtracellularSequence analysisAdd BLAST88
Transmembranei400 – 422Helical; Name=8Sequence analysisAdd BLAST23
Topological domaini423 – 442CytoplasmicSequence analysisAdd BLAST20
Transmembranei443 – 465Helical; Name=9Sequence analysisAdd BLAST23
Topological domaini466 – 474ExtracellularSequence analysis9
Transmembranei475 – 497Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini498 – 517CytoplasmicSequence analysisAdd BLAST20
Transmembranei518 – 540Helical; Name=11Sequence analysisAdd BLAST23
Topological domaini541 – 568ExtracellularSequence analysisAdd BLAST28
Transmembranei569 – 591Helical; Name=12Sequence analysisAdd BLAST23
Topological domaini592 – 628CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20 (PubMed:19033659).1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
348932

MalaCards human disease database

More...
MalaCardsi
SLC6A18

Open Targets

More...
OpenTargetsi
ENSG00000164363

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
42062 Iminoglycinuria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134982449

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC6A18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104185

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148061 – 628Inactive sodium-dependent neutral amino acid transporter B(0)AT3Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96N87

PeptideAtlas

More...
PeptideAtlasi
Q96N87

PRoteomics IDEntifications database

More...
PRIDEi
Q96N87

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77484

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96N87

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96N87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in kidney, but not in intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164363 Expressed in 17 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC6A18

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96N87 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011885

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96N87

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96N87

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116406

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG071421

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96N87

KEGG Orthology (KO)

More...
KOi
K05048

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFVEECQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08PX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96N87

TreeFam database of animal gene trees

More...
TreeFami
TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR002438 Na/ntran_symport_orphan
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00176 NANEUSMPORT
PR01206 ORPHTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96N87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAPEPDPA ACDLGDERPK WDNKAQYLLS CTGFAVGLGN IWRFPYLCQT
60 70 80 90 100
YGGGAFLIPY VIALVFEGIP IFHVELAIGQ RLRKGSVGVW TAISPYLSGV
110 120 130 140 150
GLGCVTLSFL ISLYYNTIVA WVLWYLLNSF QHPLPWSSCP PDLNRTGFVE
160 170 180 190 200
ECQGSSAVSY FWYRQTLNIT ADINDSGSIQ WWLLICLAAS WAVVYMCVIR
210 220 230 240 250
GIETTGKVIY FTALFPYLVL TIFLIRGLTL PGATKGLIYL FTPNMHILQN
260 270 280 290 300
PRVWLDAATQ IFFSLSLAFG GHIAFASYNS PRNDCQKDAV VIALVNRMTS
310 320 330 340 350
LYASIAVFSV LGFKATNDYE HCLDRNILSL INDFDFPEQS ISRDDYPAVL
360 370 380 390 400
MHLNATWPKR VAQLPLKACL LEDFLDKSAS GPGLAFVVFT ETDLHMPGAP
410 420 430 440 450
VWAMLFFGML FTLGLSTMFG TVEAVITPLL DVGVLPRWVP KEALTGLVCL
460 470 480 490 500
VCFLSATCFT LQSGNYWLEI FDNFAASPNL LMLAFLEVVG VVYVYGMKRF
510 520 530 540 550
CDDIAWMTGR RPSPYWRLTW RVVSPLLLTI FVAYIILLFW KPLRYKAWNP
560 570 580 590 600
KYELFPSRQE KLYPGWARAA CVLLSLLPVL WVPVAALAQL LTRRRRTWRD
610 620
RDARPDTDMR PDTDTRPDTD MRPDTDMR
Length:628
Mass (Da):70,897
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDFA217424060095
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in SLC6A18 is not a significant predictor for elevated systolic or diastolic blood pressure and is not associated with hypertension in the Japanese population (PubMed:16340170).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0572104A → D. Corresponds to variant dbSNP:rs34469326Ensembl.1
Natural variantiVAR_02797512C → S. Corresponds to variant dbSNP:rs7728667Ensembl.1
Natural variantiVAR_02797632T → I1 PublicationCorresponds to variant dbSNP:rs7705355Ensembl.1
Natural variantiVAR_06479679G → S1 PublicationCorresponds to variant dbSNP:rs113861454Ensembl.1
Natural variantiVAR_027977478P → L2 PublicationsCorresponds to variant dbSNP:rs4073918Ensembl.1
Natural variantiVAR_064797496G → R1 PublicationCorresponds to variant dbSNP:rs147278493Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055798 mRNA Translation: BAB71018.1
AC114291 Genomic DNA No translation available.
BC056757 mRNA Translation: AAH56757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3860.1

NCBI Reference Sequences

More...
RefSeqi
NP_872438.2, NM_182632.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.213284

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324642; ENSP00000323549; ENSG00000164363

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
348932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:348932

UCSC genome browser

More...
UCSCi
uc003jby.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055798 mRNA Translation: BAB71018.1
AC114291 Genomic DNA No translation available.
BC056757 mRNA Translation: AAH56757.1
CCDSiCCDS3860.1
RefSeqiNP_872438.2, NM_182632.2
UniGeneiHs.213284

3D structure databases

ProteinModelPortaliQ96N87
SMRiQ96N87
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323549

Protein family/group databases

TCDBi2.A.22.6.4 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiQ96N87
PhosphoSitePlusiQ96N87

Polymorphism and mutation databases

BioMutaiSLC6A18
DMDMi313104185

Proteomic databases

PaxDbiQ96N87
PeptideAtlasiQ96N87
PRIDEiQ96N87
ProteomicsDBi77484

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324642; ENSP00000323549; ENSG00000164363
GeneIDi348932
KEGGihsa:348932
UCSCiuc003jby.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
348932
DisGeNETi348932
EuPathDBiHostDB:ENSG00000164363.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC6A18

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004720
HGNCiHGNC:26441 SLC6A18
HPAiHPA011885
MalaCardsiSLC6A18
MIMi610300 gene
neXtProtiNX_Q96N87
OpenTargetsiENSG00000164363
Orphaneti42062 Iminoglycinuria
PharmGKBiPA134982449

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000158906
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ96N87
KOiK05048
OMAiGFVEECQ
OrthoDBiEOG091G08PX
PhylomeDBiQ96N87
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619079 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
R-HSA-5659729 Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC6A18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
348932

Protein Ontology

More...
PROi
PR:Q96N87

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164363 Expressed in 17 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC6A18
GenevisibleiQ96N87 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002438 Na/ntran_symport_orphan
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01206 ORPHTRNSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS6A18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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