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Protein

PWWP domain-containing protein 2A

Gene

PWWP2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.1 Publication

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 2A
Gene namesi
Name:PWWP2A
Synonyms:KIAA1935, MST101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170234.12
HGNCiHGNC:29406 PWWP2A
MIMi617823 gene
neXtProtiNX_Q96N64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170234
PharmGKBiPA162400500

Polymorphism and mutation databases

BioMutaiPWWP2A
DMDMi160419226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113631 – 755PWWP domain-containing protein 2AAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96N64
MaxQBiQ96N64
PaxDbiQ96N64
PeptideAtlasiQ96N64
PRIDEiQ96N64
ProteomicsDBi77468
77469 [Q96N64-2]

PTM databases

iPTMnetiQ96N64
PhosphoSitePlusiQ96N64

Expressioni

Gene expression databases

BgeeiENSG00000170234 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_PWWP2A
ExpressionAtlasiQ96N64 baseline and differential
GenevisibleiQ96N64 HS

Organism-specific databases

HPAiHPA046733
HPA058233

Interactioni

Subunit structurei

Interacts with H2A.Z/H2AFZ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC1Q135475EBI-6597774,EBI-301834

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125375, 8 interactors
IntActiQ96N64, 8 interactors
STRINGi9606.ENSP00000305151

Structurei

3D structure databases

ProteinModelPortaliQ96N64
SMRiQ96N64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini655 – 715PWWPPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni423 – 574Interaction with the H2A.Z/H2AFZ1 PublicationAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 146Pro-richAdd BLAST86
Compositional biasi240 – 291Pro-richAdd BLAST52
Compositional biasi575 – 632Ser-richAdd BLAST58

Phylogenomic databases

eggNOGiENOG410IXQI Eukaryota
ENOG4111IWH LUCA
GeneTreeiENSGT00530000063940
HOGENOMiHOG000060329
HOVERGENiHBG108311
InParanoidiQ96N64
OMAiARVSWFG
OrthoDBiEOG091G08LI
PhylomeDBiQ96N64
TreeFamiTF331271

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP
60 70 80 90 100
DGETDGQQSA PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA
110 120 130 140 150
ESAAAAPQGG PELPPSPASP PEQPPAPEER EEPPLPQPVA PALVPPAGGD
160 170 180 190 200
STVSQLIPGS EVRVTLDHII EDALVVSFRF GEKLFSGVLM DLSKRFGPHG
210 220 230 240 250
IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP DDPSPVPHPE
260 270 280 290 300
LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK
310 320 330 340 350
MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED
360 370 380 390 400
KKRRNESVTT VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK
410 420 430 440 450
VSAQANTSKA QLSTKKVLQS KNMDHAKARE VLKIAKEKAQ KKQNETSTSK
460 470 480 490 500
NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR YRNEENDSSL KTGLEKMRSG
510 520 530 540 550
KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT NEVHVPGDQD
560 570 580 590 600
EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS
610 620 630 640 650
SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG
660 670 680 690 700
RTICVGDIVW AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT
710 720 730 740 750
TSFLALSQLS PFLENFQSRF NKKRKGLYRK AITEAAKAAK QLTPEVRALL

TQFET
Length:755
Mass (Da):81,960
Last modified:November 13, 2007 - v2
Checksum:i6BF89E9C8D68EAA0
GO
Isoform 2 (identifier: Q96N64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-560: EAPSENQSPS...EPQTLGKKGS → LNKWQLLHQT...LTVKRAAQRH
     561-755: Missing.

Show »
Length:560
Mass (Da):60,684
Checksum:iAA8EE2743C67AB3A
GO
Isoform 3 (identifier: Q96N64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-520: GEAP → AQRH
     521-755: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:520
Mass (Da):56,315
Checksum:i951B12404F03C440
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC06H0YC06_HUMAN
PWWP domain-containing protein 2A
PWWP2A
69Annotation score:
H0YB44H0YB44_HUMAN
PWWP domain-containing protein 2A
PWWP2A
35Annotation score:
H0YC08H0YC08_HUMAN
PWWP domain-containing protein 2A
PWWP2A
49Annotation score:

Sequence cautioni

The sequence AAH35076 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB67828 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71045 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → L in AAH35076 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054064517 – 520GEAP → AQRH in isoform 3. Curated4
Alternative sequenceiVSP_029547518 – 560EAPSE…GKKGS → LNKWQLLHQTVTSPAAPLQC LTDHCGFRLGALKLTVKRAA QRH in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_054065521 – 755Missing in isoform 3. CuratedAdd BLAST235
Alternative sequenceiVSP_029548561 – 755Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067522 mRNA Translation: BAB67828.1 Different initiation.
AK055921 mRNA Translation: BAB71045.1 Different initiation.
AC008706 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61567.1
CH471062 Genomic DNA Translation: EAW61568.1
BC035076 mRNA Translation: AAH35076.2 Different initiation.
BC105110 mRNA Translation: AAI05111.1
CCDSiCCDS47331.1 [Q96N64-2]
CCDS47332.1 [Q96N64-1]
CCDS58990.1 [Q96N64-3]
RefSeqiNP_001124336.1, NM_001130864.1 [Q96N64-1]
NP_001253964.1, NM_001267035.1 [Q96N64-3]
NP_443159.1, NM_052927.2 [Q96N64-2]
UniGeneiHs.744960

Genome annotation databases

EnsembliENST00000307063; ENSP00000305151; ENSG00000170234 [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234 [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234 [Q96N64-3]
GeneIDi114825
KEGGihsa:114825
UCSCiuc003lxv.5 human [Q96N64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067522 mRNA Translation: BAB67828.1 Different initiation.
AK055921 mRNA Translation: BAB71045.1 Different initiation.
AC008706 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61567.1
CH471062 Genomic DNA Translation: EAW61568.1
BC035076 mRNA Translation: AAH35076.2 Different initiation.
BC105110 mRNA Translation: AAI05111.1
CCDSiCCDS47331.1 [Q96N64-2]
CCDS47332.1 [Q96N64-1]
CCDS58990.1 [Q96N64-3]
RefSeqiNP_001124336.1, NM_001130864.1 [Q96N64-1]
NP_001253964.1, NM_001267035.1 [Q96N64-3]
NP_443159.1, NM_052927.2 [Q96N64-2]
UniGeneiHs.744960

3D structure databases

ProteinModelPortaliQ96N64
SMRiQ96N64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125375, 8 interactors
IntActiQ96N64, 8 interactors
STRINGi9606.ENSP00000305151

PTM databases

iPTMnetiQ96N64
PhosphoSitePlusiQ96N64

Polymorphism and mutation databases

BioMutaiPWWP2A
DMDMi160419226

Proteomic databases

EPDiQ96N64
MaxQBiQ96N64
PaxDbiQ96N64
PeptideAtlasiQ96N64
PRIDEiQ96N64
ProteomicsDBi77468
77469 [Q96N64-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307063; ENSP00000305151; ENSG00000170234 [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234 [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234 [Q96N64-3]
GeneIDi114825
KEGGihsa:114825
UCSCiuc003lxv.5 human [Q96N64-1]

Organism-specific databases

CTDi114825
EuPathDBiHostDB:ENSG00000170234.12
GeneCardsiPWWP2A
H-InvDBiHIX0005372
HGNCiHGNC:29406 PWWP2A
HPAiHPA046733
HPA058233
MIMi617823 gene
neXtProtiNX_Q96N64
OpenTargetsiENSG00000170234
PharmGKBiPA162400500
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQI Eukaryota
ENOG4111IWH LUCA
GeneTreeiENSGT00530000063940
HOGENOMiHOG000060329
HOVERGENiHBG108311
InParanoidiQ96N64
OMAiARVSWFG
OrthoDBiEOG091G08LI
PhylomeDBiQ96N64
TreeFamiTF331271

Miscellaneous databases

ChiTaRSiPWWP2A human
GenomeRNAii114825
PROiPR:Q96N64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170234 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_PWWP2A
ExpressionAtlasiQ96N64 baseline and differential
GenevisibleiQ96N64 HS

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPWP2A_HUMAN
AccessioniPrimary (citable) accession number: Q96N64
Secondary accession number(s): G5EA07
, Q2HJJ2, Q8IYR3, Q96PV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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