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Protein

PWWP domain-containing protein 2A

Gene

PWWP2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone binding Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PWWP domain-containing protein 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PWWP2A
Synonyms:KIAA1935, MST101
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000170234.12

Human Gene Nomenclature Database

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HGNCi
HGNC:29406 PWWP2A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617823 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96N64

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000170234

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400500

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PWWP2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160419226

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003113631 – 755PWWP domain-containing protein 2AAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96N64

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96N64

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96N64

PeptideAtlas

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PeptideAtlasi
Q96N64

PRoteomics IDEntifications database

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PRIDEi
Q96N64

ProteomicsDB human proteome resource

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ProteomicsDBi
77468
77469 [Q96N64-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96N64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96N64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000170234 Expressed in 199 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

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CleanExi
HS_PWWP2A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96N64 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96N64 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA046733
HPA058233

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with H2A.Z/H2AFZ.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC1Q135475EBI-6597774,EBI-301834

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125375, 10 interactors

Protein interaction database and analysis system

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IntActi
Q96N64, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305151

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96N64

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96N64

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini655 – 715PWWPPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni423 – 574Interaction with the H2A.Z/H2AFZ1 PublicationAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 146Pro-richAdd BLAST86
Compositional biasi240 – 291Pro-richAdd BLAST52
Compositional biasi575 – 632Ser-richAdd BLAST58

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXQI Eukaryota
ENOG4111IWH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060329

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108311

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96N64

Identification of Orthologs from Complete Genome Data

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OMAi
ARVSWFG

Database of Orthologous Groups

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OrthoDBi
EOG091G08LI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96N64

TreeFam database of animal gene trees

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TreeFami
TF331271

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000313 PWWP_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF00855 PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00293 PWWP, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50812 PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP
60 70 80 90 100
DGETDGQQSA PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA
110 120 130 140 150
ESAAAAPQGG PELPPSPASP PEQPPAPEER EEPPLPQPVA PALVPPAGGD
160 170 180 190 200
STVSQLIPGS EVRVTLDHII EDALVVSFRF GEKLFSGVLM DLSKRFGPHG
210 220 230 240 250
IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP DDPSPVPHPE
260 270 280 290 300
LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK
310 320 330 340 350
MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED
360 370 380 390 400
KKRRNESVTT VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK
410 420 430 440 450
VSAQANTSKA QLSTKKVLQS KNMDHAKARE VLKIAKEKAQ KKQNETSTSK
460 470 480 490 500
NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR YRNEENDSSL KTGLEKMRSG
510 520 530 540 550
KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT NEVHVPGDQD
560 570 580 590 600
EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS
610 620 630 640 650
SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG
660 670 680 690 700
RTICVGDIVW AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT
710 720 730 740 750
TSFLALSQLS PFLENFQSRF NKKRKGLYRK AITEAAKAAK QLTPEVRALL

TQFET
Length:755
Mass (Da):81,960
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BF89E9C8D68EAA0
GO
Isoform 2 (identifier: Q96N64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-560: EAPSENQSPS...EPQTLGKKGS → LNKWQLLHQT...LTVKRAAQRH
     561-755: Missing.

Show »
Length:560
Mass (Da):60,684
Checksum:iAA8EE2743C67AB3A
GO
Isoform 3 (identifier: Q96N64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     517-520: GEAP → AQRH
     521-755: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:520
Mass (Da):56,315
Checksum:i951B12404F03C440
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC06H0YC06_HUMAN
PWWP domain-containing protein 2A
PWWP2A
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB44H0YB44_HUMAN
PWWP domain-containing protein 2A
PWWP2A
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC08H0YC08_HUMAN
PWWP domain-containing protein 2A
PWWP2A
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35076 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB67828 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71045 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154S → L in AAH35076 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054064517 – 520GEAP → AQRH in isoform 3. Curated4
Alternative sequenceiVSP_029547518 – 560EAPSE…GKKGS → LNKWQLLHQTVTSPAAPLQC LTDHCGFRLGALKLTVKRAA QRH in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_054065521 – 755Missing in isoform 3. CuratedAdd BLAST235
Alternative sequenceiVSP_029548561 – 755Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB067522 mRNA Translation: BAB67828.1 Different initiation.
AK055921 mRNA Translation: BAB71045.1 Different initiation.
AC008706 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61567.1
CH471062 Genomic DNA Translation: EAW61568.1
BC035076 mRNA Translation: AAH35076.2 Different initiation.
BC105110 mRNA Translation: AAI05111.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47331.1 [Q96N64-2]
CCDS47332.1 [Q96N64-1]
CCDS58990.1 [Q96N64-3]

NCBI Reference Sequences

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RefSeqi
NP_001124336.1, NM_001130864.1 [Q96N64-1]
NP_001253964.1, NM_001267035.1 [Q96N64-3]
NP_443159.1, NM_052927.2 [Q96N64-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.744960

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307063; ENSP00000305151; ENSG00000170234 [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234 [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234 [Q96N64-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114825

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114825

UCSC genome browser

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UCSCi
uc003lxv.5 human [Q96N64-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067522 mRNA Translation: BAB67828.1 Different initiation.
AK055921 mRNA Translation: BAB71045.1 Different initiation.
AC008706 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61567.1
CH471062 Genomic DNA Translation: EAW61568.1
BC035076 mRNA Translation: AAH35076.2 Different initiation.
BC105110 mRNA Translation: AAI05111.1
CCDSiCCDS47331.1 [Q96N64-2]
CCDS47332.1 [Q96N64-1]
CCDS58990.1 [Q96N64-3]
RefSeqiNP_001124336.1, NM_001130864.1 [Q96N64-1]
NP_001253964.1, NM_001267035.1 [Q96N64-3]
NP_443159.1, NM_052927.2 [Q96N64-2]
UniGeneiHs.744960

3D structure databases

ProteinModelPortaliQ96N64
SMRiQ96N64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125375, 10 interactors
IntActiQ96N64, 8 interactors
STRINGi9606.ENSP00000305151

PTM databases

iPTMnetiQ96N64
PhosphoSitePlusiQ96N64

Polymorphism and mutation databases

BioMutaiPWWP2A
DMDMi160419226

Proteomic databases

EPDiQ96N64
MaxQBiQ96N64
PaxDbiQ96N64
PeptideAtlasiQ96N64
PRIDEiQ96N64
ProteomicsDBi77468
77469 [Q96N64-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307063; ENSP00000305151; ENSG00000170234 [Q96N64-1]
ENST00000456329; ENSP00000390462; ENSG00000170234 [Q96N64-2]
ENST00000523662; ENSP00000428143; ENSG00000170234 [Q96N64-3]
GeneIDi114825
KEGGihsa:114825
UCSCiuc003lxv.5 human [Q96N64-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114825
EuPathDBiHostDB:ENSG00000170234.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PWWP2A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0005372
HGNCiHGNC:29406 PWWP2A
HPAiHPA046733
HPA058233
MIMi617823 gene
neXtProtiNX_Q96N64
OpenTargetsiENSG00000170234
PharmGKBiPA162400500

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IXQI Eukaryota
ENOG4111IWH LUCA
GeneTreeiENSGT00940000157692
HOGENOMiHOG000060329
HOVERGENiHBG108311
InParanoidiQ96N64
OMAiARVSWFG
OrthoDBiEOG091G08LI
PhylomeDBiQ96N64
TreeFamiTF331271

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PWWP2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114825

Protein Ontology

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PROi
PR:Q96N64

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170234 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_PWWP2A
ExpressionAtlasiQ96N64 baseline and differential
GenevisibleiQ96N64 HS

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPWP2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N64
Secondary accession number(s): G5EA07
, Q2HJJ2, Q8IYR3, Q96PV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 5, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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