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Entry version 153 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Tetratricopeptide repeat protein 14

Gene

TTC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 14
Short name:
TPR repeat protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC14
Synonyms:KIAA1980
ORF Names:UNQ5813/PRO19630
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163728.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24697 TTC14

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96N46

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151613

Open Targets

More...
OpenTargetsi
ENSG00000163728

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937037

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96N46 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
42559864

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063991 – 770Tetratricopeptide repeat protein 14Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei671PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96N46

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96N46

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96N46

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96N46

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96N46

PeptideAtlas

More...
PeptideAtlasi
Q96N46

PRoteomics IDEntifications database

More...
PRIDEi
Q96N46

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34069
77464 [Q96N46-1]
77465 [Q96N46-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96N46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96N46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163728 Expressed in 197 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96N46 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96N46 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009295

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127391, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q96N46, 13 interactors

Molecular INTeraction database

More...
MINTi
Q96N46

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296015

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96N46 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96N46

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 208S1 motifPROSITE-ProRule annotationAdd BLAST83
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati210 – 243TPR 1Add BLAST34
Repeati307 – 340TPR 2Add BLAST34
Repeati342 – 374TPR 3Add BLAST33
Repeati382 – 415TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi393 – 396Poly-Glu4
Compositional biasi475 – 525Ser-richAdd BLAST51
Compositional biasi475 – 483Poly-Ser9
Compositional biasi487 – 497Poly-SerAdd BLAST11
Compositional biasi580 – 583Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC14 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGWP Eukaryota
ENOG410XQJ7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154702

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96N46

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQKTQVK

Database of Orthologous Groups

More...
OrthoDBi
335343at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96N46

TreeFam database of animal gene trees

More...
TreeFami
TF325777

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR003029 S1_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039190 TTC14

The PANTHER Classification System

More...
PANTHERi
PTHR23184 PTHR23184, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF50249 SSF50249, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50126 S1, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRDLLRQSL NCHGSSLLSL LRSEQQDNPH FRSLLGSAAE PARGPPPQHP
60 70 80 90 100
LQGRKEKRVD NIEIQKFISK KADLLFALSW KSDAPATSEI NEDSEDHYAI
110 120 130 140 150
MPPLEQFMEI PSMDRRELFF RDIERGDIVI GRISSIREFG FFMVLICLGS
160 170 180 190 200
GIMRDIAHLE ITALCPLRDV PSHSNHGDPL SYYQTGDIIR AGIKDIDRYH
210 220 230 240 250
EKLAVSLYSS SLPPHLSGIK LGVISSEELP LYYRRSVELN SNSLESYENV
260 270 280 290 300
MQSSLGFVNP GVVEFLLEKL GIDESNPPSL MRGLQSKNFS EDDFASALRK
310 320 330 340 350
KQSASWALKC VKIGVDYFKV GRHVDAMNEY NKALEIDKQN VEALVARGAL
360 370 380 390 400
YATKGSLNKA IEDFELALEN CPTHRNARKY LCQTLVERGG QLEEEEKFLN
410 420 430 440 450
AESYYKKALA LDETFKDAED ALQKLHKYMQ KSLELREKQA EKEEKQKTKK
460 470 480 490 500
IETSAEKLRK LLKEEKRLKK KRRKSTSSSS VSSADESVSS SSSSSSSGHK
510 520 530 540 550
RHKKHKRNRS ESSRSSRRHS SRASSNQIDQ NRKDECYPVP ANTSASFLNH
560 570 580 590 600
KQEVEKLLGK QDRLQYEKTQ IKEKDRCPLS SSSLEIPDDF GGRSEDPRDF
610 620 630 640 650
YNSYKTQAGS SKTEKPYKSE RHFSSRRNSS DSFCRNSEDK IYGYRRFEKD
660 670 680 690 700
IEGRKEHYRR WEPGSVRHST SPASSEYSWK SVEKYKKYAH SGSRDFSRHE
710 720 730 740 750
QRYRLNTNQG EYEREDNYGE DIKTEVPEED ALSSKEHSES SVKKNLPQNL
760 770
LNIFNQIAEF EKEKGNKSKN
Length:770
Mass (Da):88,319
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7ACF31418242A6B7
GO
Isoform 2 (identifier: Q96N46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-653: GRSEDPRDFY...YRRFEKDIEG → VYSYLFKKLT...DSGIDDPDHG
     654-770: Missing.

Note: May be due to a competing donor splice site.Curated
Show »
Length:653
Mass (Da):73,826
Checksum:i430508F4CB64C1CD
GO
Isoform 3 (identifier: Q96N46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-770: KSLELREKQA...EKEKGNKSKN → VIPYFLLEI

Show »
Length:439
Mass (Da):49,735
Checksum:i658C57EFC5BD7995
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J974C9J974_HUMAN
Tetratricopeptide repeat protein 14
TTC14
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBA2C9JBA2_HUMAN
Tetratricopeptide repeat protein 14
TTC14
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDH5F8WDH5_HUMAN
Tetratricopeptide repeat protein 14
TTC14
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCY7C9JCY7_HUMAN
Tetratricopeptide repeat protein 14
TTC14
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDA3F8WDA3_HUMAN
Tetratricopeptide repeat protein 14
TTC14
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047107431 – 770KSLEL…NKSKN → VIPYFLLEI in isoform 3. CuratedAdd BLAST340
Alternative sequenceiVSP_013480592 – 653GRSED…KDIEG → VYSYLFKKLTIKQPQAGPSG DIPEEGIVIIDDSSIHVTDP EDLQVGQDMEVEDSGIDDPD HG in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_013481654 – 770Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055984 mRNA Translation: BAB71064.1
AY358762 mRNA Translation: AAQ89122.1
AC068298 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78377.1
BC027990 mRNA Translation: AAH27990.1
AB075860 mRNA Translation: BAB85566.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3237.1 [Q96N46-1]
CCDS46963.1 [Q96N46-3]
CCDS75055.1 [Q96N46-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001036066.1, NM_001042601.2 [Q96N46-3]
NP_001275511.1, NM_001288582.1 [Q96N46-2]
NP_597719.1, NM_133462.3 [Q96N46-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296015; ENSP00000296015; ENSG00000163728 [Q96N46-1]
ENST00000382584; ENSP00000372027; ENSG00000163728 [Q96N46-2]
ENST00000412756; ENSP00000413743; ENSG00000163728 [Q96N46-3]
ENST00000470669; ENSP00000419562; ENSG00000163728 [Q96N46-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
151613

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151613

UCSC genome browser

More...
UCSCi
uc003fkk.4 human [Q96N46-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055984 mRNA Translation: BAB71064.1
AY358762 mRNA Translation: AAQ89122.1
AC068298 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78377.1
BC027990 mRNA Translation: AAH27990.1
AB075860 mRNA Translation: BAB85566.2
CCDSiCCDS3237.1 [Q96N46-1]
CCDS46963.1 [Q96N46-3]
CCDS75055.1 [Q96N46-2]
RefSeqiNP_001036066.1, NM_001042601.2 [Q96N46-3]
NP_001275511.1, NM_001288582.1 [Q96N46-2]
NP_597719.1, NM_133462.3 [Q96N46-1]

3D structure databases

SMRiQ96N46
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127391, 16 interactors
IntActiQ96N46, 13 interactors
MINTiQ96N46
STRINGi9606.ENSP00000296015

PTM databases

iPTMnetiQ96N46
PhosphoSitePlusiQ96N46

Polymorphism and mutation databases

BioMutaiTTC14
DMDMi42559864

Proteomic databases

EPDiQ96N46
jPOSTiQ96N46
MassIVEiQ96N46
MaxQBiQ96N46
PaxDbiQ96N46
PeptideAtlasiQ96N46
PRIDEiQ96N46
ProteomicsDBi34069
77464 [Q96N46-1]
77465 [Q96N46-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
151613

Genome annotation databases

EnsembliENST00000296015; ENSP00000296015; ENSG00000163728 [Q96N46-1]
ENST00000382584; ENSP00000372027; ENSG00000163728 [Q96N46-2]
ENST00000412756; ENSP00000413743; ENSG00000163728 [Q96N46-3]
ENST00000470669; ENSP00000419562; ENSG00000163728 [Q96N46-3]
GeneIDi151613
KEGGihsa:151613
UCSCiuc003fkk.4 human [Q96N46-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
151613
DisGeNETi151613
EuPathDBiHostDB:ENSG00000163728.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TTC14
HGNCiHGNC:24697 TTC14
HPAiHPA009295
neXtProtiNX_Q96N46
OpenTargetsiENSG00000163728
PharmGKBiPA134937037

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGWP Eukaryota
ENOG410XQJ7 LUCA
GeneTreeiENSGT00390000013701
HOGENOMiHOG000154702
InParanoidiQ96N46
OMAiYQKTQVK
OrthoDBi335343at2759
PhylomeDBiQ96N46
TreeFamiTF325777

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTC14 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
151613
PharosiQ96N46 Tdark

Protein Ontology

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PROi
PR:Q96N46
RNActiQ96N46 protein

Gene expression databases

BgeeiENSG00000163728 Expressed in 197 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ96N46 baseline and differential
GenevisibleiQ96N46 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR003029 S1_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039190 TTC14
PANTHERiPTHR23184 PTHR23184, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N46
Secondary accession number(s): G5E9X0, Q6UWJ7, Q8TF22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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