Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 131 (22 Apr 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

AP-4 complex accessory subunit Tepsin

Gene

TEPSIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.2 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-4 complex accessory subunit TepsinCurated
Alternative name(s):
ENTH domain-containing protein 2Imported
Epsin for AP-4
Tetra-epsin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEPSIN1 PublicationImported
Synonyms:C17orf56Imported, ENTHD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26458 TEPSIN

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96N21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi467R → A: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi468D → A: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi469S → A or P: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi470L → A: Loss of interaction with AP4B1 n vitro. 1 Publication1
Mutagenesisi470L → S: Loss of interaction with AP4B1 in vitro; when associated with S-471. 1 Publication1
Mutagenesisi471F → A: Loss of interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi471F → S: Loss of interaction with AP4B1 in vitro; when associated with S-470. 1 Publication1
Mutagenesisi472A → D or P: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi473G → A: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi473G → I: Loss of interaction with AP4B1 in vitro; when associated with Q-474. 1 Publication1
Mutagenesisi474M → A: Decreased interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi474M → D: Decreased interaction with AP4B1 in vitro; when associated with A-476. 1 Publication1
Mutagenesisi474M → Q: Loss of interaction with AP4B1 in vitro; when associated with I-473. 1 Publication1
Mutagenesisi475E → A: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi476L → A: No effect on interaction with AP4B1 in vitro. Decreased interaction with AP4B1; when associated with D-474. 2 Publications1
Mutagenesisi476L → S: Decreased interaction with AP4B1 in vitro; when associated with S-477. 1 Publication1
Mutagenesisi477V → A: No effect on interaction with AP4B1 in vitro. 1 Publication1
Mutagenesisi477V → S: Decreased interaction with AP4B1 in vitro; when associated with S-476. 1 Publication1
Mutagenesisi516E → A: No effect on interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi517P → A: No effect on interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi518S → A: Loss of interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi519A → D: Loss of interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi520F → A: Loss of interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi521A → D: No effect on interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi522F → A: Loss of interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi523L → A: Loss of interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi524N → A: Decreased interaction with AP4E1 in vitro. 1 Publication1
Mutagenesisi525A → D: No effect on interaction with AP4E1 in vitro. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
146705

Open Targets

More...
OpenTargetsi
ENSG00000167302

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672239

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96N21 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEPSIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002866781 – 525AP-4 complex accessory subunit TepsinAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96N21

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96N21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96N21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96N21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96N21

PeptideAtlas

More...
PeptideAtlasi
Q96N21

PRoteomics IDEntifications database

More...
PRIDEi
Q96N21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77454 [Q96N21-1]
77455 [Q96N21-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96N21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96N21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167302 Expressed in left lobe of thyroid gland and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96N21 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96N21 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167302 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP4B1 and AP4E1; the interaction is direct and mediates the association of TEPSIN with the adapter-like complex 4 (AP-4), a heterotetramer composed of AP4B1, AP4E1, AP4M1 and AP4S1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96N21
With#Exp.IntAct
A0A384ME253EBI-11139477,EBI-10211777
AATK [Q6ZMQ8]3EBI-11139477,EBI-2008380
ACBD7 [Q8N6N7]3EBI-11139477,EBI-18657673
AGRN - isoform 6 [O00468-6]3EBI-11139477,EBI-17740588
AP1M1 [Q9BXS5]3EBI-11139477,EBI-541426
AP4B1 [Q9Y6B7]3EBI-11139477,EBI-1047606
APOL6 [Q9BWW8]3EBI-11139477,EBI-11574440
ASAP3 [Q8TDY4]3EBI-11139477,EBI-2609717
ASB3 - isoform 3 [Q9Y575-3]3EBI-11139477,EBI-14199987
BCL2L14 [Q9BZR8]3EBI-11139477,EBI-1385773
BCL2L15 [Q5TBC7]3EBI-11139477,EBI-10247136
BHLHB9 [Q6PI77]3EBI-11139477,EBI-11519926
BIRC7 [Q96CA5]3EBI-11139477,EBI-517623
BPIFA1 [Q9NP55]3EBI-11139477,EBI-953896
BTBD3 [Q9Y2F9]3EBI-11139477,EBI-311155
C1orf109 [Q9NX04]3EBI-11139477,EBI-8643161
C1QTNF4 [Q9BXJ3]3EBI-11139477,EBI-11955105
CBX8 [Q9HC52]3EBI-11139477,EBI-712912
CCDC146 [Q8IYE0]3EBI-11139477,EBI-10749669
CCNC [P24863]3EBI-11139477,EBI-395261
CDC23 [Q9UJX2]3EBI-11139477,EBI-396137
CINP [Q9BW66]3EBI-11139477,EBI-739784
CLCNKA - isoform 3 [P51800-3]3EBI-11139477,EBI-11980535
CLIC3 [O95833]3EBI-11139477,EBI-10192241
CNTF [P26441]3EBI-11139477,EBI-1050897
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-11139477,EBI-12012272
CSNK2A1 [P68400]3EBI-11139477,EBI-347804
CTAG1B [P78358]3EBI-11139477,EBI-1188472
CYSRT1 [A8MQ03]3EBI-11139477,EBI-3867333
DEF6 [Q9H4E7]3EBI-11139477,EBI-745369
DUPD1 [Q68J44]3EBI-11139477,EBI-1054321
DUSP4 [Q13115]3EBI-11139477,EBI-6591081
DZIP1L [Q8IYY4]3EBI-11139477,EBI-10264440
EIF1AD [Q8N9N8]3EBI-11139477,EBI-750700
FAM214B [Q7L5A3]3EBI-11139477,EBI-745689
FAM90A1 [Q86YD7]3EBI-11139477,EBI-6658203
FARS2 [O95363]3EBI-11139477,EBI-2513774
FKBP6 [O75344]3EBI-11139477,EBI-744771
FLACC1 - isoform 2 [Q96Q35-2]3EBI-11139477,EBI-11533409
FNDC3B - isoform 3 [Q53EP0-3]3EBI-11139477,EBI-10242151
GNG13 [Q9P2W3]3EBI-11139477,EBI-11427343
GOLGA2 [Q08379]3EBI-11139477,EBI-618309
GPANK1 [O95872]3EBI-11139477,EBI-751540
GRB10 - isoform 4 [Q13322-4]3EBI-11139477,EBI-12353035
GRIPAP1 [Q4V328]3EBI-11139477,EBI-717919
GUCD1 - isoform 2 [Q96NT3-2]3EBI-11139477,EBI-11978177
HAT1 [O14929]3EBI-11139477,EBI-2339359
HCK - isoform 2 [P08631-2]3EBI-11139477,EBI-9834454
HPCA [P84074]3EBI-11139477,EBI-12197079
HSF2BP [O75031]3EBI-11139477,EBI-7116203
HSPB7 [Q9UBY9]3EBI-11139477,EBI-739361
IL16 - isoform 2 [Q14005-2]3EBI-11139477,EBI-17178971
IQGAP1 [P46940]3EBI-11139477,EBI-297509
KCTD6 [Q8NC69]3EBI-11139477,EBI-2511344
KCTD9 [Q7L273]3EBI-11139477,EBI-4397613
KHNYN [O15037]3EBI-11139477,EBI-6148525
KLHL38 [Q2WGJ6]3EBI-11139477,EBI-6426443
KRT31 [Q15323]3EBI-11139477,EBI-948001
KRT34 [O76011]3EBI-11139477,EBI-1047093
KRT35 [Q92764]3EBI-11139477,EBI-1058674
KRTAP6-2 [Q3LI66]3EBI-11139477,EBI-11962084
LENG1 [Q96BZ8]3EBI-11139477,EBI-726510
LGALS14 [Q8TCE9]3EBI-11139477,EBI-10274069
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11139477,EBI-11742507
LSM3 [P62310]3EBI-11139477,EBI-348239
LYG2 [Q86SG7]3EBI-11139477,EBI-18312334
MAT2B [Q9NZL9]3EBI-11139477,EBI-10317491
MED18 [Q9BUE0]3EBI-11139477,EBI-394640
MFAP1 [P55081]3EBI-11139477,EBI-1048159
MLX - isoform Beta [Q9UH92-3]3EBI-11139477,EBI-8852072
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-11139477,EBI-10288852
MSGN1 [A6NI15]3EBI-11139477,EBI-11991020
MTUS2 - isoform 2 [Q5JR59-3]3EBI-11139477,EBI-11522433
NDOR1 [Q9UHB4]3EBI-11139477,EBI-10249760
NEK6 - isoform 4 [Q9HC98-4]3EBI-11139477,EBI-11750983
NGB [Q9NPG2]3EBI-11139477,EBI-10311409
NME7 [Q9Y5B8]3EBI-11139477,EBI-744782
NR2C2AP [Q86WQ0]3EBI-11139477,EBI-10260040
NUDT14 [O95848]3EBI-11139477,EBI-536866
NUDT21 [O43809]3EBI-11139477,EBI-355720
OAZ3 - isoform 2 [Q9UMX2-2]3EBI-11139477,EBI-12049527
OR6B1 [O95007]3EBI-11139477,EBI-12176191
PAX9 [P55771]3EBI-11139477,EBI-12111000
PCDHB3 [Q9Y5E6]3EBI-11139477,EBI-24224850
PLEKHA2 [Q9HB19]3EBI-11139477,EBI-4401947
PSMA6 [P60900]3EBI-11139477,EBI-357793
RAB3IP - isoform 7 [Q96QF0-7]3EBI-11139477,EBI-11984839
RAD51D [O75771]3EBI-11139477,EBI-1055693
RNF135 [Q8IUD6]3EBI-11139477,EBI-9916363
SEC14L4 [Q9UDX3]3EBI-11139477,EBI-10320311
SLU7 [O95391]3EBI-11139477,EBI-750559
SNRNP25 [Q9BV90]3EBI-11139477,EBI-9675976
SORBS2 - isoform 10 [O94875-10]3EBI-11139477,EBI-12037893
SORBS3 [O60504]3EBI-11139477,EBI-741237
SZT2 - isoform 3 [Q5T011-5]3EBI-11139477,EBI-10245139
TAPBPL [Q9BX59]3EBI-11139477,EBI-12017416
TBC1D13 [Q9NVG8]3EBI-11139477,EBI-12264956
TBC1D22B [Q9NU19]3EBI-11139477,EBI-8787464
TCEA2 [Q15560]3EBI-11139477,EBI-710310
TCL1A [P56279]3EBI-11139477,EBI-749995
TFAP2D [Q7Z6R9]3EBI-11139477,EBI-11952651
THRSP [Q92748]3EBI-11139477,EBI-1749955
TRAPPC2 - isoform 3 [P0DI81-3]3EBI-11139477,EBI-11961968
TRAPPC6A - isoform 2 [O75865-2]3EBI-11139477,EBI-8451480
TRIM23 [P36406]3EBI-11139477,EBI-740098
TRIM45 - isoform 2 [Q9H8W5-2]3EBI-11139477,EBI-11993364
TRIM50 [Q86XT4]3EBI-11139477,EBI-9867283
TRIM54 [Q9BYV2]3EBI-11139477,EBI-2130429
TRIM68 [Q6AZZ1]3EBI-11139477,EBI-2130449
TSEN15 [Q8WW01]3EBI-11139477,EBI-372432
TSEN2 [Q8NCE0]3EBI-11139477,EBI-2559818
TSHZ3 [Q63HK5]3EBI-11139477,EBI-9053916
TSSK3 [Q96PN8]3EBI-11139477,EBI-3918381
UBASH3B [Q8TF42]3EBI-11139477,EBI-1380492
UTP23 [Q9BRU9]3EBI-11139477,EBI-5457544
VPS26C [O14972]3EBI-11139477,EBI-7207091
WDR25 - isoform 2 [Q64LD2-2]3EBI-11139477,EBI-12032042
WDYHV1 [Q96HA8]3EBI-11139477,EBI-741158
ZIC1 [Q15915]3EBI-11139477,EBI-11963196
ZMYND12 [Q9H0C1]3EBI-11139477,EBI-12030590
ZNF343 [Q6P1L6]3EBI-11139477,EBI-10252492
ZNF629 [Q9UEG4]3EBI-11139477,EBI-9977294
ZRSR2 [Q15696]3EBI-11139477,EBI-6657923

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127002, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q96N21, 152 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300714

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96N21 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1525
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96N21

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 141ENTHAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni467 – 477Interaction with AP4B12 PublicationsAdd BLAST11
Regioni515 – 525Interaction with AP4E11 PublicationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 225Ser-richAdd BLAST33
Compositional biasi365 – 431Pro-richAdd BLAST67

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEKN Eukaryota
ENOG410ZYSQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030958_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96N21

Database of Orthologous Groups

More...
OrthoDBi
693000at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96N21

TreeFam database of animal gene trees

More...
TreeFami
TF331354

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR039273 TEPSIN

The PANTHER Classification System

More...
PANTHERi
PTHR21514 PTHR21514, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01417 ENTH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPPLRDR LSFLHRLPIL LKGTSDDDVP CPGYLFEEIA KISHESPGSS
60 70 80 90 100
QCLLEYLLSR LHSSSGHGKL KVLKILLYLC SHGSSFFLLI LKRNSAFIQE
110 120 130 140 150
AAAFAGPPDP LHGNSLYQKV RAAAQDLGST LFSDTVLPLA PSQPLGTPPA
160 170 180 190 200
TGMGSQARPH STLQGFGYSK EHGRTAVRHQ PGQAGGGWDE LDSGPSSQNS
210 220 230 240 250
SQNSDLSRVS DSGSHSGSDS HSGASREPGD LAERVEVVAL SDCQQELSLV
260 270 280 290 300
RTVTRGPRAF LSREEAQHFI KACGLLNCEA VLQLLTCHLR GTSECTQLRA
310 320 330 340 350
LCAIASLGSS DLLPQEHILL RTRPWLQELS MGSPGPVTNK ATKILRHFEA
360 370 380 390 400
SCGQLSPARG TSAEPGPTAA LPGPSDLLTD AVPLPGSQVF LQPLSSTPVS
410 420 430 440 450
SRSPAPSSGM PSSPVPTPPP DASPIPAPGD PSEAEARLAE SRRWRPERIP
460 470 480 490 500
GGTDSPKRGP SSCAWSRDSL FAGMELVACP RLVGAGAAAG ESCPDAPRAP
510 520
QTSSQRTAAK EPPGSEPSAF AFLNA
Length:525
Mass (Da):55,137
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB79970A37B801549
GO
Isoform 2 (identifier: Q96N21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-175: FFLLILKRNS...FGYSKEHGRT → MGSQARPHST...LLPGAIPGPR

Show »
Length:441
Mass (Da):45,755
Checksum:i29679B1DBB77B6E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV70A0A1B0GV70_HUMAN
AP-4 complex accessory subunit Teps...
TEPSIN
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4S7I3L4S7_HUMAN
AP-4 complex accessory subunit Teps...
TEPSIN
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3R3I3L3R3_HUMAN
AP-4 complex accessory subunit Teps...
TEPSIN
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4J0I3L4J0_HUMAN
AP-4 complex accessory subunit Teps...
TEPSIN
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3N1I3L3N1_HUMAN
AP-4 complex accessory subunit Teps...
TEPSIN
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q96N21-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22R → H in BAC87593 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0251411 – 85Missing in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_02514286 – 175FFLLI…EHGRT → MGSQARPHSTLQGFGYSKEH GRTGSAGEAFLSTIQKAAEV VASAMRPGPESPSTRRLLPR GDTYQPAMMPSASHGPPTLG NLLPGAIPGPR in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056090 mRNA Translation: BAB71091.1
AK127221 mRNA Translation: BAC86888.1
AK128728 mRNA Translation: BAC87593.1
BC064483 mRNA Translation: AAH64483.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11779.1 [Q96N21-1]

NCBI Reference Sequences

More...
RefSeqi
NP_653280.1, NM_144679.2 [Q96N21-1]
XP_006721775.1, XM_006721712.2 [Q96N21-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300714; ENSP00000300714; ENSG00000167302 [Q96N21-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
146705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146705

UCSC genome browser

More...
UCSCi
uc002jzu.2 human [Q96N21-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056090 mRNA Translation: BAB71091.1
AK127221 mRNA Translation: BAC86888.1
AK128728 mRNA Translation: BAC87593.1
BC064483 mRNA Translation: AAH64483.1
CCDSiCCDS11779.1 [Q96N21-1]
RefSeqiNP_653280.1, NM_144679.2 [Q96N21-1]
XP_006721775.1, XM_006721712.2 [Q96N21-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WF9X-ray1.80A1-153[»]
5WFBX-ray1.38A/B1-140[»]
SMRiQ96N21
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127002, 37 interactors
IntActiQ96N21, 152 interactors
STRINGi9606.ENSP00000300714

PTM databases

iPTMnetiQ96N21
PhosphoSitePlusiQ96N21

Polymorphism and mutation databases

BioMutaiTEPSIN
DMDMi74732479

Proteomic databases

EPDiQ96N21
jPOSTiQ96N21
MassIVEiQ96N21
MaxQBiQ96N21
PaxDbiQ96N21
PeptideAtlasiQ96N21
PRIDEiQ96N21
ProteomicsDBi77454 [Q96N21-1]
77455 [Q96N21-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53274 12 antibodies

Genome annotation databases

EnsembliENST00000300714; ENSP00000300714; ENSG00000167302 [Q96N21-1]
GeneIDi146705
KEGGihsa:146705
UCSCiuc002jzu.2 human [Q96N21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146705
DisGeNETi146705

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TEPSIN
HGNCiHGNC:26458 TEPSIN
HPAiENSG00000167302 Low tissue specificity
neXtProtiNX_Q96N21
OpenTargetsiENSG00000167302
PharmGKBiPA142672239

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEKN Eukaryota
ENOG410ZYSQ LUCA
GeneTreeiENSGT00390000015076
HOGENOMiCLU_030958_0_0_1
InParanoidiQ96N21
OrthoDBi693000at2759
PhylomeDBiQ96N21
TreeFamiTF331354

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TEPSIN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
146705
PharosiQ96N21 Tdark

Protein Ontology

More...
PROi
PR:Q96N21
RNActiQ96N21 protein

Gene expression databases

BgeeiENSG00000167302 Expressed in left lobe of thyroid gland and 158 other tissues
ExpressionAtlasiQ96N21 baseline and differential
GenevisibleiQ96N21 HS

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR013809 ENTH
IPR008942 ENTH_VHS
IPR039273 TEPSIN
PANTHERiPTHR21514 PTHR21514, 2 hits
PfamiView protein in Pfam
PF01417 ENTH, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP4AT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N21
Secondary accession number(s): Q6ZQU0, Q6ZSQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: April 22, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again