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Protein

Janus kinase and microtubule-interacting protein 1

Gene

JAKMIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.3 Publications

Caution

Was originally thought to bind single-stranded RNA molecules and regulate GABA-B receptor expression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 1
Alternative name(s):
GABA-B receptor-binding protein
Multiple alpha-helices and RNA-linker protein 1
Short name:
Marlin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAKMIP1
Synonyms:GABABRBP, JAMIP1, MARLIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152969.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26460 JAKMIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611195 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96N16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152789

Open Targets

More...
OpenTargetsi
ENSG00000152969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485508

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
JAKMIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003230081 – 626Janus kinase and microtubule-interacting protein 1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei382PhosphoserineCombined sources1
Modified residuei470PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96N16

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96N16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96N16

PeptideAtlas

More...
PeptideAtlasi
Q96N16

PRoteomics IDEntifications database

More...
PRIDEi
Q96N16

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77442
77443 [Q96N16-2]
77444 [Q96N16-3]
77445 [Q96N16-4]
77446 [Q96N16-5]
77447 [Q96N16-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96N16

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96N16

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q96N16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152969 Expressed in 113 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_JAKMIP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96N16 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96N16 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044570

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428584EBI-2680803,EBI-466029

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127465, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96N16, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386711

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96N16

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96N16

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 365Mediates association with microtubulesAdd BLAST365
Regioni365 – 626Mediates interaction with TYK2 and GABBR12 PublicationsAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili19 – 255Sequence analysisAdd BLAST237
Coiled coili284 – 413Sequence analysisAdd BLAST130
Coiled coili490 – 604Sequence analysisAdd BLAST115

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II6X Eukaryota
ENOG4110F4A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060161

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054249

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96N16

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYQSHQD

Database of Orthologous Groups

More...
OrthoDBi
727914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96N16

TreeFam database of animal gene trees

More...
TreeFami
TF331900

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C

The PANTHER Classification System

More...
PANTHERi
PTHR18935 PTHR18935, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N16-1) [UniParc]FASTAAdd to basket
Also known as: Jakmip1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER
60 70 80 90 100
LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA
110 120 130 140 150
RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLTEAREEA RRAFDGERLR
160 170 180 190 200
LQQEILELKA ARKQAEEALS NCMQADKTKA ADLRAAYQAH QDEVHRIKRE
210 220 230 240 250
CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK EALDEQLVQV
260 270 280 290 300
KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
310 320 330 340 350
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI
360 370 380 390 400
QRMEEKIKNL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL
410 420 430 440 450
QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD
460 470 480 490 500
SETLSETSYN TDRTDRTPAT PEEDLDDATA REEADLRFCQ LTREYQALQR
510 520 530 540 550
AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDS
560 570 580 590 600
KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
610 620
LEVRDSICCK LSNGADILFE PKLKFM
Length:626
Mass (Da):73,209
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A8E164E8A2A7EFB
GO
Isoform 2 (identifier: Q96N16-2) [UniParc]FASTAAdd to basket
Also known as: Jakmip1B

The sequence of this isoform differs from the canonical sequence as follows:
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Show »
Length:831
Mass (Da):97,436
Checksum:i331CB5500A662634
GO
Isoform 3 (identifier: Q96N16-3) [UniParc]FASTAAdd to basket
Also known as: Jakmip1C

The sequence of this isoform differs from the canonical sequence as follows:
     374-431: QASLKRHTSL...SKRHRGKSLK → HGAAAAGPAE...MTSVSQELGL
     432-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:431
Mass (Da):49,323
Checksum:i13C02CC36809B13C
GO
Isoform 4 (identifier: Q96N16-4) [UniParc]FASTAAdd to basket
Also known as: Jakmip1D

The sequence of this isoform differs from the canonical sequence as follows:
     495-569: YQALQRAYAL...IRTNQDLLEK → DLQAAVEKVR...FFSLAFILWP
     570-626: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:569
Mass (Da):67,000
Checksum:i3592DB24973B29D2
GO
Isoform 5 (identifier: Q96N16-5) [UniParc]FASTAAdd to basket
Also known as: Jakmip1E

The sequence of this isoform differs from the canonical sequence as follows:
     44-208: Missing.
     415-434: Missing.
     603-626: VRDSICCKLSNGADILFEPKLKFM → ERERRSPAFN...FFSLAFILWP

Show »
Length:646
Mass (Da):75,746
Checksum:iE0F39B9913C749C8
GO
Isoform 6 (identifier: Q96N16-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
     494-520: Missing.

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):45,989
Checksum:i799EBF218498F2B0
GO
Isoform 7 (identifier: Q96N16-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-208: Missing.

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):53,973
Checksum:i6E1F8C344865C8B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2K5F2Z2K5_HUMAN
Janus kinase and microtubule-intera...
JAKMIP1
569Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUE0A0A1B0GUE0_HUMAN
Janus kinase and microtubule-intera...
JAKMIP1
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05325 differs from that shown. Reason: Erroneous termination at position 285. Translated as Arg.Curated
The sequence BAC05325 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti163K → N in AAH47075 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039471251K → R1 PublicationCorresponds to variant dbSNP:rs772311401Ensembl.1
Natural variantiVAR_039472375A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs199693515Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0319891 – 208Missing in isoform 6. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_03199044 – 208Missing in isoform 5 and isoform 7. 2 PublicationsAdd BLAST165
Alternative sequenceiVSP_031991374 – 431QASLK…GKSLK → HGAAAAGPAENPRTGGQTGV SEAAPERTGGKVFVPFFVFL TSIHSVALMTSVSQELGL in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_031992415 – 434Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_031993432 – 626Missing in isoform 3. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_031994494 – 520Missing in isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_031995495 – 569YQALQ…DLLEK → DLQAAVEKVRRQILRQSREF DSQILRERMELLQQAQQRIR ELEDKLEFQKRHLKELEEKF LFLFLFFSLAFILWP in isoform 4. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_031996570 – 626Missing in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_031997603 – 626VRDSI…KLKFM → ERERRSPAFNLQITTFPENH SSALQLFCHQEGVKDVNVSE LMKKLDILGDNGNLRNEEQV AIIQAGTVLALCEKWLKQIE GTEAALTQKMLDLEKEKDLF SRQKGYLEEELDYRKQALDQ AYLKIQDLEATLYTALQQEP GRRAGEALSEGQREDLQAAV EKVRRQILRQSREFDSQILR ERMELLQQAQQRIRELEDKL EFQKRHLKELEEKFLFLFLF FSLAFILWP in isoform 2 and isoform 5. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY382340 mRNA Translation: AAR26235.1
AM412307 mRNA Translation: CAL80778.1
AM412308 mRNA Translation: CAL80779.1
AM412309 mRNA Translation: CAL80780.1
AM412310 mRNA Translation: CAL80781.1
AK056126 mRNA Translation: BAB71098.1
AK098536 mRNA Translation: BAC05325.1 Sequence problems.
AK295339 mRNA Translation: BAG58310.1
AC092442 Genomic DNA No translation available.
AC113615 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82401.1
CH471131 Genomic DNA Translation: EAW82402.1
BC047075 mRNA Translation: AAH47075.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3385.1 [Q96N16-1]
CCDS47005.1 [Q96N16-2]
CCDS77897.1 [Q96N16-7]

NCBI Reference Sequences

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RefSeqi
NP_001092903.1, NM_001099433.1 [Q96N16-2]
NP_001293062.1, NM_001306133.1 [Q96N16-1]
NP_001293063.1, NM_001306134.1 [Q96N16-7]
NP_653321.1, NM_144720.3 [Q96N16-1]
XP_011511702.1, XM_011513400.2 [Q96N16-7]
XP_016863282.1, XM_017007793.1 [Q96N16-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.479066

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000282924; ENSP00000282924; ENSG00000152969 [Q96N16-1]
ENST00000409021; ENSP00000386711; ENSG00000152969 [Q96N16-2]
ENST00000409371; ENSP00000387042; ENSG00000152969 [Q96N16-5]
ENST00000409831; ENSP00000386925; ENSG00000152969 [Q96N16-1]
ENST00000410077; ENSP00000386745; ENSG00000152969 [Q96N16-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
152789

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:152789

UCSC genome browser

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UCSCi
uc003giu.5 human [Q96N16-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382340 mRNA Translation: AAR26235.1
AM412307 mRNA Translation: CAL80778.1
AM412308 mRNA Translation: CAL80779.1
AM412309 mRNA Translation: CAL80780.1
AM412310 mRNA Translation: CAL80781.1
AK056126 mRNA Translation: BAB71098.1
AK098536 mRNA Translation: BAC05325.1 Sequence problems.
AK295339 mRNA Translation: BAG58310.1
AC092442 Genomic DNA No translation available.
AC113615 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82401.1
CH471131 Genomic DNA Translation: EAW82402.1
BC047075 mRNA Translation: AAH47075.1
CCDSiCCDS3385.1 [Q96N16-1]
CCDS47005.1 [Q96N16-2]
CCDS77897.1 [Q96N16-7]
RefSeqiNP_001092903.1, NM_001099433.1 [Q96N16-2]
NP_001293062.1, NM_001306133.1 [Q96N16-1]
NP_001293063.1, NM_001306134.1 [Q96N16-7]
NP_653321.1, NM_144720.3 [Q96N16-1]
XP_011511702.1, XM_011513400.2 [Q96N16-7]
XP_016863282.1, XM_017007793.1 [Q96N16-2]
UniGeneiHs.479066

3D structure databases

ProteinModelPortaliQ96N16
SMRiQ96N16
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127465, 3 interactors
IntActiQ96N16, 18 interactors
STRINGi9606.ENSP00000386711

PTM databases

iPTMnetiQ96N16
PhosphoSitePlusiQ96N16

Polymorphism and mutation databases

BioMutaiJAKMIP1
DMDMi74732477

Proteomic databases

jPOSTiQ96N16
MaxQBiQ96N16
PaxDbiQ96N16
PeptideAtlasiQ96N16
PRIDEiQ96N16
ProteomicsDBi77442
77443 [Q96N16-2]
77444 [Q96N16-3]
77445 [Q96N16-4]
77446 [Q96N16-5]
77447 [Q96N16-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
152789
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282924; ENSP00000282924; ENSG00000152969 [Q96N16-1]
ENST00000409021; ENSP00000386711; ENSG00000152969 [Q96N16-2]
ENST00000409371; ENSP00000387042; ENSG00000152969 [Q96N16-5]
ENST00000409831; ENSP00000386925; ENSG00000152969 [Q96N16-1]
ENST00000410077; ENSP00000386745; ENSG00000152969 [Q96N16-7]
GeneIDi152789
KEGGihsa:152789
UCSCiuc003giu.5 human [Q96N16-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
152789
DisGeNETi152789
EuPathDBiHostDB:ENSG00000152969.16

GeneCards: human genes, protein and diseases

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GeneCardsi
JAKMIP1
HGNCiHGNC:26460 JAKMIP1
HPAiHPA044570
MIMi611195 gene
neXtProtiNX_Q96N16
OpenTargetsiENSG00000152969
PharmGKBiPA143485508

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00940000157832
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ96N16
OMAiAYQSHQD
OrthoDBi727914at2759
PhylomeDBiQ96N16
TreeFamiTF331900

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
JAKMIP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152789
PMAP-CutDBiQ96N16

Protein Ontology

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PROi
PR:Q96N16

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152969 Expressed in 113 organ(s), highest expression level in frontal cortex
CleanExiHS_JAKMIP1
ExpressionAtlasiQ96N16 baseline and differential
GenevisibleiQ96N16 HS

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJKIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N16
Secondary accession number(s): A6H2J2
, A6H2J3, A6H2J4, A6H2J5, A8MTK6, B4DHZ8, B8ZZR7, D3DVT0, Q86Y69, Q8N7G3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: January 16, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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