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Entry version 111 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Uncharacterized protein C7orf26

Gene

C7orf26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C7orf26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C7orf26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21702 C7orf26

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96N11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000146576

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951741

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96N11

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C7orf26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33301033

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895821 – 449Uncharacterized protein C7orf26Add BLAST449

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96N11

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96N11

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96N11

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96N11

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96N11

PeptideAtlas

More...
PeptideAtlasi
Q96N11

PRoteomics IDEntifications database

More...
PRIDEi
Q96N11

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77440 [Q96N11-1]
77441 [Q96N11-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96N11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96N11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146576 Expressed in 209 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96N11 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96N11 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042899
HPA052175

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122499, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q96N11, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340220

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBH Eukaryota
ENOG411039P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082529

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96N11

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTPPLAY

Database of Orthologous Groups

More...
OrthoDBi
1387798at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96N11

TreeFam database of animal gene trees

More...
TreeFami
TF324587

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027844 DUF4507

The PANTHER Classification System

More...
PANTHERi
PTHR14540 PTHR14540, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14964 DUF4507, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96N11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE
60 70 80 90 100
FVFQVPKERS AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS
110 120 130 140 150
PQGNKADDSR MSLLGKLVSM AVAVCRIPVL ECAASWLQRT PVVYCVRLAK
160 170 180 190 200
ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ FITSVTALYD LSSDDLIPPM
210 220 230 240 250
DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL VGLIRWCVKA
260 270 280 290 300
PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT
310 320 330 340 350
LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD
360 370 380 390 400
RLAQALQVAM ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA
410 420 430 440
LPPGFYPHIH TPPLGYGAVP AHPAAHPALP THPGHTFISG VTFPFRPIR
Length:449
Mass (Da):50,047
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCECD14EB3E97A6BA
GO
Isoform 2 (identifier: Q96N11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-83: Missing.
     215-292: Missing.

Show »
Length:352
Mass (Da):39,027
Checksum:i987A7AE66E21F842
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZK9H7BZK9_HUMAN
Uncharacterized protein C7orf26
C7orf26
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Q5H7C0Q5_HUMAN
Uncharacterized protein C7orf26
C7orf26
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061593245R → C. Corresponds to variant dbSNP:rs35534502Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00790765 – 83Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_007908215 – 292Missing in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056149 mRNA Translation: BAB71104.1
BC005121 mRNA Translation: AAH05121.1
BC001076 mRNA Translation: AAH01076.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5353.1 [Q96N11-1]
CCDS78206.1 [Q96N11-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001289968.1, NM_001303039.1 [Q96N11-2]
NP_076972.2, NM_024067.3 [Q96N11-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344417; ENSP00000340220; ENSG00000146576 [Q96N11-1]
ENST00000359073; ENSP00000351974; ENSG00000146576 [Q96N11-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79034

UCSC genome browser

More...
UCSCi
uc003sqo.2 human [Q96N11-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056149 mRNA Translation: BAB71104.1
BC005121 mRNA Translation: AAH05121.1
BC001076 mRNA Translation: AAH01076.1
CCDSiCCDS5353.1 [Q96N11-1]
CCDS78206.1 [Q96N11-2]
RefSeqiNP_001289968.1, NM_001303039.1 [Q96N11-2]
NP_076972.2, NM_024067.3 [Q96N11-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122499, 13 interactors
IntActiQ96N11, 6 interactors
STRINGi9606.ENSP00000340220

PTM databases

iPTMnetiQ96N11
PhosphoSitePlusiQ96N11

Polymorphism and mutation databases

BioMutaiC7orf26
DMDMi33301033

Proteomic databases

EPDiQ96N11
jPOSTiQ96N11
MassIVEiQ96N11
MaxQBiQ96N11
PaxDbiQ96N11
PeptideAtlasiQ96N11
PRIDEiQ96N11
ProteomicsDBi77440 [Q96N11-1]
77441 [Q96N11-2]

Genome annotation databases

EnsembliENST00000344417; ENSP00000340220; ENSG00000146576 [Q96N11-1]
ENST00000359073; ENSP00000351974; ENSG00000146576 [Q96N11-2]
GeneIDi79034
KEGGihsa:79034
UCSCiuc003sqo.2 human [Q96N11-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79034

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C7orf26
HGNCiHGNC:21702 C7orf26
HPAiHPA042899
HPA052175
neXtProtiNX_Q96N11
OpenTargetsiENSG00000146576
PharmGKBiPA134951741

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBH Eukaryota
ENOG411039P LUCA
GeneTreeiENSGT00390000011370
HOGENOMiHOG000082529
InParanoidiQ96N11
OMAiHTPPLAY
OrthoDBi1387798at2759
PhylomeDBiQ96N11
TreeFamiTF324587

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C7orf26 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79034
PharosiQ96N11

Protein Ontology

More...
PROi
PR:Q96N11

Gene expression databases

BgeeiENSG00000146576 Expressed in 209 organ(s), highest expression level in blood
ExpressionAtlasiQ96N11 baseline and differential
GenevisibleiQ96N11 HS

Family and domain databases

InterProiView protein in InterPro
IPR027844 DUF4507
PANTHERiPTHR14540 PTHR14540, 1 hit
PfamiView protein in Pfam
PF14964 DUF4507, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCG026_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96N11
Secondary accession number(s): Q9BQ43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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