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Protein

V-set and transmembrane domain-containing protein 2-like protein

Gene

VSTM2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of neuron apoptotic process Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 2-like protein
Gene namesi
Name:VSTM2L
Synonyms:C20orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000132821.11
HGNCiHGNC:16096 VSTM2L
neXtProtiNX_Q96N03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132821
PharmGKBiPA162408904

Polymorphism and mutation databases

BioMutaiVSTM2L
DMDMi27151481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001516425 – 204V-set and transmembrane domain-containing protein 2-like proteinAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 142PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96N03
MaxQBiQ96N03
PaxDbiQ96N03
PeptideAtlasiQ96N03
PRIDEiQ96N03
ProteomicsDBi77436
77437 [Q96N03-2]
77438 [Q96N03-3]

PTM databases

iPTMnetiQ96N03
PhosphoSitePlusiQ96N03

Expressioni

Gene expression databases

BgeeiENSG00000132821 Expressed in 128 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_VSTM2L
GenevisibleiQ96N03 HS

Organism-specific databases

HPAiHPA043832

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi126121, 4 interactors
IntActiQ96N03, 2 interactors
STRINGi9606.ENSP00000362560

Structurei

3D structure databases

ProteinModelPortaliQ96N03
SMRiQ96N03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 158Ig-likeAdd BLAST118

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IIG5 Eukaryota
ENOG4111M4F LUCA
GeneTreeiENSGT00510000046940
HOGENOMiHOG000231260
HOVERGENiHBG052093
InParanoidiQ96N03
OMAiQQEDTGK
OrthoDBiEOG091G0ND0
PhylomeDBiQ96N03
TreeFamiTF331739

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR027115 VSTM2L
PANTHERiPTHR10075:SF7 PTHR10075:SF7, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96N03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAPLAVALG ALHYLALFLQ LGGATRPAGH APWDNHVSGH ALFTETPHDM
60 70 80 90 100
TARTGEDVEM ACSFRGSGSP SYSLEIQWWY VRSHRDWTDK QAWASNQLKA
110 120 130 140 150
SQQEDAGKEA TKISVVKVVG SNISHKLRLS RVKPTDEGTY ECRVIDFSDG
160 170 180 190 200
KARHHKVKAY LRVQPGENSV LHLPEAPPAA PAPPPPKPGK ELRKRSVDQE

ACSL
Length:204
Mass (Da):22,349
Last modified:December 1, 2001 - v1
Checksum:i79917025B4C8425E
GO
Isoform 2 (identifier: Q96N03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-114: Missing.
     167-204: Missing.

Note: Gene prediction based on EST data.
Show »
Length:149
Mass (Da):16,554
Checksum:i26AB2723281561E6
GO
Isoform 3 (identifier: Q96N03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-132: ALFTETPHDM...ISHKLRLSRV → GGQGGGQQHL...GGPGGLQPLD
     133-204: Missing.

Note: Gene prediction based on EST data.
Show »
Length:132
Mass (Da):13,528
Checksum:i61891B30E4B179A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139T → S in AAH33818 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02651241 – 132ALFTE…RLSRV → GGQGGGQQHLPQAAPVPGEA HGRRHLRVPRHRLQRRQGPA PQGQGLPAGAARGELRPASA RSPSRRARPAAPQARQGAEE ALGGPGGLQPLD in isoform 3. CuratedAdd BLAST92
Alternative sequenceiVSP_01338098 – 114Missing in isoform 2. CuratedAdd BLAST17
Alternative sequenceiVSP_026513133 – 204Missing in isoform 3. CuratedAdd BLAST72
Alternative sequenceiVSP_026514167 – 204Missing in isoform 2. CuratedAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056177 mRNA Translation: BAB71113.1
AL834410 mRNA Translation: CAD39072.2
AL109964 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76051.1
CH471077 Genomic DNA Translation: EAW76053.1
BC033818 mRNA Translation: AAH33818.1
CCDSiCCDS13299.1 [Q96N03-1]
RefSeqiNP_542174.1, NM_080607.2 [Q96N03-1]
UniGeneiHs.517029

Genome annotation databases

EnsembliENST00000373459; ENSP00000362558; ENSG00000132821 [Q96N03-3]
ENST00000373461; ENSP00000362560; ENSG00000132821 [Q96N03-1]
ENST00000448944; ENSP00000406537; ENSG00000132821 [Q96N03-2]
GeneIDi128434
KEGGihsa:128434
UCSCiuc002xhk.5 human [Q96N03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056177 mRNA Translation: BAB71113.1
AL834410 mRNA Translation: CAD39072.2
AL109964 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76051.1
CH471077 Genomic DNA Translation: EAW76053.1
BC033818 mRNA Translation: AAH33818.1
CCDSiCCDS13299.1 [Q96N03-1]
RefSeqiNP_542174.1, NM_080607.2 [Q96N03-1]
UniGeneiHs.517029

3D structure databases

ProteinModelPortaliQ96N03
SMRiQ96N03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126121, 4 interactors
IntActiQ96N03, 2 interactors
STRINGi9606.ENSP00000362560

PTM databases

iPTMnetiQ96N03
PhosphoSitePlusiQ96N03

Polymorphism and mutation databases

BioMutaiVSTM2L
DMDMi27151481

Proteomic databases

EPDiQ96N03
MaxQBiQ96N03
PaxDbiQ96N03
PeptideAtlasiQ96N03
PRIDEiQ96N03
ProteomicsDBi77436
77437 [Q96N03-2]
77438 [Q96N03-3]

Protocols and materials databases

DNASUi128434
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373459; ENSP00000362558; ENSG00000132821 [Q96N03-3]
ENST00000373461; ENSP00000362560; ENSG00000132821 [Q96N03-1]
ENST00000448944; ENSP00000406537; ENSG00000132821 [Q96N03-2]
GeneIDi128434
KEGGihsa:128434
UCSCiuc002xhk.5 human [Q96N03-1]

Organism-specific databases

CTDi128434
EuPathDBiHostDB:ENSG00000132821.11
GeneCardsiVSTM2L
HGNCiHGNC:16096 VSTM2L
HPAiHPA043832
neXtProtiNX_Q96N03
OpenTargetsiENSG00000132821
PharmGKBiPA162408904
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIG5 Eukaryota
ENOG4111M4F LUCA
GeneTreeiENSGT00510000046940
HOGENOMiHOG000231260
HOVERGENiHBG052093
InParanoidiQ96N03
OMAiQQEDTGK
OrthoDBiEOG091G0ND0
PhylomeDBiQ96N03
TreeFamiTF331739

Miscellaneous databases

ChiTaRSiVSTM2L human
GenomeRNAii128434
PROiPR:Q96N03

Gene expression databases

BgeeiENSG00000132821 Expressed in 128 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_VSTM2L
GenevisibleiQ96N03 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR027115 VSTM2L
PANTHERiPTHR10075:SF7 PTHR10075:SF7, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVTM2L_HUMAN
AccessioniPrimary (citable) accession number: Q96N03
Secondary accession number(s): E1P5V7
, Q5JWZ4, Q5JWZ5, Q8ND45, Q9BR37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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