UniProtKB - Q96MX6 (WDR92_HUMAN)
Protein
WD repeat-containing protein 92
Gene
WDR92
Organism
Homo sapiens (Human)
Status
Functioni
Seems to act as a modulator of apoptosis.1 Publication
GO - Molecular functioni
- ubiquitin binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q96MX6 |
SignaLinki | Q96MX6 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 92Alternative name(s): WD repeat-containing protein Monad |
Gene namesi | Name:WDR92 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000243667.6 |
HGNCi | HGNC:25176, WDR92 |
MIMi | 610729, gene |
neXtProti | NX_Q96MX6 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 116143 |
OpenTargetsi | ENSG00000243667 |
PharmGKBi | PA162409167 |
Miscellaneous databases
Pharosi | Q96MX6, Tbio |
Polymorphism and mutation databases
BioMutai | WDR92 |
DMDMi | 74760987 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000301671 | 1 – 357 | WD repeat-containing protein 92Add BLAST | 357 |
Proteomic databases
EPDi | Q96MX6 |
jPOSTi | Q96MX6 |
MassIVEi | Q96MX6 |
MaxQBi | Q96MX6 |
PaxDbi | Q96MX6 |
PeptideAtlasi | Q96MX6 |
PRIDEi | Q96MX6 |
ProteomicsDBi | 76211 77429 [Q96MX6-1] |
PTM databases
iPTMneti | Q96MX6 |
PhosphoSitePlusi | Q96MX6 |
SwissPalmi | Q96MX6 |
Expressioni
Tissue specificityi
Widely expressed with the highest expression in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000243667, Expressed in testis and 116 other tissues |
ExpressionAtlasi | Q96MX6, baseline and differential |
Genevisiblei | Q96MX6, HS |
Organism-specific databases
HPAi | ENSG00000243667, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PIH1D1.
1 PublicationBinary interactionsi
Q96MX6
With | #Exp. | IntAct |
---|---|---|
RPAP3 [Q9H6T3] | 5 | EBI-2434101,EBI-356928 |
GO - Molecular functioni
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 125479, 87 interactors |
IntActi | Q96MX6, 30 interactors |
MINTi | Q96MX6 |
STRINGi | 9606.ENSP00000477980 |
Miscellaneous databases
RNActi | Q96MX6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96MX6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96MX6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 63 – 105 | WD 1Add BLAST | 43 | |
Repeati | 115 – 154 | WD 2Add BLAST | 40 | |
Repeati | 162 – 205 | WD 3Add BLAST | 44 | |
Repeati | 207 – 249 | WD 4Add BLAST | 43 | |
Repeati | 257 – 297 | WD 5Add BLAST | 41 | |
Repeati | 319 – 357 | WD 6Add BLAST | 39 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0034, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_062543_0_0_1 |
InParanoidi | Q96MX6 |
OMAi | HMAIGDF |
PhylomeDBi | Q96MX6 |
TreeFami | TF351064 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96MX6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE
60 70 80 90 100
IQHGDLKLLR EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP
110 120 130 140 150
EMPVYSVKGH KEIINAIDGI GGLGIGEGAP EIVTGSRDGT VKVWDPRQKD
160 170 180 190 200
DPVANMEPVQ GENKRDCWTV AFGNAYNQEE RVVCAGYDNG DIKLFDLRNM
210 220 230 240 250
ALRWETNIKN GVCSLEFDRK DISMNKLVAT SLEGKFHVFD MRTQHPTKGF
260 270 280 290 300
ASVSEKAHKS TVWQVRHLPQ NRELFLTAGG AGGLHLWKYE YPIQRSKKDS
310 320 330 340 350
EGIEMGVAGS VSLLQNVTLS TQPISSLDWS PDKRGLCVCS SFDQTVRVLI
VTKLNKI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8ND98 | Q8ND98_HUMAN | WD repeat-containing protein 92 | WDR92 DKFZp434B156 | 187 | Annotation score: | ||
H7C389 | H7C389_HUMAN | WD repeat-containing protein 92 | WDR92 | 92 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053438 | 241 | M → V. Corresponds to variant dbSNP:rs13009282Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045123 | 289 – 357 | Missing in isoform 2. CuratedAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056303 mRNA Translation: BAB71143.1 AC017083 Genomic DNA Translation: AAY14713.1 BC014022 mRNA Translation: AAH14022.2 BC066657 mRNA Translation: AAH66657.1 |
CCDSi | CCDS1884.1 [Q96MX6-1] CCDS58712.1 [Q96MX6-2] |
RefSeqi | NP_001243405.1, NM_001256476.1 [Q96MX6-2] NP_612467.1, NM_138458.3 [Q96MX6-1] |
Genome annotation databases
Ensembli | ENST00000295121; ENSP00000295121; ENSG00000243667 [Q96MX6-1] ENST00000409164; ENSP00000386746; ENSG00000243667 [Q96MX6-2] |
GeneIDi | 116143 |
KEGGi | hsa:116143 |
UCSCi | uc002see.3, human [Q96MX6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056303 mRNA Translation: BAB71143.1 AC017083 Genomic DNA Translation: AAY14713.1 BC014022 mRNA Translation: AAH14022.2 BC066657 mRNA Translation: AAH66657.1 |
CCDSi | CCDS1884.1 [Q96MX6-1] CCDS58712.1 [Q96MX6-2] |
RefSeqi | NP_001243405.1, NM_001256476.1 [Q96MX6-2] NP_612467.1, NM_138458.3 [Q96MX6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3I2N | X-ray | 1.95 | A | 1-357 | [»] | |
SMRi | Q96MX6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125479, 87 interactors |
IntActi | Q96MX6, 30 interactors |
MINTi | Q96MX6 |
STRINGi | 9606.ENSP00000477980 |
PTM databases
iPTMneti | Q96MX6 |
PhosphoSitePlusi | Q96MX6 |
SwissPalmi | Q96MX6 |
Polymorphism and mutation databases
BioMutai | WDR92 |
DMDMi | 74760987 |
Proteomic databases
EPDi | Q96MX6 |
jPOSTi | Q96MX6 |
MassIVEi | Q96MX6 |
MaxQBi | Q96MX6 |
PaxDbi | Q96MX6 |
PeptideAtlasi | Q96MX6 |
PRIDEi | Q96MX6 |
ProteomicsDBi | 76211 77429 [Q96MX6-1] |
Protocols and materials databases
Antibodypediai | 48145, 94 antibodies |
DNASUi | 116143 |
Genome annotation databases
Ensembli | ENST00000295121; ENSP00000295121; ENSG00000243667 [Q96MX6-1] ENST00000409164; ENSP00000386746; ENSG00000243667 [Q96MX6-2] |
GeneIDi | 116143 |
KEGGi | hsa:116143 |
UCSCi | uc002see.3, human [Q96MX6-1] |
Organism-specific databases
CTDi | 116143 |
DisGeNETi | 116143 |
EuPathDBi | HostDB:ENSG00000243667.6 |
GeneCardsi | WDR92 |
HGNCi | HGNC:25176, WDR92 |
HPAi | ENSG00000243667, Low tissue specificity |
MIMi | 610729, gene |
neXtProti | NX_Q96MX6 |
OpenTargetsi | ENSG00000243667 |
PharmGKBi | PA162409167 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0034, Eukaryota |
GeneTreei | ENSGT00950000183091 |
HOGENOMi | CLU_062543_0_0_1 |
InParanoidi | Q96MX6 |
OMAi | HMAIGDF |
PhylomeDBi | Q96MX6 |
TreeFami | TF351064 |
Enzyme and pathway databases
PathwayCommonsi | Q96MX6 |
SignaLinki | Q96MX6 |
Miscellaneous databases
BioGRID-ORCSi | 116143, 527 hits in 858 CRISPR screens |
ChiTaRSi | WDR92, human |
EvolutionaryTracei | Q96MX6 |
GenomeRNAii | 116143 |
Pharosi | Q96MX6, Tbio |
PROi | PR:Q96MX6 |
RNActi | Q96MX6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243667, Expressed in testis and 116 other tissues |
ExpressionAtlasi | Q96MX6, baseline and differential |
Genevisiblei | Q96MX6, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR92_HUMAN | |
Accessioni | Q96MX6Primary (citable) accession number: Q96MX6 Secondary accession number(s): Q96CR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations