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Protein

CKLF-like MARVEL transmembrane domain-containing protein 3

Gene

CMTM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 3
Alternative name(s):
Chemokine-like factor superfamily member 3
Gene namesi
Name:CMTM3
Synonyms:CKLFSF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140931.19
HGNCiHGNC:19174 CMTM3
MIMi607886 gene
neXtProtiNX_Q96MX0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi123920
OpenTargetsiENSG00000140931
PharmGKBiPA38813

Polymorphism and mutation databases

BioMutaiCMTM3
DMDMi34922036

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861011 – 182CKLF-like MARVEL transmembrane domain-containing protein 3Add BLAST182

Proteomic databases

EPDiQ96MX0
MaxQBiQ96MX0
PaxDbiQ96MX0
PeptideAtlasiQ96MX0
PRIDEiQ96MX0
ProteomicsDBi77426
77427 [Q96MX0-2]

PTM databases

PhosphoSitePlusiQ96MX0
SwissPalmiQ96MX0

Expressioni

Tissue specificityi

Expressed in the leukocytes, placenta and testis.1 Publication

Gene expression databases

BgeeiENSG00000140931 Expressed in 188 organ(s), highest expression level in right testis
CleanExiHS_CMTM3
ExpressionAtlasiQ96MX0 baseline and differential
GenevisibleiQ96MX0 HS

Organism-specific databases

HPAiHPA013870
HPA072695

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125844, 7 interactors
IntActiQ96MX0, 22 interactors
MINTiQ96MX0
STRINGi9606.ENSP00000354579

Structurei

3D structure databases

ProteinModelPortaliQ96MX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 155MARVELPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOVERGENiHBG053619
InParanoidiQ96MX0
OMAiVFALDFY
OrthoDBiEOG091G11FO
PhylomeDBiQ96MX0
TreeFamiTF317387

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96MX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG
60 70 80 90 100
LSFITFICYV ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM
110 120 130 140 150
MDFLRCVTAA LIYFAISITA IAKYSDGASK AAGVFGFFAT IVFATDFYLI
160 170 180
FNDVAKFLKQ GDSADETTAH KTEEENSDSD SD
Length:182
Mass (Da):19,714
Last modified:December 1, 2001 - v1
Checksum:iC56C7B93E7E638E1
GO
Isoform 2 (identifier: Q96MX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-59: RLLLAESGLSFITFICY → PGGFVCTWCSCPHQPLW
     60-182: Missing.

Show »
Length:59
Mass (Da):6,220
Checksum:iA5ADABE4E66AC83B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUD5H3BUD5_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
150Annotation score:
H3BN06H3BN06_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
122Annotation score:
J3KSR6J3KSR6_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
165Annotation score:
B3KQJ8B3KQJ8_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3 hCG_28845
96Annotation score:
H3BU39H3BU39_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
116Annotation score:
I3L3C2I3L3C2_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
96Annotation score:
J3KSM1J3KSM1_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM3
79Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00825643 – 59RLLLA…TFICY → PGGFVCTWCSCPHQPLW in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_00825760 – 182Missing in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479813 mRNA Translation: AAN73435.1
AY166714 mRNA Translation: AAN75573.1
AK056324 mRNA Translation: BAB71150.1
AC018557 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83031.1
BC023509 mRNA Translation: AAH23509.2
BC023591 mRNA Translation: AAH23591.2
BC036042 mRNA Translation: AAH36042.2
BC040227 mRNA Translation: AAH40227.2
BC047701 mRNA Translation: AAH47701.1
CCDSiCCDS10815.1 [Q96MX0-1]
RefSeqiNP_653202.1, NM_144601.3 [Q96MX0-1]
NP_853531.1, NM_181553.2 [Q96MX0-1]
XP_006721194.1, XM_006721131.1
UniGeneiHs.298198

Genome annotation databases

EnsembliENST00000361909; ENSP00000354579; ENSG00000140931 [Q96MX0-1]
ENST00000424011; ENSP00000400482; ENSG00000140931 [Q96MX0-1]
ENST00000562707; ENSP00000455758; ENSG00000140931 [Q96MX0-1]
ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2]
ENST00000567572; ENSP00000455851; ENSG00000140931 [Q96MX0-1]
GeneIDi123920
KEGGihsa:123920
UCSCiuc002epu.5 human [Q96MX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479813 mRNA Translation: AAN73435.1
AY166714 mRNA Translation: AAN75573.1
AK056324 mRNA Translation: BAB71150.1
AC018557 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83031.1
BC023509 mRNA Translation: AAH23509.2
BC023591 mRNA Translation: AAH23591.2
BC036042 mRNA Translation: AAH36042.2
BC040227 mRNA Translation: AAH40227.2
BC047701 mRNA Translation: AAH47701.1
CCDSiCCDS10815.1 [Q96MX0-1]
RefSeqiNP_653202.1, NM_144601.3 [Q96MX0-1]
NP_853531.1, NM_181553.2 [Q96MX0-1]
XP_006721194.1, XM_006721131.1
UniGeneiHs.298198

3D structure databases

ProteinModelPortaliQ96MX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125844, 7 interactors
IntActiQ96MX0, 22 interactors
MINTiQ96MX0
STRINGi9606.ENSP00000354579

PTM databases

PhosphoSitePlusiQ96MX0
SwissPalmiQ96MX0

Polymorphism and mutation databases

BioMutaiCMTM3
DMDMi34922036

Proteomic databases

EPDiQ96MX0
MaxQBiQ96MX0
PaxDbiQ96MX0
PeptideAtlasiQ96MX0
PRIDEiQ96MX0
ProteomicsDBi77426
77427 [Q96MX0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361909; ENSP00000354579; ENSG00000140931 [Q96MX0-1]
ENST00000424011; ENSP00000400482; ENSG00000140931 [Q96MX0-1]
ENST00000562707; ENSP00000455758; ENSG00000140931 [Q96MX0-1]
ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2]
ENST00000567572; ENSP00000455851; ENSG00000140931 [Q96MX0-1]
GeneIDi123920
KEGGihsa:123920
UCSCiuc002epu.5 human [Q96MX0-1]

Organism-specific databases

CTDi123920
DisGeNETi123920
EuPathDBiHostDB:ENSG00000140931.19
GeneCardsiCMTM3
HGNCiHGNC:19174 CMTM3
HPAiHPA013870
HPA072695
MIMi607886 gene
neXtProtiNX_Q96MX0
OpenTargetsiENSG00000140931
PharmGKBiPA38813
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00530000063326
HOVERGENiHBG053619
InParanoidiQ96MX0
OMAiVFALDFY
OrthoDBiEOG091G11FO
PhylomeDBiQ96MX0
TreeFamiTF317387

Miscellaneous databases

ChiTaRSiCMTM3 human
GenomeRNAii123920
PROiPR:Q96MX0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140931 Expressed in 188 organ(s), highest expression level in right testis
CleanExiHS_CMTM3
ExpressionAtlasiQ96MX0 baseline and differential
GenevisibleiQ96MX0 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF3_HUMAN
AccessioniPrimary (citable) accession number: Q96MX0
Secondary accession number(s): A6NCL9
, Q8IUU8, Q8IWQ6, Q8IYE2, Q8IZ39, Q8IZ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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