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UniProtKB - Q96MX0 (CKLF3_HUMAN)
Protein
CKLF-like MARVEL transmembrane domain-containing protein 3
Gene
CMTM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- blastocyst hatching Source: Ensembl
- chemotaxis Source: UniProtKB-KW
- positive regulation of B cell receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | Q96MX0 |
SignaLinki | Q96MX0 |
Names & Taxonomyi
Protein namesi | Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 3Alternative name(s): Chemokine-like factor superfamily member 3 |
Gene namesi | Name:CMTM3 Synonyms:CKLFSF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19174, CMTM3 |
MIMi | 607886, gene |
neXtProti | NX_Q96MX0 |
VEuPathDBi | HostDB:ENSG00000140931 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: CACAO
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Nucleus
- nuclear membrane Source: Ensembl
Other locations
- cytoplasmic vesicle Source: CACAO
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 123920 |
OpenTargetsi | ENSG00000140931 |
PharmGKBi | PA38813 |
Miscellaneous databases
Pharosi | Q96MX0, Tbio |
Genetic variation databases
BioMutai | CMTM3 |
DMDMi | 34922036 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186101 | 1 – 182 | CKLF-like MARVEL transmembrane domain-containing protein 3Add BLAST | 182 |
Proteomic databases
EPDi | Q96MX0 |
MassIVEi | Q96MX0 |
MaxQBi | Q96MX0 |
PaxDbi | Q96MX0 |
PeptideAtlasi | Q96MX0 |
PRIDEi | Q96MX0 |
ProteomicsDBi | 77426 [Q96MX0-1] 77427 [Q96MX0-2] |
PTM databases
iPTMneti | Q96MX0 |
PhosphoSitePlusi | Q96MX0 |
SwissPalmi | Q96MX0 |
Expressioni
Tissue specificityi
Expressed in the leukocytes, placenta and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000140931, Expressed in right testis and 201 other tissues |
ExpressionAtlasi | Q96MX0, baseline and differential |
Genevisiblei | Q96MX0, HS |
Organism-specific databases
HPAi | ENSG00000140931, Low tissue specificity |
Interactioni
Binary interactionsi
Q96MX0
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 125844, 31 interactors |
IntActi | Q96MX0, 24 interactors |
MINTi | Q96MX0 |
STRINGi | 9606.ENSP00000400482 |
Miscellaneous databases
RNActi | Q96MX0, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 155 | MARVELPROSITE-ProRule annotationAdd BLAST | 120 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 19 | Pro residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the chemokine-like factor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000160432 |
HOGENOMi | CLU_108546_1_0_1 |
InParanoidi | Q96MX0 |
OMAi | ASSRKGM |
PhylomeDBi | Q96MX0 |
TreeFami | TF317387 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96MX0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG
60 70 80 90 100
LSFITFICYV ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM
110 120 130 140 150
MDFLRCVTAA LIYFAISITA IAKYSDGASK AAGVFGFFAT IVFATDFYLI
160 170 180
FNDVAKFLKQ GDSADETTAH KTEEENSDSD SD
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BN06 | H3BN06_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 122 | Annotation score: | ||
H3BU39 | H3BU39_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 116 | Annotation score: | ||
J3KSR6 | J3KSR6_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 165 | Annotation score: | ||
H3BUD5 | H3BUD5_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 150 | Annotation score: | ||
J3KSM1 | J3KSM1_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 79 | Annotation score: | ||
B3KQJ8 | B3KQJ8_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 hCG_28845 | 96 | Annotation score: | ||
I3L3C2 | I3L3C2_HUMAN | CKLF-like MARVEL transmembrane doma... | CMTM3 | 96 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008256 | 43 – 59 | RLLLA…TFICY → PGGFVCTWCSCPHQPLW in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_008257 | 60 – 182 | Missing in isoform 2. 1 PublicationAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479813 mRNA Translation: AAN73435.1 AY166714 mRNA Translation: AAN75573.1 AK056324 mRNA Translation: BAB71150.1 AC018557 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83031.1 BC023509 mRNA Translation: AAH23509.2 BC023591 mRNA Translation: AAH23591.2 BC036042 mRNA Translation: AAH36042.2 BC040227 mRNA Translation: AAH40227.2 BC047701 mRNA Translation: AAH47701.1 |
CCDSi | CCDS10815.1 [Q96MX0-1] |
RefSeqi | NP_653202.1, NM_144601.3 [Q96MX0-1] NP_853531.1, NM_181553.2 [Q96MX0-1] XP_006721194.1, XM_006721131.1 |
Genome annotation databases
Ensembli | ENST00000361909; ENSP00000354579; ENSG00000140931 ENST00000424011; ENSP00000400482; ENSG00000140931 ENST00000562707; ENSP00000455758; ENSG00000140931 ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2] ENST00000567572; ENSP00000455851; ENSG00000140931 |
GeneIDi | 123920 |
KEGGi | hsa:123920 |
MANE-Selecti | ENST00000567572.6; ENSP00000455851.1; NM_181553.4; NP_853531.1 |
UCSCi | uc002epu.5, human [Q96MX0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479813 mRNA Translation: AAN73435.1 AY166714 mRNA Translation: AAN75573.1 AK056324 mRNA Translation: BAB71150.1 AC018557 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83031.1 BC023509 mRNA Translation: AAH23509.2 BC023591 mRNA Translation: AAH23591.2 BC036042 mRNA Translation: AAH36042.2 BC040227 mRNA Translation: AAH40227.2 BC047701 mRNA Translation: AAH47701.1 |
CCDSi | CCDS10815.1 [Q96MX0-1] |
RefSeqi | NP_653202.1, NM_144601.3 [Q96MX0-1] NP_853531.1, NM_181553.2 [Q96MX0-1] XP_006721194.1, XM_006721131.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125844, 31 interactors |
IntActi | Q96MX0, 24 interactors |
MINTi | Q96MX0 |
STRINGi | 9606.ENSP00000400482 |
PTM databases
iPTMneti | Q96MX0 |
PhosphoSitePlusi | Q96MX0 |
SwissPalmi | Q96MX0 |
Genetic variation databases
BioMutai | CMTM3 |
DMDMi | 34922036 |
Proteomic databases
EPDi | Q96MX0 |
MassIVEi | Q96MX0 |
MaxQBi | Q96MX0 |
PaxDbi | Q96MX0 |
PeptideAtlasi | Q96MX0 |
PRIDEi | Q96MX0 |
ProteomicsDBi | 77426 [Q96MX0-1] 77427 [Q96MX0-2] |
Protocols and materials databases
Antibodypediai | 2892, 140 antibodies from 22 providers |
DNASUi | 123920 |
Genome annotation databases
Ensembli | ENST00000361909; ENSP00000354579; ENSG00000140931 ENST00000424011; ENSP00000400482; ENSG00000140931 ENST00000562707; ENSP00000455758; ENSG00000140931 ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2] ENST00000567572; ENSP00000455851; ENSG00000140931 |
GeneIDi | 123920 |
KEGGi | hsa:123920 |
MANE-Selecti | ENST00000567572.6; ENSP00000455851.1; NM_181553.4; NP_853531.1 |
UCSCi | uc002epu.5, human [Q96MX0-1] |
Organism-specific databases
CTDi | 123920 |
DisGeNETi | 123920 |
GeneCardsi | CMTM3 |
HGNCi | HGNC:19174, CMTM3 |
HPAi | ENSG00000140931, Low tissue specificity |
MIMi | 607886, gene |
neXtProti | NX_Q96MX0 |
OpenTargetsi | ENSG00000140931 |
PharmGKBi | PA38813 |
VEuPathDBi | HostDB:ENSG00000140931 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4788, Eukaryota |
GeneTreei | ENSGT00940000160432 |
HOGENOMi | CLU_108546_1_0_1 |
InParanoidi | Q96MX0 |
OMAi | ASSRKGM |
PhylomeDBi | Q96MX0 |
TreeFami | TF317387 |
Enzyme and pathway databases
PathwayCommonsi | Q96MX0 |
SignaLinki | Q96MX0 |
Miscellaneous databases
BioGRID-ORCSi | 123920, 5 hits in 1040 CRISPR screens |
ChiTaRSi | CMTM3, human |
GenomeRNAii | 123920 |
Pharosi | Q96MX0, Tbio |
PROi | PR:Q96MX0 |
RNActi | Q96MX0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140931, Expressed in right testis and 201 other tissues |
ExpressionAtlasi | Q96MX0, baseline and differential |
Genevisiblei | Q96MX0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKLF3_HUMAN | |
Accessioni | Q96MX0Primary (citable) accession number: Q96MX0 Secondary accession number(s): A6NCL9 Q8IZ59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families