CMTM3

Functionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst hatching Source: Ensembl
chemotaxis Source: UniProtKB-KW
positive regulation of B cell receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 3 Alternative name(s): Chemokine-like factor superfamily member 3
Gene namesⁱ	Name:CMTM3 Synonyms:CKLFSF3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140931.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19174 CMTM3
MIMⁱ	607886 gene
neXtProtⁱ	NX_Q96MX0

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	64 – 84	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	101 – 121	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	123920
Open Targets More...OpenTargetsⁱ	ENSG00000140931
PharmGKBⁱ	PA38813

Polymorphism and mutation databases

BioMutaⁱ	CMTM3
DMDMⁱ	34922036

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000186101	1 – 182	CKLF-like MARVEL transmembrane domain-containing protein 3Add BLAST		182

Proteomic databases

EPDⁱ	Q96MX0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96MX0
PaxDbⁱ	Q96MX0
PeptideAtlas More...PeptideAtlasⁱ	Q96MX0
PRIDEⁱ	Q96MX0
ProteomicsDBⁱ	77426 77427 [Q96MX0-2]

PTM databases

PhosphoSitePlusⁱ	Q96MX0
SwissPalmⁱ	Q96MX0

Expressionⁱ

Tissue specificityⁱ

Expressed in the leukocytes, placenta and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000140931 Expressed in 188 organ(s), highest expression level in right testis
CleanExⁱ	HS_CMTM3
ExpressionAtlasⁱ	Q96MX0 baseline and differential
Genevisibleⁱ	Q96MX0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013870 HPA072695

HPAⁱ

HPA013870
HPA072695

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MOB1A	Q9H8S9	3	EBI-7247651,EBI-748229
MOB3C	Q70IA8	3	EBI-7247651,EBI-9679267

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	125844, 7 interactors
IntActⁱ	Q96MX0, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q96MX0
STRINGⁱ	9606.ENSP00000354579

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96MX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 155	MARVELPROSITE-ProRule annotationAdd BLAST		120

Sequence similaritiesⁱ

Belongs to the chemokine-like factor family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063326
HOVERGENⁱ	HBG053619
InParanoidⁱ	Q96MX0
OMAⁱ	VFALDFY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11FO
PhylomeDBⁱ	Q96MX0
TreeFamⁱ	TF317387

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01284 MARVEL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96MX0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG 
        60         70         80         90        100
LSFITFICYV ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM 
       110        120        130        140        150
MDFLRCVTAA LIYFAISITA IAKYSDGASK AAGVFGFFAT IVFATDFYLI 
       160        170        180 
FNDVAKFLKQ GDSADETTAH KTEEENSDSD SD

Length:182

Mass (Da):19,714

Last modified:December 1, 2001 - v1

Checksum:ⁱC56C7B93E7E638E1

GO

Isoform 2 (identifier: Q96MX0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
43-59: RLLLAESGLSFITFICY → PGGFVCTWCSCPHQPLW
60-182: Missing.

« Hide

        10         20         30         40         50
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGPGGFVCTW 

CSCPHQPLW

Show »

Length:59

Mass (Da):6,220

Checksum:ⁱA5ADABE4E66AC83B

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BUD5	H3BUD5_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	150	Annotation score:
H3BN06	H3BN06_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	122	Annotation score:
J3KSR6	J3KSR6_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	165	Annotation score:
B3KQJ8	B3KQJ8_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain containing 3, isoform CRA_b (cDNA FLJ90594 fis, clone PLACE1001123, highly similar to CKLF-like MARVEL transmembrane domain-containing protein 3)	CMTM3 hCG_28845	96	Annotation score:
H3BU39	H3BU39_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	116	Annotation score:
I3L3C2	I3L3C2_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	96	Annotation score:
J3KSM1	J3KSM1_HUMAN	CKLF-like MARVEL transmembrane doma... CKLF-like MARVEL transmembrane domain-containing protein 3	CMTM3	79	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008256	43 – 59	RLLLA…TFICY → PGGFVCTWCSCPHQPLW in isoform 2. 1 PublicationAdd BLAST		17
Alternative sequenceⁱVSP_008257	60 – 182	Missing in isoform 2. 1 PublicationAdd BLAST		123

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF479813 mRNA Translation: AAN73435.1 AY166714 mRNA Translation: AAN75573.1 AK056324 mRNA Translation: BAB71150.1 AC018557 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83031.1 BC023509 mRNA Translation: AAH23509.2 BC023591 mRNA Translation: AAH23591.2 BC036042 mRNA Translation: AAH36042.2 BC040227 mRNA Translation: AAH40227.2 BC047701 mRNA Translation: AAH47701.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10815.1 [Q96MX0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_653202.1, NM_144601.3 [Q96MX0-1] NP_853531.1, NM_181553.2 [Q96MX0-1] XP_006721194.1, XM_006721131.1
UniGeneⁱ	Hs.298198

Genome annotation databases

Ensemblⁱ	ENST00000361909; ENSP00000354579; ENSG00000140931 [Q96MX0-1] ENST00000424011; ENSP00000400482; ENSG00000140931 [Q96MX0-1] ENST00000562707; ENSP00000455758; ENSG00000140931 [Q96MX0-1] ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2] ENST00000567572; ENSP00000455851; ENSG00000140931 [Q96MX0-1]
GeneIDⁱ	123920
KEGGⁱ	hsa:123920
UCSC genome browser More...UCSCⁱ	uc002epu.5 human [Q96MX0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96MX0	CKLF-like MARVEL transmembrane domain containing 3, isoform CRA_a		HUMAN		182	UniRef100_Q96MX0
CMTM3 isoform 15 (Fragment)		PANTR		116
CKLF-like MARVEL transmembrane domain-containing protein 3 (Fragment)		HUMAN		122
CKLF-like MARVEL transmembrane domain containing 3, isoform CRA_b		HUMAN		96
CKLF-like MARVEL transmembrane domain-containing protein 3 (Fragment)		HUMAN		116
Q96MX0-2	CKLF like MARVEL transmembrane domain containing 3		PANTR		59	UniRef100_A0A2I3TN17
Uncharacterized protein		PANPA		54

Protein	Similar proteins		Species	Score	Length	Source
Q96MX0	CKLF-like MARVEL transmembrane domain containing 3, isoform CRA_a		HUMAN		182	UniRef90_Q96MX0
CMTM3 isoform 15 (Fragment)		PANTR		116
Uncharacterized protein		MACMU		182
Uncharacterized protein		CERAT		182
Uncharacterized protein		CHLSB		182
+17
Q96MX0-2	CKLF like MARVEL transmembrane domain containing 3		PANTR		59	UniRef90_A0A2I3TN17
Uncharacterized protein		PANPA		54
Uncharacterized protein		MACMU		59
Uncharacterized protein		CERAT		59
Uncharacterized protein		RHIBE		59
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96MX0	CKLF-like MARVEL transmembrane domain containing 3, isoform CRA_a		HUMAN		182	UniRef50_Q96MX0
CMTM3 isoform 15 (Fragment)		PANTR		116
Uncharacterized protein		MACMU		182
Uncharacterized protein		CERAT		182
Uncharacterized protein		CHLSB		182
+66
Q96MX0-2	CKLF like MARVEL transmembrane domain containing 3		PANTR		59	UniRef50_A0A2I3TN17
Uncharacterized protein		PANPA		54
CMTM3 isoform 9		PONAB		59
Uncharacterized protein		MACMU		59
Uncharacterized protein		CERAT		59
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF479813 mRNA Translation: AAN73435.1 AY166714 mRNA Translation: AAN75573.1 AK056324 mRNA Translation: BAB71150.1 AC018557 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83031.1 BC023509 mRNA Translation: AAH23509.2 BC023591 mRNA Translation: AAH23591.2 BC036042 mRNA Translation: AAH36042.2 BC040227 mRNA Translation: AAH40227.2 BC047701 mRNA Translation: AAH47701.1
CCDSⁱ	CCDS10815.1 [Q96MX0-1]
RefSeqⁱ	NP_653202.1, NM_144601.3 [Q96MX0-1] NP_853531.1, NM_181553.2 [Q96MX0-1] XP_006721194.1, XM_006721131.1
UniGeneⁱ	Hs.298198

3D structure databases

ProteinModelPortalⁱ	Q96MX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125844, 7 interactors
IntActⁱ	Q96MX0, 22 interactors
MINTⁱ	Q96MX0
STRINGⁱ	9606.ENSP00000354579

PTM databases

PhosphoSitePlusⁱ	Q96MX0
SwissPalmⁱ	Q96MX0

Polymorphism and mutation databases

BioMutaⁱ	CMTM3
DMDMⁱ	34922036

Proteomic databases

EPDⁱ	Q96MX0
MaxQBⁱ	Q96MX0
PaxDbⁱ	Q96MX0
PeptideAtlasⁱ	Q96MX0
PRIDEⁱ	Q96MX0
ProteomicsDBⁱ	77426 77427 [Q96MX0-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361909; ENSP00000354579; ENSG00000140931 [Q96MX0-1] ENST00000424011; ENSP00000400482; ENSG00000140931 [Q96MX0-1] ENST00000562707; ENSP00000455758; ENSG00000140931 [Q96MX0-1] ENST00000565922; ENSP00000456426; ENSG00000140931 [Q96MX0-2] ENST00000567572; ENSP00000455851; ENSG00000140931 [Q96MX0-1]
GeneIDⁱ	123920
KEGGⁱ	hsa:123920
UCSCⁱ	uc002epu.5 human [Q96MX0-1]

Organism-specific databases

CTDⁱ	123920
DisGeNETⁱ	123920
EuPathDBⁱ	HostDB:ENSG00000140931.19
GeneCardsⁱ	CMTM3
HGNCⁱ	HGNC:19174 CMTM3
HPAⁱ	HPA013870 HPA072695
MIMⁱ	607886 gene
neXtProtⁱ	NX_Q96MX0
OpenTargetsⁱ	ENSG00000140931
PharmGKBⁱ	PA38813
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4788 Eukaryota ENOG4111IAF LUCA
GeneTreeⁱ	ENSGT00530000063326
HOVERGENⁱ	HBG053619
InParanoidⁱ	Q96MX0
OMAⁱ	VFALDFY
OrthoDBⁱ	EOG091G11FO
PhylomeDBⁱ	Q96MX0
TreeFamⁱ	TF317387

Miscellaneous databases

ChiTaRSⁱ	CMTM3 human
GenomeRNAiⁱ	123920
Protein Ontology More...PROⁱ	PR:Q96MX0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140931 Expressed in 188 organ(s), highest expression level in right testis
CleanExⁱ	HS_CMTM3
ExpressionAtlasⁱ	Q96MX0 baseline and differential
Genevisibleⁱ	Q96MX0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008253 Marvel
Pfamⁱ	View protein in Pfam PF01284 MARVEL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51225 MARVEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CKLF3_HUMAN
Accessionⁱ	Q96MX0Primary (citable) accession number: Q96MX0 Secondary accession number(s): A6NCL9 , Q8IUU8, Q8IWQ6, Q8IYE2, Q8IZ39, Q8IZ59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96MX0 (CKLF3_HUMAN)

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CKLF-like MARVEL transmembrane domain-containing protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ