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Entry version 141 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Tigger transposable element-derived protein 1

Gene

TIGD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi33 – 53H-T-H motifBy similarityAdd BLAST21
DNA bindingi103 – 142H-T-H motifBy similarityAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tigger transposable element-derived protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIGD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:14523 TIGD1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612972 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000221944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38382

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MW7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIGD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002726151 – 591Tigger transposable element-derived protein 1Add BLAST591

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96MW7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96MW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96MW7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96MW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MW7

PeptideAtlas

More...
PeptideAtlasi
Q96MW7

PRoteomics IDEntifications database

More...
PRIDEi
Q96MW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77425

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000221944 Expressed in 168 organ(s), highest expression level in neocortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MW7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041717

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128345, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-61581N

Protein interaction database and analysis system

More...
IntActi
Q96MW7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386186

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96MW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 57HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini70 – 149HTH CENPB-typePROSITE-ProRule annotationAdd BLAST80
Domaini178 – 403DDE-1Sequence analysisAdd BLAST226

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3105 Eukaryota
ENOG4110CDI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155163

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154578

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MW7

Identification of Orthologs from Complete Genome Data

More...
OMAi
MNTRMIR

Database of Orthologous Groups

More...
OrthoDBi
1343623at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MW7

TreeFam database of animal gene trees

More...
TreeFami
TF101131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00674 CENPB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96MW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV
60 70 80 90 100
VNAKEKFLKE VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL
110 120 130 140 150
SQSLIQNKAL TLFNSMKAER GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA
160 170 180 190 200
QGEAASADVE AAASYPEALA KIIDEGGYTK QQIFNVDETA FYWKKMPSRT
210 220 230 240 250
FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH SENPRALKNY
260 270 280 290 300
TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL
310 320 330 340 350
IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT
360 370 380 390 400
FHKALAAMDS DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT
410 420 430 440 450
GVWKKLIPTL IDDYEGFKTS VEEVSADVVE IAKELELEVE PEDVTELLQS
460 470 480 490 500
HDKTLTDEEL FLMDAQRKWF LEMESTPGED AVNIVEMTTK DLEYYINLVD
510 520 530 540 550
KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ LMRKASPMSY
560 570 580 590
FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D
Length:591
Mass (Da):67,299
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i920CA1F0CF2805C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249N → S in AAH35143 (PubMed:15489334).Curated1
Sequence conflicti302D → G in AAH35143 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056329 mRNA Translation: BAB71153.1
AC092165 Genomic DNA Translation: AAY24104.1
BC035143 mRNA Translation: AAH35143.2
BC063500 mRNA Translation: AAH63500.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2495.1

NCBI Reference Sequences

More...
RefSeqi
NP_663748.1, NM_145702.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000408957; ENSP00000386186; ENSG00000221944

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
200765

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200765

UCSC genome browser

More...
UCSCi
uc002vsy.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056329 mRNA Translation: BAB71153.1
AC092165 Genomic DNA Translation: AAY24104.1
BC035143 mRNA Translation: AAH35143.2
BC063500 mRNA Translation: AAH63500.2
CCDSiCCDS2495.1
RefSeqiNP_663748.1, NM_145702.2

3D structure databases

SMRiQ96MW7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128345, 4 interactors
DIPiDIP-61581N
IntActiQ96MW7, 3 interactors
STRINGi9606.ENSP00000386186

PTM databases

iPTMnetiQ96MW7
PhosphoSitePlusiQ96MW7

Polymorphism and mutation databases

BioMutaiTIGD1
DMDMi74762678

Proteomic databases

EPDiQ96MW7
jPOSTiQ96MW7
MassIVEiQ96MW7
MaxQBiQ96MW7
PaxDbiQ96MW7
PeptideAtlasiQ96MW7
PRIDEiQ96MW7
ProteomicsDBi77425

Genome annotation databases

EnsembliENST00000408957; ENSP00000386186; ENSG00000221944
GeneIDi200765
KEGGihsa:200765
UCSCiuc002vsy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200765

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TIGD1
HGNCiHGNC:14523 TIGD1
HPAiHPA041717
MIMi612972 gene
neXtProtiNX_Q96MW7
OpenTargetsiENSG00000221944
PharmGKBiPA38382

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00940000155163
HOGENOMiHOG000154578
InParanoidiQ96MW7
OMAiMNTRMIR
OrthoDBi1343623at2759
PhylomeDBiQ96MW7
TreeFamiTF101131

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TIGD1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
200765
PharosiQ96MW7

Protein Ontology

More...
PROi
PR:Q96MW7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000221944 Expressed in 168 organ(s), highest expression level in neocortex
GenevisibleiQ96MW7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIGD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MW7
Secondary accession number(s): Q6P4D2, Q6PIF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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