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Protein

Tigger transposable element-derived protein 1

Gene

TIGD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 53H-T-H motifBy similarityAdd BLAST21
DNA bindingi103 – 142H-T-H motifBy similarityAdd BLAST40

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 1
Gene namesi
Name:TIGD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000221944.4
HGNCiHGNC:14523 TIGD1
MIMi612972 gene
neXtProtiNX_Q96MW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221944
PharmGKBiPA38382

Polymorphism and mutation databases

BioMutaiTIGD1
DMDMi74762678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002726151 – 591Tigger transposable element-derived protein 1Add BLAST591

Proteomic databases

EPDiQ96MW7
MaxQBiQ96MW7
PaxDbiQ96MW7
PeptideAtlasiQ96MW7
PRIDEiQ96MW7
ProteomicsDBi77425

PTM databases

iPTMnetiQ96MW7
PhosphoSitePlusiQ96MW7

Expressioni

Gene expression databases

BgeeiENSG00000221944 Expressed in 168 organ(s), highest expression level in neocortex
CleanExiHS_TIGD1
GenevisibleiQ96MW7 HS

Organism-specific databases

HPAiHPA041717

Interactioni

Protein-protein interaction databases

BioGridi128345, 4 interactors
DIPiDIP-61581N
IntActiQ96MW7, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96MW7
SMRiQ96MW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 57HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini70 – 149HTH CENPB-typePROSITE-ProRule annotationAdd BLAST80
Domaini178 – 403DDE-1Sequence analysisAdd BLAST226

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00760000119149
HOGENOMiHOG000154578
HOVERGENiHBG053836
InParanoidiQ96MW7
OMAiMNTRMIR
OrthoDBiEOG091G07CP
PhylomeDBiQ96MW7
TreeFamiTF101131

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q96MW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV
60 70 80 90 100
VNAKEKFLKE VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL
110 120 130 140 150
SQSLIQNKAL TLFNSMKAER GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA
160 170 180 190 200
QGEAASADVE AAASYPEALA KIIDEGGYTK QQIFNVDETA FYWKKMPSRT
210 220 230 240 250
FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH SENPRALKNY
260 270 280 290 300
TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL
310 320 330 340 350
IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT
360 370 380 390 400
FHKALAAMDS DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT
410 420 430 440 450
GVWKKLIPTL IDDYEGFKTS VEEVSADVVE IAKELELEVE PEDVTELLQS
460 470 480 490 500
HDKTLTDEEL FLMDAQRKWF LEMESTPGED AVNIVEMTTK DLEYYINLVD
510 520 530 540 550
KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ LMRKASPMSY
560 570 580 590
FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D
Length:591
Mass (Da):67,299
Last modified:December 1, 2001 - v1
Checksum:i920CA1F0CF2805C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249N → S in AAH35143 (PubMed:15489334).Curated1
Sequence conflicti302D → G in AAH35143 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056329 mRNA Translation: BAB71153.1
AC092165 Genomic DNA Translation: AAY24104.1
BC035143 mRNA Translation: AAH35143.2
BC063500 mRNA Translation: AAH63500.2
CCDSiCCDS2495.1
RefSeqiNP_663748.1, NM_145702.2
UniGeneiHs.211823

Genome annotation databases

EnsembliENST00000408957; ENSP00000386186; ENSG00000221944
GeneIDi200765
KEGGihsa:200765
UCSCiuc002vsy.3 human

Similar proteinsi

Entry informationi

Entry nameiTIGD1_HUMAN
AccessioniPrimary (citable) accession number: Q96MW7
Secondary accession number(s): Q6P4D2, Q6PIF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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