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Protein

Conserved oligomeric Golgi complex subunit 8

Gene

COG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
Gene namesi
Name:COG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000213380.13
HGNCiHGNC:18623 COG8
MIMi606979 gene
neXtProtiNX_Q96MW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2H (CDG2H)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:611182

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNETi84342
GeneReviewsiCOG8
MalaCardsiCOG8
MIMi611182 phenotype
OpenTargetsiENSG00000272617
Orphaneti95428 COG8-CDG
PharmGKBiPA38606

Polymorphism and mutation databases

BioMutaiCOG8
DMDMi215273958

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135211 – 612Conserved oligomeric Golgi complex subunit 8Add BLAST612

Proteomic databases

EPDiQ96MW5
MaxQBiQ96MW5
PaxDbiQ96MW5
PeptideAtlasiQ96MW5
PRIDEiQ96MW5
ProteomicsDBi77424

PTM databases

iPTMnetiQ96MW5
PhosphoSitePlusiQ96MW5

Expressioni

Gene expression databases

BgeeiENSG00000213380 Expressed in 199 organ(s), highest expression level in oocyte
CleanExiHS_COG8
ExpressionAtlasiQ96MW5 baseline and differential
GenevisibleiQ96MW5 HS

Organism-specific databases

HPAiHPA041406
HPA049429

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

Binary interactionsi

Protein-protein interaction databases

BioGridi124063, 24 interactors
CORUMiQ96MW5
IntActiQ96MW5, 20 interactors
MINTiQ96MW5
STRINGi9606.ENSP00000305459

Structurei

3D structure databases

ProteinModelPortaliQ96MW5
SMRiQ96MW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG8 family.Curated

Phylogenomic databases

eggNOGiKOG2069 Eukaryota
ENOG410XNZ7 LUCA
GeneTreeiENSGT00390000015893
HOVERGENiHBG028357
InParanoidiQ96MW5
KOiK20295
OMAiQRCIHGV
OrthoDBiEOG091G05VZ
PhylomeDBiQ96MW5
TreeFamiTF315000

Family and domain databases

InterProiView protein in InterPro
IPR007255 COG8
IPR016632 COG8_Metazoal_Plant
IPR016159 Cullin_repeat-like_dom_sf
PANTHERiPTHR21311 PTHR21311, 1 hit
PfamiView protein in Pfam
PF04124 Dor1, 1 hit
PIRSFiPIRSF015415 COG8, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96MW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAATIPSV ATATAAALGE VEDEGLLASL FRDRFPEAQW RERPDVGRYL
60 70 80 90 100
RELSGSGLER LRREPERLAE ERAQLLQQTR DLAFANYKTF IRGAECTERI
110 120 130 140 150
HRLFGDVEAS LGRLLDRLPS FQQSCRNFVK EAEEISSNRR MNSLTLNRHT
160 170 180 190 200
EILEILEIPQ LMDTCVRNSY YEEALELAAY VRRLERKYSS IPVIQGIVNE
210 220 230 240 250
VRQSMQLMLS QLIQQLRTNI QLPACLRVIG YLRRMDVFTE AELRVKFLQA
260 270 280 290 300
RDAWLRSILT AIPNDDPYFH ITKTIEASRV HLFDIITQYR AIFSDEDPLL
310 320 330 340 350
PPAMGEHTVN ESAIFHGWVL QKVSQFLQVL ETDLYRGIGG HLDSLLGQCM
360 370 380 390 400
YFGLSFSRVG ADFRGQLAPV FQRVAISTFQ KAIQETVEKF QEEMNSYMLI
410 420 430 440 450
SAPAILGTSN MPAAVPATQP GTLQPPMVLL DFPPLACFLN NILVAFNDLR
460 470 480 490 500
LCCPVALAQD VTGALEDALA KVTKIILAFH RAEEAAFSSG EQELFVQFCT
510 520 530 540 550
VFLEDLVPYL NRCLQVLFPP AQIAQTLGIP PTQLSKYGNL GHVNIGAIQE
560 570 580 590 600
PLAFILPKRE TLFTLDDQAL GPELTAPAPE PPAEEPRLEP AGPACPEGGR
610
AETQAEPPSV GP
Length:612
Mass (Da):68,424
Last modified:November 25, 2008 - v2
Checksum:i2780349A5B037E55
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQV3H3BQV3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
534Annotation score:
H3BSH5H3BSH5_HUMAN
Conserved oligomeric Golgi complex ...
COG8
223Annotation score:
A0A087X1T3A0A087X1T3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
121Annotation score:
J3QRV3J3QRV3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
99Annotation score:

Sequence cautioni

The sequence AAH17492 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15301 differs from that shown. Reason: Frameshift at position 371.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348Q → R in BAB71157 (PubMed:14702039).Curated1
Sequence conflicti399L → H in BAB15301 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047655517L → R. Corresponds to variant dbSNP:rs3027Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056344 mRNA Translation: BAB71157.1
AK025968 mRNA Translation: BAB15301.1 Frameshift.
CH471092 Genomic DNA Translation: EAW83266.1
BC017492 mRNA Translation: AAH17492.1 Different initiation.
BC121022 mRNA Translation: AAI21023.1
BC121023 mRNA Translation: AAI21024.1
CCDSiCCDS10876.1
RefSeqiNP_115758.3, NM_032382.4
UniGeneiHs.130849

Genome annotation databases

GeneIDi84342
KEGGihsa:84342
UCSCiuc002ewy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056344 mRNA Translation: BAB71157.1
AK025968 mRNA Translation: BAB15301.1 Frameshift.
CH471092 Genomic DNA Translation: EAW83266.1
BC017492 mRNA Translation: AAH17492.1 Different initiation.
BC121022 mRNA Translation: AAI21023.1
BC121023 mRNA Translation: AAI21024.1
CCDSiCCDS10876.1
RefSeqiNP_115758.3, NM_032382.4
UniGeneiHs.130849

3D structure databases

ProteinModelPortaliQ96MW5
SMRiQ96MW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124063, 24 interactors
CORUMiQ96MW5
IntActiQ96MW5, 20 interactors
MINTiQ96MW5
STRINGi9606.ENSP00000305459

PTM databases

iPTMnetiQ96MW5
PhosphoSitePlusiQ96MW5

Polymorphism and mutation databases

BioMutaiCOG8
DMDMi215273958

Proteomic databases

EPDiQ96MW5
MaxQBiQ96MW5
PaxDbiQ96MW5
PeptideAtlasiQ96MW5
PRIDEiQ96MW5
ProteomicsDBi77424

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84342
KEGGihsa:84342
UCSCiuc002ewy.3 human

Organism-specific databases

CTDi84342
DisGeNETi84342
EuPathDBiHostDB:ENSG00000213380.13
GeneCardsiCOG8
ENSG00000272617
GeneReviewsiCOG8
HGNCiHGNC:18623 COG8
HPAiHPA041406
HPA049429
MalaCardsiCOG8
MIMi606979 gene
611182 phenotype
neXtProtiNX_Q96MW5
OpenTargetsiENSG00000272617
Orphaneti95428 COG8-CDG
PharmGKBiPA38606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2069 Eukaryota
ENOG410XNZ7 LUCA
GeneTreeiENSGT00390000015893
HOVERGENiHBG028357
InParanoidiQ96MW5
KOiK20295
OMAiQRCIHGV
OrthoDBiEOG091G05VZ
PhylomeDBiQ96MW5
TreeFamiTF315000

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiCOG8 human
GeneWikiiCOG8
GenomeRNAii84342
PROiPR:Q96MW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213380 Expressed in 199 organ(s), highest expression level in oocyte
CleanExiHS_COG8
ExpressionAtlasiQ96MW5 baseline and differential
GenevisibleiQ96MW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007255 COG8
IPR016632 COG8_Metazoal_Plant
IPR016159 Cullin_repeat-like_dom_sf
PANTHERiPTHR21311 PTHR21311, 1 hit
PfamiView protein in Pfam
PF04124 Dor1, 1 hit
PIRSFiPIRSF015415 COG8, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOG8_HUMAN
AccessioniPrimary (citable) accession number: Q96MW5
Secondary accession number(s): Q0VAK2, Q8WVV6, Q9H6F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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