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Entry version 151 (16 Oct 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Conserved oligomeric Golgi complex subunit 8

Gene

COG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 8
Short name:
COG complex subunit 8
Alternative name(s):
Component of oligomeric Golgi complex 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18623 COG8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606979 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MW5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2H (CDG2H)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Related information in OMIM

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84342

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
COG8

MalaCards human disease database

More...
MalaCardsi
COG8
MIMi611182 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000213380

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
95428 COG8-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38606

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MW5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105880

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COG8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273958

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135211 – 612Conserved oligomeric Golgi complex subunit 8Add BLAST612

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96MW5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96MW5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96MW5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96MW5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MW5

PeptideAtlas

More...
PeptideAtlasi
Q96MW5

PRoteomics IDEntifications database

More...
PRIDEi
Q96MW5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77424

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MW5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213380 Expressed in 199 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96MW5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MW5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041406
HPA049429

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124063, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96MW5

Protein interaction database and analysis system

More...
IntActi
Q96MW5, 29 interactors

Molecular INTeraction database

More...
MINTi
Q96MW5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305459

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2069 Eukaryota
ENOG410XNZ7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015893

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MW5

KEGG Orthology (KO)

More...
KOi
K20295

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGEHTVN

Database of Orthologous Groups

More...
OrthoDBi
1531483at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MW5

TreeFam database of animal gene trees

More...
TreeFami
TF315000

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007255 COG8
IPR016632 COG8_Metazoal_Plant
IPR016159 Cullin_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21311 PTHR21311, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04124 Dor1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015415 COG8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74788 SSF74788, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96MW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAATIPSV ATATAAALGE VEDEGLLASL FRDRFPEAQW RERPDVGRYL
60 70 80 90 100
RELSGSGLER LRREPERLAE ERAQLLQQTR DLAFANYKTF IRGAECTERI
110 120 130 140 150
HRLFGDVEAS LGRLLDRLPS FQQSCRNFVK EAEEISSNRR MNSLTLNRHT
160 170 180 190 200
EILEILEIPQ LMDTCVRNSY YEEALELAAY VRRLERKYSS IPVIQGIVNE
210 220 230 240 250
VRQSMQLMLS QLIQQLRTNI QLPACLRVIG YLRRMDVFTE AELRVKFLQA
260 270 280 290 300
RDAWLRSILT AIPNDDPYFH ITKTIEASRV HLFDIITQYR AIFSDEDPLL
310 320 330 340 350
PPAMGEHTVN ESAIFHGWVL QKVSQFLQVL ETDLYRGIGG HLDSLLGQCM
360 370 380 390 400
YFGLSFSRVG ADFRGQLAPV FQRVAISTFQ KAIQETVEKF QEEMNSYMLI
410 420 430 440 450
SAPAILGTSN MPAAVPATQP GTLQPPMVLL DFPPLACFLN NILVAFNDLR
460 470 480 490 500
LCCPVALAQD VTGALEDALA KVTKIILAFH RAEEAAFSSG EQELFVQFCT
510 520 530 540 550
VFLEDLVPYL NRCLQVLFPP AQIAQTLGIP PTQLSKYGNL GHVNIGAIQE
560 570 580 590 600
PLAFILPKRE TLFTLDDQAL GPELTAPAPE PPAEEPRLEP AGPACPEGGR
610
AETQAEPPSV GP
Length:612
Mass (Da):68,424
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2780349A5B037E55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DYU2B4DYU2_HUMAN
Conserved oligomeric Golgi complex ...
COG8
639Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQV3H3BQV3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
534Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSH5H3BSH5_HUMAN
Conserved oligomeric Golgi complex ...
COG8
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1T3A0A087X1T3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRV3J3QRV3_HUMAN
Conserved oligomeric Golgi complex ...
COG8
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17492 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15301 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti348Q → R in BAB71157 (PubMed:14702039).Curated1
Sequence conflicti399L → H in BAB15301 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047655517L → R. Corresponds to variant dbSNP:rs3027Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056344 mRNA Translation: BAB71157.1
AK025968 mRNA Translation: BAB15301.1 Frameshift.
CH471092 Genomic DNA Translation: EAW83266.1
BC017492 mRNA Translation: AAH17492.1 Different initiation.
BC121022 mRNA Translation: AAI21023.1
BC121023 mRNA Translation: AAI21024.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10876.1

NCBI Reference Sequences

More...
RefSeqi
NP_115758.3, NM_032382.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000648169; ENSP00000497669; ENSG00000213380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84342

UCSC genome browser

More...
UCSCi
uc002ewy.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056344 mRNA Translation: BAB71157.1
AK025968 mRNA Translation: BAB15301.1 Frameshift.
CH471092 Genomic DNA Translation: EAW83266.1
BC017492 mRNA Translation: AAH17492.1 Different initiation.
BC121022 mRNA Translation: AAI21023.1
BC121023 mRNA Translation: AAI21024.1
CCDSiCCDS10876.1
RefSeqiNP_115758.3, NM_032382.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124063, 26 interactors
CORUMiQ96MW5
IntActiQ96MW5, 29 interactors
MINTiQ96MW5
STRINGi9606.ENSP00000305459

Chemistry databases

ChEMBLiCHEMBL4105880

PTM databases

iPTMnetiQ96MW5
PhosphoSitePlusiQ96MW5

Polymorphism and mutation databases

BioMutaiCOG8
DMDMi215273958

Proteomic databases

EPDiQ96MW5
jPOSTiQ96MW5
MassIVEiQ96MW5
MaxQBiQ96MW5
PaxDbiQ96MW5
PeptideAtlasiQ96MW5
PRIDEiQ96MW5
ProteomicsDBi77424

Genome annotation databases

EnsembliENST00000648169; ENSP00000497669; ENSG00000213380
GeneIDi84342
KEGGihsa:84342
UCSCiuc002ewy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84342
DisGeNETi84342

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COG8
GeneReviewsiCOG8
HGNCiHGNC:18623 COG8
HPAiHPA041406
HPA049429
MalaCardsiCOG8
MIMi606979 gene
611182 phenotype
neXtProtiNX_Q96MW5
OpenTargetsiENSG00000213380
Orphaneti95428 COG8-CDG
PharmGKBiPA38606

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2069 Eukaryota
ENOG410XNZ7 LUCA
GeneTreeiENSGT00390000015893
InParanoidiQ96MW5
KOiK20295
OMAiMGEHTVN
OrthoDBi1531483at2759
PhylomeDBiQ96MW5
TreeFamiTF315000

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COG8 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COG8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84342
PharosiQ96MW5

Protein Ontology

More...
PROi
PR:Q96MW5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213380 Expressed in 199 organ(s), highest expression level in oocyte
ExpressionAtlasiQ96MW5 baseline and differential
GenevisibleiQ96MW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007255 COG8
IPR016632 COG8_Metazoal_Plant
IPR016159 Cullin_repeat-like_dom_sf
PANTHERiPTHR21311 PTHR21311, 1 hit
PfamiView protein in Pfam
PF04124 Dor1, 1 hit
PIRSFiPIRSF015415 COG8, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MW5
Secondary accession number(s): Q0VAK2, Q8WVV6, Q9H6F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 25, 2008
Last modified: October 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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