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Entry version 146 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Palmitoyltransferase ZDHHC15

Gene

ZDHHC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (PubMed:19956733).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi131Zinc 1By similarity1
Metal bindingi134Zinc 1By similarity1
Metal bindingi144Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi148Zinc 2By similarity1
Metal bindingi151Zinc 1By similarity1
Metal bindingi158Zinc 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei159S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1
Metal bindingi165Zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96MV8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC15Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Acyltransferase ZDHHC15By similarity (EC:2.3.1.-By similarity)
Zinc finger DHHC domain-containing protein 15
Short name:
DHHC-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDHHC15Imported
ORF Names:UNQ1969/PRO4501
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000102383.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20342, ZDHHC15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300576, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MV8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicBy similarityAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalBy similarityAdd BLAST21
Topological domaini42 – 56LumenalBy similarityAdd BLAST15
Transmembranei57 – 77HelicalBy similarityAdd BLAST21
Topological domaini78 – 172CytoplasmicBy similarityAdd BLAST95
Transmembranei173 – 193HelicalBy similarityAdd BLAST21
Topological domaini194 – 210LumenalBy similarityAdd BLAST17
Transmembranei211 – 234HelicalBy similarityAdd BLAST24
Topological domaini235 – 337CytoplasmicBy similarityAdd BLAST103

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, X-linked 91 (MRX91)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
158866
MIMi300577, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102383

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134945089

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MV8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZDHHC15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999855

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128931 – 337Palmitoyltransferase ZDHHC15Add BLAST337

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autopalmitoylated (in vitro).By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MV8

PeptideAtlas

More...
PeptideAtlasi
Q96MV8

PRoteomics IDEntifications database

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PRIDEi
Q96MV8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77419 [Q96MV8-1]
77420 [Q96MV8-2]
77421 [Q96MV8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MV8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, liver, lung, kidney, heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102383, Expressed in vagina and 138 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96MV8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000102383, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96MV8
With#Exp.IntAct
ADCYAP1R1 - isoform N-HOP1 [P41586-2]3EBI-12837904,EBI-17241711
ARL13B [Q3SXY8]3EBI-12837904,EBI-11343438
BNIP3 [Q12983]3EBI-12837904,EBI-749464
C16orf58 [Q96GQ5]3EBI-12837904,EBI-8636004
C2CD2L [O14523]3EBI-12837904,EBI-12822627
CD79A [P11912]3EBI-12837904,EBI-7797864
CELA2B [P08218]3EBI-12837904,EBI-11478642
CERCAM [Q5T4B2]3EBI-12837904,EBI-12261896
CLEC10A [Q8IUN9]3EBI-12837904,EBI-2873246
CLRN1 [P58418]3EBI-12837904,EBI-17274839
CREB3L1 [Q96BA8]5EBI-12837904,EBI-6942903
CYB5R3 [P00387]3EBI-12837904,EBI-1046040
CYP4F2 [P78329]3EBI-12837904,EBI-1752413
DHRSX [Q8N5I4]3EBI-12837904,EBI-3923585
ERGIC3 [Q9Y282]3EBI-12837904,EBI-781551
FAM241B - isoform 2 [Q96D05-2]3EBI-12837904,EBI-12118888
GIMAP1 [Q8WWP7]3EBI-12837904,EBI-11991950
GOLGA7B [Q2TAP0]3EBI-12837904,EBI-13310443
GPR152 [Q8TDT2]3EBI-12837904,EBI-13345167
LEMD1 [Q68G75]3EBI-12837904,EBI-12268900
LEPROTL1 [O95214]3EBI-12837904,EBI-750776
LHFPL5 [Q8TAF8]3EBI-12837904,EBI-2820517
LSMEM1 [Q8N8F7]3EBI-12837904,EBI-10200825
MCEMP1 [Q8IX19]3EBI-12837904,EBI-2816356
MTIF3 [Q9H2K0]3EBI-12837904,EBI-3923617
NRAC [Q8N912]3EBI-12837904,EBI-12051377
ORMDL1 [Q9P0S3]3EBI-12837904,EBI-1054848
ORMDL2 [Q53FV1]3EBI-12837904,EBI-11075081
PEX16 [Q9Y5Y5]3EBI-12837904,EBI-981985
PLLP [Q9Y342]3EBI-12837904,EBI-3919291
PRAF2 [O60831]3EBI-12837904,EBI-2506064
PVR [P15151]3EBI-12837904,EBI-3919694
SFXN3 [A0A1P0AYU5]3EBI-12837904,EBI-14193895
SLC10A6 [Q3KNW5]3EBI-12837904,EBI-18159983
SMIM1 [B2RUZ4]3EBI-12837904,EBI-12188413
SNORC [Q6UX34]3EBI-12837904,EBI-11957067
STX3 [Q13277]3EBI-12837904,EBI-1394295
TBXA2R [Q0VAB0]3EBI-12837904,EBI-18271435
TMEFF2 [Q9UIK5]3EBI-12837904,EBI-11423693
TMEM120A [Q9BXJ8]3EBI-12837904,EBI-727322
TMEM120B [A0PK00]3EBI-12837904,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-12837904,EBI-10694905
TMEM14C [Q9P0S9]3EBI-12837904,EBI-2339195
TMEM222 [Q9H0R3]3EBI-12837904,EBI-347385
TMEM42 [Q69YG0]3EBI-12837904,EBI-12038591
TMEM52B [Q4KMG9]3EBI-12837904,EBI-18178701
TNFRSF10B [O14763]6EBI-12837904,EBI-518882
TSNARE1 [A0AVG3]3EBI-12837904,EBI-12003468
TUFM [A0A384ME17]3EBI-12837904,EBI-12261790
UBE2J1 [Q9Y385]3EBI-12837904,EBI-988826
VAMP5 [O95183]3EBI-12837904,EBI-10191195
VAPB [O95292]3EBI-12837904,EBI-1188298
YIPF4 [Q9BSR8]3EBI-12837904,EBI-751253

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
127719, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96MV8, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362465

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96MV8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96MV8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 179DHHCPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1315, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_027721_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96MV8

KEGG Orthology (KO)

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KOi
K20028

Identification of Orthologs from Complete Genome Data

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OMAi
NGPAKFH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MV8

TreeFam database of animal gene trees

More...
TreeFami
TF316044

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001594, Palmitoyltrfase_DHHC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01529, DHHC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50216, DHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96MV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRGWKMALS GGLRCCRRVL SWVPVLVIVL VVLWSYYAYV FELCLVTVLS
60 70 80 90 100
PAEKVIYLIL YHAIFVFFTW TYWKSIFTLP QQPNQKFHLS YTDKERYENE
110 120 130 140 150
ERPEVQKQML VDMAKKLPVY TRTGSGAVRF CDRCHLIKPD RCHHCSVCAM
160 170 180 190 200
CVLKMDHHCP WVNNCIGFSN YKFFLQFLAY SVLYCLYIAT TVFSYFIKYW
210 220 230 240 250
RGELPSVRSK FHVLFLLFVA CMFFVSLVIL FGYHCWLVSR NKTTLEAFCT
260 270 280 290 300
PVFTSGPEKN GFNLGFIKNI QQVFGDKKKF WLIPIGSSPG DGHSFPMRSM
310 320 330
NESQNPLLAN EETWEDNEDD NQDYPEGSSS LAVETET
Length:337
Mass (Da):39,331
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D7F920921E5D124
GO
Isoform 2 (identifier: Q96MV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.
     127-152: AVRFCDRCHLIKPDRCHHCSVCAMCV → GQFIQRQLERQLSKYLRKAKSYMFSN
     153-337: Missing.

Show »
Length:143
Mass (Da):17,255
Checksum:i3B7A9A07E0690619
GO
Isoform 3 (identifier: Q96MV8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-54: Missing.

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Length:328
Mass (Da):38,406
Checksum:iAA13351DA5587183
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01320646 – 54Missing in isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_013207127 – 152AVRFC…CAMCV → GQFIQRQLERQLSKYLRKAK SYMFSN in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_013208153 – 337Missing in isoform 2. 1 PublicationAdd BLAST185

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY358786 mRNA Translation: AAQ89146.1
AK056374 mRNA Translation: BAB71168.1
AK122885 mRNA Translation: BAG53779.1
AC020717 Genomic DNA No translation available.
AL137013 Genomic DNA No translation available.
AL391055 Genomic DNA No translation available.
BC103980 mRNA Translation: AAI03981.1
BC103981 mRNA Translation: AAI03982.1
BC103982 mRNA Translation: AAI03983.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14430.1 [Q96MV8-1]
CCDS55454.1 [Q96MV8-3]

NCBI Reference Sequences

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RefSeqi
NP_001139728.1, NM_001146256.1 [Q96MV8-3]
NP_001139729.1, NM_001146257.1 [Q96MV8-2]
NP_659406.1, NM_144969.2 [Q96MV8-1]
XP_006724687.1, XM_006724624.3 [Q96MV8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373367; ENSP00000362465; ENSG00000102383 [Q96MV8-1]
ENST00000541184; ENSP00000445420; ENSG00000102383 [Q96MV8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
158866

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:158866

UCSC genome browser

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UCSCi
uc004ecg.4, human [Q96MV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358786 mRNA Translation: AAQ89146.1
AK056374 mRNA Translation: BAB71168.1
AK122885 mRNA Translation: BAG53779.1
AC020717 Genomic DNA No translation available.
AL137013 Genomic DNA No translation available.
AL391055 Genomic DNA No translation available.
BC103980 mRNA Translation: AAI03981.1
BC103981 mRNA Translation: AAI03982.1
BC103982 mRNA Translation: AAI03983.1
CCDSiCCDS14430.1 [Q96MV8-1]
CCDS55454.1 [Q96MV8-3]
RefSeqiNP_001139728.1, NM_001146256.1 [Q96MV8-3]
NP_001139729.1, NM_001146257.1 [Q96MV8-2]
NP_659406.1, NM_144969.2 [Q96MV8-1]
XP_006724687.1, XM_006724624.3 [Q96MV8-1]

3D structure databases

SMRiQ96MV8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127719, 1 interactor
IntActiQ96MV8, 53 interactors
STRINGi9606.ENSP00000362465

PTM databases

iPTMnetiQ96MV8
PhosphoSitePlusiQ96MV8

Polymorphism and mutation databases

BioMutaiZDHHC15
DMDMi37999855

Proteomic databases

PaxDbiQ96MV8
PeptideAtlasiQ96MV8
PRIDEiQ96MV8
ProteomicsDBi77419 [Q96MV8-1]
77420 [Q96MV8-2]
77421 [Q96MV8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13846, 86 antibodies

Genome annotation databases

EnsembliENST00000373367; ENSP00000362465; ENSG00000102383 [Q96MV8-1]
ENST00000541184; ENSP00000445420; ENSG00000102383 [Q96MV8-3]
GeneIDi158866
KEGGihsa:158866
UCSCiuc004ecg.4, human [Q96MV8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
158866
DisGeNETi158866
EuPathDBiHostDB:ENSG00000102383.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZDHHC15
HGNCiHGNC:20342, ZDHHC15
HPAiENSG00000102383, Low tissue specificity
MIMi300576, gene
300577, phenotype
neXtProtiNX_Q96MV8
OpenTargetsiENSG00000102383
PharmGKBiPA134945089

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1315, Eukaryota
GeneTreeiENSGT00940000158214
HOGENOMiCLU_027721_1_1_1
InParanoidiQ96MV8
KOiK20028
OMAiNGPAKFH
PhylomeDBiQ96MV8
TreeFamiTF316044

Enzyme and pathway databases

PathwayCommonsiQ96MV8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
158866, 3 hits in 503 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZDHHC15, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
158866
PharosiQ96MV8, Tdark

Protein Ontology

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PROi
PR:Q96MV8
RNActiQ96MV8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102383, Expressed in vagina and 138 other tissues
GenevisibleiQ96MV8, HS

Family and domain databases

InterProiView protein in InterPro
IPR001594, Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529, DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216, DHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDH15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MV8
Secondary accession number(s): B3KVG7, Q3SY30, Q6UWH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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