UniProtKB - Q96MV1 (TLCD4_HUMAN)
Protein
TLC domain-containing protein 4
Gene
TLCD4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- lipid homeostasis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96MV1 |
Names & Taxonomyi
Protein namesi | Recommended name: TLC domain-containing protein 4CuratedAlternative name(s): Transmembrane protein 56 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26477, TLCD4 |
neXtProti | NX_Q96MV1 |
VEuPathDBi | HostDB:ENSG00000152078.9 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 148534 |
OpenTargetsi | ENSG00000152078 |
PharmGKBi | PA142670772 |
Miscellaneous databases
Pharosi | Q96MV1, Tdark |
Genetic variation databases
BioMutai | TMEM56 |
DMDMi | 74732443 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286701 | 1 – 263 | TLC domain-containing protein 4Add BLAST | 263 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 165 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | Q96MV1 |
MassIVEi | Q96MV1 |
MaxQBi | Q96MV1 |
PaxDbi | Q96MV1 |
PeptideAtlasi | Q96MV1 |
PRIDEi | Q96MV1 |
ProteomicsDBi | 77418 |
PTM databases
CarbonylDBi | Q96MV1 |
iPTMneti | Q96MV1 |
PhosphoSitePlusi | Q96MV1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152078, Expressed in pigmented layer of retina and 196 other tissues |
ExpressionAtlasi | Q96MV1, baseline and differential |
Genevisiblei | Q96MV1, HS |
Organism-specific databases
HPAi | ENSG00000152078, Tissue enhanced (liver) |
Interactioni
Binary interactionsi
Q96MV1
Protein-protein interaction databases
BioGRIDi | 127154, 90 interactors |
IntActi | Q96MV1, 82 interactors |
STRINGi | 9606.ENSP00000359222 |
Miscellaneous databases
RNActi | Q96MV1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 246 | TLCPROSITE-ProRule annotationAdd BLAST | 203 |
Sequence similaritiesi
Belongs to the TLCD4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4561, Eukaryota |
GeneTreei | ENSGT01010000222313 |
HOGENOMi | CLU_034597_2_0_1 |
InParanoidi | Q96MV1 |
OMAi | AVMPVYY |
OrthoDBi | 1354968at2759 |
PhylomeDBi | Q96MV1 |
TreeFami | TF324847 |
Family and domain databases
InterProi | View protein in InterPro IPR006634, TLC-dom |
Pfami | View protein in Pfam PF03798, TRAM_LAG1_CLN8, 1 hit |
SMARTi | View protein in SMART SM00724, TLC, 1 hit |
PROSITEi | View protein in PROSITE PS50922, TLC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q96MV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN
60 70 80 90 100
SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI
110 120 130 140 150
SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL
160 170 180 190 200
SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY
210 220 230 240 250
SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ
260
EKAKNSLQNG KLD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J6J2 | C9J6J2_HUMAN | TLC domain-containing protein 4 | TLCD4 | 143 | Annotation score: | ||
C9JJM2 | C9JJM2_HUMAN | TLC domain-containing protein 4 | TLCD4 | 154 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056404 mRNA Translation: BAB71177.1 CH471097 Genomic DNA Translation: EAW73024.1 CH471097 Genomic DNA Translation: EAW73025.1 BC137457 mRNA Translation: AAI37458.1 BC137458 mRNA Translation: AAI37459.1 BC139737 mRNA Translation: AAI39738.1 |
CCDSi | CCDS753.1 |
RefSeqi | NP_001186608.1, NM_001199679.1 NP_689700.1, NM_152487.2 |
Genome annotation databases
Ensembli | ENST00000370203; ENSP00000359222; ENSG00000152078 |
GeneIDi | 148534 |
KEGGi | hsa:148534 |
UCSCi | uc001drb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056404 mRNA Translation: BAB71177.1 CH471097 Genomic DNA Translation: EAW73024.1 CH471097 Genomic DNA Translation: EAW73025.1 BC137457 mRNA Translation: AAI37458.1 BC137458 mRNA Translation: AAI37459.1 BC139737 mRNA Translation: AAI39738.1 |
CCDSi | CCDS753.1 |
RefSeqi | NP_001186608.1, NM_001199679.1 NP_689700.1, NM_152487.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127154, 90 interactors |
IntActi | Q96MV1, 82 interactors |
STRINGi | 9606.ENSP00000359222 |
PTM databases
CarbonylDBi | Q96MV1 |
iPTMneti | Q96MV1 |
PhosphoSitePlusi | Q96MV1 |
Genetic variation databases
BioMutai | TMEM56 |
DMDMi | 74732443 |
Proteomic databases
jPOSTi | Q96MV1 |
MassIVEi | Q96MV1 |
MaxQBi | Q96MV1 |
PaxDbi | Q96MV1 |
PeptideAtlasi | Q96MV1 |
PRIDEi | Q96MV1 |
ProteomicsDBi | 77418 |
Protocols and materials databases
Antibodypediai | 71812, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000370203; ENSP00000359222; ENSG00000152078 |
GeneIDi | 148534 |
KEGGi | hsa:148534 |
UCSCi | uc001drb.4, human |
Organism-specific databases
CTDi | 148534 |
DisGeNETi | 148534 |
GeneCardsi | TLCD4 |
HGNCi | HGNC:26477, TLCD4 |
HPAi | ENSG00000152078, Tissue enhanced (liver) |
neXtProti | NX_Q96MV1 |
OpenTargetsi | ENSG00000152078 |
PharmGKBi | PA142670772 |
VEuPathDBi | HostDB:ENSG00000152078.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4561, Eukaryota |
GeneTreei | ENSGT01010000222313 |
HOGENOMi | CLU_034597_2_0_1 |
InParanoidi | Q96MV1 |
OMAi | AVMPVYY |
OrthoDBi | 1354968at2759 |
PhylomeDBi | Q96MV1 |
TreeFami | TF324847 |
Enzyme and pathway databases
PathwayCommonsi | Q96MV1 |
Miscellaneous databases
BioGRID-ORCSi | 148534, 4 hits in 986 CRISPR screens |
GenomeRNAii | 148534 |
Pharosi | Q96MV1, Tdark |
PROi | PR:Q96MV1 |
RNActi | Q96MV1, protein |
Gene expression databases
Bgeei | ENSG00000152078, Expressed in pigmented layer of retina and 196 other tissues |
ExpressionAtlasi | Q96MV1, baseline and differential |
Genevisiblei | Q96MV1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006634, TLC-dom |
Pfami | View protein in Pfam PF03798, TRAM_LAG1_CLN8, 1 hit |
SMARTi | View protein in SMART SM00724, TLC, 1 hit |
PROSITEi | View protein in PROSITE PS50922, TLC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TLCD4_HUMAN | |
Accessioni | Q96MV1Primary (citable) accession number: Q96MV1 Secondary accession number(s): B2RPI2, D3DT48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families