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Protein

Transmembrane protein 56

Gene

TMEM56

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 56
Gene namesi
Name:TMEM56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000152078.9
HGNCiHGNC:26477 TMEM56
neXtProtiNX_Q96MV1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi148534
OpenTargetsiENSG00000152078
PharmGKBiPA142670772

Polymorphism and mutation databases

BioMutaiTMEM56
DMDMi74732443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867011 – 263Transmembrane protein 56Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96MV1
PaxDbiQ96MV1
PeptideAtlasiQ96MV1
PRIDEiQ96MV1
ProteomicsDBi77418

PTM databases

CarbonylDBiQ96MV1
iPTMnetiQ96MV1
PhosphoSitePlusiQ96MV1

Expressioni

Gene expression databases

BgeeiENSG00000152078 Expressed in 176 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_TMEM56
ExpressionAtlasiQ96MV1 baseline and differential
GenevisibleiQ96MV1 HS

Organism-specific databases

HPAiHPA046762

Interactioni

Protein-protein interaction databases

BioGridi127154, 14 interactors
IntActiQ96MV1, 59 interactors
STRINGi9606.ENSP00000359222

Structurei

3D structure databases

ProteinModelPortaliQ96MV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 246TLCPROSITE-ProRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the TMEM56 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4561 Eukaryota
ENOG410XPW0 LUCA
GeneTreeiENSGT00510000047701
HOGENOMiHOG000007105
HOVERGENiHBG100306
InParanoidiQ96MV1
OMAiDKFFVIH
OrthoDBiEOG091G0RUV
PhylomeDBiQ96MV1
TreeFamiTF324847

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
PfamiView protein in Pfam
PF03798 TRAM_LAG1_CLN8, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q96MV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN
60 70 80 90 100
SRVVSTCHSL VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI
110 120 130 140 150
SDLSIIILYW KVIGDKFFIM HHCASLYAYY LVLKNGVLAY IGNFRLLAEL
160 170 180 190 200
SSPFVNQRWF FEALKYPKFS KAIVINGILM TVVFFIVRIA SMLPHYGFMY
210 220 230 240 250
SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG CIKVISHIRQ
260
EKAKNSLQNG KLD
Length:263
Mass (Da):30,041
Last modified:December 1, 2001 - v1
Checksum:i51480330FACC8ABF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6J2C9J6J2_HUMAN
Transmembrane protein 56
TMEM56
143Annotation score:
C9JJM2C9JJM2_HUMAN
Transmembrane protein 56
TMEM56
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056404 mRNA Translation: BAB71177.1
CH471097 Genomic DNA Translation: EAW73024.1
CH471097 Genomic DNA Translation: EAW73025.1
BC137457 mRNA Translation: AAI37458.1
BC137458 mRNA Translation: AAI37459.1
BC139737 mRNA Translation: AAI39738.1
CCDSiCCDS753.1
RefSeqiNP_001186608.1, NM_001199679.1
NP_689700.1, NM_152487.2
UniGeneiHs.483512

Genome annotation databases

EnsembliENST00000370203; ENSP00000359222; ENSG00000152078
GeneIDi148534
KEGGihsa:148534
UCSCiuc001drb.4 human

Similar proteinsi

Entry informationi

Entry nameiTMM56_HUMAN
AccessioniPrimary (citable) accession number: Q96MV1
Secondary accession number(s): B2RPI2, D3DT48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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