YTHDC1

Functionⁱ

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244).

M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451).

Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937).

Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).

In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).

May also regulate alternative splice site selection (PubMed:20167602).

Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).

Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).

Also recognizes and binds m6A on other RNA molecules (PubMed:27602518).

Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518).

Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306).

Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).

By similarity7 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	428	N6-methyladenosine residue in RNA1 Publication		1
Binding siteⁱ	476	N6-methyladenosine residue in RNACombined sources1 Publication		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

PathwayCommonsⁱ	Q96MU7
SignaLinkⁱ	Q96MU7
SIGNORⁱ	Q96MU7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: YTH domain-containing protein 1Curated Alternative name(s): Splicing factor YT5211 Publication Short name: YT521-B1 Publication
Gene namesⁱ	Name:YTHDC1Imported Synonyms:KIAA19661 Publication, YT5211 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30626, YTHDC1
neXtProtⁱ	NX_Q96MU7
VEuPathDBⁱ	HostDB:ENSG00000083896

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	361	K → L: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	362	S → A: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	367	N → D: Abolished binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	377	W → A: Abolishes binding to N6-methyladenosine (m6A)-containing RNAs. Abolishes binding to m6A-containing mRNAs; when associated with A-428. 2 Publications	1
Mutagenesisⁱ	377	W → D: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	380	L → T: Reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	387	L → E: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	399	L → E: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	401	F → D: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	402	S → A: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	409	F → D: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	411	G → I: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	428	W → A: Abolishes binding to N6-methyladenosine (m6A)-containing RNAs. Abolishes binding to m6A-containing mRNAs; when associated with A-377. 2 Publications	1
Mutagenesisⁱ	428	W → D: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	438	M → A: Reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication	1
Mutagenesisⁱ	447	W → D: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	466	N → D: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	475	R → A: Reduced binding affinity for N6-methyladenosine (m6A)-containing RNAs by 100-fold. 1 Publication	1
Mutagenesisⁱ	475	R → D: Does not affect ability to influence alternative splice site selection. 1 Publication	1
Mutagenesisⁱ	475	R → F: Reduced binding affinity for N6-methyladenosine (m6A)-containing RNAs by 9-fold. 1 Publication	1
Mutagenesisⁱ	476	D → K: Does not affect ability to influence alternative splice site selection. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	91746
Open Targets More...OpenTargetsⁱ	ENSG00000083896
PharmGKBⁱ	PA143485673

Miscellaneous databases

Pharosⁱ	Q96MU7, Tbio

Pharosⁱ

Q96MU7, Tbio

Genetic variation databases

BioMutaⁱ	YTHDC1
DMDMⁱ	47606762

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000223076	1 – 727	YTH domain-containing protein 1Add BLAST		727

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	35	PhosphoserineBy similarity	1
Cross-linkⁱ	96	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	118	PhosphoserineCombined sources	1
Modified residueⁱ	120	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphothreonineCombined sources	1
Modified residueⁱ	308	PhosphoserineCombined sources	1
Modified residueⁱ	315	PhosphoserineCombined sources	1
Modified residueⁱ	317	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1
Modified residueⁱ	424	PhosphoserineCombined sources	1
Modified residueⁱ	435	PhosphoserineCombined sources	1
Modified residueⁱ	545	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Tyrosine phosphorylated.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96MU7
jPOSTⁱ	Q96MU7
MassIVEⁱ	Q96MU7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96MU7
PaxDbⁱ	Q96MU7
PeptideAtlas More...PeptideAtlasⁱ	Q96MU7
PRIDEⁱ	Q96MU7
ProteomicsDBⁱ	77413 [Q96MU7-1] 77414 [Q96MU7-2]

PTM databases

GlyGenⁱ	Q96MU7, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q96MU7
PhosphoSitePlusⁱ	Q96MU7
SwissPalmⁱ	Q96MU7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000083896, Expressed in female gonad and 253 other tissues
ExpressionAtlasⁱ	Q96MU7, baseline and differential
Genevisibleⁱ	Q96MU7, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000083896, Low tissue specificity

HPAⁱ

ENSG00000083896, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with SRSF1 (By similarity).

Interacts with SRSF2 (By similarity).

Interacts with SRSF3 (PubMed:26876937, PubMed:28984244).

Interacts with SRSF7 (By similarity).

Interacts with SRSF10 (PubMed:26876937).

Interacts with CPSF6 (By similarity).

Interacts with KHDRBS1/SAM68 (By similarity).

Interacts with TRA2B (By similarity).

Interacts with KHDRBS3 (By similarity).

Interacts with EMD (PubMed:12755701).

Interacts with RBMX (PubMed:19282290).

Interacts with ZCCHC8 (PubMed:28984244).

By similarity4 Publications

Binary interactionsⁱ

Hide details

Q96MU7

With	#Exp.	IntAct
ANKRD28 [O15084]	3	EBI-2849854,EBI-359567
CLK2 [P49760]	6	EBI-2849854,EBI-750020
DVL3 [Q92997]	6	EBI-2849854,EBI-739789
HNRNPK [P61978]	4	EBI-2849854,EBI-304185
HNRNPK - isoform 2 [P61978-2]	3	EBI-2849854,EBI-7060731
KHDRBS2 [Q5VWX1]	6	EBI-2849854,EBI-742808
KHDRBS3 [O75525]	6	EBI-2849854,EBI-722504
KRTAP10-6 [P60371]	3	EBI-2849854,EBI-12012928
PHF19 [Q5T6S3]	3	EBI-2849854,EBI-2339674
PICK1 [Q9NRD5]	3	EBI-2849854,EBI-79165
RBMY1A1 - isoform 2 [P0DJD3-2]	3	EBI-2849854,EBI-11994018
RBMY1J [Q15415]	6	EBI-2849854,EBI-8642021
RNPS1 [Q15287]	3	EBI-2849854,EBI-395959
SDCBP2 [Q9H190]	7	EBI-2849854,EBI-742426
SRPK1 [Q96SB4]	3	EBI-2849854,EBI-539478
SRPK2 [P78362]	4	EBI-2849854,EBI-593303
TRA2B [P62995]	4	EBI-2849854,EBI-725485

Protein-protein interaction databases

BioGRIDⁱ	124871, 178 interactors
IntActⁱ	Q96MU7, 64 interactors
Molecular INTeraction database More...MINTⁱ	Q96MU7
STRINGⁱ	9606.ENSP00000339245

Miscellaneous databases

RNActⁱ	Q96MU7, protein

RNActⁱ

Q96MU7, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	346 – 352	Combined sources	7
Beta strandⁱ	356 – 363	Combined sources	8
Helixⁱ	365 – 374	Combined sources	10
Beta strandⁱ	376 – 378	Combined sources	3
Helixⁱ	381 – 393	Combined sources	13
Beta strandⁱ	397 – 403	Combined sources	7
Beta strandⁱ	406 – 409	Combined sources	4
Beta strandⁱ	411 – 415	Combined sources	5
Beta strandⁱ	420 – 424	Combined sources	5
Beta strandⁱ	432 – 434	Combined sources	3
Helixⁱ	436 – 438	Combined sources	3
Beta strandⁱ	442 – 449	Combined sources	8
Helixⁱ	455 – 458	Combined sources	4
Helixⁱ	464 – 466	Combined sources	3
Beta strandⁱ	467 – 469	Combined sources	3
Beta strandⁱ	478 – 480	Combined sources	3
Helixⁱ	482 – 491	Combined sources	10
Beta strandⁱ	496 – 498	Combined sources	3
Helixⁱ	501 – 506	Combined sources	6

Show more details

3D structure databases

AlphaFoldDBⁱ	Q96MU7
BMRBⁱ	Q96MU7
SMRⁱ	Q96MU7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96MU7

EvolutionaryTraceⁱ

Q96MU7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	355 – 492	YTHPROSITE-ProRule annotationAdd BLAST		138

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 338	DisorderedSequence analysisAdd BLAST	338
Regionⁱ	361 – 363	N6-methyladenosine residue in RNA bindingCombined sources1 Publication	3
Regionⁱ	377 – 378	N6-methyladenosine residue in RNA bindingCombined sources2 Publications	2
Regionⁱ	508 – 564	DisorderedSequence analysisAdd BLAST	57
Regionⁱ	607 – 643	DisorderedSequence analysisAdd BLAST	37
Regionⁱ	669 – 727	DisorderedSequence analysisAdd BLAST	59

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1 – 16	Basic and acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	33 – 63	Basic and acidic residuesSequence analysisAdd BLAST	31
Compositional biasⁱ	64 – 91	Polar residuesSequence analysisAdd BLAST	28
Compositional biasⁱ	92 – 120	Basic and acidic residuesSequence analysisAdd BLAST	29
Compositional biasⁱ	129 – 180	Basic and acidic residuesSequence analysisAdd BLAST	52
Compositional biasⁱ	181 – 195	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	196 – 256	Acidic residuesSequence analysisAdd BLAST	61
Compositional biasⁱ	271 – 290	Polar residuesSequence analysisAdd BLAST	20
Compositional biasⁱ	291 – 308	Basic and acidic residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	324 – 338	Basic and acidic residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	520 – 564	Basic and acidic residuesSequence analysisAdd BLAST	45
Compositional biasⁱ	607 – 637	Pro residuesSequence analysisAdd BLAST	31
Compositional biasⁱ	673 – 727	Basic and acidic residuesSequence analysisAdd BLAST	55

Domainⁱ

The YTH domain mediates RNA-binding.1 Publication

Phylogenomic databases

eggNOGⁱ	KOG1902, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155803
InParanoidⁱ	Q96MU7
OMAⁱ	CHTSTVY
Database of Orthologous Groups More...OrthoDBⁱ	1523119at2759
PhylomeDBⁱ	Q96MU7
TreeFamⁱ	TF325590

Family and domain databases

InterProⁱ	View protein in InterPro IPR007275, YTH_domain IPR045168, YTH_prot
PANTHERⁱ	PTHR12357, PTHR12357, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04146, YTH, 2 hits
PROSITEⁱ	View protein in PROSITE PS50882, YTH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96MU7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSD 
        60         70         80         90        100
RMESTDTKRQ KPSVHSRQLV SKPLSSSVSN NKRIVSTKGK SATEYKNEEY 
       110        120        130        140        150
QRSERNKRLD ADRKIRLSSS ASREPYKNQP EKTCVRKRDP ERRAKSPTPD 
       160        170        180        190        200
GSERIGLEVD RRASRSSQSS KEEVNSEEYG SDHETGSSGS SDEQGNNTEN 
       210        220        230        240        250
EEEGVEEDVE EDEEVEEDAE EDEEVDEDGE EEEEEEEEEE EEEEEEEEEY 
       260        270        280        290        300
EQDERDQKEE GNDYDTRSEA SDSGSESVSF TDGSVRSGSG TDGSDEKKKE 
       310        320        330        340        350
RKRARGISPI VFDRSGSSAS ESYAGSEKKH EKLSSSVRAV RKDQTSKLKY 
       360        370        380        390        400
VLQDARFFLI KSNNHENVSL AKAKGVWSTL PVNEKKLNLA FRSARSVILI 
       410        420        430        440        450
FSVRESGKFQ GFARLSSESH HGGSPIHWVL PAGMSAKMLG GVFKIDWICR 
       460        470        480        490        500
RELPFTKSAH LTNPWNEHKP VKIGRDGQEI ELECGTQLCL LFPPDESIDL 
       510        520        530        540        550
YQVIHKMRHK RRMHSQPRSR GRPSRREPVR DVGRRRPEDY DIHNSRKKPR 
       560        570        580        590        600
IDYPPEFHQR PGYLKDPRYQ EVDRRFSGVR RDVFLNGSYN DYVREFHNMG 
       610        620        630        640        650
PPPPWQGMPP YPGMEQPPHH PYYQHHAPPP QAHPPYSGHH PVPHEARYRD 
       660        670        680        690        700
KRVHDYDMRV DDFLRRTQAV VSGRRSRPRE RDRERERDRP RDNRRDRERD 
       710        720 
RGRDRERERE RLCDRDRDRG ERGRYRR

Length:727

Mass (Da):84,700

Last modified:May 24, 2004 - v3

Checksum:ⁱ536032FD44582EAF

GO

Isoform 2 (identifier: Q96MU7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
325-342: Missing.

« Hide

        10         20         30         40         50
MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSD 
        60         70         80         90        100
RMESTDTKRQ KPSVHSRQLV SKPLSSSVSN NKRIVSTKGK SATEYKNEEY 
       110        120        130        140        150
QRSERNKRLD ADRKIRLSSS ASREPYKNQP EKTCVRKRDP ERRAKSPTPD 
       160        170        180        190        200
GSERIGLEVD RRASRSSQSS KEEVNSEEYG SDHETGSSGS SDEQGNNTEN 
       210        220        230        240        250
EEEGVEEDVE EDEEVEEDAE EDEEVDEDGE EEEEEEEEEE EEEEEEEEEY 
       260        270        280        290        300
EQDERDQKEE GNDYDTRSEA SDSGSESVSF TDGSVRSGSG TDGSDEKKKE 
       310        320        330        340        350
RKRARGISPI VFDRSGSSAS ESYADQTSKL KYVLQDARFF LIKSNNHENV 
       360        370        380        390        400
SLAKAKGVWS TLPVNEKKLN LAFRSARSVI LIFSVRESGK FQGFARLSSE 
       410        420        430        440        450
SHHGGSPIHW VLPAGMSAKM LGGVFKIDWI CRRELPFTKS AHLTNPWNEH 
       460        470        480        490        500
KPVKIGRDGQ EIELECGTQL CLLFPPDESI DLYQVIHKMR HKRRMHSQPR 
       510        520        530        540        550
SRGRPSRREP VRDVGRRRPE DYDIHNSRKK PRIDYPPEFH QRPGYLKDPR 
       560        570        580        590        600
YQEVDRRFSG VRRDVFLNGS YNDYVREFHN MGPPPPWQGM PPYPGMEQPP 
       610        620        630        640        650
HHPYYQHHAP PPQAHPPYSG HHPVPHEARY RDKRVHDYDM RVDDFLRRTQ 
       660        670        680        690        700
AVVSGRRSRP RERDRERERD RPRDNRRDRE RDRGRDRERE RERLCDRDRD 

RGERGRYRR

Show »

Length:709

Mass (Da):82,692

Checksum:ⁱC02121B27DDEFF0E

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QR07	J3QR07_HUMAN	YTH domain-containing protein 1 YTH domain-containing protein 1	YTHDC1	735	Annotation score:
J3KS01	J3KS01_HUMAN	YTH domain-containing protein 1 YTH domain-containing protein 1	YTHDC1	37	Annotation score:
J3KRG5	J3KRG5_HUMAN	YTH domain-containing protein 1 YTH domain-containing protein 1	YTHDC1	93	Annotation score:
J3KRW0	J3KRW0_HUMAN	YTH domain-containing protein 1 YTH domain-containing protein 1	YTHDC1	12	Annotation score:

Sequence cautionⁱ

The sequence AAY41024 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence BAB71181 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	619	H → Q in BAB71181 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053746	183	H → R. Corresponds to variant dbSNP:rs3813832Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006818	325 – 342	Missing in isoform 2. 2 PublicationsAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056430 mRNA Translation: BAB71181.1 Different initiation. AC074378 Genomic DNA Translation: AAY41024.1 Sequence problems. BC041119 mRNA Translation: AAH41119.1 BC053863 mRNA Translation: AAH53863.1 AB075846 mRNA Translation: BAB85552.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33992.1 [Q96MU7-1] CCDS3522.2 [Q96MU7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001026902.1, NM_001031732.3 [Q96MU7-1] NP_001317627.1, NM_001330698.1 NP_588611.2, NM_133370.3 [Q96MU7-2]

Genome annotation databases

Ensemblⁱ	ENST00000344157.9; ENSP00000339245.4; ENSG00000083896.13 ENST00000355665.7; ENSP00000347888.3; ENSG00000083896.13 [Q96MU7-2] ENST00000613637.3; ENSP00000484604.1; ENSG00000275272.4 [Q96MU7-2] ENST00000615500.4; ENSP00000479213.1; ENSG00000275272.4
GeneIDⁱ	91746
KEGGⁱ	hsa:91746
MANE-Selectⁱ	ENST00000344157.9; ENSP00000339245.4; NM_001031732.4; NP_001026902.1
UCSC genome browser More...UCSCⁱ	uc003hdx.4, human [Q96MU7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96MU7	YTH domain-containing protein 1	)	RAT		738	UniRef50_Q96MU7
YTH domain-containing protein 1		MOUSE		736
YTH domain-containing protein 1 isoform X1		NEOAA		737
YTH domain containing 1		HORSE		781
YTH domain-containing protein 1		MICOH		584
+540
Q96MU7-2	YTH domain-containing protein 1 isoform X4		HIPAR		708	UniRef50_Q96MU7-2
YTH domain containing 1		CEBIM		708
YTH domain-containing protein 1 isoform X5		Enhydra lutris kenyoni		712
YTH domain containing 1		GORGO		710
YTH domain-containing protein 1 isoform X4		SAPAP		710
+233

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056430 mRNA Translation: BAB71181.1 Different initiation. AC074378 Genomic DNA Translation: AAY41024.1 Sequence problems. BC041119 mRNA Translation: AAH41119.1 BC053863 mRNA Translation: AAH53863.1 AB075846 mRNA Translation: BAB85552.1
CCDSⁱ	CCDS33992.1 [Q96MU7-1] CCDS3522.2 [Q96MU7-2]
RefSeqⁱ	NP_001026902.1, NM_001031732.3 [Q96MU7-1] NP_001317627.1, NM_001330698.1 NP_588611.2, NM_133370.3 [Q96MU7-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YUD	NMR	-	A	337-509	[»]
	4R3H	X-ray	1.90	A/B	345-509	[»]
	4R3I	X-ray	1.80	A	345-509	[»]
	6RT4	X-ray	1.49	A/B	345-509	[»]
	6RT5	X-ray	2.30	B/C	345-509	[»]
	6RT6	X-ray	1.46	B/C	345-509	[»]
	6RT7	X-ray	1.73	B/C	345-509	[»]
	6SYZ	X-ray	2.28	A/B	345-509	[»]
	6SZ1	X-ray	1.75	A/B	345-509	[»]
	6SZ2	X-ray	1.52	A/B	345-509	[»]
	6SZ3	X-ray	1.28	A/B	345-509	[»]
	6SZL	X-ray	1.45	A/B	345-509	[»]
	6SZN	X-ray	1.47	A/B	345-509	[»]
	6SZR	X-ray	1.64	A/B	345-509	[»]
	6SZT	X-ray	1.50	A/B	345-509	[»]
	6SZX	X-ray	1.17	A/B	345-509	[»]
	6SZY	X-ray	1.79	A/B	345-509	[»]
	6T01	X-ray	1.50	A/B	345-509	[»]
	6T02	X-ray	1.10	A/B	345-509	[»]
	6T03	X-ray	1.50	A/B	345-509	[»]
	6T04	X-ray	1.50	A/B	345-509	[»]
	6T05	X-ray	1.50	A/B	345-509	[»]
	6T06	X-ray	2.40	A/B	345-509	[»]
	6T07	X-ray	1.50	A/B	345-509	[»]
	6T08	X-ray	1.41	A/B	345-509	[»]
	6T09	X-ray	1.75	A/B	345-509	[»]
	6T0A	X-ray	2.02	A/B	345-509	[»]
	6T0C	X-ray	2.03	A/B	345-509	[»]
	6T0D	X-ray	1.43	A/B	345-509	[»]
	6T0O	X-ray	1.71	A/B	345-509	[»]
	6T0X	X-ray	1.36	A/B	345-509	[»]
	6T0Z	X-ray	1.43	A/B	345-509	[»]
	6T10	X-ray	1.48	A/B	345-509	[»]
	6T11	X-ray	1.49	A/B	345-509	[»]
	6T12	X-ray	1.46	A/B	345-509	[»]
	6WE8	X-ray	1.18	A/B	345-509	[»]
	6WE9	X-ray	1.59	A/C	345-509	[»]
	6WEA	X-ray	1.80	A/B/C/D	345-509	[»]
	6YKE	X-ray	1.52	A/B	345-509	[»]
	6YKI	X-ray	1.30	A/B	345-509	[»]
	6YKJ	X-ray	1.60	A/B	345-509	[»]
	6YKZ	X-ray	1.20	A/B	345-509	[»]
	6YL0	X-ray	1.20	A/B	345-509	[»]
	6YL8	X-ray	1.50	A/B	345-509	[»]
	6YL9	X-ray	1.50	A/B	345-509	[»]
	6YM2	X-ray	1.70	A/B	345-509	[»]
	6YM6	X-ray	1.20	A/B	345-509	[»]
	6YM7	X-ray	1.30	A/B	345-509	[»]
	6YM8	X-ray	1.50	A/B	345-509	[»]
	6YNI	X-ray	1.36	A/B	345-509	[»]
	6YNJ	X-ray	1.50	A/B	345-509	[»]
	6YNK	X-ray	1.30	A/B	345-509	[»]
	6YNL	X-ray	1.50	A/B	345-509	[»]
	6YNM	X-ray	1.50	A/B	345-509	[»]
	6YNN	X-ray	1.20	A/B	345-509	[»]
	6YNO	X-ray	1.40	A/B	345-509	[»]
	6YNP	X-ray	1.10	A/B	345-509	[»]
	6YOQ	X-ray	1.30	A/B	345-509	[»]
	6ZCM	X-ray	1.24	A/B	345-509	[»]
	6ZCN	X-ray	1.60	A/B	345-509	[»]
	6ZD9	X-ray	1.51	A/B	345-509	[»]
	7L4X	X-ray	1.79	B	345-509	[»]
	7L4Y	X-ray	1.79	B	345-509	[»]
7P87	X-ray	1.30	A/B	345-509	[»]
7P88	X-ray	1.50	A/B	345-509	[»]
7P8A	X-ray	1.70	A/B	345-509	[»]
7P8B	X-ray	1.20	A/B	345-509	[»]
7P8F	X-ray	1.50	A/B	345-509	[»]
7PJ7	X-ray	1.41	A/B	345-509	[»]
7PJ8	X-ray	1.40	A/B	345-509	[»]
7PJ9	X-ray	1.72	A/B	345-509	[»]
7PJA	X-ray	1.85	A/B	345-509	[»]
7PJB	X-ray	1.90	A/B	345-509	[»]
7PJP	X-ray	1.61	A/B	345-509	[»]
7PJQ	X-ray	1.20	A/B	345-509	[»]
AlphaFoldDBⁱ	Q96MU7
BMRBⁱ	Q96MU7
SMRⁱ	Q96MU7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	124871, 178 interactors
IntActⁱ	Q96MU7, 64 interactors
MINTⁱ	Q96MU7
STRINGⁱ	9606.ENSP00000339245

PTM databases

GlyGenⁱ	Q96MU7, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q96MU7
PhosphoSitePlusⁱ	Q96MU7
SwissPalmⁱ	Q96MU7

Genetic variation databases

BioMutaⁱ	YTHDC1
DMDMⁱ	47606762

Proteomic databases

EPDⁱ	Q96MU7
jPOSTⁱ	Q96MU7
MassIVEⁱ	Q96MU7
MaxQBⁱ	Q96MU7
PaxDbⁱ	Q96MU7
PeptideAtlasⁱ	Q96MU7
PRIDEⁱ	Q96MU7
ProteomicsDBⁱ	77413 [Q96MU7-1] 77414 [Q96MU7-2]

Protocols and materials databases

Antibodypediaⁱ	52214, 95 antibodies from 23 providers
The DNASU plasmid repository More...DNASUⁱ	91746

Genome annotation databases

Ensemblⁱ	ENST00000344157.9; ENSP00000339245.4; ENSG00000083896.13 ENST00000355665.7; ENSP00000347888.3; ENSG00000083896.13 [Q96MU7-2] ENST00000613637.3; ENSP00000484604.1; ENSG00000275272.4 [Q96MU7-2] ENST00000615500.4; ENSP00000479213.1; ENSG00000275272.4
GeneIDⁱ	91746
KEGGⁱ	hsa:91746
MANE-Selectⁱ	ENST00000344157.9; ENSP00000339245.4; NM_001031732.4; NP_001026902.1
UCSCⁱ	uc003hdx.4, human [Q96MU7-1]

Organism-specific databases

CTDⁱ	91746
DisGeNETⁱ	91746
GeneCardsⁱ	YTHDC1
HGNCⁱ	HGNC:30626, YTHDC1
HPAⁱ	ENSG00000083896, Low tissue specificity
neXtProtⁱ	NX_Q96MU7
OpenTargetsⁱ	ENSG00000083896
PharmGKBⁱ	PA143485673
VEuPathDBⁱ	HostDB:ENSG00000083896
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1902, Eukaryota
GeneTreeⁱ	ENSGT00940000155803
InParanoidⁱ	Q96MU7
OMAⁱ	CHTSTVY
OrthoDBⁱ	1523119at2759
PhylomeDBⁱ	Q96MU7
TreeFamⁱ	TF325590

Enzyme and pathway databases

PathwayCommonsⁱ	Q96MU7
SignaLinkⁱ	Q96MU7
SIGNORⁱ	Q96MU7

Miscellaneous databases

BioGRID-ORCSⁱ	91746, 448 hits in 1082 CRISPR screens
ChiTaRSⁱ	YTHDC1, human
EvolutionaryTraceⁱ	Q96MU7
GeneWikiⁱ	YTHDC1
GenomeRNAiⁱ	91746
Pharosⁱ	Q96MU7, Tbio
Protein Ontology More...PROⁱ	PR:Q96MU7
RNActⁱ	Q96MU7, protein

Gene expression databases

Bgeeⁱ	ENSG00000083896, Expressed in female gonad and 253 other tissues
ExpressionAtlasⁱ	Q96MU7, baseline and differential
Genevisibleⁱ	Q96MU7, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007275, YTH_domain IPR045168, YTH_prot
PANTHERⁱ	PTHR12357, PTHR12357, 1 hit
Pfamⁱ	View protein in Pfam PF04146, YTH, 2 hits
PROSITEⁱ	View protein in PROSITE PS50882, YTH, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YTDC1_HUMAN
Accessionⁱ	Q96MU7Primary (citable) accession number: Q96MU7 Secondary accession number(s): Q4W5Q3, Q7Z622, Q8TF35
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
	Last sequence update:	May 24, 2004
	Last modified:	May 25, 2022
	This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96MU7 (YTDC1_HUMAN)

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YTH domain-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

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Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96MU7

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ