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UniProtKB - Q96MU7 (YTDC1_HUMAN)

Entry version 172 (07 Apr 2021)
Sequence version 3 (24 May 2004)
Previous versions | rss
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Protein

YTH domain-containing protein 1

Gene

YTHDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).By similarity7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei428N6-methyladenosine1 Publication1
Binding sitei476N6-methyladenosineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96MU7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96MU7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96MU7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YTH domain-containing protein 1Curated
Alternative name(s):
Splicing factor YT5211 Publication
Short name:
YT521-B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YTHDC1Imported
Synonyms:KIAA19661 Publication, YT5211 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30626, YTHDC1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96MU7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000083896.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi361K → L: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi362S → A: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi367N → D: Abolished binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication1
Mutagenesisi377W → A: Abolishes binding to N6-methyladenosine (m6A)-containing RNAs. Abolishes binding to m6A-containing mRNAs; when associated with A-428. 2 Publications1
Mutagenesisi377W → D: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi380L → T: Reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication1
Mutagenesisi387L → E: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi399L → E: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi401F → D: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi402S → A: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi409F → D: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi411G → I: Abolishes RNA-binding and ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi428W → A: Abolishes binding to N6-methyladenosine (m6A)-containing RNAs. Abolishes binding to m6A-containing mRNAs; when associated with A-377. 2 Publications1
Mutagenesisi428W → D: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi438M → A: Reduced binding to N6-methyladenosine (m6A)-containing RNAs. 1 Publication1
Mutagenesisi447W → D: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi466N → D: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi475R → A: Reduced binding affinity for N6-methyladenosine (m6A)-containing RNAs by 100-fold. 1 Publication1
Mutagenesisi475R → D: Does not affect ability to influence alternative splice site selection. 1 Publication1
Mutagenesisi475R → F: Reduced binding affinity for N6-methyladenosine (m6A)-containing RNAs by 9-fold. 1 Publication1
Mutagenesisi476D → K: Does not affect ability to influence alternative splice site selection. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		91746

Open Targets

More...OpenTargetsi		ENSG00000083896

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485673

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96MU7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YTHDC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		47606762

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002230761 – 727YTH domain-containing protein 1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96MU7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96MU7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96MU7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96MU7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96MU7

PeptideAtlas

More...PeptideAtlasi		Q96MU7

PRoteomics IDEntifications database

More...PRIDEi		Q96MU7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77413 [Q96MU7-1]
77414 [Q96MU7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96MU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96MU7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96MU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000083896, Expressed in female gonad and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96MU7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96MU7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000083896, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SRSF1 (By similarity).

Interacts with SRSF2 (By similarity).

Interacts with SRSF3 (PubMed:26876937, PubMed:28984244).

Interacts with SRSF7 (By similarity).

Interacts with SRSF10 (PubMed:26876937).

Interacts with CPSF6 (By similarity).

Interacts with KHDRBS1/SAM68 (By similarity).

Interacts with TRA2B (By similarity).

Interacts with KHDRBS3 (By similarity).

Interacts with EMD (PubMed:12755701).

Interacts with RBMX (PubMed:19282290).

Interacts with ZCCHC8 (PubMed:28984244).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124871, 132 interactors

Protein interaction database and analysis system

More...IntActi		Q96MU7, 63 interactors

Molecular INTeraction database

More...MINTi		Q96MU7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339245

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96MU7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q96MU7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96MU7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96MU7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini355 – 492YTHPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni361 – 363N6-methyladenosine bindingCombined sources1 Publication3
Regioni377 – 378N6-methyladenosine bindingCombined sources2 Publications2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi172 – 260Glu-richAdd BLAST89
Compositional biasi508 – 581Arg-richAdd BLAST74
Compositional biasi601 – 643Pro-richAdd BLAST43
Compositional biasi647 – 727Arg-richAdd BLAST81

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The YTH domain mediates RNA-binding.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1902, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155803

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96MU7

Database of Orthologous Groups

More...OrthoDBi		1523119at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96MU7

TreeFam database of animal gene trees

More...TreeFami		TF325590

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007275, YTH_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04146, YTH, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50882, YTH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96MU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSD 
        60         70         80         90        100
RMESTDTKRQ KPSVHSRQLV SKPLSSSVSN NKRIVSTKGK SATEYKNEEY 
       110        120        130        140        150
QRSERNKRLD ADRKIRLSSS ASREPYKNQP EKTCVRKRDP ERRAKSPTPD 
       160        170        180        190        200
GSERIGLEVD RRASRSSQSS KEEVNSEEYG SDHETGSSGS SDEQGNNTEN 
       210        220        230        240        250
EEEGVEEDVE EDEEVEEDAE EDEEVDEDGE EEEEEEEEEE EEEEEEEEEY 
       260        270        280        290        300
EQDERDQKEE GNDYDTRSEA SDSGSESVSF TDGSVRSGSG TDGSDEKKKE 
       310        320        330        340        350
RKRARGISPI VFDRSGSSAS ESYAGSEKKH EKLSSSVRAV RKDQTSKLKY 
       360        370        380        390        400
VLQDARFFLI KSNNHENVSL AKAKGVWSTL PVNEKKLNLA FRSARSVILI 
       410        420        430        440        450
FSVRESGKFQ GFARLSSESH HGGSPIHWVL PAGMSAKMLG GVFKIDWICR 
       460        470        480        490        500
RELPFTKSAH LTNPWNEHKP VKIGRDGQEI ELECGTQLCL LFPPDESIDL 
       510        520        530        540        550
YQVIHKMRHK RRMHSQPRSR GRPSRREPVR DVGRRRPEDY DIHNSRKKPR 
       560        570        580        590        600
IDYPPEFHQR PGYLKDPRYQ EVDRRFSGVR RDVFLNGSYN DYVREFHNMG 
       610        620        630        640        650
PPPPWQGMPP YPGMEQPPHH PYYQHHAPPP QAHPPYSGHH PVPHEARYRD 
       660        670        680        690        700
KRVHDYDMRV DDFLRRTQAV VSGRRSRPRE RDRERERDRP RDNRRDRERD 
       710        720 
RGRDRERERE RLCDRDRDRG ERGRYRR
Length:727
Mass (Da):84,700
Last modified:May 24, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i536032FD44582EAF
GO
Isoform 2 (identifier: Q96MU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-342: Missing.

Show »
Length:709
Mass (Da):82,692
Checksum:iC02121B27DDEFF0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR07J3QR07_HUMAN
YTH domain-containing protein 1
YTHDC1
735Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRG5J3KRG5_HUMAN
YTH domain-containing protein 1
YTHDC1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS01J3KS01_HUMAN
YTH domain-containing protein 1
YTHDC1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRW0J3KRW0_HUMAN
YTH domain-containing protein 1
YTHDC1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY41024 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB71181 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti619H → Q in BAB71181 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053746183H → R. Corresponds to variant dbSNP:rs3813832Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006818325 – 342Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056430 mRNA Translation: BAB71181.1 Different initiation.
AC074378 Genomic DNA Translation: AAY41024.1 Sequence problems.
BC041119 mRNA Translation: AAH41119.1
BC053863 mRNA Translation: AAH53863.1
AB075846 mRNA Translation: BAB85552.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33992.1 [Q96MU7-1]
CCDS3522.2 [Q96MU7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001026902.1, NM_001031732.3 [Q96MU7-1]
NP_001317627.1, NM_001330698.1
NP_588611.2, NM_133370.3 [Q96MU7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344157; ENSP00000339245; ENSG00000083896 [Q96MU7-1]
ENST00000355665; ENSP00000347888; ENSG00000083896 [Q96MU7-2]
ENST00000613637; ENSP00000484604; ENSG00000275272 [Q96MU7-2]
ENST00000615500; ENSP00000479213; ENSG00000275272 [Q96MU7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		91746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:91746

UCSC genome browser

More...UCSCi		uc003hdx.4, human [Q96MU7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056430 mRNA Translation: BAB71181.1 Different initiation.
AC074378 Genomic DNA Translation: AAY41024.1 Sequence problems.
BC041119 mRNA Translation: AAH41119.1
BC053863 mRNA Translation: AAH53863.1
AB075846 mRNA Translation: BAB85552.1
CCDSiCCDS33992.1 [Q96MU7-1]
CCDS3522.2 [Q96MU7-2]
RefSeqiNP_001026902.1, NM_001031732.3 [Q96MU7-1]
NP_001317627.1, NM_001330698.1
NP_588611.2, NM_133370.3 [Q96MU7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUDNMR-A337-509[»]
4R3HX-ray1.90A/B345-509[»]
4R3IX-ray1.80A345-509[»]
6RT4X-ray1.49A/B345-509[»]
6RT5X-ray2.30B/C345-509[»]
6RT6X-ray1.46B/C345-509[»]
6RT7X-ray1.73B/C345-509[»]
6SYZX-ray2.28A/B345-509[»]
6SZ1X-ray1.75A/B345-509[»]
6SZ2X-ray1.52A/B345-509[»]
6SZ3X-ray1.28A/B345-509[»]
6SZLX-ray1.45A/B345-509[»]
6SZNX-ray1.47A/B345-509[»]
6SZRX-ray1.64A/B345-509[»]
6SZTX-ray1.50A/B345-509[»]
6SZXX-ray1.17A/B345-509[»]
6SZYX-ray1.79A/B345-509[»]
6T01X-ray1.50A/B345-509[»]
6T02X-ray1.10A/B345-509[»]
6T03X-ray1.50A/B345-509[»]
6T04X-ray1.50A/B345-509[»]
6T05X-ray1.50A/B345-509[»]
6T06X-ray2.40A/B345-509[»]
6T07X-ray1.50A/B345-509[»]
6T08X-ray1.41A/B345-509[»]
6T09X-ray1.75A/B345-509[»]
6T0AX-ray2.02A/B345-509[»]
6T0CX-ray2.03A/B345-509[»]
6T0DX-ray1.43A/B345-509[»]
6T0OX-ray1.71A/B345-509[»]
6T0XX-ray1.36A/B345-509[»]
6T0ZX-ray1.43A/B345-509[»]
6T10X-ray1.48A/B345-509[»]
6T11X-ray1.49A/B345-509[»]
6T12X-ray1.46A/B345-509[»]
6WE8X-ray1.18A/B345-509[»]
6WE9X-ray1.59A/C345-509[»]
6WEAX-ray1.80A/B/C/D345-509[»]
6YKEX-ray1.52A/B345-509[»]
6YKIX-ray1.30A/B345-509[»]
6YKJX-ray1.60A/B345-509[»]
6YKZX-ray1.20A/B345-509[»]
6YL0X-ray1.20A/B345-509[»]
6YL8X-ray1.50A/B345-509[»]
6YL9X-ray1.50A/B345-509[»]
6YNIX-ray1.36A/B345-509[»]
6YNJX-ray1.50A/B345-509[»]
6YNKX-ray1.30A/B345-509[»]
6YNLX-ray1.50A/B345-509[»]
6YNMX-ray1.50A/B345-509[»]
6YNNX-ray1.20A/B345-509[»]
6YNOX-ray1.40A/B345-509[»]
6YNPX-ray1.10A/B345-509[»]
6YOQX-ray1.30A/B345-509[»]
6ZCMX-ray1.24A/B345-509[»]
6ZCNX-ray1.60A/B345-509[»]
6ZD9X-ray1.51A/B345-509[»]
BMRBiQ96MU7
SMRiQ96MU7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124871, 132 interactors
IntActiQ96MU7, 63 interactors
MINTiQ96MU7
STRINGi9606.ENSP00000339245

PTM databases

iPTMnetiQ96MU7
PhosphoSitePlusiQ96MU7
SwissPalmiQ96MU7

Genetic variation databases

BioMutaiYTHDC1
DMDMi47606762

Proteomic databases

EPDiQ96MU7
jPOSTiQ96MU7
MassIVEiQ96MU7
MaxQBiQ96MU7
PaxDbiQ96MU7
PeptideAtlasiQ96MU7
PRIDEiQ96MU7
ProteomicsDBi77413 [Q96MU7-1]
77414 [Q96MU7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52214, 88 antibodies

Genome annotation databases

EnsembliENST00000344157; ENSP00000339245; ENSG00000083896 [Q96MU7-1]
ENST00000355665; ENSP00000347888; ENSG00000083896 [Q96MU7-2]
ENST00000613637; ENSP00000484604; ENSG00000275272 [Q96MU7-2]
ENST00000615500; ENSP00000479213; ENSG00000275272 [Q96MU7-1]
GeneIDi91746
KEGGihsa:91746
UCSCiuc003hdx.4, human [Q96MU7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		91746
DisGeNETi91746

GeneCards: human genes, protein and diseases

More...GeneCardsi		YTHDC1
HGNCiHGNC:30626, YTHDC1
HPAiENSG00000083896, Low tissue specificity
neXtProtiNX_Q96MU7
OpenTargetsiENSG00000083896
PharmGKBiPA143485673
VEuPathDBiHostDB:ENSG00000083896.12

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1902, Eukaryota
GeneTreeiENSGT00940000155803
InParanoidiQ96MU7
OrthoDBi1523119at2759
PhylomeDBiQ96MU7
TreeFamiTF325590

Enzyme and pathway databases

PathwayCommonsiQ96MU7
SignaLinkiQ96MU7
SIGNORiQ96MU7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		91746, 441 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YTHDC1, human
EvolutionaryTraceiQ96MU7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YTHDC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		91746
PharosiQ96MU7, Tbio

Protein Ontology

More...PROi		PR:Q96MU7
RNActiQ96MU7, protein

Gene expression databases

BgeeiENSG00000083896, Expressed in female gonad and 252 other tissues
ExpressionAtlasiQ96MU7, baseline and differential
GenevisibleiQ96MU7, HS

Family and domain databases

InterProiView protein in InterPro
IPR007275, YTH_domain
PfamiView protein in Pfam
PF04146, YTH, 2 hits
PROSITEiView protein in PROSITE
PS50882, YTH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYTDC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MU7
Secondary accession number(s): Q4W5Q3, Q7Z622, Q8TF35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 24, 2004
Last modified: April 7, 2021
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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