Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (11 Dec 2019)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger protein 778

Gene

ZNF778

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri115 – 140C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri253 – 275C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 331C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 778
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF778
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170100.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26479 ZNF778

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
197320

Open Targets

More...
OpenTargetsi
ENSG00000170100

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410400

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MU6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF778

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373490

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002631091 – 729Zinc finger protein 778Add BLAST729

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96MU6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96MU6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96MU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MU6

PeptideAtlas

More...
PeptideAtlasi
Q96MU6

PRoteomics IDEntifications database

More...
PRIDEi
Q96MU6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77411 [Q96MU6-1]
77412 [Q96MU6-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96MU6-1 [Q96MU6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MU6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96MU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170100 Expressed in 159 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96MU6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MU6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052057
HPA057151

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P604093EBI-10291463,EBI-10172290

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128247, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96MU6, 4 interactors

Molecular INTeraction database

More...
MINTi
Q96MU6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405289

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96MU6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96MU6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 110KRABPROSITE-ProRule annotationAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri115 – 140C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri253 – 275C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri309 – 331C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MU6

KEGG Orthology (KO)

More...
KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MU6

TreeFam database of animal gene trees

More...
TreeFami
TF342172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96MU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPDLAHGG HVSRDSVCLH EEQTQAAGMV AGWLINCYQD AVTFDDVAVD
60 70 80 90 100
FTQEEWTLLD PSQRDLYRDV MLENYENLAS VEWRLKTKGP ALRQDRSWFR
110 120 130 140 150
ASNETQTARS HNGGQLCDRT QCGEAFSEHS GLSTHVRTQN TGDSCVSNHY
160 170 180 190 200
ERDFFIPCQK TLFKIGEQFS VLGQCGKAFS STPNVVSQQA CTRDRSLDYS
210 220 230 240 250
SCGEVFLNQS YLQARAGSHN GEETWKWKPC GKALTHSMGC ATPVEMHAVR
260 270 280 290 300
NPHVCRECGK AFRYTAYLTG RVQVHPGEKP CELEECGKAS PVSSSLTQHV
310 320 330 340 350
RIHAAEKPCE CKECGKAFTG LSGLSKHVQT DPGQKPYECK DCGKACGGFY
360 370 380 390 400
LLNEHGKTHT REKPFACVVC GKYFRNSSCL NNHVRIHTGI KPYTCSYCGK
410 420 430 440 450
AFTVRCGLTR HVRTHTGEKP YTCKDCGKAF CTSSGLTEHV RTHTGEKPYE
460 470 480 490 500
CKDCGKSFTV SSSLTEHARI HTGEKPYECK QCGKAFTGRS GLTKHMRTHT
510 520 530 540 550
GEKPYECKDC GKAYNRVYLL NEHVKTHTEE KPFICTVCRK SFRNSSCLNK
560 570 580 590 600
HIQIHTGIKP YECKDCGKTF TVSSSLTEHI RTHTGEKPYE CKVCGKAFTT
610 620 630 640 650
SSHLIVHIRT HTGEKPYICK ECGKAFASSS HLIEHRRTHT GEKPYICNEC
660 670 680 690 700
GKAFRASSHL HKHGRIHTGQ KPYKCKECGK AYNRFYLLKE HLKTYTEEQV
710 720
FVCKDCGKSF KNSSCLNHHT QIHTDEKPF
Length:729
Mass (Da):81,964
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86E9F02F0A19FC68
GO
Isoform 2 (identifier: Q96MU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     81-81: V → VGHHLFQPSVIYWLEQEEELRAGRRAVLQ

Show »
Length:687
Mass (Da):77,517
Checksum:i916FBCB1EB56AF1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSW5A0A0A0MSW5_HUMAN
Zinc finger protein 778
ZNF778
757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUU4H3BUU4_HUMAN
Zinc finger protein 778
ZNF778
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSD4H3BSD4_HUMAN
Zinc finger protein 778
ZNF778
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71183 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164K → T in BAB71183 (PubMed:14702039).Curated1
Sequence conflicti393Y → H in BAB71183 (PubMed:14702039).Curated1
Sequence conflicti534I → T in BAB71183 (PubMed:14702039).Curated1
Sequence conflicti553Q → H in BAB71183 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061966683N → D. Corresponds to variant dbSNP:rs55974122Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0403381 – 70Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04033981V → VGHHLFQPSVIYWLEQEEEL RAGRRAVLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056437 mRNA Translation: BAB71183.1 Frameshift.
AC009113 Genomic DNA No translation available.
BC125192 mRNA Translation: AAI25193.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45550.1 [Q96MU6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_872337.2, NM_182531.3 [Q96MU6-1]
XP_016878504.1, XM_017023015.1 [Q96MU6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306502; ENSP00000305203; ENSG00000170100 [Q96MU6-2]
ENST00000620195; ENSP00000481538; ENSG00000170100 [Q96MU6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
197320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:197320

UCSC genome browser

More...
UCSCi
uc002fmv.4 human [Q96MU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056437 mRNA Translation: BAB71183.1 Frameshift.
AC009113 Genomic DNA No translation available.
BC125192 mRNA Translation: AAI25193.3
CCDSiCCDS45550.1 [Q96MU6-1]
RefSeqiNP_872337.2, NM_182531.3 [Q96MU6-1]
XP_016878504.1, XM_017023015.1 [Q96MU6-2]

3D structure databases

SMRiQ96MU6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128247, 3 interactors
IntActiQ96MU6, 4 interactors
MINTiQ96MU6
STRINGi9606.ENSP00000405289

PTM databases

iPTMnetiQ96MU6
PhosphoSitePlusiQ96MU6
SwissPalmiQ96MU6

Polymorphism and mutation databases

BioMutaiZNF778
DMDMi317373490

Proteomic databases

jPOSTiQ96MU6
MassIVEiQ96MU6
MaxQBiQ96MU6
PaxDbiQ96MU6
PeptideAtlasiQ96MU6
PRIDEiQ96MU6
ProteomicsDBi77411 [Q96MU6-1]
77412 [Q96MU6-2]
TopDownProteomicsiQ96MU6-1 [Q96MU6-1]

Genome annotation databases

EnsembliENST00000306502; ENSP00000305203; ENSG00000170100 [Q96MU6-2]
ENST00000620195; ENSP00000481538; ENSG00000170100 [Q96MU6-1]
GeneIDi197320
KEGGihsa:197320
UCSCiuc002fmv.4 human [Q96MU6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
197320
DisGeNETi197320
EuPathDBiHostDB:ENSG00000170100.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF778
HGNCiHGNC:26479 ZNF778
HPAiHPA052057
HPA057151
neXtProtiNX_Q96MU6
OpenTargetsiENSG00000170100
PharmGKBiPA162410400

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162638
HOGENOMiHOG000234617
InParanoidiQ96MU6
KOiK09228
OrthoDBi1318335at2759
PhylomeDBiQ96MU6
TreeFamiTF342172

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF778 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
197320
PharosiQ96MU6 Tdark

Protein Ontology

More...
PROi
PR:Q96MU6
RNActiQ96MU6 protein

Gene expression databases

BgeeiENSG00000170100 Expressed in 159 organ(s), highest expression level in testis
ExpressionAtlasiQ96MU6 baseline and differential
GenevisibleiQ96MU6 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN778_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MU6
Secondary accession number(s): Q08AG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again