ID   CFA44_HUMAN             Reviewed;        1854 AA.
AC   Q96MT7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 2.
DT   24-JAN-2024, entry version 172.
DE   RecName: Full=Cilia- and flagella-associated protein 44 {ECO:0000312|HGNC:HGNC:25631};
DE   AltName: Full=WD repeat-containing protein 52 {ECO:0000312|HGNC:HGNC:25631};
GN   Name=CFAP44 {ECO:0000312|HGNC:HGNC:25631};
GN   Synonyms=WDR52 {ECO:0000312|HGNC:HGNC:25631};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1083, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [6]
RP   INVOLVEMENT IN SPGF20.
RX   PubMed=28552195; DOI=10.1016/j.ajhg.2017.04.012;
RA   Tang S., Wang X., Li W., Yang X., Li Z., Liu W., Li C., Zhu Z., Wang L.,
RA   Wang J., Zhang L., Sun X., Zhi E., Wang H., Li H., Jin L., Luo Y., Wang J.,
RA   Yang S., Zhang F.;
RT   "Biallelic mutations in CFAP43 and CFAP44 cause male infertility with
RT   multiple morphological abnormalities of the sperm flagella.";
RL   Am. J. Hum. Genet. 100:854-864(2017).
RN   [7]
RP   INVOLVEMENT IN SPGF20, TISSUE SPECIFICITY, AND VARIANTS SPGF20
RP   463-GLU--LEU-1854 DEL AND 1059-ARG--LEU-1854 DEL.
RX   PubMed=29449551; DOI=10.1038/s41467-017-02792-7;
RA   Coutton C., Vargas A.S., Amiri-Yekta A., Kherraf Z.E., Ben Mustapha S.F.,
RA   Le Tanno P., Wambergue-Legrand C., Karaouzene T., Martinez G., Crouzy S.,
RA   Daneshipour A., Hosseini S.H., Mitchell V., Halouani L., Marrakchi O.,
RA   Makni M., Latrous H., Kharouf M., Deleuze J.F., Boland A., Hennebicq S.,
RA   Satre V., Jouk P.S., Thierry-Mieg N., Conne B., Dacheux D., Landrein N.,
RA   Schmitt A., Stouvenel L., Lores P., El Khouri E., Bottari S.P., Faure J.,
RA   Wolf J.P., Pernet-Gallay K., Escoffier J., Gourabi H., Robinson D.R.,
RA   Nef S., Dulioust E., Zouari R., Bonhivers M., Toure A., Arnoult C.,
RA   Ray P.F.;
RT   "Mutations in CFAP43 and CFAP44 cause male infertility and flagellum
RT   defects in Trypanosoma and human.";
RL   Nat. Commun. 9:686-686(2018).
CC   -!- FUNCTION: Flagellar protein involved in sperm flagellum axoneme
CC       organization and function. {ECO:0000250|UniProtKB:E9Q5M6}.
CC   -!- INTERACTION:
CC       Q96MT7; O95257: GADD45G; NbExp=3; IntAct=EBI-12551219, EBI-448202;
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8J1V4}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000250|UniProtKB:Q57WH1}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2;
CC         IsoId=Q96MT7-2; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q96MT7-1; Sequence=VSP_059893, VSP_059894;
CC   -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:29449551}.
CC   -!- DISEASE: Spermatogenic failure 20 (SPGF20) [MIM:617593]: An infertility
CC       disorder caused by spermatogenesis defects and characterized by
CC       abnormally shaped spermatozoa in the semen of affected individuals.
CC       SPGF20 patients have spermatozoa with absent, short, coiled, bent,
CC       and/or irregular-caliber flagella, which impair sperm motility.
CC       {ECO:0000269|PubMed:28552195, ECO:0000269|PubMed:29449551}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- SIMILARITY: Belongs to the CFAP44 family. {ECO:0000305}.
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DR   EMBL; AK056472; BAB71193.1; -; mRNA.
DR   EMBL; AC023894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471052; EAW79641.1; -; Genomic_DNA.
DR   EMBL; BC101582; AAI01583.1; -; mRNA.
DR   EMBL; BC113553; AAI13554.1; -; mRNA.
DR   CCDS; CCDS2972.1; -. [Q96MT7-1]
DR   CCDS; CCDS54624.1; -. [Q96MT7-2]
DR   RefSeq; NP_001157968.1; NM_001164496.1. [Q96MT7-2]
DR   RefSeq; NP_060808.2; NM_018338.3. [Q96MT7-1]
DR   PDB; 8J07; EM; 4.10 A; i7/i9=1-1854.
DR   PDBsum; 8J07; -.
DR   AlphaFoldDB; Q96MT7; -.
DR   EMDB; EMD-35888; -.
DR   SMR; Q96MT7; -.
DR   BioGRID; 120894; 9.
DR   IntAct; Q96MT7; 4.
DR   STRING; 9606.ENSP00000377428; -.
DR   iPTMnet; Q96MT7; -.
DR   PhosphoSitePlus; Q96MT7; -.
DR   BioMuta; CFAP44; -.
DR   DMDM; 74760982; -.
DR   EPD; Q96MT7; -.
DR   jPOST; Q96MT7; -.
DR   MassIVE; Q96MT7; -.
DR   PaxDb; 9606-ENSP00000377428; -.
DR   PeptideAtlas; Q96MT7; -.
DR   ProteomicsDB; 77404; -. [Q96MT7-1]
DR   ProteomicsDB; 77405; -. [Q96MT7-2]
DR   Antibodypedia; 68151; 69 antibodies from 15 providers.
DR   Ensembl; ENST00000295868.6; ENSP00000295868.2; ENSG00000206530.11. [Q96MT7-1]
DR   Ensembl; ENST00000393845.9; ENSP00000377428.2; ENSG00000206530.11. [Q96MT7-2]
DR   GeneID; 55779; -.
DR   KEGG; hsa:55779; -.
DR   MANE-Select; ENST00000393845.9; ENSP00000377428.2; NM_001164496.2; NP_001157968.1.
DR   UCSC; uc003ead.2; human. [Q96MT7-2]
DR   AGR; HGNC:25631; -.
DR   CTD; 55779; -.
DR   DisGeNET; 55779; -.
DR   GeneCards; CFAP44; -.
DR   HGNC; HGNC:25631; CFAP44.
DR   HPA; ENSG00000206530; Low tissue specificity.
DR   MalaCards; CFAP44; -.
DR   MIM; 617559; gene.
DR   MIM; 617593; phenotype.
DR   neXtProt; NX_Q96MT7; -.
DR   OpenTargets; ENSG00000206530; -.
DR   Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR   PharmGKB; PA134928828; -.
DR   VEuPathDB; HostDB:ENSG00000206530; -.
DR   eggNOG; KOG2106; Eukaryota.
DR   GeneTree; ENSGT00940000161555; -.
DR   HOGENOM; CLU_000928_0_0_1; -.
DR   InParanoid; Q96MT7; -.
DR   OMA; FIMDRVH; -.
DR   OrthoDB; 5480899at2759; -.
DR   PhylomeDB; Q96MT7; -.
DR   TreeFam; TF323192; -.
DR   PathwayCommons; Q96MT7; -.
DR   SignaLink; Q96MT7; -.
DR   BioGRID-ORCS; 55779; 11 hits in 1150 CRISPR screens.
DR   ChiTaRS; CFAP44; human.
DR   GenomeRNAi; 55779; -.
DR   Pharos; Q96MT7; Tbio.
DR   PRO; PR:Q96MT7; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96MT7; Protein.
DR   Bgee; ENSG00000206530; Expressed in right uterine tube and 132 other cell types or tissues.
DR   ExpressionAtlas; Q96MT7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IDA:MGI.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IDA:MGI.
DR   GO; GO:0007288; P:sperm axoneme assembly; IMP:UniProtKB.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR14885:SF3; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44; 1.
DR   PANTHER; PTHR14885; UNCHARACTERIZED; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; WD40 repeat-like; 3.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   Genevisible; Q96MT7; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell projection; Cilium; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Flagellum; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..1854
FT                   /note="Cilia- and flagella-associated protein 44"
FT                   /id="PRO_0000305102"
FT   REPEAT          226..267
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          270..309
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          315..358
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          365..402
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          468..507
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          513..553
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          573..612
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          804..843
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          856..895
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REGION          1..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1057..1093
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1282..1322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1500..1538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          931..958
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        718..740
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1058..1083
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1505..1538
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1083
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:19690332"
FT   VAR_SEQ         979..982
FT                   /note="DFDV -> VSLI (in isoform 1)"
FT                   /id="VSP_059893"
FT   VAR_SEQ         983..1854
FT                   /note="Missing (in isoform 1)"
FT                   /id="VSP_059894"
FT   VARIANT         53
FT                   /note="K -> E (in dbSNP:rs59722850)"
FT                   /id="VAR_062105"
FT   VARIANT         284
FT                   /note="K -> N (in dbSNP:rs16845107)"
FT                   /id="VAR_053435"
FT   VARIANT         463..1854
FT                   /note="Missing (in SPGF20)"
FT                   /evidence="ECO:0000269|PubMed:29449551"
FT                   /id="VAR_080886"
FT   VARIANT         1059..1854
FT                   /note="Missing (in SPGF20)"
FT                   /evidence="ECO:0000269|PubMed:29449551"
FT                   /id="VAR_080887"
SQ   SEQUENCE   1854 AA;  213865 MW;  B086EB5D6455C187 CRC64;
     MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE
     EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP
     FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS
     SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG
     NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE
     MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG
     TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD
     KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP
     LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV
     RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF
     FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD
     VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK
     EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP
     PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP
     SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK
     VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC
     NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK
     NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR
     KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK
     KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG
     HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH
     PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR
     DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF
     DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ
     WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE
     VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL
     DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP
     LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL
     IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK
     EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE
     ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
//