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Entry version 154 (11 Dec 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Prickle-like protein 1

Gene

PRICKLE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-4608870 Asymmetric localization of PCP proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prickle-like protein 1
Alternative name(s):
REST/NRSF-interacting LIM domain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRICKLE1
Synonyms:RILP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000139174.10

Human Gene Nomenclature Database

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HGNCi
HGNC:17019 PRICKLE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MT3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, progressive myoclonic 1B (EPM1B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by myoclonus that progressed in severity over time, tonic-clonic seizures and ataxia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054663104R → Q in EPM1B; affects interaction with REST. 2 PublicationsCorresponds to variant dbSNP:rs113994140EnsemblClinVar.1
Natural variantiVAR_065580144R → H in EPM1B. 1 PublicationCorresponds to variant dbSNP:rs281865563EnsemblClinVar.1
Natural variantiVAR_065581472Y → H in EPM1B. 1 PublicationCorresponds to variant dbSNP:rs281865564EnsemblClinVar.1
Neural tube defects (NTD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi828 – 831Missing : Abolishes localization to the nuclear membrane. 1 Publication4

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
144165

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PRICKLE1

MalaCards human disease database

More...
MalaCardsi
PRICKLE1
MIMi182940 phenotype
612437 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000139174

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
308 Unverricht-Lundborg disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134906946

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MT3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRICKLE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59800163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758891 – 828Prickle-like protein 1Add BLAST828
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000396712829 – 831Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei315PhosphoserineBy similarity1
Modified residuei591PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei828Cysteine methyl esterCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi828S-farnesyl cysteine2 Publications1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96MT3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96MT3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96MT3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96MT3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96MT3

PeptideAtlas

More...
PeptideAtlasi
Q96MT3

PRoteomics IDEntifications database

More...
PRIDEi
Q96MT3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
77402

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2062

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139174 Expressed in 200 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96MT3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96MT3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001379
HPA050037

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with REST.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126835, 18 interactors

Protein interaction database and analysis system

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IntActi
Q96MT3, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345064

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96MT3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96MT3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 122PETPROSITE-ProRule annotationAdd BLAST109
Domaini124 – 189LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST66
Domaini189 – 249LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini249 – 313LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 682Arg/His-richAdd BLAST28
Compositional biasi761 – 772Ser-richAdd BLAST12
Compositional biasi816 – 821Poly-Lys6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1704 Eukaryota
ENOG410XP0W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000290649

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96MT3

KEGG Orthology (KO)

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KOi
K04511

Identification of Orthologs from Complete Genome Data

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OMAi
ANEEFWK

Database of Orthologous Groups

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OrthoDBi
997264at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96MT3

TreeFam database of animal gene trees

More...
TreeFami
TF313265

Family and domain databases

Conserved Domains Database

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CDDi
cd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412 LIM, 3 hits
PF06297 PET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00132 LIM, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96MT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA
60 70 80 90 100
CLPEEKVPYV NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF
110 120 130 140 150
SAQRKKEALG RGTIKLLSRA VMHAVCEQCG LKINGGEVAV FASRAGPGVC
160 170 180 190 200
WHPSCFVCFT CNELLVDLIY FYQDGKIHCG RHHAELLKPR CSACDEIIFA
210 220 230 240 250
DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC GCFESLYAEY
260 270 280 290 300
CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI
310 320 330 340 350
YCSKTCSLGE DVHASDSSDS AFQSARSRDS RRSVRMGKSS RSADQCRQSL
360 370 380 390 400
LLSPALNYKF PGLSGNADDT LSRKLDDLSL SRQGTSFASE EFWKGRVEQE
410 420 430 440 450
TPEDPEEWAD HEDYMTQLLL KFGDKSLFQP QPNEMDIRAS EHWISDNMVK
460 470 480 490 500
SKTELKQNNQ SLASKKYQSD MYWAQSQDGL GDSAYGSHPG PASSRRLQEL
510 520 530 540 550
ELDHGASGYN HDETQWYEDS LECLSDLKPE QSVRDSMDSL ALSNITGASV
560 570 580 590 600
DGENKPRPSL YSLQNFEEME TEDCEKMSNM GTLNSSMLHR SAESLKSLSS
610 620 630 640 650
ELCPEKILPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GNYDIEIRQP
660 670 680 690 700
PMSERTRRRV YNFEERGSRS HHHRRRRSRK SRSDNALNLV TERKYSPKDR
710 720 730 740 750
LRLYTPDNYE KFIQNKSARE IQAYIQNADL YGQYAHATSD YGLQNPGMNR
760 770 780 790 800
FLGLYGEDDD SWCSSSSSSS DSEEEGYFLG QPIPQPRPQR FAYYTDDLSS
810 820 830
PPSALPTPQF GQRTTKSKKK KGHKGKNCII S
Length:831
Mass (Da):94,300
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i753D68BD5A4D0935
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1J1F8W1J1_HUMAN
Prickle-like protein 1
PRICKLE1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1Q8F8W1Q8_HUMAN
Prickle-like protein 1
PRICKLE1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUG8F8VUG8_HUMAN
Prickle-like protein 1
PRICKLE1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPC7A0A1W2PPC7_HUMAN
Prickle-like protein 1
PRICKLE1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti739S → P in BAB71198 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06685069I → T May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs141795695Ensembl.1
Natural variantiVAR_06685181N → H May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs796052934Ensembl.1
Natural variantiVAR_054663104R → Q in EPM1B; affects interaction with REST. 2 PublicationsCorresponds to variant dbSNP:rs113994140EnsemblClinVar.1
Natural variantiVAR_066852121V → I May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs371720624Ensembl.1
Natural variantiVAR_066853124A → T1 PublicationCorresponds to variant dbSNP:rs79087668EnsemblClinVar.1
Natural variantiVAR_065580144R → H in EPM1B. 1 PublicationCorresponds to variant dbSNP:rs281865563EnsemblClinVar.1
Natural variantiVAR_066854275T → M May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs559947948EnsemblClinVar.1
Natural variantiVAR_065581472Y → H in EPM1B. 1 PublicationCorresponds to variant dbSNP:rs281865564EnsemblClinVar.1
Natural variantiVAR_066855682R → C May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs768954477Ensembl.1
Natural variantiVAR_066856739S → F May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs138452760EnsemblClinVar.1
Natural variantiVAR_056164746P → S. Corresponds to variant dbSNP:rs3827522EnsemblClinVar.1
Natural variantiVAR_066857771D → N May be associated with NTD. 1 PublicationCorresponds to variant dbSNP:rs146670726Ensembl.1
Natural variantiVAR_066858799S → C May be associated with NTD. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF399844 mRNA Translation: AAQ03035.1
AK056189 mRNA Translation: BAB71116.1
AK056499 mRNA Translation: BAB71198.1
BC114939 mRNA Translation: AAI14940.1
BC114940 mRNA Translation: AAI14941.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8742.1

NCBI Reference Sequences

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RefSeqi
NP_001138353.1, NM_001144881.1
NP_001138354.1, NM_001144882.1
NP_001138355.1, NM_001144883.1
NP_694571.2, NM_153026.2
XP_011536248.1, XM_011537946.1
XP_011536249.1, XM_011537947.2
XP_016874327.1, XM_017018838.1
XP_016874328.1, XM_017018839.1
XP_016874329.1, XM_017018840.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000345127; ENSP00000345064; ENSG00000139174
ENST00000445766; ENSP00000398947; ENSG00000139174
ENST00000455697; ENSP00000401060; ENSG00000139174
ENST00000548696; ENSP00000448359; ENSG00000139174
ENST00000552240; ENSP00000449819; ENSG00000139174
ENST00000639566; ENSP00000492332; ENSG00000139174
ENST00000639589; ENSP00000491051; ENSG00000139174
ENST00000639958; ENSP00000492644; ENSG00000139174
ENST00000640055; ENSP00000492763; ENSG00000139174
ENST00000640132; ENSP00000491228; ENSG00000139174

Database of genes from NCBI RefSeq genomes

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GeneIDi
144165

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:144165

UCSC genome browser

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UCSCi
uc001rnl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399844 mRNA Translation: AAQ03035.1
AK056189 mRNA Translation: BAB71116.1
AK056499 mRNA Translation: BAB71198.1
BC114939 mRNA Translation: AAI14940.1
BC114940 mRNA Translation: AAI14941.1
CCDSiCCDS8742.1
RefSeqiNP_001138353.1, NM_001144881.1
NP_001138354.1, NM_001144882.1
NP_001138355.1, NM_001144883.1
NP_694571.2, NM_153026.2
XP_011536248.1, XM_011537946.1
XP_011536249.1, XM_011537947.2
XP_016874327.1, XM_017018838.1
XP_016874328.1, XM_017018839.1
XP_016874329.1, XM_017018840.1

3D structure databases

SMRiQ96MT3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126835, 18 interactors
IntActiQ96MT3, 11 interactors
STRINGi9606.ENSP00000345064

PTM databases

GlyConnecti2062
iPTMnetiQ96MT3
PhosphoSitePlusiQ96MT3

Polymorphism and mutation databases

BioMutaiPRICKLE1
DMDMi59800163

Proteomic databases

EPDiQ96MT3
jPOSTiQ96MT3
MassIVEiQ96MT3
MaxQBiQ96MT3
PaxDbiQ96MT3
PeptideAtlasiQ96MT3
PRIDEiQ96MT3
ProteomicsDBi77402

Genome annotation databases

EnsembliENST00000345127; ENSP00000345064; ENSG00000139174
ENST00000445766; ENSP00000398947; ENSG00000139174
ENST00000455697; ENSP00000401060; ENSG00000139174
ENST00000548696; ENSP00000448359; ENSG00000139174
ENST00000552240; ENSP00000449819; ENSG00000139174
ENST00000639566; ENSP00000492332; ENSG00000139174
ENST00000639589; ENSP00000491051; ENSG00000139174
ENST00000639958; ENSP00000492644; ENSG00000139174
ENST00000640055; ENSP00000492763; ENSG00000139174
ENST00000640132; ENSP00000491228; ENSG00000139174
GeneIDi144165
KEGGihsa:144165
UCSCiuc001rnl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144165
DisGeNETi144165
EuPathDBiHostDB:ENSG00000139174.10

GeneCards: human genes, protein and diseases

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GeneCardsi
PRICKLE1
GeneReviewsiPRICKLE1
HGNCiHGNC:17019 PRICKLE1
HPAiHPA001379
HPA050037
MalaCardsiPRICKLE1
MIMi182940 phenotype
608500 gene
612437 phenotype
neXtProtiNX_Q96MT3
OpenTargetsiENSG00000139174
Orphaneti308 Unverricht-Lundborg disease
PharmGKBiPA134906946

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00940000157529
HOGENOMiHOG000290649
InParanoidiQ96MT3
KOiK04511
OMAiANEEFWK
OrthoDBi997264at2759
PhylomeDBiQ96MT3
TreeFamiTF313265

Enzyme and pathway databases

ReactomeiR-HSA-4608870 Asymmetric localization of PCP proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRICKLE1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
144165
PharosiQ96MT3 Tbio

Protein Ontology

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PROi
PR:Q96MT3
RNActiQ96MT3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139174 Expressed in 200 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ96MT3 baseline and differential
GenevisibleiQ96MT3 HS

Family and domain databases

CDDicd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit
InterProiView protein in InterPro
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRIC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MT3
Secondary accession number(s): Q14C83, Q71QF8, Q96N00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: December 11, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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