UniProtKB - Q96MS0 (ROBO3_HUMAN)
Roundabout homolog 3
ROBO3
Functioni
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity).
In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity).
Required for hindbrain axon midline crossing (PubMed:15105459).
By similarity1 PublicationGO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
GO - Biological processi
- axon guidance Source: UniProtKB
- axon midline choice point recognition Source: UniProtKB
- dendrite self-avoidance Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Chemotaxis, Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q96MS0 |
Reactomei | R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO [Q96MS0-1] R-HSA-9010553, Regulation of expression of SLITs and ROBOs [Q96MS0-1] R-HSA-9010642, ROBO receptors bind AKAP5 [Q96MS0-1] |
SignaLinki | Q96MS0 |
Names & Taxonomyi
Protein namesi | Recommended name: Roundabout homolog 3Alternative name(s): Roundabout-like protein 3 |
Gene namesi | Name:ROBO3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13433, ROBO3 |
MIMi | 608630, gene |
neXtProti | NX_Q96MS0 |
VEuPathDBi | HostDB:ENSG00000154134 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 891 | ExtracellularSequence analysisAdd BLAST | 871 | |
Transmembranei | 892 – 912 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 913 – 1386 | CytoplasmicSequence analysisAdd BLAST | 474 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Gaze palsy, familial horizontal, with progressive scoliosis, 1 (HGPPS1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019119 | 5 | L → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918275EnsemblClinVar. | 1 | |
Natural variantiVAR_019120 | 66 | I → L in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918276EnsemblClinVar. | 1 | |
Natural variantiVAR_019073 | 319 | E → K in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918274EnsemblClinVar. | 1 | |
Natural variantiVAR_019121 | 361 | G → E in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918270EnsemblClinVar. | 1 | |
Natural variantiVAR_019074 | 703 | R → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918271EnsemblClinVar. | 1 | |
Natural variantiVAR_019075 | 705 | S → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918272EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 64221 |
MalaCardsi | ROBO3 |
MIMi | 607313, phenotype |
OpenTargetsi | ENSG00000154134 |
Orphaneti | 2744, Horizontal gaze palsy with progressive scoliosis |
PharmGKBi | PA134896648 |
Miscellaneous databases
Pharosi | Q96MS0, Tbio |
Genetic variation databases
BioMutai | ROBO3 |
DMDMi | 49036492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000031038 | 21 – 1386 | Roundabout homolog 3Add BLAST | 1366 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 85 ↔ 143 | PROSITE-ProRule annotation | ||
Glycosylationi | 156 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 187 ↔ 236 | PROSITE-ProRule annotation | ||
Disulfide bondi | 279 ↔ 326 | PROSITE-ProRule annotation | ||
Disulfide bondi | 368 ↔ 424 | PROSITE-ProRule annotation | ||
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 459 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 472 ↔ 521 | PROSITE-ProRule annotation | ||
Glycosylationi | 503 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 784 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 813 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 820 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1263 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q96MS0 |
jPOSTi | Q96MS0 |
MassIVEi | Q96MS0 |
MaxQBi | Q96MS0 |
PaxDbi | Q96MS0 |
PeptideAtlasi | Q96MS0 |
PRIDEi | Q96MS0 |
ProteomicsDBi | 77392 [Q96MS0-1] 77393 [Q96MS0-2] |
PTM databases
GlyGeni | Q96MS0, 12 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96MS0 |
PhosphoSitePlusi | Q96MS0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154134, Expressed in left ovary and 212 other tissues |
ExpressionAtlasi | Q96MS0, baseline and differential |
Genevisiblei | Q96MS0, HS |
Organism-specific databases
HPAi | ENSG00000154134, Tissue enhanced (ovary) |
Interactioni
Subunit structurei
Probably interacts with SLIT2.
By similarityBinary interactionsi
Q96MS0
With | #Exp. | IntAct |
---|---|---|
NELL2 - isoform 1 [Q99435-1] | 3 | EBI-1220465,EBI-16185191 |
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 122111, 15 interactors |
DIPi | DIP-38410N |
IntActi | Q96MS0, 3 interactors |
STRINGi | 9606.ENSP00000380903 |
Miscellaneous databases
RNActi | Q96MS0, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q96MS0 |
SMRi | Q96MS0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 160 | Ig-like C2-type 1Add BLAST | 97 | |
Domaini | 166 – 253 | Ig-like C2-type 2Add BLAST | 88 | |
Domaini | 258 – 342 | Ig-like C2-type 3Add BLAST | 85 | |
Domaini | 347 – 440 | Ig-like C2-type 4Add BLAST | 94 | |
Domaini | 450 – 531 | Ig-like C2-type 5Add BLAST | 82 | |
Domaini | 558 – 652 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 671 – 766 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 771 – 869 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 541 – 563 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 639 – 662 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 965 – 989 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1028 – 1310 | DisorderedSequence analysisAdd BLAST | 283 | |
Regioni | 1327 – 1386 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 967 – 981 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1080 – 1094 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1122 – 1156 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1157 – 1171 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1217 – 1238 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1263 – 1277 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1331 – 1375 | Polar residuesSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000155457 |
HOGENOMi | CLU_003227_5_1_1 |
InParanoidi | Q96MS0 |
OMAi | GKAVQMP |
OrthoDBi | 173520at2759 |
PhylomeDBi | Q96MS0 |
TreeFami | TF351053 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR032987, Robo3 |
PANTHERi | PTHR12231:SF236, PTHR12231:SF236, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRYLLKTLL QMNLFADSLA GDISNSSELL LGFNSSLAAL NHTLLPPGDP
60 70 80 90 100
SLNGSRVGPE DAMPRIVEQP PDLLVSRGEP ATLPCRAEGR PRPNIEWYKN
110 120 130 140 150
GARVATVRED PRAHRLLLPS GALFFPRIVH GRRARPDEGV YTCVARNYLG
160 170 180 190 200
AAASRNASLE VAVLRDDFRQ SPGNVVVAVG EPAVLECVPP RGHPEPSVSW
210 220 230 240 250
RKDGARLKEE EGRITIRGGK LMMSHTLKSD AGMYVCVASN MAGERESAAA
260 270 280 290 300
EVMVLERPSF LRRPVNQVVL ADAPVTFLCE VKGDPPPRLR WRKEDGELPT
310 320 330 340 350
GRYEIRSDHS LWIGHVSAED EGTYTCVAEN SVGRAEASGS LSVHVPPQLV
360 370 380 390 400
TQPQDQMAAP GESVAFQCET KGNPPPAIFW QKEGSQVLLF PSQSLQPTGR
410 420 430 440 450
FSVSPRGQLN ITAVQRGDAG YYVCQAVSVA GSILAKALLE IKGASLDGLP
460 470 480 490 500
PVILQGPANQ TLVLGSSVWL PCRVTGNPQP SVRWKKDGQW LQGDDLQFKT
510 520 530 540 550
MANGTLYIAN VQEMDMGFYS CVAKSSTGEA TWSGWLKMRE DWGVSPDPPT
560 570 580 590 600
EPSSPPGAPS QPVVTEITKN SITLTWKPNP QTGAAVTSYV IEAFSPAAGN
610 620 630 640 650
TWRTVADGVQ LETHTVSGLQ PNTIYLFLVR AVGAWGLSEP SPVSEPVRTQ
660 670 680 690 700
DSSPSRPVED PWRGQQGLAE VAVRLQEPIV LGPRTLQVSW TVDGPVQLVQ
710 720 730 740 750
GFRVSWRVAG PEGGSWTMLD LQSPSQQSTV LRGLPPGTQI QIKVQAQGQE
760 770 780 790 800
GLGAESLSVT RSIPEEAPSG PPQGVAVALG GDGNSSITVS WEPPLPSQQN
810 820 830 840 850
GVITEYQIWC LGNESRFHLN RSAAGWARSA MLRGLVPGLL YRTLVAAATS
860 870 880 890 900
AGVGVPSAPV LVQLPSPPDL EPGLEVGAGL AVRLARVLRE PAFLAGSGAA
910 920 930 940 950
CGALLLGLCA ALYWRRKQRK ELSHYTASFA YTPAVSFPHS EGLSGASSRP
960 970 980 990 1000
PMGLGPAPYS WLADSWPHPS RSPSAQEPRG SCCPSNPDPD DRYYNEAGIS
1010 1020 1030 1040 1050
LYLAQTARGT AAPGEGPVYS TIDPAGEELQ TFHGGFPQHP SGDLGPWSQY
1060 1070 1080 1090 1100
APPEWSQGDS GAKGGKVKLL GKPVQMPSLN WPEALPPPPP SCELSCLEGP
1110 1120 1130 1140 1150
EEELEGSSEP EEWCPPMPER SHLTEPSSSG GCLVTPSRRE TPSPTPSYGQ
1160 1170 1180 1190 1200
QSTATLTPSP PDPPQPPTDM PHLHQMPRRV PLGPSSPLSV SQPMLGIREA
1210 1220 1230 1240 1250
RPAGLGAGPA ASPHLSPSPA PSTASSAPGR TWQGNGEMTP PLQGPRARFR
1260 1270 1280 1290 1300
KKPKALPYRR ENSPGDLPPP PLPPPEEEAS WALELRAAGS MSSLERERSG
1310 1320 1330 1340 1350
ERKAVQAVPL AAQRVLHPDE EAWLPYSRPS FLSRGQGTST CSTAGSNSSR
1360 1370 1380
GSSSSRGSRG PGRSRSRSQS RSQSQRPGQK RREEPR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GWJ5 | F5GWJ5_HUMAN | Roundabout homolog 3 | ROBO3 | 1,364 | Annotation score: | ||
F5H0K7 | F5H0K7_HUMAN | Roundabout homolog 3 | ROBO3 | 149 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019119 | 5 | L → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918275EnsemblClinVar. | 1 | |
Natural variantiVAR_019120 | 66 | I → L in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918276EnsemblClinVar. | 1 | |
Natural variantiVAR_019073 | 319 | E → K in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918274EnsemblClinVar. | 1 | |
Natural variantiVAR_019121 | 361 | G → E in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918270EnsemblClinVar. | 1 | |
Natural variantiVAR_053642 | 416 | R → H. Corresponds to variant dbSNP:rs3862618EnsemblClinVar. | 1 | |
Natural variantiVAR_034474 | 423 | V → M1 PublicationCorresponds to variant dbSNP:rs4935898EnsemblClinVar. | 1 | |
Natural variantiVAR_019074 | 703 | R → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918271EnsemblClinVar. | 1 | |
Natural variantiVAR_019075 | 705 | S → P in HGPPS1. 1 PublicationCorresponds to variant dbSNP:rs121918272EnsemblClinVar. | 1 | |
Natural variantiVAR_062145 | 868 | P → L1 PublicationCorresponds to variant dbSNP:rs55706177EnsemblClinVar. | 1 | |
Natural variantiVAR_034475 | 1369 | Q → R. Corresponds to variant dbSNP:rs35723495Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010650 | 1025 – 1034 | AGEELQTFHG → LTTPLLILTT in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_010651 | 1035 – 1386 | Missing in isoform 2. 1 PublicationAdd BLAST | 352 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY509035 mRNA Translation: AAS91662.1 AK056544 mRNA Translation: BAB71212.1 |
CCDSi | CCDS44755.1 [Q96MS0-1] |
RefSeqi | NP_071765.2, NM_022370.3 [Q96MS0-1] |
Genome annotation databases
Ensembli | ENST00000397801.6; ENSP00000380903.1; ENSG00000154134.15 |
GeneIDi | 64221 |
KEGGi | hsa:64221 |
MANE-Selecti | ENST00000397801.6; ENSP00000380903.1; NM_022370.4; NP_071765.2 |
UCSCi | uc001qbc.4, human [Q96MS0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY509035 mRNA Translation: AAS91662.1 AK056544 mRNA Translation: BAB71212.1 |
CCDSi | CCDS44755.1 [Q96MS0-1] |
RefSeqi | NP_071765.2, NM_022370.3 [Q96MS0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6POG | X-ray | 2.75 | A | 551-663 | [»] | |
6POK | X-ray | 1.80 | A | 664-870 | [»] | |
6POL | X-ray | 1.80 | A/C/E | 549-652 | [»] | |
AlphaFoldDBi | Q96MS0 | |||||
SMRi | Q96MS0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122111, 15 interactors |
DIPi | DIP-38410N |
IntActi | Q96MS0, 3 interactors |
STRINGi | 9606.ENSP00000380903 |
PTM databases
GlyGeni | Q96MS0, 12 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q96MS0 |
PhosphoSitePlusi | Q96MS0 |
Genetic variation databases
BioMutai | ROBO3 |
DMDMi | 49036492 |
Proteomic databases
EPDi | Q96MS0 |
jPOSTi | Q96MS0 |
MassIVEi | Q96MS0 |
MaxQBi | Q96MS0 |
PaxDbi | Q96MS0 |
PeptideAtlasi | Q96MS0 |
PRIDEi | Q96MS0 |
ProteomicsDBi | 77392 [Q96MS0-1] 77393 [Q96MS0-2] |
Protocols and materials databases
Antibodypediai | 2550, 201 antibodies from 33 providers |
DNASUi | 64221 |
Genome annotation databases
Ensembli | ENST00000397801.6; ENSP00000380903.1; ENSG00000154134.15 |
GeneIDi | 64221 |
KEGGi | hsa:64221 |
MANE-Selecti | ENST00000397801.6; ENSP00000380903.1; NM_022370.4; NP_071765.2 |
UCSCi | uc001qbc.4, human [Q96MS0-1] |
Organism-specific databases
CTDi | 64221 |
DisGeNETi | 64221 |
GeneCardsi | ROBO3 |
HGNCi | HGNC:13433, ROBO3 |
HPAi | ENSG00000154134, Tissue enhanced (ovary) |
MalaCardsi | ROBO3 |
MIMi | 607313, phenotype 608630, gene |
neXtProti | NX_Q96MS0 |
OpenTargetsi | ENSG00000154134 |
Orphaneti | 2744, Horizontal gaze palsy with progressive scoliosis |
PharmGKBi | PA134896648 |
VEuPathDBi | HostDB:ENSG00000154134 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4222, Eukaryota |
GeneTreei | ENSGT00940000155457 |
HOGENOMi | CLU_003227_5_1_1 |
InParanoidi | Q96MS0 |
OMAi | GKAVQMP |
OrthoDBi | 173520at2759 |
PhylomeDBi | Q96MS0 |
TreeFami | TF351053 |
Enzyme and pathway databases
PathwayCommonsi | Q96MS0 |
Reactomei | R-HSA-428542, Regulation of commissural axon pathfinding by SLIT and ROBO [Q96MS0-1] R-HSA-9010553, Regulation of expression of SLITs and ROBOs [Q96MS0-1] R-HSA-9010642, ROBO receptors bind AKAP5 [Q96MS0-1] |
SignaLinki | Q96MS0 |
Miscellaneous databases
BioGRID-ORCSi | 64221, 5 hits in 1069 CRISPR screens |
ChiTaRSi | ROBO3, human |
GeneWikii | ROBO3 |
GenomeRNAii | 64221 |
Pharosi | Q96MS0, Tbio |
PROi | PR:Q96MS0 |
RNActi | Q96MS0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154134, Expressed in left ovary and 212 other tissues |
ExpressionAtlasi | Q96MS0, baseline and differential |
Genevisiblei | Q96MS0, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR032987, Robo3 |
PANTHERi | PTHR12231:SF236, PTHR12231:SF236, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 5 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ROBO3_HUMAN | |
Accessioni | Q96MS0Primary (citable) accession number: Q96MS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families