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Entry version 145 (02 Jun 2021)
Sequence version 3 (13 Jul 2010)
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Protein

Cilia- and flagella-associated protein 57

Gene

CFAP57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96MR6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96MR6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 57Imported
Alternative name(s):
WD repeat-containing protein 65Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP57Imported
Synonyms:WDR65Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26485, CFAP57

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614259, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MR6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000243710.7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
149465

Open Targets

More...
OpenTargetsi
ENSG00000243710

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MR6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CFAP57

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669699

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002426531 – 1250Cilia- and flagella-associated protein 57CuratedAdd BLAST1250

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96MR6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96MR6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96MR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MR6

PeptideAtlas

More...
PeptideAtlasi
Q96MR6

PRoteomics IDEntifications database

More...
PRIDEi
Q96MR6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77387 [Q96MR6-1]
77388 [Q96MR6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

May be an IRF6-target.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000243710, Expressed in right uterine tube and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96MR6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MR6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000243710, Tissue enhanced (fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127214, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96MR6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96MR6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati105 – 148WD 1Add BLAST44
Repeati151 – 190WD 2Add BLAST40
Repeati195 – 233WD 3Add BLAST39
Repeati336 – 375WD 4Add BLAST40
Repeati387 – 426WD 5Add BLAST40
Repeati428 – 470WD 6Add BLAST43
Repeati472 – 507WD 7Add BLAST36
Repeati510 – 549WD 8Add BLAST40
Repeati552 – 591WD 9Add BLAST40
Repeati636 – 675WD 10Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili691 – 1057Sequence analysisAdd BLAST367
Coiled coili1095 – 1166Sequence analysisAdd BLAST72
Coiled coili1198 – 1225Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTIS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000088018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003598_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MR6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MR6

TreeFam database of animal gene trees

More...
TreeFami
TF324236

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96MR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAVVAQTLH VFGLRSHVAN NIFYFDEQII IFPSGNHCVK YNVDQKWQKF
60 70 80 90 100
IPGSEKSQGM LALSISPNRR YLAISETVQE KPAITIYELS SIPCRKRKVL
110 120 130 140 150
NNFDFQVQKF ISMAFSPDSK YLLAQTSPPE SNLVYWLWEK QKVMAIVRID
160 170 180 190 200
TQNNPVYQVS FSPQDNTQVC VTGNGMFKLL RFAEGTLKQT SFQRGEPQNY
210 220 230 240 250
LAHTWVADDK IVVGTDTGKL FLFESGDQRW ETSIMVKEPT NGSKSLDVIQ
260 270 280 290 300
ESESLIEFPP VSSPLPSYEQ MVAASSHSQM SMPQVFAIAA YSKGFACSAG
310 320 330 340 350
PGRVLLFEKM EEKDFYRESR EIRIPVDPQS NDPSQSDKQD VLCLCFSPSE
360 370 380 390 400
ETLVASTSKN QLYSITMSLT EISKGEPAHF EYLMYPLHSA PITGLATCIR
410 420 430 440 450
KPLIATCSLD RSIRLWNYET NTLELFKEYQ EEAYSISLHP SGHFIVVGFA
460 470 480 490 500
DKLRLMNLLI DDIRSFKEYS VRGCGECSFS NGGHLFAAVN GNVIHVYTTT
510 520 530 540 550
SLENISSLKG HTGKIRSIVW NADDSKLISG GTDGAVYEWN LSTGKRETEC
560 570 580 590 600
VLKSCSYNCV TVSPDAKIIF AVGSDHTLKE IADSLILREI SAFDVTYTAI
610 620 630 640 650
VISHSGRMMF VGTSVGTIRA MKYPLPLQKE FNEYQAHAGP ITKMLLTFDD
660 670 680 690 700
QFLLTAAEDG CLFTWKVFDK DGRGIKRERE VGFAEEVLVT KTDMEEKAQV
710 720 730 740 750
MLELKTRVEE LKMENEYQLR LKDMNYSEKI KELTDKFIQE MESLKTKNQV
760 770 780 790 800
LRTEKEKQDV YHHEHIEDLL DKQSRELQDM ECCNNQKLLL EYEKYQELQL
810 820 830 840 850
KSQRMQEEYE KQLRDNDETK SQALEELTEF YEAKLQEKTT LLEEAQEDVR
860 870 880 890 900
QQLREFEETK KQIEEDEDRE IQDIKTKYEK KLRDEKESNL RLKGETGIMR
910 920 930 940 950
KKFSSLQKEI EERTNDIETL KGEQMKLQGV IKSLEKDIQG LKREIQERDE
960 970 980 990 1000
TIQDKEKRIY DLKKKNQELG KFKFVLDYKI KELKKQIEPR ENEIRVMKEQ
1010 1020 1030 1040 1050
IQEMEAELEN FHKQNTQLEL NITELWQKLR ATDQEMRRER QKERDLEALV
1060 1070 1080 1090 1100
KRFKTDLHNC VAYIQEPRLL KEKVRGLFEK YVQRADMVEI AGLNTDLQQE
1110 1120 1130 1140 1150
YTRQREHLER NLATLKKKVV KEGELHRTDY VRIMQENVSL IKEINELRRE
1160 1170 1180 1190 1200
LKFTRSQVYD LEAALKLTKK VRPQEVSETE PSRDMLSTAP TARLNEQEET
1210 1220 1230 1240 1250
GRIIEMQRLE IQRLRDQIQE QEQVTGFHTL AGVRLPSLSN SEVDLEVKTN
Length:1,250
Mass (Da):144,961
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB98CB10A30D64E16
GO
Isoform 2 (identifier: Q96MR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     644-698: MLLTFDDQFL...VTKTDMEEKA → VSRALSPGTQ...HLLTMNILFV
     699-1250: Missing.

Show »
Length:698
Mass (Da):78,164
Checksum:iF0E20EB330E81809
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVY5A0A087WVY5_HUMAN
Cilia- and flagella-associated prot...
CFAP57
1,283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4D4H7C4D4_HUMAN
Cilia- and flagella-associated prot...
CFAP57
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRV3E9PRV3_HUMAN
Cilia- and flagella-associated prot...
CFAP57
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP89E9PP89_HUMAN
Cilia- and flagella-associated prot...
CFAP57
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q96MR6-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti647A → T in BAB71217 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026850183A → S. Corresponds to variant dbSNP:rs6663799Ensembl.1
Natural variantiVAR_026851241N → D1 PublicationCorresponds to variant dbSNP:rs663824Ensembl.1
Natural variantiVAR_026852345C → S. Corresponds to variant dbSNP:rs11210805Ensembl.1
Natural variantiVAR_066494523D → Y Rare variant found in a patient with Van der Woude syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs387907122EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039520644 – 698MLLTF…MEEKA → VSRALSPGTQSHTCLLRALF IPSTSQCLFSLLLLSYLFIH HSLNHHLLTMNILFV in isoform 2. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_039521699 – 1250Missing in isoform 2. 2 PublicationsAdd BLAST552

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056562 mRNA Translation: BAB71217.1
AC093420 Genomic DNA No translation available.
AL139138 Genomic DNA No translation available.
BC117280 mRNA Translation: AAI17281.1
BC117306 mRNA Translation: AAI17307.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS479.1 [Q96MR6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161437.1, NM_001167965.1 [Q96MR6-2]
NP_001182760.2, NM_001195831.2
NP_689711.2, NM_152498.3 [Q96MR6-2]
XP_005270577.1, XM_005270520.1
XP_011539095.1, XM_011540793.1 [Q96MR6-1]
XP_011539096.1, XM_011540794.1 [Q96MR6-1]
XP_011539097.1, XM_011540795.2 [Q96MR6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372492; ENSP00000361570; ENSG00000243710 [Q96MR6-1]
ENST00000528956; ENSP00000435310; ENSG00000243710 [Q96MR6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
149465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:149465

UCSC genome browser

More...
UCSCi
uc001cip.2, human [Q96MR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056562 mRNA Translation: BAB71217.1
AC093420 Genomic DNA No translation available.
AL139138 Genomic DNA No translation available.
BC117280 mRNA Translation: AAI17281.1
BC117306 mRNA Translation: AAI17307.1
CCDSiCCDS479.1 [Q96MR6-2]
RefSeqiNP_001161437.1, NM_001167965.1 [Q96MR6-2]
NP_001182760.2, NM_001195831.2
NP_689711.2, NM_152498.3 [Q96MR6-2]
XP_005270577.1, XM_005270520.1
XP_011539095.1, XM_011540793.1 [Q96MR6-1]
XP_011539096.1, XM_011540794.1 [Q96MR6-1]
XP_011539097.1, XM_011540795.2 [Q96MR6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127214, 3 interactors
IntActiQ96MR6, 2 interactors
STRINGi9606.ENSP00000479773

PTM databases

iPTMnetiQ96MR6
PhosphoSitePlusiQ96MR6

Genetic variation databases

BioMutaiCFAP57
DMDMi300669699

Proteomic databases

EPDiQ96MR6
MassIVEiQ96MR6
MaxQBiQ96MR6
PaxDbiQ96MR6
PeptideAtlasiQ96MR6
PRIDEiQ96MR6
ProteomicsDBi77387 [Q96MR6-1]
77388 [Q96MR6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34814, 21 antibodies

The DNASU plasmid repository

More...
DNASUi
149465

Genome annotation databases

EnsembliENST00000372492; ENSP00000361570; ENSG00000243710 [Q96MR6-1]
ENST00000528956; ENSP00000435310; ENSG00000243710 [Q96MR6-2]
GeneIDi149465
KEGGihsa:149465
UCSCiuc001cip.2, human [Q96MR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
149465
DisGeNETi149465

GeneCards: human genes, protein and diseases

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GeneCardsi
CFAP57
HGNCiHGNC:26485, CFAP57
HPAiENSG00000243710, Tissue enhanced (fallopian tube, testis)
MIMi614259, gene
neXtProtiNX_Q96MR6
OpenTargetsiENSG00000243710
PharmGKBiPA142670598
VEuPathDBiHostDB:ENSG00000243710.7

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QTIS, Eukaryota
GeneTreeiENSGT00620000088018
HOGENOMiCLU_003598_0_0_1
InParanoidiQ96MR6
PhylomeDBiQ96MR6
TreeFamiTF324236

Enzyme and pathway databases

PathwayCommonsiQ96MR6
SignaLinkiQ96MR6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
149465, 7 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CFAP57, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
149465
PharosiQ96MR6, Tdark

Protein Ontology

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PROi
PR:Q96MR6
RNActiQ96MR6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000243710, Expressed in right uterine tube and 114 other tissues
ExpressionAtlasiQ96MR6, baseline and differential
GenevisibleiQ96MR6, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA57_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MR6
Secondary accession number(s): A6NKQ3, Q17RI9, Q5TAI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 13, 2010
Last modified: June 2, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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