UniProtKB - Q96MN9 (ZN488_HUMAN)
Protein
Zinc finger protein 488
Gene
ZNF488
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 302 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 317 – 339 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: Ensembl
- oligodendrocyte development Source: GO_Central
- positive regulation of myelination Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Neurogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96MN9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 488 |
Gene namesi | Name:ZNF488 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23535, ZNF488 |
neXtProti | NX_Q96MN9 |
VEuPathDBi | HostDB:ENSG00000265763.3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 118738 |
OpenTargetsi | ENSG00000265763 |
PharmGKBi | PA134917840 |
Miscellaneous databases
Pharosi | Q96MN9, Tdark |
Genetic variation databases
BioMutai | ZNF488 |
DMDMi | 68566223 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047612 | 1 – 340 | Zinc finger protein 488Add BLAST | 340 |
Proteomic databases
PaxDbi | Q96MN9 |
PeptideAtlasi | Q96MN9 |
PRIDEi | Q96MN9 |
ProteomicsDBi | 77383 [Q96MN9-1] |
PTM databases
iPTMneti | Q96MN9 |
PhosphoSitePlusi | Q96MN9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000265763, Expressed in C1 segment of cervical spinal cord and 100 other tissues |
Genevisiblei | Q96MN9, HS |
Organism-specific databases
HPAi | ENSG00000265763, Group enriched (brain, intestine) |
Interactioni
Subunit structurei
Interacts with OLIG2.
By similarityBinary interactionsi
Hide detailsQ96MN9
Isoform 2 [Q96MN9-2]
Protein-protein interaction databases
BioGRIDi | 125620, 15 interactors |
IntActi | Q96MN9, 43 interactors |
STRINGi | 9606.ENSP00000462269 |
Miscellaneous databases
RNActi | Q96MN9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 187 | Important for transcriptional repression activityBy similarityAdd BLAST | 116 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 298 – 305 | Nuclear localization signalPROSITE-ProRule annotation | 8 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 302 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 317 – 339 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00890000139463 |
HOGENOMi | CLU_070344_0_0_1 |
InParanoidi | Q96MN9 |
OMAi | APTLWLE |
OrthoDBi | 1327331at2759 |
PhylomeDBi | Q96MN9 |
TreeFami | TF327090 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96MN9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL
60 70 80 90 100
EKTNRLGPEA AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS
110 120 130 140 150
AFTELPRMKD RQVDAQAQER EHDDPTGQPG APQLTQNIPR GPAGSKVFSV
160 170 180 190 200
WPSGARSEQR SAFSKPTKRP AERPELTSVF PAGESADALG ELSGLLNTTD
210 220 230 240 250
LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW LEHTQAQVPP
260 270 280 290 300
PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK
310 320 330 340
EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033571 | 72 | A → V. Corresponds to variant dbSNP:rs35618062Ensembl. | 1 | |
Natural variantiVAR_033572 | 106 | P → L. Corresponds to variant dbSNP:rs12251609Ensembl. | 1 | |
Natural variantiVAR_033573 | 249 | P → S. Corresponds to variant dbSNP:rs3814160Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055961 | 1 – 107 | Missing in isoform 2. 1 PublicationAdd BLAST | 107 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056666 mRNA Translation: BAB71246.1 AL731561 Genomic DNA No translation available. BC026895 mRNA Translation: AAH26895.1 BC051323 mRNA Translation: AAH51323.1 |
CCDSi | CCDS73120.1 [Q96MN9-1] |
RefSeqi | NP_001333861.1, NM_001346932.1 [Q96MN9-1] NP_001333862.1, NM_001346933.1 [Q96MN9-1] NP_001333863.1, NM_001346934.1 [Q96MN9-1] NP_001333864.1, NM_001346935.1 [Q96MN9-1] NP_001333865.1, NM_001346936.1 [Q96MN9-1] NP_694579.1, NM_153034.3 [Q96MN9-1] XP_006717680.1, XM_006717617.3 [Q96MN9-1] XP_011537546.1, XM_011539244.2 [Q96MN9-1] XP_016871132.1, XM_017015643.1 [Q96MN9-1] |
Genome annotation databases
Ensembli | ENST00000585316; ENSP00000462269; ENSG00000265763 [Q96MN9-1] ENST00000591025; ENSP00000468133; ENSG00000265763 [Q96MN9-2] |
GeneIDi | 118738 |
KEGGi | hsa:118738 |
UCSCi | uc001jex.3, human [Q96MN9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056666 mRNA Translation: BAB71246.1 AL731561 Genomic DNA No translation available. BC026895 mRNA Translation: AAH26895.1 BC051323 mRNA Translation: AAH51323.1 |
CCDSi | CCDS73120.1 [Q96MN9-1] |
RefSeqi | NP_001333861.1, NM_001346932.1 [Q96MN9-1] NP_001333862.1, NM_001346933.1 [Q96MN9-1] NP_001333863.1, NM_001346934.1 [Q96MN9-1] NP_001333864.1, NM_001346935.1 [Q96MN9-1] NP_001333865.1, NM_001346936.1 [Q96MN9-1] NP_694579.1, NM_153034.3 [Q96MN9-1] XP_006717680.1, XM_006717617.3 [Q96MN9-1] XP_011537546.1, XM_011539244.2 [Q96MN9-1] XP_016871132.1, XM_017015643.1 [Q96MN9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125620, 15 interactors |
IntActi | Q96MN9, 43 interactors |
STRINGi | 9606.ENSP00000462269 |
PTM databases
iPTMneti | Q96MN9 |
PhosphoSitePlusi | Q96MN9 |
Genetic variation databases
BioMutai | ZNF488 |
DMDMi | 68566223 |
Proteomic databases
PaxDbi | Q96MN9 |
PeptideAtlasi | Q96MN9 |
PRIDEi | Q96MN9 |
ProteomicsDBi | 77383 [Q96MN9-1] |
Protocols and materials databases
Antibodypediai | 72957, 171 antibodies |
DNASUi | 118738 |
Genome annotation databases
Ensembli | ENST00000585316; ENSP00000462269; ENSG00000265763 [Q96MN9-1] ENST00000591025; ENSP00000468133; ENSG00000265763 [Q96MN9-2] |
GeneIDi | 118738 |
KEGGi | hsa:118738 |
UCSCi | uc001jex.3, human [Q96MN9-1] |
Organism-specific databases
CTDi | 118738 |
DisGeNETi | 118738 |
GeneCardsi | ZNF488 |
HGNCi | HGNC:23535, ZNF488 |
HPAi | ENSG00000265763, Group enriched (brain, intestine) |
neXtProti | NX_Q96MN9 |
OpenTargetsi | ENSG00000265763 |
PharmGKBi | PA134917840 |
VEuPathDBi | HostDB:ENSG00000265763.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00890000139463 |
HOGENOMi | CLU_070344_0_0_1 |
InParanoidi | Q96MN9 |
OMAi | APTLWLE |
OrthoDBi | 1327331at2759 |
PhylomeDBi | Q96MN9 |
TreeFami | TF327090 |
Enzyme and pathway databases
PathwayCommonsi | Q96MN9 |
Miscellaneous databases
BioGRID-ORCSi | 118738, 2 hits in 879 CRISPR screens |
ChiTaRSi | ZNF488, human |
GenomeRNAii | 118738 |
Pharosi | Q96MN9, Tdark |
PROi | PR:Q96MN9 |
RNActi | Q96MN9, protein |
Gene expression databases
Bgeei | ENSG00000265763, Expressed in C1 segment of cervical spinal cord and 100 other tissues |
Genevisiblei | Q96MN9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN488_HUMAN | |
Accessioni | Q96MN9Primary (citable) accession number: Q96MN9 Secondary accession number(s): Q05CE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants