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UniProtKB - Q96MN9 (ZN488_HUMAN)

Entry version 153 (10 Feb 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Zinc finger protein 488

Gene

ZNF488

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri275 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processNeurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96MN9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 488
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF488
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23535, ZNF488

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96MN9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000265763.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		118738

Open Targets

More...OpenTargetsi		ENSG00000265763

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134917840

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96MN9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF488

Domain mapping of disease mutations (DMDM)

More...DMDMi		68566223

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476121 – 340Zinc finger protein 488Add BLAST340

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96MN9

PeptideAtlas

More...PeptideAtlasi		Q96MN9

PRoteomics IDEntifications database

More...PRIDEi		Q96MN9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77383 [Q96MN9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96MN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96MN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000265763, Expressed in C1 segment of cervical spinal cord and 100 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96MN9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000265763, Group enriched (brain, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with OLIG2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q96MN9
With#Exp.IntAct
ATXN1 [P54253]9EBI-948288,EBI-930964
BANP [Q8N9N5]3EBI-948288,EBI-744695
DAB1 [O75553]3EBI-948288,EBI-7875264
GOLGA2 [Q08379]4EBI-948288,EBI-618309
KRT40 [Q6A162]3EBI-948288,EBI-10171697
MAGED1 [Q9Y5V3]3EBI-948288,EBI-716006
PRR20C [P86479]3EBI-948288,EBI-10172814
RBPMS [Q93062]4EBI-948288,EBI-740322
RIMBP3 [Q9UFD9]3EBI-948288,EBI-10182375
TRAF2 [Q12933]3EBI-948288,EBI-355744
Isoform 2 [Q96MN9-2]
With#Exp.IntAct
APBB2 - isoform 2 [Q92870-2]3EBI-25831733,EBI-21535880
ATXN1 [P54253]6EBI-25831733,EBI-930964
BAG6 - isoform 2 [P46379-2]3EBI-25831733,EBI-10988864
COL26A1 - isoform 2 [Q96A83-2]3EBI-25831733,EBI-21553822
DDIT4 [Q9NX09]3EBI-25831733,EBI-715104
DMWD [G5E9A7]3EBI-25831733,EBI-10976677
DNALI1 [O14645]3EBI-25831733,EBI-395638
DR1 [Q01658]3EBI-25831733,EBI-750300
GFAP [P14136]3EBI-25831733,EBI-744302
GRN [P28799]3EBI-25831733,EBI-747754
GTF2B [Q00403]3EBI-25831733,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-25831733,EBI-1054873
HSPB1 [P04792]3EBI-25831733,EBI-352682
KIF1B - isoform 2 [O60333-2]3EBI-25831733,EBI-10975473
KLF11 [O14901]3EBI-25831733,EBI-948266
LMNA [P02545]3EBI-25831733,EBI-351935
NEFL [P07196]3EBI-25831733,EBI-475646
NUP58 [Q9BVL2]3EBI-25831733,EBI-2811583
OPTN [Q96CV9]3EBI-25831733,EBI-748974
PKN1 [Q16512]3EBI-25831733,EBI-602382
PMP22 [D3DTS7]3EBI-25831733,EBI-25882629
PRPS1 [P60891]3EBI-25831733,EBI-749195
RNF11 [Q9Y3C5]3EBI-25831733,EBI-396669
SPRED1 [Q7Z699]3EBI-25831733,EBI-5235340
TSC1 [Q86WV8]3EBI-25831733,EBI-12806590
TUBB2A [Q13885]3EBI-25831733,EBI-711595
UQCRC1 [P31930]3EBI-25831733,EBI-1052596
VBP1 [P61758]3EBI-25831733,EBI-357430
WFS1 [O76024]3EBI-25831733,EBI-720609

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125620, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q96MN9, 43 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000462269

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96MN9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 187Important for transcriptional repression activityBy similarityAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi298 – 305Nuclear localization signalPROSITE-ProRule annotation8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00890000139463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070344_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96MN9

Identification of Orthologs from Complete Genome Data

More...OMAi		APTLWLE

Database of Orthologous Groups

More...OrthoDBi		1327331at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96MN9

TreeFam database of animal gene trees

More...TreeFami		TF327090

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96MN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL 
        60         70         80         90        100
EKTNRLGPEA AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS 
       110        120        130        140        150
AFTELPRMKD RQVDAQAQER EHDDPTGQPG APQLTQNIPR GPAGSKVFSV 
       160        170        180        190        200
WPSGARSEQR SAFSKPTKRP AERPELTSVF PAGESADALG ELSGLLNTTD 
       210        220        230        240        250
LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW LEHTQAQVPP 
       260        270        280        290        300
PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK 
       310        320        330        340
EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS
Length:340
Mass (Da):36,962
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0584ABA6A8F36CBF
GO
Isoform 2 (identifier: Q96MN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:233
Mass (Da):25,670
Checksum:iB161BC2AAD577CE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03357172A → V. Corresponds to variant dbSNP:rs35618062Ensembl.1
Natural variantiVAR_033572106P → L. Corresponds to variant dbSNP:rs12251609Ensembl.1
Natural variantiVAR_033573249P → S. Corresponds to variant dbSNP:rs3814160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559611 – 107Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056666 mRNA Translation: BAB71246.1
AL731561 Genomic DNA No translation available.
BC026895 mRNA Translation: AAH26895.1
BC051323 mRNA Translation: AAH51323.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73120.1 [Q96MN9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001333861.1, NM_001346932.1 [Q96MN9-1]
NP_001333862.1, NM_001346933.1 [Q96MN9-1]
NP_001333863.1, NM_001346934.1 [Q96MN9-1]
NP_001333864.1, NM_001346935.1 [Q96MN9-1]
NP_001333865.1, NM_001346936.1 [Q96MN9-1]
NP_694579.1, NM_153034.3 [Q96MN9-1]
XP_006717680.1, XM_006717617.3 [Q96MN9-1]
XP_011537546.1, XM_011539244.2 [Q96MN9-1]
XP_016871132.1, XM_017015643.1 [Q96MN9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000585316; ENSP00000462269; ENSG00000265763 [Q96MN9-1]
ENST00000591025; ENSP00000468133; ENSG00000265763 [Q96MN9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		118738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:118738

UCSC genome browser

More...UCSCi		uc001jex.3, human [Q96MN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056666 mRNA Translation: BAB71246.1
AL731561 Genomic DNA No translation available.
BC026895 mRNA Translation: AAH26895.1
BC051323 mRNA Translation: AAH51323.1
CCDSiCCDS73120.1 [Q96MN9-1]
RefSeqiNP_001333861.1, NM_001346932.1 [Q96MN9-1]
NP_001333862.1, NM_001346933.1 [Q96MN9-1]
NP_001333863.1, NM_001346934.1 [Q96MN9-1]
NP_001333864.1, NM_001346935.1 [Q96MN9-1]
NP_001333865.1, NM_001346936.1 [Q96MN9-1]
NP_694579.1, NM_153034.3 [Q96MN9-1]
XP_006717680.1, XM_006717617.3 [Q96MN9-1]
XP_011537546.1, XM_011539244.2 [Q96MN9-1]
XP_016871132.1, XM_017015643.1 [Q96MN9-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125620, 15 interactors
IntActiQ96MN9, 43 interactors
STRINGi9606.ENSP00000462269

PTM databases

iPTMnetiQ96MN9
PhosphoSitePlusiQ96MN9

Genetic variation databases

BioMutaiZNF488
DMDMi68566223

Proteomic databases

PaxDbiQ96MN9
PeptideAtlasiQ96MN9
PRIDEiQ96MN9
ProteomicsDBi77383 [Q96MN9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72957, 171 antibodies

The DNASU plasmid repository

More...DNASUi		118738

Genome annotation databases

EnsembliENST00000585316; ENSP00000462269; ENSG00000265763 [Q96MN9-1]
ENST00000591025; ENSP00000468133; ENSG00000265763 [Q96MN9-2]
GeneIDi118738
KEGGihsa:118738
UCSCiuc001jex.3, human [Q96MN9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		118738
DisGeNETi118738

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF488
HGNCiHGNC:23535, ZNF488
HPAiENSG00000265763, Group enriched (brain, intestine)
neXtProtiNX_Q96MN9
OpenTargetsiENSG00000265763
PharmGKBiPA134917840
VEuPathDBiHostDB:ENSG00000265763.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00890000139463
HOGENOMiCLU_070344_0_0_1
InParanoidiQ96MN9
OMAiAPTLWLE
OrthoDBi1327331at2759
PhylomeDBiQ96MN9
TreeFamiTF327090

Enzyme and pathway databases

PathwayCommonsiQ96MN9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		118738, 2 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF488, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		118738
PharosiQ96MN9, Tdark

Protein Ontology

More...PROi		PR:Q96MN9
RNActiQ96MN9, protein

Gene expression databases

BgeeiENSG00000265763, Expressed in C1 segment of cervical spinal cord and 100 other tissues
GenevisibleiQ96MN9, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 2 hits
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN488_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MN9
Secondary accession number(s): Q05CE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: February 10, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with genetic variants
    List of human entries with genetic variants
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