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Entry version 174 (22 Apr 2020)
Sequence version 3 (12 Jun 2007)
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Protein

NACHT, LRR and PYD domains-containing protein 4

Gene

NLRP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi155 – 162ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1606341 IRF3 mediated activation of type 1 IFN
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 4
Alternative name(s):
Cancer/testis antigen 58
Short name:
CT58
PAAD and NACHT-containing protein 2
Short name:
PAN2
PYRIN and NACHT-containing protein 2
PYRIN-containing APAF1-like protein 4
Short name:
PYPAF4
Ribonuclease inhibitor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRP4
Synonyms:NALP4, PAN2, PYPAF4, RNH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22943 NLRP4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609645 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
147945

Open Targets

More...
OpenTargetsi
ENSG00000160505

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397947

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96MN2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NLRP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
148887404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000808891 – 994NACHT, LRR and PYD domains-containing protein 4Add BLAST994

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96MN2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96MN2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MN2

PeptideAtlas

More...
PeptideAtlasi
Q96MN2

PRoteomics IDEntifications database

More...
PRIDEi
Q96MN2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
77378 [Q96MN2-1]
77379 [Q96MN2-2]
77380 [Q96MN2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MN2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160505 Expressed in secondary oocyte and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96MN2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MN2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160505 Group enriched (brain, lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHUK/IKKA, inhibiting its kinase activity.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127102, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-60912N

Protein interaction database and analysis system

More...
IntActi
Q96MN2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301295

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96MN2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1994
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96MN2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 94PyrinPROSITE-ProRule annotationAdd BLAST94
Domaini149 – 472NACHTPROSITE-ProRule annotationAdd BLAST324
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati637 – 660LRR 1Add BLAST24
Repeati698 – 721LRR 2Add BLAST24
Repeati722 – 745LRR 3Add BLAST24
Repeati750 – 777LRR 4Add BLAST28
Repeati806 – 833LRR 5Add BLAST28
Repeati863 – 886LRR 6Add BLAST24
Repeati920 – 943LRR 7Add BLAST24
Repeati949 – 972LRR 8Add BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pyrin domain is sufficient for suppression of NF-kappaB activity, it adopts a typical death domain fold, but in contrast to several NLRP family pyrin domains it doesn't bind homotypically to the ASC adapter, which supports the observation that NLRP4 has no effect on IL1B activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308 Eukaryota
ENOG410ZBX3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002274_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MN2

KEGG Orthology (KO)

More...
KOi
K22265

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMLAFCH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MN2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96MN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASFFSDFG LMWYLEELKK EEFRKFKEHL KQMTLQLELK QIPWTEVKKA
60 70 80 90 100
SREELANLLI KHYEEQQAWN ITLRIFQKMD RKDLCMKVMR ERTGYTKTYQ
110 120 130 140 150
AHAKQKFSRL WSSKSVTEIH LYFEEEVKQE ECDHLDRLFA PKEAGKQPRT
160 170 180 190 200
VIIQGPQGIG KTTLLMKLMM AWSDNKIFRD RFLYTFYFCC RELRELPPTS
210 220 230 240 250
LADLISREWP DPAAPITEIV SQPERLLFVI DSFEELQGGL NEPDSDLCGD
260 270 280 290 300
LMEKRPVQVL LSSLLRKKML PEASLLIAIK PVCPKELRDQ VTISEIYQPR
310 320 330 340 350
GFNESDRLVY FCCFFKDPKR AMEAFNLVRE SEQLFSICQI PLLCWILCTS
360 370 380 390 400
LKQEMQKGKD LALTCQSTTS VYSSFVFNLF TPEGAEGPTP QTQHQLKALC
410 420 430 440 450
SLAAEGMWTD TFEFCEDDLR RNGVVDADIP ALLGTKILLK YGERESSYVF
460 470 480 490 500
LHVCIQEFCA ALFYLLKSHL DHPHPAVRCV QELLVANFEK ARRAHWIFLG
510 520 530 540 550
CFLTGLLNKK EQEKLDAFFG FQLSQEIKQQ IHQCLKSLGE RGNPQGQVDS
560 570 580 590 600
LAIFYCLFEM QDPAFVKQAV NLLQEANFHI IDNVDLVVSA YCLKYCSSLR
610 620 630 640 650
KLCFSVQNVF KKEDEHSSTS DYSLICWHHI CSVLTTSGHL RELQVQDSTL
660 670 680 690 700
SESTFVTWCN QLRHPSCRLQ KLGINNVSFS GQSVLLFEVL FYQPDLKYLS
710 720 730 740 750
FTLTKLSRDD IRSLCDALNY PAGNVKELAL VNCHLSPIDC EVLAGLLTNN
760 770 780 790 800
KKLTYLNVSC NQLDTGVPLL CEALCSPDTV LVYLMLAFCH LSEQCCEYIS
810 820 830 840 850
EMLLRNKSVR YLDLSANVLK DEGLKTLCEA LKHPDCCLDS LCLVKCFITA
860 870 880 890 900
AGCEDLASAL ISNQNLKILQ IGCNEIGDVG VQLLCRALTH TDCRLEILGL
910 920 930 940 950
EECGLTSTCC KDLASVLTCS KTLQQLNLTL NTLDHTGVVV LCEALRHPEC
960 970 980 990
ALQVLGLRKT DFDEETQALL TAEEERNPNL TITDDCDTIT RVEI
Length:994
Mass (Da):113,415
Last modified:June 12, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2DDA1239274B2D1
GO
Isoform 2 (identifier: Q96MN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-435: Missing.
     731-786: Missing.

Note: Incomplete sequence.Curated
Show »
Length:503
Mass (Da):56,764
Checksum:i8DC99CE33DE2F9A9
GO
Isoform 3 (identifier: Q96MN2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MAASFFSDFG...LCMKVMRERT → MQECLTLWVFSPLALTDS

Show »
Length:919
Mass (Da):103,968
Checksum:i99DFA4C1AC473A5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES09K7ES09_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESK5K7ESK5_HUMAN
NACHT, LRR and PYD domains-containi...
NLRP4
504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL88672 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55L → P in AAL88672 (Ref. 4) Curated1
Sequence conflicti99Y → H in AAL88672 (Ref. 4) Curated1
Sequence conflicti177I → T in AAL88672 (Ref. 4) Curated1
Sequence conflicti209W → R in AAL88672 (Ref. 4) Curated1
Sequence conflicti296I → V in AAL88672 (Ref. 4) Curated1
Sequence conflicti720Y → C in AAL88672 (Ref. 4) Curated1
Sequence conflicti957L → P in AAL88672 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024179144A → T5 PublicationsCorresponds to variant dbSNP:rs441827Ensembl.1
Natural variantiVAR_024827383E → D1 PublicationCorresponds to variant dbSNP:rs17857373Ensembl.1
Natural variantiVAR_024828390P → Q1 PublicationCorresponds to variant dbSNP:rs17857374Ensembl.1
Natural variantiVAR_032764708R → H. Corresponds to variant dbSNP:rs12462372Ensembl.1
Natural variantiVAR_024829774L → M1 PublicationCorresponds to variant dbSNP:rs17854614Ensembl.1
Natural variantiVAR_020007925Q → L1 PublicationCorresponds to variant dbSNP:rs302453Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0440061 – 435Missing in isoform 2. 1 PublicationAdd BLAST435
Alternative sequenceiVSP_0039161 – 93MAASF…MRERT → MQECLTLWVFSPLALTDS in isoform 3. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_044007731 – 786Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF442488 mRNA Translation: AAL35293.1
AY072792 mRNA Translation: AAL68396.1
AF479747 mRNA Translation: AAL87104.1
AF482706 mRNA Translation: AAL88672.1 Sequence problems.
AK056688 mRNA Translation: BAB71254.1
BC016443 mRNA Translation: AAH16443.1
BC050326 mRNA Translation: AAH50326.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12936.1 [Q96MN2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_604393.2, NM_134444.4 [Q96MN2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301295; ENSP00000301295; ENSG00000160505 [Q96MN2-1]
ENST00000587891; ENSP00000465463; ENSG00000160505 [Q96MN2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
147945

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:147945

UCSC genome browser

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UCSCi
uc002qmd.5 human [Q96MN2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442488 mRNA Translation: AAL35293.1
AY072792 mRNA Translation: AAL68396.1
AF479747 mRNA Translation: AAL87104.1
AF482706 mRNA Translation: AAL88672.1 Sequence problems.
AK056688 mRNA Translation: BAB71254.1
BC016443 mRNA Translation: AAH16443.1
BC050326 mRNA Translation: AAH50326.1
CCDSiCCDS12936.1 [Q96MN2-1]
RefSeqiNP_604393.2, NM_134444.4 [Q96MN2-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EWIX-ray2.28A/B1-110[»]
SMRiQ96MN2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127102, 6 interactors
DIPiDIP-60912N
IntActiQ96MN2, 2 interactors
STRINGi9606.ENSP00000301295

PTM databases

iPTMnetiQ96MN2
PhosphoSitePlusiQ96MN2

Polymorphism and mutation databases

BioMutaiNLRP4
DMDMi148887404

Proteomic databases

jPOSTiQ96MN2
MassIVEiQ96MN2
PaxDbiQ96MN2
PeptideAtlasiQ96MN2
PRIDEiQ96MN2
ProteomicsDBi77378 [Q96MN2-1]
77379 [Q96MN2-2]
77380 [Q96MN2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33159 141 antibodies

The DNASU plasmid repository

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DNASUi
147945

Genome annotation databases

EnsembliENST00000301295; ENSP00000301295; ENSG00000160505 [Q96MN2-1]
ENST00000587891; ENSP00000465463; ENSG00000160505 [Q96MN2-3]
GeneIDi147945
KEGGihsa:147945
UCSCiuc002qmd.5 human [Q96MN2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
147945
DisGeNETi147945

GeneCards: human genes, protein and diseases

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GeneCardsi
NLRP4
HGNCiHGNC:22943 NLRP4
HPAiENSG00000160505 Group enriched (brain, lymphoid tissue, testis)
MIMi609645 gene
neXtProtiNX_Q96MN2
OpenTargetsiENSG00000160505
PharmGKBiPA162397947

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00940000162284
HOGENOMiCLU_002274_2_1_1
InParanoidiQ96MN2
KOiK22265
OMAiLMLAFCH
PhylomeDBiQ96MN2

Enzyme and pathway databases

ReactomeiR-HSA-1606341 IRF3 mediated activation of type 1 IFN
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NLRP4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NLRP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147945
PharosiQ96MN2 Tbio

Protein Ontology

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PROi
PR:Q96MN2
RNActiQ96MN2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160505 Expressed in secondary oocyte and 26 other tissues
ExpressionAtlasiQ96MN2 baseline and differential
GenevisibleiQ96MN2 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR041267 NLRC_HD2
IPR041075 NOD2_WH
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF17776 NLRC4_HD2, 1 hit
PF17779 NOD2_WH, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNALP4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MN2
Secondary accession number(s): Q86W87, Q96AY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 12, 2007
Last modified: April 22, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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