ZFP42

Functionⁱ

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	188 – 212	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	217 – 239	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	245 – 269	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	275 – 299	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 14688391
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

female gonad development
Source: UniProtKB
Inferred from expression patternⁱ
- 18281244
male gonad development
Source: UniProtKB
Inferred from expression patternⁱ
- 18281244
meiotic cell cycle
Source: UniProtKB
Non-traceable author statementⁱ
- 18281244
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q96MM3
SIGNORⁱ	Q96MM3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 42 homolog Short name: Zfp-42 Alternative name(s): Reduced expression protein 1 Short name: REX-1 Short name: hREX-1 Zinc finger protein 754
Gene namesⁱ	Name:ZFP42 Synonyms:REX1, ZNF754
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179059.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30949 ZFP42
MIMⁱ	614572 gene
neXtProtⁱ	NX_Q96MM3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	132625
Open Targets More...OpenTargetsⁱ	ENSG00000179059
PharmGKBⁱ	PA142670530

Polymorphism and mutation databases

BioMutaⁱ	ZFP42
DMDMⁱ	296453032

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287289	1 – 310	Zinc finger protein 42 homologAdd BLAST		310

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	231	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	233	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationⁱ

Polyubiquitinated by RNF12, leading to proteasomal degradation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q96MM3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96MM3
PaxDbⁱ	Q96MM3
PeptideAtlas More...PeptideAtlasⁱ	Q96MM3
PRIDEⁱ	Q96MM3
ProteomicsDBⁱ	77373

PTM databases

iPTMnetⁱ	Q96MM3
PhosphoSitePlusⁱ	Q96MM3

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.4 Publications

Inductionⁱ

Down-regulated upon retinoic acid addition to F9 stem cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179059 Expressed in 37 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ZFP42
Genevisibleⁱ	Q96MM3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025557

HPAⁱ

CAB025557

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	126327, 6 interactors
IntActⁱ	Q96MM3, 6 interactors
STRINGⁱ	9606.ENSP00000317686

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96MM3
SMRⁱ	Q96MM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	188 – 212	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	217 – 239	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	245 – 269	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	275 – 299	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000008232
HOVERGENⁱ	HBG006823
InParanoidⁱ	Q96MM3
KEGG Orthology (KO) More...KOⁱ	K11516
OMAⁱ	DCYIECI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03FM
PhylomeDBⁱ	Q96MM3
TreeFamⁱ	TF106493

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96MM3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC 
        60         70         80         90        100
DGYVCYEPGP QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK 
       110        120        130        140        150
GSEQQLSQKV FEASSLECSL EYMKKGVKKE LPQKIVGENS LEYSEYMTGK 
       160        170        180        190        200
KLPPGGIPGI DLSDPKQLAE FARKKPPINK EYDSLSAIAC PQSGCTRKLR 
       210        220        230        240        250
NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT GEKPFRCTFE 
       260        270        280        290        300
GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA 
       310
NTNKNEQEGK

Length:310

Mass (Da):34,802

Last modified:May 18, 2010 - v2

Checksum:ⁱFBF4D7470DC37325

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	88	E → G in AAR07993 (Ref. 2) Curated		1
Sequence conflictⁱ	88	E → G in BAB71264 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF450454 mRNA Translation: AAL47167.1 AY429593 mRNA Translation: AAR07993.1 AK056719 mRNA Translation: BAB71264.1 AC108073 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04610.1 CH471056 Genomic DNA Translation: EAX04611.1 CH471056 Genomic DNA Translation: EAX04612.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3849.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001291287.1, NM_001304358.1 NP_777560.2, NM_174900.4 XP_011529906.1, XM_011531604.2 XP_011529907.1, XM_011531605.1 XP_011529908.1, XM_011531606.1 XP_011529909.1, XM_011531607.2
UniGeneⁱ	Hs.335787

Genome annotation databases

Ensemblⁱ	ENST00000326866; ENSP00000317686; ENSG00000179059 ENST00000509524; ENSP00000424662; ENSG00000179059 ENST00000618147; ENSP00000483363; ENSG00000179059
GeneIDⁱ	132625
KEGGⁱ	hsa:132625
UCSC genome browser More...UCSCⁱ	uc003izh.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96MM3	ZFP42 isoform 1		PONAB		311	UniRef90_Q96MM3
ZFP42 isoform 1		PANTR		310
Uncharacterized protein		PANPA		310
ZFP42 zinc finger protein		GORGO		310
UPI00020AD168		NOMLE		311
+1

Protein	Similar proteins		Species	Score	Length	Source
Q96MM3	ZFP42 isoform 1		PONAB		311	UniRef50_Q96MM3
ZFP42 zinc finger protein		GORGO		310
ZFP42 isoform 1		PANTR		310
Uncharacterized protein		PANPA		310
Zinc finger protein 42 like protein		MYODS		301
+101

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF450454 mRNA Translation: AAL47167.1 AY429593 mRNA Translation: AAR07993.1 AK056719 mRNA Translation: BAB71264.1 AC108073 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04610.1 CH471056 Genomic DNA Translation: EAX04611.1 CH471056 Genomic DNA Translation: EAX04612.1
CCDSⁱ	CCDS3849.1
RefSeqⁱ	NP_001291287.1, NM_001304358.1 NP_777560.2, NM_174900.4 XP_011529906.1, XM_011531604.2 XP_011529907.1, XM_011531605.1 XP_011529908.1, XM_011531606.1 XP_011529909.1, XM_011531607.2
UniGeneⁱ	Hs.335787

3D structure databases

ProteinModelPortalⁱ	Q96MM3
SMRⁱ	Q96MM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126327, 6 interactors
IntActⁱ	Q96MM3, 6 interactors
STRINGⁱ	9606.ENSP00000317686

PTM databases

iPTMnetⁱ	Q96MM3
PhosphoSitePlusⁱ	Q96MM3

Polymorphism and mutation databases

BioMutaⁱ	ZFP42
DMDMⁱ	296453032

Proteomic databases

EPDⁱ	Q96MM3
MaxQBⁱ	Q96MM3
PaxDbⁱ	Q96MM3
PeptideAtlasⁱ	Q96MM3
PRIDEⁱ	Q96MM3
ProteomicsDBⁱ	77373

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	132625
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000326866; ENSP00000317686; ENSG00000179059 ENST00000509524; ENSP00000424662; ENSG00000179059 ENST00000618147; ENSP00000483363; ENSG00000179059
GeneIDⁱ	132625
KEGGⁱ	hsa:132625
UCSCⁱ	uc003izh.2 human

Organism-specific databases

CTDⁱ	132625
DisGeNETⁱ	132625
EuPathDBⁱ	HostDB:ENSG00000179059.9
GeneCardsⁱ	ZFP42
HGNCⁱ	HGNC:30949 ZFP42
HPAⁱ	CAB025557
MIMⁱ	614572 gene
neXtProtⁱ	NX_Q96MM3
OpenTargetsⁱ	ENSG00000179059
PharmGKBⁱ	PA142670530
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000008232
HOVERGENⁱ	HBG006823
InParanoidⁱ	Q96MM3
KOⁱ	K11516
OMAⁱ	DCYIECI
OrthoDBⁱ	EOG091G03FM
PhylomeDBⁱ	Q96MM3
TreeFamⁱ	TF106493

Enzyme and pathway databases

SignaLinkⁱ	Q96MM3
SIGNORⁱ	Q96MM3

Miscellaneous databases

GeneWikiⁱ	Rex1
GenomeRNAiⁱ	132625
Protein Ontology More...PROⁱ	PR:Q96MM3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179059 Expressed in 37 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ZFP42
Genevisibleⁱ	Q96MM3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP42_HUMAN
Accessionⁱ	Q96MM3Primary (citable) accession number: Q96MM3 Secondary accession number(s): D3DP65, Q8WXE2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96MM3 (ZFP42_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein 42 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ