UniProtKB - Q96MM3 (ZFP42_HUMAN)
Protein
Zinc finger protein 42 homolog
Gene
ZFP42
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 188 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 217 – 239 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 269 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 275 – 299 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- female gonad development Source: UniProtKB
- male gonad development Source: UniProtKB
- meiotic cell cycle Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96MM3 |
SignaLinki | Q96MM3 |
SIGNORi | Q96MM3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 42 homologShort name: Zfp-42 Alternative name(s): Reduced expression protein 1 Short name: REX-1 Short name: hREX-1 Zinc finger protein 754 |
Gene namesi | Name:ZFP42 Synonyms:REX1, ZNF754 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30949, ZFP42 |
MIMi | 614572, gene |
neXtProti | NX_Q96MM3 |
VEuPathDBi | HostDB:ENSG00000179059.9 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- PcG protein complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 132625 |
OpenTargetsi | ENSG00000179059 |
PharmGKBi | PA142670530 |
Miscellaneous databases
Pharosi | Q96MM3, Tbio |
Genetic variation databases
BioMutai | ZFP42 |
DMDMi | 296453032 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287289 | 1 – 310 | Zinc finger protein 42 homologAdd BLAST | 310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 231 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 233 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity |
Post-translational modificationi
Polyubiquitinated by RNF12, leading to proteasomal degradation.By similarity
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q96MM3 |
jPOSTi | Q96MM3 |
MassIVEi | Q96MM3 |
MaxQBi | Q96MM3 |
PaxDbi | Q96MM3 |
PeptideAtlasi | Q96MM3 |
PRIDEi | Q96MM3 |
ProteomicsDBi | 77373 |
PTM databases
iPTMneti | Q96MM3 |
PhosphoSitePlusi | Q96MM3 |
Expressioni
Tissue specificityi
Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.4 Publications
Inductioni
Down-regulated upon retinoic acid addition to F9 stem cells.1 Publication
Gene expression databases
Bgeei | ENSG00000179059, Expressed in amniotic fluid and 46 other tissues |
Genevisiblei | Q96MM3, HS |
Organism-specific databases
HPAi | ENSG00000179059, Tissue enhanced (blood, placenta, testis) |
Interactioni
Binary interactionsi
Hide detailsQ96MM3
Protein-protein interaction databases
BioGRIDi | 126327, 13 interactors |
IntActi | Q96MM3, 5 interactors |
STRINGi | 9606.ENSP00000317686 |
Miscellaneous databases
RNActi | Q96MM3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 188 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 217 – 239 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 245 – 269 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 275 – 299 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163257 |
HOGENOMi | CLU_085915_0_0_1 |
InParanoidi | Q96MM3 |
OMAi | PDCYIEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96MM3 |
TreeFami | TF106493 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q96MM3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC
60 70 80 90 100
DGYVCYEPGP QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK
110 120 130 140 150
GSEQQLSQKV FEASSLECSL EYMKKGVKKE LPQKIVGENS LEYSEYMTGK
160 170 180 190 200
KLPPGGIPGI DLSDPKQLAE FARKKPPINK EYDSLSAIAC PQSGCTRKLR
210 220 230 240 250
NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT GEKPFRCTFE
260 270 280 290 300
GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
310
NTNKNEQEGK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | E → G in AAR07993 (Ref. 2) Curated | 1 | |
Sequence conflicti | 88 | E → G in BAB71264 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF450454 mRNA Translation: AAL47167.1 AY429593 mRNA Translation: AAR07993.1 AK056719 mRNA Translation: BAB71264.1 AC108073 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04610.1 CH471056 Genomic DNA Translation: EAX04611.1 CH471056 Genomic DNA Translation: EAX04612.1 |
CCDSi | CCDS3849.1 |
RefSeqi | NP_001291287.1, NM_001304358.1 NP_777560.2, NM_174900.4 XP_011529906.1, XM_011531604.2 XP_011529907.1, XM_011531605.1 XP_011529908.1, XM_011531606.1 XP_011529909.1, XM_011531607.2 |
Genome annotation databases
Ensembli | ENST00000326866; ENSP00000317686; ENSG00000179059 ENST00000509524; ENSP00000424662; ENSG00000179059 ENST00000618147; ENSP00000483363; ENSG00000179059 |
GeneIDi | 132625 |
KEGGi | hsa:132625 |
UCSCi | uc003izh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF450454 mRNA Translation: AAL47167.1 AY429593 mRNA Translation: AAR07993.1 AK056719 mRNA Translation: BAB71264.1 AC108073 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04610.1 CH471056 Genomic DNA Translation: EAX04611.1 CH471056 Genomic DNA Translation: EAX04612.1 |
CCDSi | CCDS3849.1 |
RefSeqi | NP_001291287.1, NM_001304358.1 NP_777560.2, NM_174900.4 XP_011529906.1, XM_011531604.2 XP_011529907.1, XM_011531605.1 XP_011529908.1, XM_011531606.1 XP_011529909.1, XM_011531607.2 |
3D structure databases
SMRi | Q96MM3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126327, 13 interactors |
IntActi | Q96MM3, 5 interactors |
STRINGi | 9606.ENSP00000317686 |
PTM databases
iPTMneti | Q96MM3 |
PhosphoSitePlusi | Q96MM3 |
Genetic variation databases
BioMutai | ZFP42 |
DMDMi | 296453032 |
Proteomic databases
EPDi | Q96MM3 |
jPOSTi | Q96MM3 |
MassIVEi | Q96MM3 |
MaxQBi | Q96MM3 |
PaxDbi | Q96MM3 |
PeptideAtlasi | Q96MM3 |
PRIDEi | Q96MM3 |
ProteomicsDBi | 77373 |
Protocols and materials databases
Antibodypediai | 17568, 366 antibodies |
DNASUi | 132625 |
Genome annotation databases
Ensembli | ENST00000326866; ENSP00000317686; ENSG00000179059 ENST00000509524; ENSP00000424662; ENSG00000179059 ENST00000618147; ENSP00000483363; ENSG00000179059 |
GeneIDi | 132625 |
KEGGi | hsa:132625 |
UCSCi | uc003izh.2, human |
Organism-specific databases
CTDi | 132625 |
DisGeNETi | 132625 |
GeneCardsi | ZFP42 |
HGNCi | HGNC:30949, ZFP42 |
HPAi | ENSG00000179059, Tissue enhanced (blood, placenta, testis) |
MIMi | 614572, gene |
neXtProti | NX_Q96MM3 |
OpenTargetsi | ENSG00000179059 |
PharmGKBi | PA142670530 |
VEuPathDBi | HostDB:ENSG00000179059.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163257 |
HOGENOMi | CLU_085915_0_0_1 |
InParanoidi | Q96MM3 |
OMAi | PDCYIEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96MM3 |
TreeFami | TF106493 |
Enzyme and pathway databases
PathwayCommonsi | Q96MM3 |
SignaLinki | Q96MM3 |
SIGNORi | Q96MM3 |
Miscellaneous databases
BioGRID-ORCSi | 132625, 10 hits in 1009 CRISPR screens |
GeneWikii | Rex1 |
GenomeRNAii | 132625 |
Pharosi | Q96MM3, Tbio |
PROi | PR:Q96MM3 |
RNActi | Q96MM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179059, Expressed in amniotic fluid and 46 other tissues |
Genevisiblei | Q96MM3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP42_HUMAN | |
Accessioni | Q96MM3Primary (citable) accession number: Q96MM3 Secondary accession number(s): D3DP65, Q8WXE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families