Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 42 homolog

Gene

ZFP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 269C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • female gonad development Source: UniProtKB
  • male gonad development Source: UniProtKB
  • meiotic cell cycle Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96MM3
SIGNORiQ96MM3

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 42 homolog
Short name:
Zfp-42
Alternative name(s):
Reduced expression protein 1
Short name:
REX-1
Short name:
hREX-1
Zinc finger protein 754
Gene namesi
Name:ZFP42
Synonyms:REX1, ZNF754
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000179059.9
HGNCiHGNC:30949 ZFP42
MIMi614572 gene
neXtProtiNX_Q96MM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi132625
OpenTargetsiENSG00000179059
PharmGKBiPA142670530

Polymorphism and mutation databases

BioMutaiZFP42
DMDMi296453032

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872891 – 310Zinc finger protein 42 homologAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Polyubiquitinated by RNF12, leading to proteasomal degradation.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96MM3
MaxQBiQ96MM3
PaxDbiQ96MM3
PeptideAtlasiQ96MM3
PRIDEiQ96MM3
ProteomicsDBi77373

PTM databases

iPTMnetiQ96MM3
PhosphoSitePlusiQ96MM3

Expressioni

Tissue specificityi

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.4 Publications

Inductioni

Down-regulated upon retinoic acid addition to F9 stem cells.1 Publication

Gene expression databases

BgeeiENSG00000179059
CleanExiHS_ZFP42
GenevisibleiQ96MM3 HS

Organism-specific databases

HPAiCAB025557

Interactioni

Protein-protein interaction databases

BioGridi126327, 6 interactors
IntActiQ96MM3, 6 interactors
STRINGi9606.ENSP00000317686

Structurei

3D structure databases

ProteinModelPortaliQ96MM3
SMRiQ96MM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 269C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri275 – 299C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000008232
HOVERGENiHBG006823
InParanoidiQ96MM3
KOiK11516
OMAiDCYIECI
OrthoDBiEOG091G03FM
PhylomeDBiQ96MM3
TreeFamiTF106493

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q96MM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQLKKRAK TRHQKGLGGR APSGAKPRQG KSSQDLQAEI EPVSAVWALC
60 70 80 90 100
DGYVCYEPGP QALGGDDFSD CYIECVIRGE FSQPILEEDS LFESLEYLKK
110 120 130 140 150
GSEQQLSQKV FEASSLECSL EYMKKGVKKE LPQKIVGENS LEYSEYMTGK
160 170 180 190 200
KLPPGGIPGI DLSDPKQLAE FARKKPPINK EYDSLSAIAC PQSGCTRKLR
210 220 230 240 250
NRAALRKHLL IHGPRDHVCA ECGKAFVESS KLKRHFLVHT GEKPFRCTFE
260 270 280 290 300
GCGKRFSLDF NLRTHVRIHT GEKRFVCPFQ GCNRRFIQSN NLKAHILTHA
310
NTNKNEQEGK
Length:310
Mass (Da):34,802
Last modified:May 18, 2010 - v2
Checksum:iFBF4D7470DC37325
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88E → G in AAR07993 (Ref. 2) Curated1
Sequence conflicti88E → G in BAB71264 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450454 mRNA Translation: AAL47167.1
AY429593 mRNA Translation: AAR07993.1
AK056719 mRNA Translation: BAB71264.1
AC108073 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX04610.1
CH471056 Genomic DNA Translation: EAX04611.1
CH471056 Genomic DNA Translation: EAX04612.1
CCDSiCCDS3849.1
RefSeqiNP_001291287.1, NM_001304358.1
NP_777560.2, NM_174900.4
XP_011529906.1, XM_011531604.2
XP_011529907.1, XM_011531605.1
XP_011529908.1, XM_011531606.1
XP_011529909.1, XM_011531607.2
UniGeneiHs.335787

Genome annotation databases

EnsembliENST00000326866; ENSP00000317686; ENSG00000179059
ENST00000509524; ENSP00000424662; ENSG00000179059
ENST00000618147; ENSP00000483363; ENSG00000179059
GeneIDi132625
KEGGihsa:132625
UCSCiuc003izh.2 human

Similar proteinsi

Entry informationi

Entry nameiZFP42_HUMAN
AccessioniPrimary (citable) accession number: Q96MM3
Secondary accession number(s): D3DP65, Q8WXE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health