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UniProtKB - Q96MH7 (CE034_HUMAN)

Entry version 114 (12 Aug 2020)
Sequence version 2 (28 Jun 2011)
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Protein

Uncharacterized protein C5orf34

Gene

C5orf34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96MH7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C5orf34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C5orf34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000172244.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:24738, C5orf34

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96MH7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		375444

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162380068

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96MH7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C5orf34

Domain mapping of disease mutations (DMDM)

More...DMDMi		338817858

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002958971 – 638Uncharacterized protein C5orf34Add BLAST638

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96MH7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96MH7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96MH7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96MH7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96MH7

PeptideAtlas

More...PeptideAtlasi		Q96MH7

PRoteomics IDEntifications database

More...PRIDEi		Q96MH7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		77360

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96MH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96MH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172244, Expressed in secondary oocyte and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96MH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96MH7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172244, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131979, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q96MH7, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303490

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96MH7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSYT, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029198_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96MH7

Database of Orthologous Groups

More...OrthoDBi		833549at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96MH7

TreeFam database of animal gene trees

More...TreeFami		TF328443

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027865, DUF4520
IPR027830, DUF4524

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15016, DUF4520, 1 hit
PF15025, DUF4524, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96MH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAELRMILY EDDSVQVQYV DGSTLQLSPC GTEFLFEKSP PVSAHPLEQP 
        60         70         80         90        100
ERIRQRTHFV ISTYREQLQR ALDFRNSSAT CPFLSETIIP SERKKHIFID 
       110        120        130        140        150
ITEVRWPSLD TDGTMIYMES GIVKITSLDG HAYLCLPRSQ HEFTVHFLCK 
       160        170        180        190        200
VSQKSDSSAV LSETNNKAPK DKLVEKTGKI CIRGNLPGQR LKNKENEFHC 
       210        220        230        240        250
QIMKSKETLK KMSCVNGTEG REELPSPGTK HTCVYTWVKQ CWSVAACPEE 
       260        270        280        290        300
WKYPLSLALH FHNKISNMSK IDAHITQSRF LTSDISEERG KVVSVLPRAL 
       310        320        330        340        350
SLSCPVPHLH RWNFCDSLLQ RQSDEYSYPE LVKMVWYKGV TYRLTHQNMN 
       360        370        380        390        400
SIEIYSGDGS VFKSEGAYFG NYFTYYSIQE GSGKREEKTY SVNNLPPDRP 
       410        420        430        440        450
GSPFTVGSLI KQATRILQHC VKMRLSLSHN YRICCWKMVP GINDSNILPL 
       460        470        480        490        500
VLKESLIPSV GRFLAYSDDK VHAIFLDGIT LTLNWNFSSP IEKRQVNQGL 
       510        520        530        540        550
NLGWCKLTFP DGQEQLIQIE HPEPYERYVT TVTSWCRRLT QTSPREMPTH 
       560        570        580        590        600
SSSSVLQENW SVASELEKIQ KFNLLLENSG ILNQISNKKN EQQSFDHYKP 
       610        620        630 
GSSETLLGEV NENRVSIALK KTSEILHDID CLLSNSKK
Length:638
Mass (Da):72,898
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F5C27973D136105
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBC3E9PBC3_HUMAN
Uncharacterized protein C5orf34
C5orf34
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAD0H0YAD0_HUMAN
Uncharacterized protein C5orf34
C5orf34
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06158932T → S2 PublicationsCorresponds to variant dbSNP:rs6872851Ensembl.1
Natural variantiVAR_035618266S → R in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056925 mRNA Translation: BAB71311.1
AC025457 Genomic DNA No translation available.
AC114956 Genomic DNA No translation available.
BC036867 mRNA Translation: AAH36867.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3946.1

NCBI Reference Sequences

More...RefSeqi		NP_940968.1, NM_198566.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306862; ENSP00000303490; ENSG00000172244

Database of genes from NCBI RefSeq genomes

More...GeneIDi		375444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:375444

UCSC genome browser

More...UCSCi		uc003jnz.3, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056925 mRNA Translation: BAB71311.1
AC025457 Genomic DNA No translation available.
AC114956 Genomic DNA No translation available.
BC036867 mRNA Translation: AAH36867.1
CCDSiCCDS3946.1
RefSeqiNP_940968.1, NM_198566.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131979, 14 interactors
IntActiQ96MH7, 14 interactors
STRINGi9606.ENSP00000303490

PTM databases

iPTMnetiQ96MH7
PhosphoSitePlusiQ96MH7

Polymorphism and mutation databases

BioMutaiC5orf34
DMDMi338817858

Proteomic databases

EPDiQ96MH7
jPOSTiQ96MH7
MassIVEiQ96MH7
MaxQBiQ96MH7
PaxDbiQ96MH7
PeptideAtlasiQ96MH7
PRIDEiQ96MH7
ProteomicsDBi77360

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50296, 22 antibodies

Genome annotation databases

EnsembliENST00000306862; ENSP00000303490; ENSG00000172244
GeneIDi375444
KEGGihsa:375444
UCSCiuc003jnz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		375444
DisGeNETi375444
EuPathDBiHostDB:ENSG00000172244.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		C5orf34
HGNCiHGNC:24738, C5orf34
HPAiENSG00000172244, Low tissue specificity
neXtProtiNX_Q96MH7
PharmGKBiPA162380068

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSYT, Eukaryota
HOGENOMiCLU_029198_0_0_1
InParanoidiQ96MH7
OrthoDBi833549at2759
PhylomeDBiQ96MH7
TreeFamiTF328443

Enzyme and pathway databases

PathwayCommonsiQ96MH7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		375444, 2 hits in 858 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C5orf34, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		375444
PharosiQ96MH7, Tdark

Protein Ontology

More...PROi		PR:Q96MH7
RNActiQ96MH7, protein

Gene expression databases

BgeeiENSG00000172244, Expressed in secondary oocyte and 153 other tissues
ExpressionAtlasiQ96MH7, baseline and differential
GenevisibleiQ96MH7, HS

Family and domain databases

InterProiView protein in InterPro
IPR027865, DUF4520
IPR027830, DUF4524
PfamiView protein in Pfam
PF15016, DUF4520, 1 hit
PF15025, DUF4524, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE034_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 28, 2011
Last modified: August 12, 2020
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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