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Protein

Protein HEXIM2

Gene

HEXIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.2 Publications

GO - Molecular functioni

  • 7SK snRNA binding Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: HGNC
  • identical protein binding Source: IntAct
  • snRNA binding Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HEXIM2
Alternative name(s):
Hexamethylene bis-acetamide-inducible protein 2
Gene namesi
Name:HEXIM2
ORF Names:L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000168517.10
HGNCiHGNC:28591 HEXIM2
MIMi615695 gene
neXtProtiNX_Q96MH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi143T → A: Loss of interaction with P-TEFb. 1 Publication1
Mutagenesisi143T → D: Loss of interaction with P-TEFb. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000168517
PharmGKBiPA142671695

Polymorphism and mutation databases

BioMutaiHEXIM2
DMDMi74732374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052671 – 286Protein HEXIM2Add BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineCombined sources1
Modified residuei32PhosphothreonineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei46PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96MH2
MaxQBiQ96MH2
PaxDbiQ96MH2
PeptideAtlasiQ96MH2
PRIDEiQ96MH2
ProteomicsDBi77356

PTM databases

iPTMnetiQ96MH2
PhosphoSitePlusiQ96MH2

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.1 Publication

Inductioni

Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000168517 Expressed in 145 organ(s), highest expression level in gastrocnemius
CleanExiHS_HEXIM2
ExpressionAtlasiQ96MH2 baseline and differential
GenevisibleiQ96MH2 HS

Organism-specific databases

HPAiHPA023323
HPA028455

Interactioni

Subunit structurei

Homooligomer and heterooligomer with HEXIM1; probably dimeric (PubMed:15713661, PubMed:15994294). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:15713661, PubMed:15713662, PubMed:15994294). Interacts with CCNT2 (PubMed:19883659).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125888, 38 interactors
IntActiQ96MH2, 51 interactors
MINTiQ96MH2
STRINGi9606.ENSP00000302276

Structurei

3D structure databases

ProteinModelPortaliQ96MH2
SMRiQ96MH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 143Interaction with P-TEFb4
Regioni226 – 286Interaction with CCNT1, HEXIM1 and HEXIM22 PublicationsAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili207 – 277Sequence analysisAdd BLAST71

Domaini

The coiled-coil domain mediates oligomerization.

Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH8I Eukaryota
ENOG4111K9Z LUCA
GeneTreeiENSGT00390000002808
HOGENOMiHOG000060338
HOVERGENiHBG107976
InParanoidiQ96MH2
KOiK15189
OMAiPCRQVEE
OrthoDBiEOG091G0Y9A
PhylomeDBiQ96MH2
TreeFamiTF336851

Family and domain databases

InterProiView protein in InterPro
IPR024872 HEXIM
IPR024876 HEXIM2
PANTHERiPTHR13469 PTHR13469, 1 hit
PTHR13469:SF3 PTHR13469:SF3, 1 hit
PfamiView protein in Pfam
PF15313 HEXIM, 1 hit
PRINTSiPR02094 HEXIMFAMILY

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96MH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMATPNQTAC NAESPVALEE AKTSGAPGSP QTPPERHDSG GSLPLTPRME
60 70 80 90 100
SHSEDEDLAG AVGGLGWNSR SPRTQSPGGC SAEAVLARKK HRRRPSKRKR
110 120 130 140 150
HWRPYLELSW AEKQQRDERQ SQRASRVREE MFAKGQPVAP YNTTQFLMND
160 170 180 190 200
RDPEEPNLDV PHGISHPGSS GESEAGDSDG RGRAHGEFQR KDFSETYERF
210 220 230 240 250
HTESLQGRSK QELVRDYLEL EKRLSQAEEE TRRLQQLQAC TGQQSCRQVE
260 270 280
ELAAEVQRLR TENQRLRQEN QMWNREGCRC DEEPGT
Length:286
Mass (Da):32,419
Last modified:December 1, 2001 - v1
Checksum:i58576D72096A8A6F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELS4K7ELS4_HUMAN
Protein HEXIM2
HEXIM2
139Annotation score:
K7EJA3K7EJA3_HUMAN
Protein HEXIM2
HEXIM2
144Annotation score:
K7ESM2K7ESM2_HUMAN
Protein HEXIM2
HEXIM2
122Annotation score:
K7EIM4K7EIM4_HUMAN
Protein HEXIM2
HEXIM2
79Annotation score:
K7ERG7K7ERG7_HUMAN
Protein HEXIM2
HEXIM2
203Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598322 mRNA Translation: AAT06733.1
AK056946 mRNA Translation: BAB71319.1
CH471178 Genomic DNA Translation: EAW51541.1
CH471178 Genomic DNA Translation: EAW51542.1
BC003531 mRNA Translation: AAH03531.1
BC012474 mRNA Translation: AAH12474.1
BC025970 mRNA Translation: AAH25970.1
CCDSiCCDS11496.1
RefSeqiNP_001290365.1, NM_001303436.1
NP_001290366.1, NM_001303437.1
NP_001290367.1, NM_001303438.1
NP_001290368.1, NM_001303439.1
NP_001290369.1, NM_001303440.1
NP_001290370.1, NM_001303441.1
NP_001290371.1, NM_001303442.1
NP_001290372.1, NM_001303443.1
NP_001290373.1, NM_001303444.1
NP_653209.1, NM_144608.2
XP_011522608.1, XM_011524306.2
XP_011522609.2, XM_011524307.2
XP_011522610.2, XM_011524308.2
XP_016879656.1, XM_017024167.1
XP_016879657.1, XM_017024168.1
XP_016879658.1, XM_017024169.1
XP_016879659.1, XM_017024170.1
UniGeneiHs.56382
Hs.594840

Genome annotation databases

EnsembliENST00000307275; ENSP00000302276; ENSG00000168517
ENST00000591576; ENSP00000465727; ENSG00000168517
ENST00000592695; ENSP00000467517; ENSG00000168517
GeneIDi124790
KEGGihsa:124790
UCSCiuc002iih.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598322 mRNA Translation: AAT06733.1
AK056946 mRNA Translation: BAB71319.1
CH471178 Genomic DNA Translation: EAW51541.1
CH471178 Genomic DNA Translation: EAW51542.1
BC003531 mRNA Translation: AAH03531.1
BC012474 mRNA Translation: AAH12474.1
BC025970 mRNA Translation: AAH25970.1
CCDSiCCDS11496.1
RefSeqiNP_001290365.1, NM_001303436.1
NP_001290366.1, NM_001303437.1
NP_001290367.1, NM_001303438.1
NP_001290368.1, NM_001303439.1
NP_001290369.1, NM_001303440.1
NP_001290370.1, NM_001303441.1
NP_001290371.1, NM_001303442.1
NP_001290372.1, NM_001303443.1
NP_001290373.1, NM_001303444.1
NP_653209.1, NM_144608.2
XP_011522608.1, XM_011524306.2
XP_011522609.2, XM_011524307.2
XP_011522610.2, XM_011524308.2
XP_016879656.1, XM_017024167.1
XP_016879657.1, XM_017024168.1
XP_016879658.1, XM_017024169.1
XP_016879659.1, XM_017024170.1
UniGeneiHs.56382
Hs.594840

3D structure databases

ProteinModelPortaliQ96MH2
SMRiQ96MH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125888, 38 interactors
IntActiQ96MH2, 51 interactors
MINTiQ96MH2
STRINGi9606.ENSP00000302276

PTM databases

iPTMnetiQ96MH2
PhosphoSitePlusiQ96MH2

Polymorphism and mutation databases

BioMutaiHEXIM2
DMDMi74732374

Proteomic databases

EPDiQ96MH2
MaxQBiQ96MH2
PaxDbiQ96MH2
PeptideAtlasiQ96MH2
PRIDEiQ96MH2
ProteomicsDBi77356

Protocols and materials databases

DNASUi124790
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307275; ENSP00000302276; ENSG00000168517
ENST00000591576; ENSP00000465727; ENSG00000168517
ENST00000592695; ENSP00000467517; ENSG00000168517
GeneIDi124790
KEGGihsa:124790
UCSCiuc002iih.2 human

Organism-specific databases

CTDi124790
EuPathDBiHostDB:ENSG00000168517.10
GeneCardsiHEXIM2
HGNCiHGNC:28591 HEXIM2
HPAiHPA023323
HPA028455
MIMi615695 gene
neXtProtiNX_Q96MH2
OpenTargetsiENSG00000168517
PharmGKBiPA142671695
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH8I Eukaryota
ENOG4111K9Z LUCA
GeneTreeiENSGT00390000002808
HOGENOMiHOG000060338
HOVERGENiHBG107976
InParanoidiQ96MH2
KOiK15189
OMAiPCRQVEE
OrthoDBiEOG091G0Y9A
PhylomeDBiQ96MH2
TreeFamiTF336851

Miscellaneous databases

ChiTaRSiHEXIM2 human
GeneWikiiHEXIM2
GenomeRNAii124790
PROiPR:Q96MH2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168517 Expressed in 145 organ(s), highest expression level in gastrocnemius
CleanExiHS_HEXIM2
ExpressionAtlasiQ96MH2 baseline and differential
GenevisibleiQ96MH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024872 HEXIM
IPR024876 HEXIM2
PANTHERiPTHR13469 PTHR13469, 1 hit
PTHR13469:SF3 PTHR13469:SF3, 1 hit
PfamiView protein in Pfam
PF15313 HEXIM, 1 hit
PRINTSiPR02094 HEXIMFAMILY
ProtoNetiSearch...

Entry informationi

Entry nameiHEXI2_HUMAN
AccessioniPrimary (citable) accession number: Q96MH2
Secondary accession number(s): D3DX66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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