STAC3

Functionⁱ

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca²⁺ release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335).

Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity).

Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335).

By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	89 – 140	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		52

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q96MF2
SignaLinkⁱ	Q96MF2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH3 and cysteine-rich domain-containing protein 3
Gene namesⁱ	Name:STAC3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28423, STAC3
MIMⁱ	615521, gene
neXtProtⁱ	NX_Q96MF2
VEuPathDBⁱ	HostDB:ENSG00000185482

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Myopathy, congenital, Bailey-Bloch (MYPBB)3 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disease characterized by congenital weakness and arthrogryposis, cleft palate, ptosis, short stature, kyphoscoliosis, talipes deformities, and susceptibility to malignant hyperthermia provoked by anesthesia.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071313	284	W → S in MYPBB; loss of interaction with CACNA1S. 3 PublicationsCorresponds to variant dbSNP:rs140291094EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	246329
GeneReviewsⁱ	STAC3
MalaCards human disease database More...MalaCardsⁱ	STAC3
MIMⁱ	255995, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000185482
Orphanetⁱ	168572, Native American myopathy
PharmGKBⁱ	PA134877600

Miscellaneous databases

Pharosⁱ	Q96MF2, Tbio

Pharosⁱ

Q96MF2, Tbio

Genetic variation databases

BioMutaⁱ	STAC3
DMDMⁱ	74732360

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000232582	1 – 364	SH3 and cysteine-rich domain-containing protein 3Add BLAST		364

Proteomic databases

jPOSTⁱ	Q96MF2
MassIVEⁱ	Q96MF2
PaxDbⁱ	Q96MF2
PeptideAtlas More...PeptideAtlasⁱ	Q96MF2
PRIDEⁱ	Q96MF2
ProteomicsDBⁱ	5195 77345 [Q96MF2-1] 77346 [Q96MF2-2]

PTM databases

iPTMnetⁱ	Q96MF2
PhosphoSitePlusⁱ	Q96MF2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185482, Expressed in skeletal muscle tissue and 158 other tissues
ExpressionAtlasⁱ	Q96MF2, baseline and differential
Genevisibleⁱ	Q96MF2, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000185482, Group enriched (skeletal muscle, tongue)

HPAⁱ

ENSG00000185482, Group enriched (skeletal muscle, tongue)

Interactionⁱ

Subunit structureⁱ

Interacts (via SH3 domains) with the calcium channels CACNA1S and CACNA1C (PubMed:29078335).

Component of a calcium channel complex with CACNA1S and CACNB1.

Component of a calcium channel complex with CACNA1C and CACNB1 (By similarity).

By similarity1 Publication

Binary interactionsⁱ

Hide details

Q96MF2

With	#Exp.	IntAct
ANKRD36 [A1A5B0]	3	EBI-745680,EBI-14100900
BAZ2B - isoform 2 [Q9UIF8-2]	3	EBI-745680,EBI-10321972
CSNK2A1 [P68400]	7	EBI-745680,EBI-347804
DDIT4L [Q96D03]	3	EBI-745680,EBI-742054
DIP2A - isoform 6 [Q14689-6]	3	EBI-745680,EBI-10233719
EAF1 [Q96JC9]	5	EBI-745680,EBI-769261
ENKD1 [Q9H0I2]	4	EBI-745680,EBI-744099
FAM124A [Q86V42]	3	EBI-745680,EBI-744506
FAM133A [Q8N9E0]	6	EBI-745680,EBI-10268158
FAM90A1 [Q86YD7]	6	EBI-745680,EBI-6658203
FAM9A [Q8IZU1]	3	EBI-745680,EBI-8468186
FGF11 [Q92914]	3	EBI-745680,EBI-11987787
FGF12 - isoform 2 [P61328-2]	3	EBI-745680,EBI-10699759
GAS8 [O95995]	3	EBI-745680,EBI-1052570
GIGYF1 [O75420]	3	EBI-745680,EBI-947774
GRB7 - isoform 3 [Q14451-3]	3	EBI-745680,EBI-11991632
HMGXB4 [Q9UGU5]	3	EBI-745680,EBI-7261162
INO80B [Q9C086]	3	EBI-745680,EBI-715611
L3MBTL2 [Q969R5]	6	EBI-745680,EBI-739909
MAB21L3 [Q8N8X9]	7	EBI-745680,EBI-10268010
MFAP1 [P55081]	3	EBI-745680,EBI-1048159
MMTAG2 [Q9BU76]	5	EBI-745680,EBI-742459
NKAPD1 [Q6ZUT1]	6	EBI-745680,EBI-3920396
NKAPD1 - isoform 2 [Q6ZUT1-2]	3	EBI-745680,EBI-10180231
PMP22 [D3DTS7]	3	EBI-745680,EBI-25882629
RPL22 [P35268]	3	EBI-745680,EBI-354533
RPL9P9 [P32969]	3	EBI-745680,EBI-358122
RPS25 [P62851]	3	EBI-745680,EBI-353054
SOD1 [P00441]	3	EBI-745680,EBI-990792
SPANXN2 [Q5MJ10]	3	EBI-745680,EBI-12023934
SPANXN3 [Q5MJ09]	3	EBI-745680,EBI-12037215
SREK1IP1 [Q8N9Q2]	6	EBI-745680,EBI-10268630
itself	6	EBI-745680,EBI-745680
TCEA2 [Q15560]	3	EBI-745680,EBI-710310
TNFAIP8L1 [Q8WVP5]	3	EBI-745680,EBI-752102
U2AF2 - isoform 2 [P26368-2]	3	EBI-745680,EBI-11097439
VCX2 [Q3SXR9]	3	EBI-745680,EBI-11983741
ZCCHC10 [Q8TBK6]	7	EBI-745680,EBI-597063
ZGPAT [Q8N5A5]	3	EBI-745680,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]	3	EBI-745680,EBI-10183064

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	128899, 45 interactors
IntActⁱ	Q96MF2, 44 interactors
Molecular INTeraction database More...MINTⁱ	Q96MF2
STRINGⁱ	9606.ENSP00000329200

Miscellaneous databases

RNActⁱ	Q96MF2, protein

RNActⁱ

Q96MF2, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	87 – 89	Combined sources	3
Beta strandⁱ	92 – 96	Combined sources	5
Beta strandⁱ	104 – 106	Combined sources	3
Helixⁱ	112 – 115	Combined sources	4
Beta strandⁱ	116 – 123	Combined sources	8
Turnⁱ	129 – 132	Combined sources	4
Helixⁱ	133 – 135	Combined sources	3
Beta strandⁱ	136 – 139	Combined sources	4
Beta strandⁱ	249 – 254	Combined sources	6
Beta strandⁱ	273 – 278	Combined sources	6
Beta strandⁱ	281 – 283	Combined sources	3
Beta strandⁱ	285 – 289	Combined sources	5
Beta strandⁱ	292 – 296	Combined sources	5
Helixⁱ	298 – 300	Combined sources	3
Beta strandⁱ	301 – 305	Combined sources	5
Beta strandⁱ	310 – 313	Combined sources	4
Helixⁱ	321 – 323	Combined sources	3
Beta strandⁱ	333 – 341	Combined sources	9
Beta strandⁱ	344 – 348	Combined sources	5
Beta strandⁱ	353 – 357	Combined sources	5
Helixⁱ	358 – 360	Combined sources	3
Beta strandⁱ	361 – 364	Combined sources	4

Show more details

3D structure databases

AlphaFoldDBⁱ	Q96MF2
SMRⁱ	Q96MF2
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96MF2

EvolutionaryTraceⁱ

Q96MF2

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	247 – 306	SH3 1PROSITE-ProRule annotationAdd BLAST		60
Domainⁱ	307 – 364	SH3 2PROSITE-ProRule annotationAdd BLAST		58

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 89	DisorderedSequence analysisAdd BLAST		89
Regionⁱ	189 – 244	DisorderedSequence analysisAdd BLAST		56

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	14 – 31	Polar residuesSequence analysisAdd BLAST		18
Compositional biasⁱ	63 – 78	Acidic residuesSequence analysisAdd BLAST		16

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	89 – 140	Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST		52

Keywords - Domainⁱ

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG502QT6I, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000183092
HOGENOMⁱ	CLU_048120_1_1_1
InParanoidⁱ	Q96MF2
OMAⁱ	DQQYACV
PhylomeDBⁱ	Q96MF2
TreeFamⁱ	TF332878

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029, C1, 1 hit cd11986, SH3_Stac3_1, 1 hit
InterProⁱ	View protein in InterPro IPR046349, C1-like_sf IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR039688, STAC1/2/3 IPR035736, Stac3_SH3_1
PANTHERⁱ	PTHR15135, PTHR15135, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130, C1_1, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit
PRINTSⁱ	PR00452, SH3DOMAIN
SMARTⁱ	View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 2 hits
SUPFAMⁱ	SSF50044, SSF50044, 2 hits SSF57889, SSF57889, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96MF2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG 
        60         70         80         90        100
EAVGAGGGPI YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP 
       110        120        130        140        150
KFCDVCARMI VLNNKFGLRC KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR 
       160        170        180        190        200
AYSSPLYSNQ QYACVKDLSA ANRNDPVFET LRTGVIMANK ERKKGQADKK 
       210        220        230        240        250
NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK HKQPGFQQSH 
       260        270        280        290        300
YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF 
       310        320        330        340        350
IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG 
       360 
RKVGLFPTDF LEEI

Length:364

Mass (Da):41,507

Last modified:December 1, 2001 - v1

Checksum:ⁱ9464C4F035FEDB98

GO

Isoform 2 (identifier: Q96MF2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-39: Missing.

« Hide

        10         20         30         40         50
MELPPEPQAN GEAVGAGGGP IYYIYEEEEE EEEEEEEPPP EPPKLVNDKP 
        60         70         80         90        100
HKFKDHFFKK PKFCDVCARM IVLNNKFGLR CKNCKTNIHE HCQSYVEMQR 
       110        120        130        140        150
CFGKIPPGFH RAYSSPLYSN QQYACVKDLS AANRNDPVFE TLRTGVIMAN 
       160        170        180        190        200
KERKKGQADK KNPVAAMMEE EPESARPEEG KPQDGNPEGD KKAEKKTPDD 
       210        220        230        240        250
KHKQPGFQQS HYFVALYRFK ALEKDDLDFP PGEKITVIDD SNEEWWRGKI 
       260        270        280        290        300
GEKVGFFPPN FIIRVRAGER VHRVTRSFVG NREIGQITLK KDQIVVQKGD 
       310        320 
EAGGYVKVYT GRKVGLFPTD FLEEI

Show »

Length:325

Mass (Da):37,138

Checksum:ⁱ89A5DB6F1CD2022F

GO

Isoform 3 (identifier: Q96MF2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-186: Missing.

« Hide

        10         20         30         40         50
MANKERKKGQ ADKKNPVAAM MEEEPESARP EEGKPQDGNP EGDKKAEKKT 
        60         70         80         90        100
PDDKHKQPGF QQSHYFVALY RFKALEKDDL DFPPGEKITV IDDSNEEWWR 
       110        120        130        140        150
GKIGEKVGFF PPNFIIRVRA GERVHRVTRS FVGNREIGQI TLKKDQIVVQ 
       160        170 
KGDEAGGYVK VYTGRKVGLF PTDFLEEI

Show »

Length:178

Mass (Da):20,304

Checksum:ⁱ185FF8AD4BE8CB38

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V5D4	G3V5D4_HUMAN	SH3 and cysteine-rich domain-contai... SH3 and cysteine-rich domain-containing protein 3	STAC3	168	Annotation score:
G3V2L9	G3V2L9_HUMAN	SH3 and cysteine-rich domain-contai... SH3 and cysteine-rich domain-containing protein 3	STAC3	104	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071313	284	W → S in MYPBB; loss of interaction with CACNA1S. 3 PublicationsCorresponds to variant dbSNP:rs140291094EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055272	1 – 186	Missing in isoform 3. 1 PublicationAdd BLAST		186
Alternative sequenceⁱVSP_017914	1 – 39	Missing in isoform 2. 1 PublicationAdd BLAST		39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057013 mRNA Translation: BAB71343.1 AK300688 mRNA Translation: BAG62371.1 AC137834 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97005.1 BC008069 mRNA Translation: AAH08069.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS66405.1 [Q96MF2-3] CCDS66406.1 [Q96MF2-2] CCDS8936.1 [Q96MF2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273185.1, NM_001286256.1 [Q96MF2-2] NP_001273186.1, NM_001286257.1 [Q96MF2-3] NP_659501.1, NM_145064.2 [Q96MF2-1] XP_011536428.1, XM_011538126.2 [Q96MF2-1]

Genome annotation databases

Ensemblⁱ	ENST00000332782.7; ENSP00000329200.2; ENSG00000185482.8 ENST00000546246.2; ENSP00000441515.2; ENSG00000185482.8 [Q96MF2-3] ENST00000554578.5; ENSP00000452068.1; ENSG00000185482.8 [Q96MF2-2]
GeneIDⁱ	246329
KEGGⁱ	hsa:246329
MANE-Selectⁱ	ENST00000332782.7; ENSP00000329200.2; NM_145064.3; NP_659501.1
UCSC genome browser More...UCSCⁱ	uc001snp.4, human [Q96MF2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96MF2	SH3 and cysteine rich domain 3, isoform CRA_a		HUMAN		364	UniRef100_Q96MF2
Isoform 2 of SH3 and cysteine-rich domain-containing protein 3		HUMAN		325
SH3 and cysteine-rich domain-containing protein 3 (Fragment)		HUMAN		168
Isoform 3 of SH3 and cysteine-rich domain-containing protein 3		HUMAN		178

Protein	Similar proteins		Species	Score	Length	Source
Q96MF2	SH3 and cysteine rich domain 3, isoform CRA_a		HUMAN		364	UniRef90_Q96MF2
SH3 and cysteine-rich domain-containing protein 3 isoform X1		Florida manatee		377
Uncharacterized protein		CHLSB		364
SH3 and cysteine rich domain 3		Ugandan red Colobus		364
Uncharacterized protein		RHIRO		364
+65

Protein	Similar proteins		Species	Score	Length	Source
Q96MF2	SH3 and cysteine rich domain 3, isoform CRA_a		HUMAN		364	UniRef50_Q96MF2
SH3 and cysteine-rich domain-containing protein 3 isoform X1		Florida manatee		377
SH3 and cysteine rich domain 3		GORGO		364
SH3 and cysteine rich domain 3		MANLE		364
SH3 and cysteine rich domain 3		THEGE		364
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057013 mRNA Translation: BAB71343.1 AK300688 mRNA Translation: BAG62371.1 AC137834 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97005.1 BC008069 mRNA Translation: AAH08069.1
CCDSⁱ	CCDS66405.1 [Q96MF2-3] CCDS66406.1 [Q96MF2-2] CCDS8936.1 [Q96MF2-1]
RefSeqⁱ	NP_001273185.1, NM_001286256.1 [Q96MF2-2] NP_001273186.1, NM_001286257.1 [Q96MF2-3] NP_659501.1, NM_145064.2 [Q96MF2-1] XP_011536428.1, XM_011538126.2 [Q96MF2-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DB6	NMR	-	A	80-140	[»]
	6B29	X-ray	1.30	A/B/C/D	309-364	[»]
	6UY7	X-ray	2.10	A	245-364	[»]
	6UY8	X-ray	1.65	A/B	245-364	[»]
	6UY9	X-ray	1.60	A	245-364	[»]
AlphaFoldDBⁱ	Q96MF2
SMRⁱ	Q96MF2
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	128899, 45 interactors
IntActⁱ	Q96MF2, 44 interactors
MINTⁱ	Q96MF2
STRINGⁱ	9606.ENSP00000329200

PTM databases

iPTMnetⁱ	Q96MF2
PhosphoSitePlusⁱ	Q96MF2

Genetic variation databases

BioMutaⁱ	STAC3
DMDMⁱ	74732360

Proteomic databases

jPOSTⁱ	Q96MF2
MassIVEⁱ	Q96MF2
PaxDbⁱ	Q96MF2
PeptideAtlasⁱ	Q96MF2
PRIDEⁱ	Q96MF2
ProteomicsDBⁱ	5195 77345 [Q96MF2-1] 77346 [Q96MF2-2]

Protocols and materials databases

Antibodypediaⁱ	28547, 88 antibodies from 24 providers
The DNASU plasmid repository More...DNASUⁱ	246329

Genome annotation databases

Ensemblⁱ	ENST00000332782.7; ENSP00000329200.2; ENSG00000185482.8 ENST00000546246.2; ENSP00000441515.2; ENSG00000185482.8 [Q96MF2-3] ENST00000554578.5; ENSP00000452068.1; ENSG00000185482.8 [Q96MF2-2]
GeneIDⁱ	246329
KEGGⁱ	hsa:246329
MANE-Selectⁱ	ENST00000332782.7; ENSP00000329200.2; NM_145064.3; NP_659501.1
UCSCⁱ	uc001snp.4, human [Q96MF2-1]

Organism-specific databases

CTDⁱ	246329
DisGeNETⁱ	246329
GeneCardsⁱ	STAC3
GeneReviewsⁱ	STAC3
HGNCⁱ	HGNC:28423, STAC3
HPAⁱ	ENSG00000185482, Group enriched (skeletal muscle, tongue)
MalaCardsⁱ	STAC3
MIMⁱ	255995, phenotype 615521, gene
neXtProtⁱ	NX_Q96MF2
OpenTargetsⁱ	ENSG00000185482
Orphanetⁱ	168572, Native American myopathy
PharmGKBⁱ	PA134877600
VEuPathDBⁱ	HostDB:ENSG00000185482
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QT6I, Eukaryota
GeneTreeⁱ	ENSGT00950000183092
HOGENOMⁱ	CLU_048120_1_1_1
InParanoidⁱ	Q96MF2
OMAⁱ	DQQYACV
PhylomeDBⁱ	Q96MF2
TreeFamⁱ	TF332878

Enzyme and pathway databases

PathwayCommonsⁱ	Q96MF2
SignaLinkⁱ	Q96MF2

Miscellaneous databases

BioGRID-ORCSⁱ	246329, 17 hits in 1069 CRISPR screens
EvolutionaryTraceⁱ	Q96MF2
GenomeRNAiⁱ	246329
Pharosⁱ	Q96MF2, Tbio
Protein Ontology More...PROⁱ	PR:Q96MF2
RNActⁱ	Q96MF2, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185482, Expressed in skeletal muscle tissue and 158 other tissues
ExpressionAtlasⁱ	Q96MF2, baseline and differential
Genevisibleⁱ	Q96MF2, HS

Family and domain databases

CDDⁱ	cd00029, C1, 1 hit cd11986, SH3_Stac3_1, 1 hit
InterProⁱ	View protein in InterPro IPR046349, C1-like_sf IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR039688, STAC1/2/3 IPR035736, Stac3_SH3_1
PANTHERⁱ	PTHR15135, PTHR15135, 1 hit
Pfamⁱ	View protein in Pfam PF00130, C1_1, 1 hit PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit
PRINTSⁱ	PR00452, SH3DOMAIN
SMARTⁱ	View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 2 hits
SUPFAMⁱ	SSF50044, SSF50044, 2 hits SSF57889, SSF57889, 1 hit
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STAC3_HUMAN
Accessionⁱ	Q96MF2Primary (citable) accession number: Q96MF2 Secondary accession number(s): B4DUK9, Q96HU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	December 1, 2001
	Last modified:	May 25, 2022
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96MF2 (STAC3_HUMAN)

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SH3 and cysteine-rich domain-containing protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Plasma membrane

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Cytosol

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Genetic variation databases

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Molecule processing

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PTM databases

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Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96MF2

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Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

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Domains and Repeats

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Zinc finger

Keywords - Domaini

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Keywords - Coding sequence diversityi

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Sequence databases

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Protocols and materials databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ